Visionisti Oy is a privately held company, which is specialized in developing and commercializing a new suprachoroidal injection tool for ophthalmic drug delivery.
VSN.st has developed a new tool to facilitate safe, fast, targeted, simple and repeatable injections of intraocular and suprachoroidal pharmaceuticals.
Posterior Segment Company Showcase - Alimera SciencesHealthegy
Posterior Segment Company Showcase - Alimera Sciences at OIS@AAO 2016.
Presenter:
Dan Myers, CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
VSN.st has developed a new tool to facilitate safe, fast, targeted, simple and repeatable injections of intraocular and suprachoroidal pharmaceuticals.
Posterior Segment Company Showcase - Alimera SciencesHealthegy
Posterior Segment Company Showcase - Alimera Sciences at OIS@AAO 2016.
Presenter:
Dan Myers, CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Anterior Segment Company Showcase - Novaliq GmbHHealthegy
Anterior Segment Company Showcase - Novaliq GmbH at OIS@AAO 2016.
Presenter:
Bernhard Guenther, CEO & Managing Director
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
The early diagnosis of neurodegenerative diseases is crucial, as it could lead to early treatment and better chances of stopping the process. Machine learning algorithms provide an opportunity to diagnose these diseases earlier through automatic diagnosis, but their application to the medical domain is not straightforward. From data set size to interpretability, we will see why the beautiful, trendy and complex solution we can first think about might not be the best one.
Anterior Segment Company Showcase - TearScienceHealthegy
Anterior Segment Company Showcase - TearScience at OIS@AAO 2016.
Presenter:
Joseph Boorady, President & CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Why are most clinical research findings not spectacular?scanFOAM
A presentation by Morten Hylander Møller at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All available content from SSAI2017: https://scanfoam.org/ssai2017/
Delivered in collaboration between scanFOAM, SSAI & SFAI.
Anterior Segment Company Showcase - AvedroHealthegy
Anterior Segment Company Showcase - Avedro at OIS@AAO 2016.
Presenter:
Rajesh K. Rajpal, MD, Chief Medical Officer
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Hirshberg promise of digital technology astra_zenecaThe Promise of Digital Te...Levi Shapiro
Presentation by Boaz Hirshberg, VP, Clinical Development, Cardiovascular, Renal, Metabolic Disease at AstraZeneca
- The Promise of Digital Technology in Drug Development Clinical Trials. Includes the following:
- The vision for patient-centric medical care delivery
- End-to-end patient experience enhanced by digital technologies
- Digital technologies have a potential to transform clinical trial & medical care delivery
- Example: transforming our understanding of Type 2 diabetes with remote patient monitoring
- Frequent sampling demonstrates glucose lowering very soon after first dose, which might be unappreciated in typical trial design
- Multiple data points reduce uncertainty about the glucose outcome and enable future machine learning of unanticipated relationships
- Lessons learned from CGM pilot: data storage, transfer, and analysis
- Defining the clinical science questions to be answered
- Operational considerations for incorporating digital data into clinical development
- Addressing challenges of digital technologies’ disruption
Anterior Segment Company Showcase - AcuFocusHealthegy
Anterior Segment Company Showcase - AcuFocus at OIS@AAO 2016.
Presenter:
Al Waterhouse, President
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
CCM Journal Club: Vasopressin-Epinephrine-Steroids for in hospital cardiac ar...Hon Liang
Mayo Critical Care Journal Club (15 Dec 2014). RCT: Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest. JAMA 2013.
Anterior Segment Company Showcase - Novaliq GmbHHealthegy
Anterior Segment Company Showcase - Novaliq GmbH at OIS@AAO 2016.
Presenter:
Bernhard Guenther, CEO & Managing Director
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
The early diagnosis of neurodegenerative diseases is crucial, as it could lead to early treatment and better chances of stopping the process. Machine learning algorithms provide an opportunity to diagnose these diseases earlier through automatic diagnosis, but their application to the medical domain is not straightforward. From data set size to interpretability, we will see why the beautiful, trendy and complex solution we can first think about might not be the best one.
Anterior Segment Company Showcase - TearScienceHealthegy
Anterior Segment Company Showcase - TearScience at OIS@AAO 2016.
Presenter:
Joseph Boorady, President & CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Why are most clinical research findings not spectacular?scanFOAM
A presentation by Morten Hylander Møller at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All available content from SSAI2017: https://scanfoam.org/ssai2017/
Delivered in collaboration between scanFOAM, SSAI & SFAI.
Anterior Segment Company Showcase - AvedroHealthegy
Anterior Segment Company Showcase - Avedro at OIS@AAO 2016.
Presenter:
Rajesh K. Rajpal, MD, Chief Medical Officer
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Hirshberg promise of digital technology astra_zenecaThe Promise of Digital Te...Levi Shapiro
Presentation by Boaz Hirshberg, VP, Clinical Development, Cardiovascular, Renal, Metabolic Disease at AstraZeneca
- The Promise of Digital Technology in Drug Development Clinical Trials. Includes the following:
- The vision for patient-centric medical care delivery
- End-to-end patient experience enhanced by digital technologies
- Digital technologies have a potential to transform clinical trial & medical care delivery
- Example: transforming our understanding of Type 2 diabetes with remote patient monitoring
- Frequent sampling demonstrates glucose lowering very soon after first dose, which might be unappreciated in typical trial design
- Multiple data points reduce uncertainty about the glucose outcome and enable future machine learning of unanticipated relationships
- Lessons learned from CGM pilot: data storage, transfer, and analysis
- Defining the clinical science questions to be answered
- Operational considerations for incorporating digital data into clinical development
- Addressing challenges of digital technologies’ disruption
Anterior Segment Company Showcase - AcuFocusHealthegy
Anterior Segment Company Showcase - AcuFocus at OIS@AAO 2016.
Presenter:
Al Waterhouse, President
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
CCM Journal Club: Vasopressin-Epinephrine-Steroids for in hospital cardiac ar...Hon Liang
Mayo Critical Care Journal Club (15 Dec 2014). RCT: Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest. JAMA 2013.
When you or your child has an eye turn all too often the first recommendation for intervention is surgery. You should know the outcomes, risks and complications associated with this surgical procedure and alternative ways to manage these problems.
Wireless healthcare: the next generationJeffrey Funk
These slides use concepts from my (Jeff Funk) course entitled analyzing hi-tech opportunities to analyze how wireless healthcare are becoming economic feasible. Improvements in microprocessor and transceiver ICs, MEMS, photo-sensors, and other electronic components are making wireless healthcare economically feasible. These slides show how improvements in these components are making capsule endoscopy, smart drug delivery, and digital pills economically feasible. Capsule endoscopy involves sending a small device through the body, particularly the digestive system, to take images. Further improvements in electronic components are needed to further reduce the size of these devices. Drugs can be dispensed through smart pills at programmed times or can be triggered by sensors that detect the correct location. Digital pills send signals to mobile phones or other devices when the pills have been taken. The slides conclude by discussing the role of mobile phones in increasing the number of wireless healthcare applications.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
1. A New Ocular
Therapeutics Tool
Looking for business opportunities
Timo Kangastupa
Managing Director, Visionisti Oy
non-confidential
2. 30-50M patients with AMD
out of whom 3-10M have the wet form - an overwhelming burden
67M with glaucoma
uveitis, corneal infections, gene therapy, stem cell treatments, and others
350M with diabetic retinopathy
potential therapies for oedemas, RVO, and others
3. 6M IVT injections estimated
in USA during 2016
More than twice the number of
cataract procedures!!! [1], [2], [3]
4. Double-digit continued growth
he number of IVT injections mayreach nearly6 million in 2016." ...more than twice the number of cataract procedures!!!
projected, driven by aging population and new indications
5. “
“Dose reduction and convenience
technologies are needed”
Kevin Buehler
Former Alcon Division Head
Novartis Investor Day
22 November 2013
6. A new solution for
suprachoroidal
injections
Suitable also for precisely transmitting heat,
cold, electricity, light or other energy to directly
stimulate, damage, or heal a specific tissue or
for diagnostic purposes
7. “
“An effective drug delivery system for the
back of the eye should embody four
general characteristics. Current methods
cannot meet all of these requirements.”
- SR Patel, Co-founder Clearside Biomedical
9. Fulfilled by Visionist’s Tool:
• Does not penetrate the delicate tissues
• No need for a surgical operation – in office procedure
• Closes the entry wound automatically
• Minimizes the risk for endophthalmitis
• Less discomfort for the patients and faster wound
healing
10. 2.
Well targeted to the
desired tissues
high bioavailability while reducing
adverse events and toxicity
11. Fulfilled by Visionist’s Tool:
• Direct contact to the sites of therapeutic action
• Effective distribution and faster influence
• Limits exposure to other regions of the eye
• Less side effects and complications
• Does not effect the optical axis
12. 3.
Capable of sustained delivery
to reduce the frequency of administration and
allow for better therapeutic control
13. Fulfilled by Visionist’s Tool:
• Higher drug concentrations for months
• More accurate dosing and dose sparing
• Suitable for sustained delivery and implants
• Eases the treatment burden for all parties
15. Fulfilled by Visionist’s Tool:
• Repeatable, Faster, Easier and Safer
• Standardizes the procedure and increases the
efficiency
• Stabilizes the eye and keeps the lids open
• Enables administration by trained non-physicians?
• Disposable product with great margins
• Class I medical device
16. Proof of concept – ex vivo porcine eyes
• The distribution of methylene blue in
the suprachoroidal space (black
arrows).
• 1 μm FluoSpheres (below in red) were
localized in the suprachoroidal space.
CONCLUSIONS: The proprietary ocular injection
device is well suitable for precise delivery of
injected material into suprachoroidal space.
Data on file
18. Business opportunities
Rare technology, rare opportunity.
Superior to the known alternatives for
suprachoroidal drug delivery.
Visionisti Oy is open for any kind of business
opportunities you are interested in.
Visionisti presents a novel delivery platform
for your molecules, with no limitations.