Topic: B and T cell development B cells and T cells are the two main types of lymphocytes that mediate adaptive immunity. They both undergo a complex process of development and maturation in primary lymphoid organs before they can participate in immune responses. In this topic, we will compare and contrast B cell development in the bone marrow and T cell development in the thymus, and discuss the similarities and differences between these two processes. Choose one of these prompts to address. Be sure to state which one you chose at the start of your post. Similarities and Differences in T-Cell and B-Cell Lineage Commitment: Compare and contrast the lineage commitment pathways of T cells and B cells. How are these pathways similar, and how do they differ? What factors determine the commitment of a cell to the T-cell versus B-cell lineage? Positive and Negative Selection in T-Cell and B-Cell Development: Analyze the role of positive and negative selection in T-cell and B-cell development. How do these processes differ between the two cell types, and what are the consequences of successful versus unsuccessful selection? Mechanisms of Self-Tolerance in T-Cells versus B-Cells: Summarize the mechanisms that maintain self-tolerance in T cells and B cells, and compare how these mechanisms differ between the two cell types. What are the unique challenges that each cell type faces in achieving self-tolerance? T-Cell versus B-Cell Receptor Development: Compare and contrast the development of T-cell receptors and B-cell receptors. How are these receptors generated, and how do they differ in their structure and function?.

1. Topic: B and T cell development
B cells and T cells are the two main types of lymphocytes that mediate adaptive immunity. They
both undergo a complex process of development and maturation in primary lymphoid organs
before they can participate in immune responses. In this topic, we will compare and contrast B
cell development in the bone marrow and T cell development in the thymus, and discuss the
similarities and differences between these two processes.
Choose one of these prompts to address. Be sure to state which one you chose at the start of your
post.
Similarities and Differences in T-Cell and B-Cell Lineage Commitment: Compare and contrast
the lineage commitment pathways of T cells and B cells. How are these pathways similar, and
how do they differ? What factors determine the commitment of a cell to the T-cell versus B-cell
lineage?
Positive and Negative Selection in T-Cell and B-Cell Development: Analyze the role of positive
and negative selection in T-cell and B-cell development. How do these processes differ between
the two cell types, and what are the consequences of successful versus unsuccessful selection?
Mechanisms of Self-Tolerance in T-Cells versus B-Cells: Summarize the mechanisms that
maintain self-tolerance in T cells and B cells, and compare how these mechanisms differ
between the two cell types. What are the unique challenges that each cell type faces in achieving
self-tolerance?
T-Cell versus B-Cell Receptor Development: Compare and contrast the development of T-cell
receptors and B-cell receptors. How are these receptors generated, and how do they differ in their
structure and function?