Water has its own taste, color, smell and constituents. Not all water can be used for all purposes. Eg. Sea water can not be used by us for drinking. The suitability of water for different purposes is determined by its quality parameters. The Quality of water is equally important than quantity. Even if present in huge amounts, we can not use salt water in many life support activities. Water has its own Physical properties, Chemical composition and Biological Properties. This module highlights the water quality parameters that are essential.
This presentation describes, how the water can be analyzed using the basic parameters like DO, COD, BOD, Alkalinity and so on. The physical, chemical, and biological parameters were discussed here.
Here you will find brief description about water sampling. actually it's so important to examine the water we use our daily life in order to avoid negative impact of water.
wholesomeness, Requirements for Domestic Use. Impurities in Water. Objects & purpose of Water Analysis.Collection of Samples. Classification of Analysis of Water: Physical,
Chemical & Biological Examination of Water.
This presentation describes, how the water can be analyzed using the basic parameters like DO, COD, BOD, Alkalinity and so on. The physical, chemical, and biological parameters were discussed here.
Here you will find brief description about water sampling. actually it's so important to examine the water we use our daily life in order to avoid negative impact of water.
wholesomeness, Requirements for Domestic Use. Impurities in Water. Objects & purpose of Water Analysis.Collection of Samples. Classification of Analysis of Water: Physical,
Chemical & Biological Examination of Water.
Water quality is one of the most important factors in a healthy ecosystem. Clean water supports a diversity of plants and animals.
The quality of the water you consume or use in municipal or industrial processes must meet specific parameters to ensure that drinking water remains free from contaminants that could cause health issues.
Water quality measurements include physical, chemical, and biological parameters.
Quality of water :
It includes all the physical, chemical and biological parameters along with test to be used for defining water quality and water schemes for city
Over the last decade, demand for spring management has increased as traditional spring sources have started drying up or becoming contaminated. In response, communities, NGOs and state agencies began dedicated spring protection programmes. In the Himalayas, the State of Sikkim and organizations such as Central Himalayan Action and Research Group (CHIRAG) and People Science Institute (PSI) started identifying and protecting spring recharge areas around 2007. The difference between these programmes and many other previous efforts is that they went beyond supply-side improvements to focus on the use of hydrogeology to map springsheds for targeted interventions.
The Advanced Centre for Water Resources Development and Management (ACWADAM), a research and capacity-building organization comprised of hydrogeologists and other experts began lending their expertise and building capacity of stakeholders. ACWADAM provides technical support, training and materials in hydrogeology to all network partners as well as others in India and the region. Similar programmes began independently in most of the mountain regions of India. Arghyam, a funding organization that was supporting many of these programmes, noticed that these disparate initiatives shared commonalities despite geographic diversity. They thus organized and funded a meeting of these various organizations in June 2014, and the Springs Initiative was born.
The springs initiative aims to tackle the current water crisis and to ensure safe and sustainable access to water for all, by promoting responsible and appropriate management of aquifers, springsheds, and watersheds and conserving ecosystems in partnership with communities, governments and other stakeholders.
This presentation has been developed as a part of the springs initiative to promote an understanding of springs and their role in mountainous areas.
This Presentation Clarifying about potable Water analysis and their methods which i gave training on operation and maintenance team for Oman Al Ghubrah Independence Water Project (SWRO Desalination 42 MIGD)
Sedimentation is the tendency for particles in suspension to settle out of the fluid in which they are entrained and come to rest against a barrier. This is due to their motion through the fluid in response to the forces acting on them: these forces can be due to gravity, centrifugal acceleration, or electromagnetism.
COMPARATIVE ANALYSIS OF WATER QUALITY IN TAMIRABARANI RIVER ENCROACHED BY WAT...Jenson Samraj
This dissertation explains the analysis of water quality in which the Eichhornia crassipes lives further from many different samples the water was analyzed by my friend Mr. Esakki Raja
This presentation deals with the recent advancement in the field of ground water sampling and analysis technique and water born survey as well as Indian scenario to interpret.
Urban Land Cover Change Detection Analysis and Modelling Spatio-Temporal Grow...Bayes Ahmed
This is my final Mater thesis presentation. The thesis defense was held on March' 07, 2011 at 15:30 in the seminar room of Universitat Jaume I (UJI), Castellón, Spain.
Water quality is one of the most important factors in a healthy ecosystem. Clean water supports a diversity of plants and animals.
The quality of the water you consume or use in municipal or industrial processes must meet specific parameters to ensure that drinking water remains free from contaminants that could cause health issues.
Water quality measurements include physical, chemical, and biological parameters.
Quality of water :
It includes all the physical, chemical and biological parameters along with test to be used for defining water quality and water schemes for city
Over the last decade, demand for spring management has increased as traditional spring sources have started drying up or becoming contaminated. In response, communities, NGOs and state agencies began dedicated spring protection programmes. In the Himalayas, the State of Sikkim and organizations such as Central Himalayan Action and Research Group (CHIRAG) and People Science Institute (PSI) started identifying and protecting spring recharge areas around 2007. The difference between these programmes and many other previous efforts is that they went beyond supply-side improvements to focus on the use of hydrogeology to map springsheds for targeted interventions.
The Advanced Centre for Water Resources Development and Management (ACWADAM), a research and capacity-building organization comprised of hydrogeologists and other experts began lending their expertise and building capacity of stakeholders. ACWADAM provides technical support, training and materials in hydrogeology to all network partners as well as others in India and the region. Similar programmes began independently in most of the mountain regions of India. Arghyam, a funding organization that was supporting many of these programmes, noticed that these disparate initiatives shared commonalities despite geographic diversity. They thus organized and funded a meeting of these various organizations in June 2014, and the Springs Initiative was born.
The springs initiative aims to tackle the current water crisis and to ensure safe and sustainable access to water for all, by promoting responsible and appropriate management of aquifers, springsheds, and watersheds and conserving ecosystems in partnership with communities, governments and other stakeholders.
This presentation has been developed as a part of the springs initiative to promote an understanding of springs and their role in mountainous areas.
This Presentation Clarifying about potable Water analysis and their methods which i gave training on operation and maintenance team for Oman Al Ghubrah Independence Water Project (SWRO Desalination 42 MIGD)
Sedimentation is the tendency for particles in suspension to settle out of the fluid in which they are entrained and come to rest against a barrier. This is due to their motion through the fluid in response to the forces acting on them: these forces can be due to gravity, centrifugal acceleration, or electromagnetism.
COMPARATIVE ANALYSIS OF WATER QUALITY IN TAMIRABARANI RIVER ENCROACHED BY WAT...Jenson Samraj
This dissertation explains the analysis of water quality in which the Eichhornia crassipes lives further from many different samples the water was analyzed by my friend Mr. Esakki Raja
This presentation deals with the recent advancement in the field of ground water sampling and analysis technique and water born survey as well as Indian scenario to interpret.
Urban Land Cover Change Detection Analysis and Modelling Spatio-Temporal Grow...Bayes Ahmed
This is my final Mater thesis presentation. The thesis defense was held on March' 07, 2011 at 15:30 in the seminar room of Universitat Jaume I (UJI), Castellón, Spain.
This is presentation is intended for middle school students. It provides a short introduction to GIS and how to use GIS in the real-world.
ArcGIS Explorer is the software used to demonstrate concepts.
45 minutes + 15 minutes demo
Download ArcGIS Explorer here...
http://www.esri.com/software/arcgis/explorer/
Solvent properties of water; principles of physico-chemical analysis, major ionic components of natural water. Chemistry of natural waters, water quality requirements, standards for potable water, irrigation and livestock. Types of water, lithological control of surface and ground water
In this report we have analyzed different water samples of major areas of Dhaka city. Then we have analyzed the Mineral water Samples and some soft drinks of different brands. From the areas we have gone through almost 300 samples and tried to find out the best possible drinking water from a particular area. After analyzing the samples within area, we made a throughout analysis on the areas. Also we have found out that water qualities vary from area to area. For drinking water we found out that filtered water is the best option. Moreover, we analyzed the mineral water samples and found out some best possible options and analyzed the soft drinks too.
Water is one of the most important substances on earth. We already know another name of water is life. We human beings, all plants and animals must need water to survive. If there was no water there would be no life on earth. Apart from drinking it to survive, people have many other uses for water. It is used in both household and industrial purposes. Water is also essential for the healthy growth of farm crops and farm stock and is used in the manufacture of many products. But in our country Bangladesh, water pollution is one of the most significant dangers to general wellbeing. Especially water turns into curse for the city dwellers in Dhaka. Water pollution is common throughout our country but in Dhaka, it has presented itself as a very serious problem. A city which has nearly 20 million inhabitants, Dhaka faces challenges for inadequate sanitation, polluted rivers, and chemical outpouring from the surrounding industries, faulty sewage management etc. Most of these are resulting from the unplanned nature of urbanization. Also the people are not aware of that situation for that reason different health hazards like diarrhea, typhoid, dysentery, colon, kidney problems and many other health concerns are a direct result of city-wide water pollution. However, the quality of the mineral water samples of all brands is not standard and drinkable at all. The scenario for soft drinks is even worse.
To find out the current situation of water quality and to know more about water variation in different areas, we collected different samples of water from the different areas of Dhaka city under the ENV107 Lab. Here in this report we will present the water quality of Dhaka city.
An explanation of water basics, designed to facilitate an understanding of typical water contaminants. This presentation will be very helpful for those interested in water filtration.
E-content is a Comprehensive package of teaching material put into hypermedia format. Hypermedia is multimedia with internet deplorability. E-content can not be created by a teaching faculty alone . It needs the role of teacher, Video editor, production assistants, web developers (HTML 5 or Adobe captivate, etc). Analyze the learner needs and goals of the instructional material development, development of a delivery system and content, pilot study of the material developed, implementation, evaluating, refining the materials etc. In designing and development of E-content we have to adopt one of the instructional design models based on our requirements.
Pedagogy is the most commonly understood approach to teaching. It refers to the theory and practice of learning. Pedagogy is often described as the act of teaching. Pedagogy has little variations between traditional teaching and online teaching. Online teaching pedagogy is a method of effective teaching practice specifically developed for teaching via the internet. It has a set of prescribed methods, strategies, and practices for teaching academic subjects in an online (or blended) environment, where students are in a physical location separate from the faculty member.
Technology has changed the possibilities within teaching and learning. Classes, which prior to the digital era were restricted to lectures, talks, and physical objects, no longer have to be designed in that manner. Training in a synchronous virtual classroom can only be successful with the active participation and engagement of the learners. Explore the Virtual Classroom’s features and see how they can support and enhance your tutoring style.
• The monitoring and evaluation of the institutional processes require a carefully structured system of internal and external review. The NAAC expects the Institutions to undertake continuous Academic and Administrative Audits (AAA). This presentation is intended to serve as advisory to all accredited HEIs who volunteer to undertake AAA. The pros and cons of this process are also highlighted. Academic and Administrative Audit is the process of evaluating the efficiency and effectiveness of the administrative procedure. It includes assessment of policies, strategies & functions of the various administrative departments, control of the overall administrative system, etc. This checklist gives an overview what the audit committee members may look into while visiting an institution for this purpose. It invariably follows the Quality Indicators Framework prescribed by Accreditation Council in India.
• The monitoring and evaluation of the institutional processes require a carefully structured system of internal and external review. The NAAC expects the Institutions to undertake continuous Academic and Administrative Audits (AAA). This presentation is intended to serve as advisory to all accredited HEIs who volunteer to undertake AAA.
Chemical analysis data of water samples can not be used directly for understanding. They are to be used for various calculations in order to determine the quality parameters that have a lot of significances. A. Balasubramanian and D. Nagaraju, of the Department of Studies in Earth Science, Centre for Advanced Studies, University of Mysore, Mysore-570006, Karnataka, India have recently brought out a software and its application manual as a good book for reference and execution. The Name of the software is WATCHIT meaning Water Chemistry Interpretation Techniques. This software computes more than 100 parameters pertaining to water quality interpretations. The software follows its own method of approach to determine the required results. Systems International Units are used. Limited input parameters are required. This is suitable for all scientific research, government water quality data interpretations and for understanding the quality of water before using it.
Water conservation refers to reducing the usage of water and recycling of waste water for different purposes like domestic usage, industries, agriculture etc. This technical article highlights most of the popular methods of water conservation. A special note on rainwater harvesting is also provided.
This module gives an overview of general applications of current hydrogeological aspects. It is for the basic understanding of students and research scholars.
Climate Extreme (extreme weather or climate event) refers to the occurrence of a value of a weather or climate variable above (or below) a threshold value near the upper (or lower) ends of the range of observed values of the variable. Extreme weather and climate events, interacting with exposed and vulnerable human and natural systems, can lead to disasters.
WATER RESOURCES PLANNING AND MANAGEMENT POSSIBILITIES IN CHAMARAJANAGAR TALUK...Prof. A.Balasubramanian
Any unplanned development and utilization of water resources with result in water scarcity. In many parts of the developing world. Such a situation exists. In order to do proper planning and
management of water resources, it is necessary to conduct detailed analyses of the factors, which influence the water availability and its uses. In the present study, a comprehensive analysis have been undertaken for proper utilization of water resources in Chamarajanagar Taluk, which has been identified as one of the drought hit districts of Karnataka, in India. The factors analysed in this work are, surface and groundwater availability, land use, cropping pattern, recharge potential of soils and the rainfall pattern in typical areas of Taluk. It is observed that the problem of water scarcity is mainly due to the lack of irrigation planning and management. Hence, a
modified cropping pattern is suggested by taking into consideration of all available water resources and other conditions.
In broad terms, cultural geography examines the cultural values, practices, discursive and material expressions and artefacts of people, the cultural diversity and plurality of society.
It also emphasizes on how cultures are distributed over space, how places and identities are produced, how people make sense of places and build senses of place, and how people produce and communicate knowledge and meaning.
Minerals are formed by changes in chemical energy in systems which contain one fluid or vapor phase. In nature, minerals are formed by crystallisation or precipitation from concentrated solutions. These solutions are called as ore-bearing fluids. Ore-bearing fluids are characterised by high concentration of certain metallic or other elements.
Fluids are the most effective agents for the transport of material in the mantle and the Earth's crust.
Soils are complex mixers forming the skin of the earth's surface. Soil is a dynamic layer in which many complex chemical, physical and biological activities are going on constantly. Soils become adjusted to conditions of climate, landform and vegetation, and will change internally when those controlling conditions change. Soils are products of weathering. Soils play a dominant role in earth's geomorphic processes in a cyclic manner. The characteristics of soils are very essential for several reasons. This module highlights these characteristics.
GIS TECHNIQUES IN WATER RESOURCES PLANNING AND MANAGEMENT IN CHAMARAJANAGAR ...Prof. A.Balasubramanian
The over-exploitation and contamination of groundwater continue to threaten the long-term sustainability of our precious water resources, in spite of the best efforts made by various agencies.
This has many serious implications to the economic development of a country like India. Lack of
judicious planning and integration of environmental consideration to ground water development
projects are primarily responsible for such a state of affair in the ground water sector. Geographical Information Systems could be of immense help in planning sustainable ground water management strategies, especially in hard rock areas with limited ground water potential. Data collected from
Satellite Imagery and through field investigations have been integrated, on a GIS platform, for demarcation and prioritization of areas suitable for ground water development and ground water augmentation. An attempt has also been made to assess the vulnerability of the area to ground water
contamination. This paper demonstrates the utility of GIS in planning judicious management of ground water resources in a typical hard rock area of Chamarajanagar Taluk, Karnataka, state India.
Nanobiomaterials are very effective components for several biomedical and pharmaceutical studies. Among the metallic, organic, ceramic and polymeric nanomaterials, metallic nanomaterials have shown certain prominent biomedical applications. Enormous works have been done to synthesize, analyse and administer the metallic nanoparticles for various kinds of medical and therapeutic applications, during the last forty years. In these analyses, the prominent biomedical applications of ten metallic nanobiomaterials have been reviewed from various sources and works. It has been found that almost nine of them are used in a very wide spectrum of medical and theranostic applications.
A variety of Nano-biomaterials are synthesised, characterised and tested to find out their potentialities by global scientific communities, during the last three decades. Among those, nanostructured ceramics, cements and coatings are being considered for major use in orthopaedic, dental and other medical applications. The development of novel biocompatible ceramic materials with improved biomedical functions is at the forefront of health-related applications, all over the world. Understanding of the potential biomedical applications of ceramic nanomaterials will provide a major insight into the future developments. This study reviews and enlists the prominent potential biomedical applications of ceramic nanomaterials, like Calcium Phosphate (CaP), Tri-Calcium Phosphate (TCP), Hydroxy-Apatite(HAP), TCP+HAP, Si substituted HAP, Calcium Sulphate and Carbonate, Bioactive Glasses, Bioactive Glass Ceramics, Titania-Based Ceramics, Zirconia Ceramics, Alumina Ceramcis and Ceramic Polymer Composites.
The present forest and tree cover of the country is 78.37 million ha in 2007 which is 23.84% of the geographical areas and it includes 2.82% tree cover. This becomes 25.25%, if the areas above tree line i.e., 4000m are excluded from the total geographical area. The forest cover is classified into 3 canopy density classes.
1. Very Dense Forest (VDF) with canopy density more than 70%
2. Moderately Dense Forest (MDF) with Canopy density between 40-70% and
3. Open Forest (OF) with Canopy density between 10-40%
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
2. Importance of Water:Importance of Water:
Water is an essential commodity
to all life
Without water, there can be no
life.
Every living thing--plants, animals,
and people--must have water to
live.
Water is used in almost all
activities of life support systems
Water is a major abiotic factor in
the environment
3. Natural water:Natural water:
The endless circulation of water
between atmosphere, lithosphere,
hydrosphere and biosphere is
known as hydrologic cycle.
We get water from Precipitation of
water vapor in the atmosphere
4. World’s Water Distribution:World’s Water Distribution:
Earth has tremendous amount of
water
Three fourth’s of the earth surface is
covered by water
97% of World’s water is in the seas and
oceans. This water is saline.
Only 3% is present on the continents.
This water is fresh.
The distribution of water over land is
uneven.
5. Water is everywhere:Water is everywhere:
Water is a common substance.
It fills the oceans, rivers, and
lakes.
It is in the ground and also in
the air we breathe.
Water is used for drinking, all
domestic purposes, agriculture,
industrial applications, cleaning
and recreation.
6. Quality determines its Usage:Quality determines its Usage:
Water has its own taste, color,
smell and constituents.
Not all water can be used for all
purposes.
Eg. Sea water can not be used
by us for drinking.
The suitability of water for
different purposes is
determined by its quality
parameters.
7. Quantity and quality:Quantity and quality:
On an average, each person in a
developed country uses about
260 litres of water a day in the
home.
The Quality of water is equally
important than quantity.
Even if present in huge
amounts, we can not use salt
water in many life support
activities.
8. Characteristics ofCharacteristics of
Water:Water:
Water is a good solvent
Water never occurs in its pure
form
All waters contain some dissolved
substances
The quality of water is determined
by these substances.
It has the ability to dissolve many
inorganic and organic substances.
9. Water Quality Parameters:Water Quality Parameters:
Water has its own
Physical properties
Chemical composition and
Biological Properties
11. Temperature (T) of Water:Temperature (T) of Water:
Essential for all environmental
studies
Controls many ecological
processes including chemical
reactions.
T of surface water varies from
space and time
T of groundwater varies not only
with reference to space and time
but also with reference to depth.
12. Temperature of Water:Temperature of Water:
Measured using Thermometers
It ranges from 0 to 100 degree Celsius
Unit of measurement is degree
Celsius
The temperature of Surface water is
influenced by the atmospheric
conditions
The temperature of groundwater is
controlled by the thermal
characteristics of bedrocks and the
depth.
13. Color of water:Color of water:
The color of water is due to the
suspended particles and organic
matter
Ranges form light to dark
brown
Brownish color in water comes
due to the presence of iron
Greenish color in pond water is
seen due to the presence of
organic substances including
algae
14. OdorOdor::
Pure water is odorless
When water dissolves other
substances, the odor is
determined by them
Mostly decayed organic
substances give fouling smell
Inorganic substances give earthy
smell
15. Turbidity:Turbidity:
Muddiness in water
Comes due to suspended
particles from clay, silt and
organic matter
Controls the transparency of
water
Transparency is measured using
Secchi Disc
Water Turbidity is measured
using Nephelometer
16. Electrical Conductivity(EC):Electrical Conductivity(EC):
Ability of a substance to conduct an
electrical current.
The presence of charged ionic
species makes water conductive.
It is measured using EC meters.
Directly related to temperature of
water.
Unit of measurement is mmhos/cm
at std temperatures. Ranges from
100-1,00,000
Pure water is less conductive
18. pH of water:pH of water:
Refers to the effective
concentration of hydrogen ions in
water
It ranges from 0 to 14. Measured
using pH meters
Water is said to be acidic( less than
7)
or alkaline ( above 7) depending on
the relative concentration of
hydrogen ions from the neutral
value which is 7.
19. Total DissolvedTotal Dissolved
Solids(TDS):Solids(TDS):
Concentration of non-volatile
substances present in colloidal or
molecular state
Total of all ions present in water,
expressed in ppm or mg/L
Increases due to dissolution of more
mineral substances by water on its
path
TDS determines the suitability of
water for our use and consumption.
20. Quality of Water :Quality of Water :
Total dissolved solids(ppm)
< 1000 fresh water
1000-10,000 brackish water
10,000 to 1,00,000 saline
> 1,00,000 hypersaline or
brine
21. Classification of DissolvedClassification of Dissolved
constituents:constituents:
Basis of concentrations-
mg/L
Charges( positive or
negative)
Level of Toxicity ( toxic or
non-toxic)
22. Based on Concentrations:Based on Concentrations:
Major ions( > 10 mg/L)
◦ Mostly Bicarbonate, calcium, Magnesium,
Chloride, sodium, sulphate and silicon
Minor ions ( 0.1-10 mg/L)
◦ Mostly Carbonate, fluoride, nitrate, potassium,
iron, strontium, boron.
Trace elements( < 0.1 mg/L)
◦ Mostly Aluminium, Arsenic, Barium, Bromide,
Cadmium, Chromium, Cobalt, Copper, Lead,
Zinc, Nickel, Phosphate, Silver, Tin and
Vanadium.
23. Based on ionic Charges:Based on ionic Charges:
Major ions
Positively charged = Cations
Negatively charged = anions
24. Major Cations in water:Major Cations in water:
Calcium
Magnesium
Sodium
Potassium
( Source: lithosphere)
25. Major Anions in Water:Major Anions in Water:
Bicarbonate
Carbonate
Chloride
Sulphate
Nitrate
Phosphate
26. Trace elements in water:Trace elements in water:
Play a significant role in the use
of water
Some are essential elements for
health & growth
Some are injurious to health
and toxic also.
Deficiency or excess intake of
some of these elements may
cause serious health problems
to life.
27. Hardness:Hardness:
Hardness of water is defined as its
content of metallic ions which react
with sodium soaps to produce a
residue
Expressed as total concentration of
Calcium and Magnesium in ppm.
Total hardness= 2.5 Ca + 4.1 Mg.
Softwater (Temporary)
Hardwater (permanent ).
28. Salinity of Water:Salinity of Water:
Comes due to sodium
and chloride
Sea water contains
35,000 ppm or mg/L of
dissolved salts
29. Alkalinity of water:Alkalinity of water:
Combined effect of Bicarbonates
and Carbonates with calcium
ions
It has a direct relationships with
pH.
Carbonates will be noticeable
for water having a pH of more
than 8.2
31. Dissolved Oxygen(DO):Dissolved Oxygen(DO):
Is related to the solubility of air in water
at 0 deg. C
Solubility of oxygen in water decreases
with high temperatures
Important property for aquatic
organisms
Surface water bodies should have enough
DO
If DO depletes, it will be difficult to many
aquatic organisms for their survival.
34. Water Quality Parameters:Water Quality Parameters:
Limits the suitability of water
for different purposes
Drinking
Domestic consumption
Agriculture
Industrial Processes
Cleaning and Recreation.