Ansible can be used like Makefiles to define tasks for building and deploying applications. It offers advantages over Makefiles like increased readability through YAML syntax and the ability to easily run tasks on remote servers. Various Makefiles tasks like cleaning builds, copying files and dependencies, and creating symlinks can be defined as Ansible tasks/plays with variables to make them reusable across different projects. Ansible allows consolidating these tasks in one place for improved collaboration compared to complex Makefiles.