Double Machine Learning (Double ML) is a method for estimating treatment effects in high-dimensional data, such as online advertising data, that has many predictor variables. It involves using machine learning to first predict the outcome and treatment, and then regressing the treatment effect parameter on the residuals. This provides accurate estimates of treatment effects compared to methods like single equation regression. The document demonstrates Double ML through simulations using a large online advertising dataset, finding it outperforms other methods like naive averaging and standard lasso in estimating average treatment effects even in the presence of sampling bias.