Physiological monitors in hospitals generate many false alarms, up to 90%, which causes caregivers to ignore alarms or turn them off entirely, endangering patient safety. To address this, the authors developed an algorithm combining electrocardiograms and photoplethysmograms to reduce false alarms. Initial results show promise in suppressing false alarms while allowing clinically important alarms. The algorithm has potential to improve patient safety by making alarms more accurate for nurses and hospitals.