The document outlines a five step approach for clusters to support the implementation of megatrends in their region. The steps are: 1) trace relevant research; 2) become a forerunner by studying leading examples; 3) integrate stakeholder feedback through surveys and workshops; 4) support willing companies and establish role models; and 5) develop standardized metrics and tools to measure progress. The approach is demonstrated through Upper Austria's efforts to implement Industry 4.0.