Anterior Segment Company Showcase - AcuFocus at OIS@AAO 2016. Presenter: Al Waterhouse, President Powered by: Healthegy For more ophthalmology innovation Visit us at www.ois.net

1. Al Waterhouse
President
OIS@AAO 2016

2. Extending Depth of Focus with Small
Aperture Optics
Small aperture technology is the only corneal-based presbyopia
correcting procedure that does not rely on the use of “plus
power” in the cornea to provide near vision.
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3. The Simple & Elegant Solution for EDOF
• Small Aperture Safety & Effectiveness:
– Extended Range of Vision: Provides a
natural range of vision from near to far
– Preserves Far Vision: Unlike monovision,
small aperture optics provides near vision
while maintaining far vision in both eyes
– Long-Lasting: Delivers long-term
performance to maintain clear near vision
over time
• Strong Science: 40+ peer-reviewed papers
• Inlay Experience: Over 30,000 patients
– Long-Term Data: >9 years
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KAMRA® Inlay
IC-8™ IOL

4. Untapped Market Opportunity
Presbyopia Cataract
Combined ~$10 Billion Market
• Global market opportunity exceeds $5 billion1
- 40% of procedures are performed in the US
• 70+ million baby boomer population is at least
50 years old2
• Presbyopia-correcting procedures are elective
- Pricing determined by market forces, not
reimbursement rates; patients expect superior
results
• Other surgical options exist but require
significant compromise
- Sacrifice intermediate and/or distance acuity
- Loss of effect over time; glare and halo
complaints
- Irreversible
• #1 performed surgical procedure worldwide
- 3 million performed annually in the US
• Global IOL market opportunity expected to reach
$4.2 billion by 20192
- Majority of growth to be driven by premium
IOLs
• By the year 2020, nearly 14% of the global
population will be age 60 or over2
- 60+ population segment growing 3x faster than
the total global population
- Patients seeking cataract surgery at an earlier
age in developed countries
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1 Company estimate of global cumulative addressable market for 2015-2020
2 Market Scope

5. 18 25 35
Condition by Age
45 55
Vision Correction Life Cycle
Small aperture optics improves vision for a broad spectrum
65
PRESBYOPIAAMETROPIA
KAMRA® Inlay
• Glasses
• Contact Lenses
• Monovision
• Other Inlays
75+
IC-8™ IOL
• Monofocal IOL
• Multifocal IOL
(Bifocal/Trifocal)
• EDOF IOL
• Accommodating IOL
Small Aperture Opportunity
CATARACT
• Glasses
• Contact Lenses
• LASIK/ PRK
• Phakic IOL
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6. PRESBYOPES
MYOPES
HYPEROPES
Positioning the KAMRA® Inlay
Market Scope 2014 Refractive Surgery Market Report
• KAMRA inlay is ideal for:
– Plano presbyopes
– Myopic presbyopes
– Post-LASIK presbyopes
– Unhappy monovision
patients
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7. Physician
Building & Growing the Market
Business
Development
Clinical
Support
Sales
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8. Expanding the Proven Small Aperture Platform
The IC-8™ IOL
• Hydrophobic Acrylic Material
– ABBE No. 49
• Optical Design
– Single piece 360o square edge
– 6.00 mm optic diameter
– 12.50 mm overall diameter
• CE Mark Approved
• Overcomes Other PC-IOL Limitations
– Incomplete range of vision, unreliability,
glare/halo, neuroadaptation
• Commercializing in Europe, Australia
and New Zealand
• Working Toward US Approval
IOL Material
Single-piece hydrophobic acrylic
Mask
PVDF & nano-particles of carbon
1.36mm aperture
3.23mm total diameter
3200 microperforations
5 microns thick
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9. Well Capitalized for Growth
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10. THANK YOU