This document discusses vitamin and mineral metabolism after kidney transplantation. It notes that vitamin D, calcium, PTH, and phosphorus levels often improve within the first 3-18 months after transplantation but may remain suboptimal. Immunosuppressive medications like glucocorticoids and calcineurin inhibitors can impact vitamin D levels. Poor vitamin D status increases risks of post-transplant bone disease, cardiovascular disease, infection, and mortality. The document recommends monitoring mineral levels and considering vitamin D supplementation after transplantation. It also discusses magnesium, antioxidants, vitamin B12, and vitamin B6 status in transplant recipients.
vitamins in chronic kidney disease and hemodialysis patientsPediatric Nephrology
Vitamins are organic substances that cannot be synthesized by the
human body
Their functions are essential for normal human metabolism
In contrast to well-defined standards for healthy children/To date, there have been no randomized controlled trials examining the intake and/or needs of vitamins and trace elements in pediatric (CKD) or ESRD
Natural dietary sources of water-soluble vitamins and key trace elements are found in foods such as fruits, legumes, red meat, and dairy, all of which may be limited in the ESRD population on dialysis because of high potassium and phosphorus contents
losses of both vitamin D binding protein and 25(OH)D in the urine
The urinary losses of vitamin D binding protein may be secondary to proteinuria.
Deficiency in 25(OH)D may lead to hypocalcemia, hyperparathyroidism, and diminished bone mineral density/content.
Vitamin D deficiency has also been associated with multiple systemic effects including elevated blood pressure ,metabolic syndrome, cardiovascular disease ,anemia and impaired immune system regulation .
Urinary tract infections (UTIs) are one of the more common infections encountered in everyday clinical practice.
They account for 10–20% of all infections treated in primary care units and 30–40% of those treated in hospitals.
The prevalence of the disease in boys and girls is 1% and 5.3%, respectively.
The prevalence of bacterial etiology results in a large consumption of broad-spectrum antibiotics, which in turn leads to increased rates of resistant uropathogens.
Therefore, non-antibiotic prevention and treatment options are now of great importance.
KidneyVite is a state of the art multivitamin supplement specially designed for ALL patients:
- with kidney disease
- receiving hemodialysis and peritoneal dialysis
- and kidney transplant recipients
- with diabetes or hypertension, and therefore at risk for kidney disease.
vitamins in chronic kidney disease and hemodialysis patientsPediatric Nephrology
Vitamins are organic substances that cannot be synthesized by the
human body
Their functions are essential for normal human metabolism
In contrast to well-defined standards for healthy children/To date, there have been no randomized controlled trials examining the intake and/or needs of vitamins and trace elements in pediatric (CKD) or ESRD
Natural dietary sources of water-soluble vitamins and key trace elements are found in foods such as fruits, legumes, red meat, and dairy, all of which may be limited in the ESRD population on dialysis because of high potassium and phosphorus contents
losses of both vitamin D binding protein and 25(OH)D in the urine
The urinary losses of vitamin D binding protein may be secondary to proteinuria.
Deficiency in 25(OH)D may lead to hypocalcemia, hyperparathyroidism, and diminished bone mineral density/content.
Vitamin D deficiency has also been associated with multiple systemic effects including elevated blood pressure ,metabolic syndrome, cardiovascular disease ,anemia and impaired immune system regulation .
Urinary tract infections (UTIs) are one of the more common infections encountered in everyday clinical practice.
They account for 10–20% of all infections treated in primary care units and 30–40% of those treated in hospitals.
The prevalence of the disease in boys and girls is 1% and 5.3%, respectively.
The prevalence of bacterial etiology results in a large consumption of broad-spectrum antibiotics, which in turn leads to increased rates of resistant uropathogens.
Therefore, non-antibiotic prevention and treatment options are now of great importance.
KidneyVite is a state of the art multivitamin supplement specially designed for ALL patients:
- with kidney disease
- receiving hemodialysis and peritoneal dialysis
- and kidney transplant recipients
- with diabetes or hypertension, and therefore at risk for kidney disease.
Anemia during pregnancy/types/causes/prevention and managementBabitha Mathew
It's normal to have mild anemia when you are pregnant. But you may have more severe anemia from low iron or vitamin levels or from other reasons. Anemia can leave you feeling tired and weak. If it is severe but goes untreated, it can increase your risk of serious complications like preterm delivery
Anemia during pregnancy/types/causes/prevention and managementBabitha Mathew
It's normal to have mild anemia when you are pregnant. But you may have more severe anemia from low iron or vitamin levels or from other reasons. Anemia can leave you feeling tired and weak. If it is severe but goes untreated, it can increase your risk of serious complications like preterm delivery
Acetabularia Information For Class 9 .docxvaibhavrinwa19
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This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
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A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
3. Vitamin D Metabolism After Successful
Kidney Transplantation
Rapid reduction of FGF-23 level within the first 3
months
PTH levels rapidly decrease within the first 3
months, and remain stable and often elevated after
the first post-transplant year.
4. P↓ and Ca↑ are common in the early post-transplant
period and tend to normalise after the third month
of KT.
It takes ≤18 months for VD status to improve
Despite the presence of a functioning graft, VD status
is usually suboptimal.
5.
6. Recovery of graft function, inappropriately high PTH
levels and P↓ accelerate the conversion of 25(OH)D
into 1,25(OH).
Conversely, high FGF23 levels during the first
months post-transplant could inhibit 1-α-hydroxylase
and enhance 24-α-hydroxylase, thereby reducing
1,25(OH) and 25(OH)D levels.
7. Immunosuppressive therapy and vitamin
D
Glucocorticoids alter vitamin D metabolism, expressing
enzymes involved in vitamin D catabolism and increasing PTH
and FGF23 levels .
The cumulative prednisone dose is inversely correlated with
1,25(OH)D levels 2 years after transplantation
Low 1,25(OH)D levels could also be favored by higher FGF23
concentrations induced by steroid therapy.
8. Immunosuppressive therapy and vitamin
D
CNI is associated with lower 25(OH)D levels among
KTRs
CNI-induced vitamin D resistance through VDR
downregulation .
Sirolimus has no effect on renal calcium excretion,
vitamin D metabolism, calcium channel expression
or calcium-binding proteins.
9. Importance of Vitamin D in the Post-Transplant
Period
The two major clinical issues concerning VD
after KT are mineral-bone disease and VD
pleiotropy.
10. Post-transplant mineral bone disease (PTr-
MBD)
Poor VD status is one of the factors for developing PTr-
MBD, together with immunosuppressive therapy,
persistent hyperparathyroidism, malnutrition, persistent
CKD, duration of CKD Stage 5, duration of dialysis,
obesity, and diabetes mellitus.
11. Biochemical abnormalities in post-
transplant mineral bone disease
Biochemical findings are highly dependent on
Pre-transplant CKD-MBD,
Immunosuppressive treatment,
Post-transplant graft function,
Concomitant diseases,
Medications.
12. Mineral–bone indicators should be monitored closely
immediately after KT.
The frequency of testing for ca , p , PTH, AlkP, and 25VD
should be determined according to graft function, duration of
transplantation, magnitude of abnormalities, and when
supplementation was initiated.
13. Post-transplant bone disease
A rapid reduction in bone density is widely
reported, with faster bone loss during the first
months after successful KT.
Major complication is increased fracture risk,
associated with increased morbidity and mortality.
Pre-transplant bone health is crucial for post-
transplant outcomes.
14. A key factor in deteriorating bone health prior to
kidney transplantation are excessive VD doses, which
are associated with increased incidence of adynamic
bone disease before KT.
Therefore, adequate treatment of CKD-related MBD
should be performed in the pre and post-transplant
period.
15. Vitamin D and cardiovascular disease after
transplantation
The risk for CVD is increased after transplantation
compared to the general population, due to the
persistent CKD-associated vascular and cardiac
abnormalities, especially vascular calcifications.
16. Poor VD status is associated with arteriosclerosis and
endothelial dysfunction in ESRD patients.
VDR activation in cardiomyocytes suppresses their
proliferation.
Furthermore, higher doses of VD may be associated
with increased risk for vascular calcifications.
17. Vitamin D and rejection
VDR is expressed in all immune cells, including those of the
innate immune dendritic cells and macrophages.
Calcitriol suppresses T and B-lymphocyte proliferation;
inhibits dendritic cells and macrophages, suppresses IL and
Ig G production, and downregulates MHC class II expression.
Better VD status is associated with lower incidence of acute
rejection.
18. Vitamin D and infection
Infection represents a major cause of patient death and graft
loss after successful kidney transplantation.
VD upregulates the synthesis of the lysosome protein
cathelicidin and the anti-microbial protein β–defensin.
Better VD status was associated with lower incidence of viral,
bacterial, and fungal infections.
19. Vitamin D and malignancy
Neoplasia is one of the most common causes for
patient and graft loss in KTRs.
VD suppresses cellular proliferation and
angiogenesis, and stimulates cell differentiation and
apoptosis.
20. Vitamin D and mortality
All-cause mortality is increased in KTRs, due to
persistent CKD, persistent cardio-vascular disease,
post-transplant mineral bone disease, and increased
neoplastic incidence and infection rate.
Sub-optimal VD is associated with higher all-cause
mortality in KTRs.
21. Vitamin D Treatment in Kidney Transplant
Recipients
Treatment should be tailored to the initial VD status after KT,
post-transplant ca–ph metabolism, due to the increased
incidence of Ca↑ and P↓ after successful KT.
The values for Ca , Ph , ALKP, and PTH should be evaluated
regularly.
The frequency of laboratory testing should be based on
graft function, degree of biochemical abnormalities, and
supplementation initiated.
22. The 2017 KDIGO CKD-MBD Guideline recommended BMD
testing in the first 3 months following transplantation in
patients with an GFR greater than 30 if they receive
corticosteroids or have risk factors for osteoporosis.
In patients in the first 12 months after kidney transplant with
an GFR greater than approximately 30 and low BMD,
treatment with vitamin D, calcitriol be considered .
23. Magnesium Status after Kidney
Transplantation
Hypomagnesemia is frequently observed after kidney
transplantation, in part to
Immunosuppressive regimens including CNI that induce Mg
urinary waste.
Sirolimus might induce hypomagnesemia through inhibition
of Na-K-Cl co-transporter 2 expression in the thick
ascending loop of Henle .
24. Many other factors influence Mg levels after kidney
transplantation, such as post-transplantation volume
expansion, metabolic acidosis, insulin resistance,
decreased gastro-intestinal absorption due to
diarrhea, low Mg intake and medication such as
diuretics or proton pump inhibitors.
25.
26. Serum Magnesium and New-Onset
Diabetes Mellitus after Transplantation
In a retrospective cohort of 173 young recipients
with a median age of 7 years, 20 patients developed
PTDM at 9 days post transplantation on average.
Hypomagnesemia and high tacrolimus levels were
significant and independent risk factors for PTDM
27. Magnesium Status and Cardiovascular
Risk after Kidney Transplantation
Hypomagnesemia has been shown to play a role in
the pathogenesis of arterial hypertension,
endothelial dysfunction, dyslipidemia and
inflammation, with all these factors contributing to
coronary heart disease (CHD).
28.
29. Antioxidant Supplementation
Dysfunction of the renal graft may not only be due
to rejection but also other causes such as ischemia
and reperfusion injury and CNI nephrotoxicity.
Antioxidant free radical scavengers may decrease
oxidative stress and lipid peroxidation.
Antioxidant supplementation with vitamin C or E
may improve renal transplant function
30. Antioxidant supplementation reduces CsA trough-
levels in renal transplant recipients. Injudicious use of
vitamin C and E supplementation should therefore be
avoided.
Decreased CsA levels associated with their use pose
no risk for transplant rejection.
Transplant nephrologists should be aware of the CsA
trough level lowering effect of anti-oxidants.
31. KTRs may be at increased risk of B12 deficiency due to :
The recommendation to decrease the intake of animal protein before
KT (during non-dialysis treatment);
The excessive weight gain that is common in KTR;
The use of MMF.
32. Including KTR with a minimum of 6 months of transplantation,
B12 deficiency prevalence was 14 %.
The intake of B12 was significantly lower in participants with
B12 deficiency . the intake of protein presented a tendency to
be lower in the B12-deficient group .
B12 dietary intake needs to be carefully monitored in KTR,
especially in those with lower protein intake.
33. B12 deficiency was associated with increased central body
adiposity .
In KTR with adequate B12 intake, the frequency of B12 deficiency
was higher in patients using MMF than in those using AZA. This
finding suggests that KTR using MMF may be at increased risk of
B12 deficiency even if they present adequate B12 intake.
34. Higher prevalence of vitamin B-6 deficiency in RTRs
Vitamin B-6 intake in RTRs is similar to that in controls and yet plasma PLP
concentrations are lower
Poor vitamin B-6 status in RTRs is the consequence of altered vitamin B-6
handling rather than inadequate intake.
35. Gradual increase in all-cause and cardiovascular mortality
across groups with worse vitamin B-6 status
No associations between plasma PLP concentrations and graft
failure were observed .
A diet based on foods rich in this vitamin, in particular fruits
and legumes, in RTRs with a low vitamin B-6 status.
36. Treatment of stable kidney transplant recipients with a
multivitamin containing high-dose folic acid, B6, and B12
lowers tHcy levels relative to standard multivitamin
supplementation and in many cases to normal levels but does
not reduce CVD outcomes or total mortality .