Vaccines work by introducing a harmless version of a pathogen into the body to stimulate an immune response without causing illness. There are several types of vaccines including live attenuated, killed/inactivated, subunit, toxoid, conjugate, and recombinant vaccines. An ideal vaccine would provide long-lasting immunity after a single dose, stimulate both antibody and cellular immune responses, be safe, stable, and inexpensive to produce.
A vaccine is a biological agent that provides active acquired immunity to a particular disease. A vaccine usually contains an agent that resembles a disease-causing microorganism. It is often made from killed or weakened forms of the microbe, its toxins or one of its surface proteins. Body's immune system is stimulated to recognize the agent as a threat and destroy it, and any of these microorganisms that it later encounters.
vaccine train user immune system to create antibodies, just as it when it is exposed to a disease. However, because vaccine contain only killed or weakened forms of germs like viruses or bacteria, they do not cause the disease or put you at the risk of complications.
vaccine is a biological preparation that improve immunity to a particular disease.
A vaccine typically contain an agent that resembles a disease causing microorganisms and is often made from weakened or killed forms of the microbes.
Immunity: Protection from an infectious disease. If you are immune to a disease, you can be exposed to it without becoming infected.
Vaccine: A preparation that is used to stimulate the body’s immune response against diseases. Vaccines are usually administered through needle injections, but some can be administered by mouth or sprayed into the nose.
Vaccination: The act of introducing a vaccine into the body to produce protection from a specific disease.
Vaccine:It’s Uses and Advantages & Disadvantages.HaladharHembram2
Therapeutics and Heath Management In Aquaculture: AQC:507
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms the microbe. The agent stimulates the body’s immune system to recognize the agent as foreign, destroy it, and “remember” it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters in future.
Aquaculture continues to expand, disease problems will increase. Therefore, disease research and the implementation of new disease control concepts are important to maintain sustainability.
The development of an effective vaccine is a complex process. One of the prerequisites understanding of basic epidemiology of diseases and the immune system of the target species is required.
The importance of disease control is increasingly recognized by both farmers and governments due to the significant economic losses caused by diseases and international pressure on the use of chemicals and antibiotics.
A number of vaccines have been in used by the salmonid industry for decades, however, commercial vaccine development for other aquaculture sectors, including warm water fish, is still quite limited.
A vaccine is a biological agent that provides active acquired immunity to a particular disease. A vaccine usually contains an agent that resembles a disease-causing microorganism. It is often made from killed or weakened forms of the microbe, its toxins or one of its surface proteins. Body's immune system is stimulated to recognize the agent as a threat and destroy it, and any of these microorganisms that it later encounters.
vaccine train user immune system to create antibodies, just as it when it is exposed to a disease. However, because vaccine contain only killed or weakened forms of germs like viruses or bacteria, they do not cause the disease or put you at the risk of complications.
vaccine is a biological preparation that improve immunity to a particular disease.
A vaccine typically contain an agent that resembles a disease causing microorganisms and is often made from weakened or killed forms of the microbes.
Immunity: Protection from an infectious disease. If you are immune to a disease, you can be exposed to it without becoming infected.
Vaccine: A preparation that is used to stimulate the body’s immune response against diseases. Vaccines are usually administered through needle injections, but some can be administered by mouth or sprayed into the nose.
Vaccination: The act of introducing a vaccine into the body to produce protection from a specific disease.
Vaccine:It’s Uses and Advantages & Disadvantages.HaladharHembram2
Therapeutics and Heath Management In Aquaculture: AQC:507
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms the microbe. The agent stimulates the body’s immune system to recognize the agent as foreign, destroy it, and “remember” it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters in future.
Aquaculture continues to expand, disease problems will increase. Therefore, disease research and the implementation of new disease control concepts are important to maintain sustainability.
The development of an effective vaccine is a complex process. One of the prerequisites understanding of basic epidemiology of diseases and the immune system of the target species is required.
The importance of disease control is increasingly recognized by both farmers and governments due to the significant economic losses caused by diseases and international pressure on the use of chemicals and antibiotics.
A number of vaccines have been in used by the salmonid industry for decades, however, commercial vaccine development for other aquaculture sectors, including warm water fish, is still quite limited.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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2. What is a vaccine?
Preparation of dead or attenuated pathogens, or their products, that when
introduced into the body, stimulates the production of protective antibodies
or T-cells without causing the disease.
It is the most important immunological products able to eradicate numerous
infectious diseases like smallpox.
Eradication of diphtheria, tetanus, whooping cough, poliomyelitis, measles
and rubella also achieved where deploy vaccines effectively.
Vaccines for several other purposes
therapy of cancer; prevention of allergies; desensitization of allergic patients;
fertility control; and treatment of addictions.
3. Etymology and background
Edward Jenner who, over 200 years ago, showed that inoculating people with material
from skin lesions caused by cowpox (L. vaccinus, of cows; vacca, cow) protected them
from the highly contagious and frequently fatal disease smallpox
He tested his theory in 1796 by inoculating 8-year-old James Philipps with liquid from
cowpox pustule Subsequent inoculation of the boy with smallpox produced no disease.
Before Jenner’s time in India and China where they performed variolation, used
a live smallpox vaccine to generate immunity
Variola virus=smallpox virus
4. REQUIREMENTS OF AN IDEAL VACCINE
Provide long lasting immunity.
Should induce both humoral and cellular immunity.
Should not induce autoimmunity or hypersensitivity.
Vaccines must also be perceived to be safe.
Require a single dose.
Given early in life.
Given through nonparenteral route
Combined form in order to reduce the number of visits to a doctor or medical center.
Heat stable and retain activity during transport and storage, especially in tropical climates.
Should be inexpensive to produce, easy to store and administer.
5. How do vaccines work?
• Following injection, the immunogenic agent is phagocytosed by immature dendritic
cells.
• Processed peptides will be presented on the cell surface as separate MHC I or II:
antigenic fragment complexes.
• Th2, each with a receptor for a separate antigenic fragment will be activated.
• B cells, each with a B-Cell Receptor for a separate antigenic fragment will bind antigens
that drain along lymph channels.
• This will induce B-cell activation, differentiation and proliferation with subsequent
isotype switch (IgM to IgG) and memory B cell formation.
7. Live/attenuated vaccines
Live/attenuated vaccines are the successful viral vaccines.
Prepared from attenuated strains that are almost or completely devoid of
pathogenicity but are still immunogenic.
Live vaccines more closely mimic an actual infection. They multiply in the human
host and provide continuous antigenic stimulation over a period of time.
8. Methods used for attenuation
Related virus from another animal – e.g. the use of cowpox to prevent
smallpox
Development of temperature sensitive mutants
Administration of pathogenic/attenuated virus by an unnatural route
• the virulence of the virus is often reduced when administered by
an unnatural route
9. Methods used for attenuation…
Passage of the virus in an "unnatural host" or host cell
• the major vaccines been derived this way
• After repeated passages, the virus is administered to the natural host
• Examples: Polioviruses (in monkey kidney cells) and measles (in chick embryo
fibroblasts)
Genetic engineering techniques
Attenuate a virus irreversibly by selectively removing genes that are
necessary for virulence. Example: herpesvirus vaccine for pigs (thymidine kinase
gene was removed).
10. Bacteria/virus Method Route
Vibrio Genetically modified Oral
Salmonella Genetically modified Oral
Mycobacterium Prolonged subculture ID
Polio Passage in MK cells Oral
Influenza Temperature sensitive mutant IN
Mesales, Mumps,
Rubella
Passage in fibroblasts cells SC
Chicken pox Human diploid cell cultures SC
11. Advantages:
• Infectious microbes can stimulate generation of memory cellular as well as
humoral immune responses.
• Since these can multiply in the host, fewer quantities must be injected to induce
protection.
• A single administration of vaccine often has a high efficacy in producing long-lived
immunity. Multiple booster doses may not be required.
• Whole microbes stimulate response to antigens in their natural conformation. They
raise immune response to all protective antigens.
• Some live vaccines can be given orally; such vaccines induce mucosal immunity and
IgA synthesis, which gives more protection at the normal site of entry.
• Oral preparations are less expensive than giving injections.
• They can lead to elimination of wild type virus from the community
12. Disadvantages
• May very rarely revert to its virulent form and cause disease.
• Live vaccines cannot be given safely to immunosuppressed individuals.
Administration of live attenuated vaccines to people with impaired immune
function can cause serious illness or death in the vaccine recipient.
• Since they are live and because their activity depends on their viability,
proper storage is critical.
• Spread to contacts of vaccinee who have not consented to be vaccinated. In
some cases, it turns out be an advantage.
13. Killed/Inactivated vaccines
• The term killed generally refers to bacterial vaccines whereas inactivated relates to
viral vaccines
• An inactivated whole organism vaccine uses pathogens which are killed and are no
longer capable of replicating within the host
• The pathogens are inactivated by heat or chemical means while assuring that the
surface antigens are intact
• Inactivated vaccines are generally safe, but are not entirely risk free
14. Microorganism Method Route
Salmonella typhi Heat, Phenol, Acetone SC
Bordetella pertussis Merthiolate IM
Poliomyelitis Formalin IM
Rabies virus Phenol SC
Influenza virus Formalin IM
Hepatitis A Formalin IM
Yersinia pestis Formalin IM
15. Advantages
First, they are safe because they cannot cause the disease they prevent and there is
no possibility of reversion to virulence.
Second, because the vaccine antigens are not actively multiplying, they cannot
spread to unimmunized individuals.
Third, they are usually stable and long lasting as they are less susceptible to
changes in temperature, humidity and light which can result when vaccines are
used out in the community.
Fourth, all the antigens associated with infection are present and will result in
antibodies being produced against each of them.
16. Disadvantages:
• Since the microorganisms cannot multiply, a large number are required to
stimulate immunity.
• Periodic boosters must be given to maintain immunity.
• Only humoral immunity can be induced.
• Most killed vaccines have to be injected.
• Some vaccines such as Bordetella pertussis induce ill effects like postvaccinial
encephalomyelitis. Anaphylactic reaction to neomycin or streptomycin may occur in
(Inactivated Polio Vaccine) recipients. Anaphylactic hypersensitivity to eggs may
occur in recipients of influenza vaccine.
• Inactivation, such as by formaldehyde in the case of the Salk vaccine, may alter
antigenicity.
• Presence of some un-inactivated microbes can lead to vaccine-associated disease.
17. SUBUNIT VACCINES:
Subunit vaccines contain purified antigens instead of whole organisms. Such a preparation
consists of only those antigens that elicit protective immunity. Subunit vaccines are
composed of toxoids, subcellular fragments, or surface antigens.
Administration of whole organism, as in case of pertussis was found unfavorable immune
reactions resulting in severe side effects.
The effectiveness of subunit vaccines in increased by giving them in adjuvants. Adjuvants
slow antigen release for a more sustained immune stimulation.
18. Antigen Microorganism Route
Cell wall
polysaccharide
Hemophilus influenzae b
Nesseria meningitides
Streptococcus pneumoniae
Group B Streptococcus
IM
Toxoid Clostridium tetani IM
Membrane proteins Influenza virus IM
Microbial proteins Bordetella pertussis IM
19. Advantages
• They can safely be given to immunosuppressed people
• They are less likely to induce side effects.
Disadvantages
• Antigens may not retain their native conformation, so that antibodies produced against
the subunit may not recognize the same protein on the pathogen surface.
• Isolated protein does not stimulate the immune system as well as a whole organism
vaccine.
20. Recombinant vaccines
Contains either a protein or a gene encoding a protein that is immunogenic
The desire genes identified and isolated from a pathogen and expressed in E. coli
or suitable host for production of the proteins
The proteins then purified and mixed with suitable stabilizers and adjuvants and
used for immunization.
The vaccines based on recombinant proteins are also called subunit vaccines.
e.g. Malaria vaccine, passed phase II now entering phase III.
21. Examples of expression vectors
1. Genetically engineered microorganisms, e.g., yeast for the expression of hepatitis B
surface antigen (HBsAg) used as vaccine against hepatitis B virus
2. Cultured animal cells, e.g., HBsAg expressed in CHO (Chinese hamster ovary) cell line
and C-127 cell line
3. Transgenic plants, e.g., HBsAg, HIV-l (human immunodeficiency virus-I) epitope (in
experimental stages)
4. Insect larvae; the gene is integrated into a bacculovirus genome, which is used to
infect insect larvae. Often a very high quantity of the recombinant protein is
produced .
22.
23. Vector vaccines
DNA sequence coding for the foreign gene (SARS-CoV-2) is inserted into the
plasmid vector along with a Chimpanzee Adenovirus promoter sequences.
The resultant recombination Chimpanzee adenovirus vector is then introduced
into cells to generate a virus that expresses the foreign gene.
The recombinant virus vaccine can then multiply in infected cells and produce
the antigens against which immunity develops.
The genes of several viruses can be inserted, so the potential exists for
producing polyvalent live vaccines.
24. …Vector vaccines
• Proteins encoded by these genes are appropriately expressed in vivo with respect to
glycosylation and secretion.
• They are processed for major histocompatibility complex (MHC) presentation by the
infected cells, thus effectively endowing the host with both humoral immunity and cell-
mediated immunity.
• A number of organisms have been used for vector vaccines, including the vaccinia virus,
canarypox virus, attenuated poliovirus, adenoviruses, attenuated strains of Salmonella,
the BCG strain of Mycobacterium bovis, and certain strains of streptococcus that normally
exist in the oral cavity
25.
26. Advantages
• Those vectors that are not only safe but also easy to grow and store can be chosen.
• Antigens which do not elicit protective immunity or which elicit damaging responses can
be eliminated from the vaccine. Example Cholera toxin A can be safely removed from
cholera toxin.
Disadvantages
• Since the genes for the desired antigens must be located, cloned, and expressed
efficiently in the new vector, the cost of production is high.
• When engineered vaccinia virus is used to vaccinate, care must be taken to spare
immunodeficient individuals.
27. Toxoids
A toxoid is a chemically or physically modified toxin that is no longer harmful but
retains immunogenicity
Certain pathogens cause disease by secreting an exotoxin:
these include tetanus, diphtheria, botulism and cholera
In addition, some infections, for example pertussis, appear to be partly toxin mediated
Specific physical or chemical modification of the toxins produces a toxoid, which is a
vaccine
Fig: Modification of toxin to toxoid
28. Tetanus Toxoid (TT)
Manufactured by growing a highly toxigenic strain of Clostridium tetani in a
semi-synthetic medium.
Formaldehyde treatment converts the toxin to a toxoid by altering particular
amino acids and inducing minor molecular conformational changes.
The toxoid is physicochemically similar to the native toxin thus inducing cross-
reacting antibodies. But, the changes induced by formaldehyde treatment
render it non-toxigenic
29. Advantages of toxoids
There are three principal advantages:
First, they are safe because they cannot cause the disease they prevent
and there is no possibility of reversion to virulence.
Second, because the vaccine antigens are not actively multiplying, they
cannot spread to unimmunized individuals.
Third, they are usually stable and long lasting as they are less susceptible
to changes in temperature, humidity and light which can result when
vaccines are used out in the community