The document presents lessons learned from successful cluster building and operation in Europe, highlighting the role of the European Secretariat for Cluster Analysis (ESCA) and the importance of cluster management and development. It discusses effective strategies, services, and government support for fostering vibrant clusters, using examples from various sectors such as the chemical industry and the Saxony state in Germany. The focus is on collaborative efforts between businesses, academia, and policy makers to create competitive value chains and innovation ecosystems.