RD, a 59-year-old male with newly diagnosed Burkitt's lymphoma, presents with high risk of tumor lysis syndrome based on his labs. The best treatment is rasburicase to rapidly reduce his high uric acid level and prevent renal failure, along with IV fluids and allopurinol for comprehensive management. MM, a 62-year-old female with severe febrile neutropenia following chemotherapy, requires inpatient treatment with broad-spectrum IV antibiotics like meropenem and vancomycin due to her high risk status from low ANC, mucositis, and hypotension. This document provides guidelines for prevention, risk stratification, and treatment of tumor lysis syndrome