This document summarizes a presentation given by Gerasimos Moschonas on the evolving threats facing CISOs and the challenges they face. It discusses how threats are becoming more advanced as attacks grow more aggressive and attackers become more professional. It also examines how the role of CISO has evolved from an IT security administrator to an independent and strategic role responsible for information security governance. Specific threats discussed include big data, the internet of things, cybercrime, social engineering, mobility, and an increasingly regulated environment. The challenges for CISOs are aligning security and business strategies, reducing risks to an acceptable level while protecting the business brand, and preparing for security incidents.