3. Introduction
Active vitamin was isolated from wheat germ
oil .
Tocopherol (tokos : child birth , pheros : to
bear , ol : alcohol ).
Induced Vit E deficiency caused infertility in
laboratory animals .
Anti infertility vitamin .
Most potent biological anti oxidant .
3
5. Vitamin E – most powerful antioxidant .
Free radicals are continuously being generated in
living systems ,these free radicals attack the plasma
membrane .
Therefore their inactivation is necessary .
Vit E which is powerful antioxidant is able to quench
the lipid peroxidation chain and protects the plasma
membrane from attack of free radicals .
Therefore Vit E is known as biological antioxidant
5
6. • Vit E protect RBC from hemolysis .
• Free radical attacks the bio
membranes .
• Vit E prevent the peroxidation thereb
keeping structural and functional
integrity of all cell .
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7. o Vit E boosts immune responses.
o Vit E reduced risk of atherosclerosis by
reducing oxidation of LDL.
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8. Oxidation of LDL lead leads to
inflammation in arteries and finally
atherosclerosis .
Vit E reduces oxidation of LDL
8
10. ⮚ In rat , inability to produce healthy ovum ,
loss of motility of spermatozoa ,
hemolysis of RBC acute hepatic necrosis
and muscular dystrophy are observed.
⮚ Vit E deficiency is seen in persons who
cannot absorb dietary fat , premature
infants weighing less than 1500 grams ,
mutation in gene for tocopherol transfer
protein and people with
abetalipoproteinemia .
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11. 11
Vit E deficiency causes neurological
problems due to poor nerve conduction .
Some neuromuscular problems include :
Retinopathy ,
Peripheral neuropathy ,
Myopathies .
12. 20XX
12
⮚Vit E deficiency can cause anemia
(oxidative damage to RBC ).
⮚Absence of deep tendon reflexes
⮚ + ve Babinski sign
13. 13
In adults or children over 2 years old, a positive Babinski sign happens when the big toe bends up and back to
the top of the foot and the other toes fan out. This can mean that you may have an underlying nervous
system or brain condition that's causing your reflexes to react abnormally.
Running a sharp
instrument along
the lateral
border of
forefoot from
calcaneus
14. ⮚Age related macular degeneration (AMD) is an important
cause of visual impairment and blindness among people
65 years and older .
Combination of Vit E with anti oxidants like Zn and Vit C
have a protective effect against onset and progression of
AMD .
⮚ Vit E supplementation is beneficial in Alzheimer's
disease.
⮚Vit E supplements recommended for persons
consuming diet rich in poly unsaturated fatty acid as
they tend to form free radicals .
⮚Excessive intake of Vit E increases risk of bleeding .
