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StatPearls [Internet].
Tarsal Tunnel Syndrome
John Kiel; Kimberly Kaiser.
Last Update: August 12, 2021.
Continuing Education Activity
Tarsal tunnel syndrome is sometimes referred to as tibial nerve dysfunction or posterior tibial nerve neuralgia. It is an
entrapment neuropathy that is associated with the compression of the structures within the tarsal tunnel. It can be
thought of as analogous to carpal tunnel syndrome of the wrist, but occurs at the ankle and is much less common than
carpal tunnel syndrome. This activity addresses the presentation, evaluation, and management of tarsal tunnel
syndrome and examines the role of an interprofessional team approach on the care of affected patients.
Objectives:
Identify the signs and symptoms of tarsal tunnel syndrome with the structures that are entrapped.
Describe the management strategies for tarsal tunnel syndrome.
Review the potential complications of tarsal tunnel syndrome.
Outline interprofessional team strategies for improving care coordination and communication to enhance
outcomes for patients affected by tarsal tunnel syndrome.
Access free multiple choice questions on this topic.
Introduction
Tarsal tunnel syndrome sometimes referred to as tibial nerve dysfunction or posterior tibial nerve neuralgia, is an
entrapment neuropathy that is associated with the compression of the structures within the tarsal tunnel. It is similar to
carpal tunnel syndrome of the wrist although much less common.[1][2][3][4]
The tarsal tunnel is a narrow fibro-osseous space that runs behind and inferior to the medial malleolus. It is bounded
by the medial malleolus anterosuperiorly, by the posterior talus and calcaneus laterally, and is held against the bone by
the flexor retinaculum which extends from the medial malleolus to the medial calcaneus and prevents medial
displacement of its contents.
The tarsal tunnel includes multiple important structures. It contains the tendons of the posterior tibialis, flexor
digitorum longus (FDL), and flexor hallucis longus (FHL) muscles. The posterior tibial artery and vein, as well as
posterior tibial nerve (L4-S3), also pass through it. The orientation of these structures within the tarsal tunnel is
noteworthy. From medial to lateral, they are the tibialis posterior tendon, FDL tendon, posterior tibial artery and vein,
posterior tibial nerve, and FHL tendon.
The posterior tibial nerve passes between the FDL and FHL muscles before it bifurcates in the tarsal tunnel, forming
the medial and lateral plantar nerves. In 5% of people, the bifurcation occurs before the tarsal tunnel. The medial
plantar nerve passes deep to the abductor hallucis and FHL muscles and provides sensation to the medial half of the
foot and first 3.5 digits and motor function to the lumbricals, abductor hallucis, flexor digitorum brevis, and flexor
hallucis brevis. The lateral plantar nerve passes directly through the abductor hallucis muscle belly and provides
sensory innervation of the medial calcaneus and lateral heel and motor function to the flexor digitorum brevis,
quadratus plantae, and abductor digiti minimi. The medial calcaneal nerve typically branches off of the posterior tibial
nerve proximal to the tarsal tunnel and provides sensory innervation to the posteromedial heel. In 25% of patients, it
branches off of the lateral plantar nerve or runs superficial to the flexor retinaculum.
Etiology
Tarsal tunnel syndrome is divided into intrinsic and extrinsic etiologies.[5][6]
Extrinsic causes include poorly fitting shoes, trauma, anatomic-biomechanical abnormalities (tarsal coalition,
valgus or varus hindfoot), post-surgical scarring, systemic diseases, generalized lower extremity edema,
systemic inflammatory arthropathies, diabetes, and post-surgical scarring.
Intrinsic causes include tendinopathy, tenosynovitis, perineural fibrosis, osteophytes, hypertrophic retinaculum,
and space-occupying or mass effect lesions (enlarged or varicose veins, ganglion cyst, lipoma, neoplasm, and
neuroma). Arterial insufficiency can lead to nerve ischemia.
The mechanism of impingement can be identified in approximately 80% of cases.
Epidemiology
The incidence of tarsal tunnel syndrome is unknown. It is a relatively rare and often underdiagnosed disease. It is
higher in females than in males and can be seen at any age.
Pathophysiology
Tarsal tunnel syndrome results from the compression of the posterior tibial nerve or one of its two branches, the
lateral or medial plantar nerve, within the tarsal tunnel. Up to 43% of patients have a history of trauma including
events such as ankle sprains. Abnormal biomechanics can contribute to disease progression. Risk factors include
systemic diseases such as diabetes mellitus, hypothyroidism, gout, mucopolysaccharidosis, and hyperlipidemia.
History and Physical
There is no specific test for the diagnosis of tarsal tunnel syndrome, and diagnosis is made with a detailed history and
clinical examination.
The predominant complaint is pain directly over the tarsal tunnel that radiates to the arch and plantar foot. Patients
with tarsal tunnel syndrome will frequently report a sharp shooting pain in the foot, numbness on the plantar surface,
radiation of pain and paresthesias along the distribution of the posterior tibial nerve, pain with extremes of
dorsiflexion and eversion, and a tingling or burning sensation. These symptoms may localize to the medial ankle or
plantar surface of the foot or be vaguer, making diagnosis difficult. Their symptoms will vary depending on whether
the entire posterior tibial nerve is compressed or if it is the lateral or medial plantar branches. The symptoms may
worsen at night, with walking or standing, or after physical activity, and typically get better with rest. Dysesthesias
may worsen at night, disturbing sleep. The patient may note weakness in the muscles of the foot.
On exam, the provider may observe pes planus, pronated foot, or talipes equinovarus. In chronic cases, atrophy,
weakness of the intrinsic foot muscles, and contractures of the toes may be appreciated. They are typically tender on
deep palpation of the tarsal tunnel. The gait should be analyzed for abnormalities including excessive pronation or
supination, toe eversion, excessive foot inversion or eversion, and antalgic gait.
Light touch and two-point discrimination should be tested. The patient may have diminished plantar sensation in the
distribution of either the medial or lateral plantar nerve. Muscle strength and foot range of motion should be assessed.
Strength deficits are typically a late finding in tarsal tunnel syndrome.
The Tinel test involves lightly tapping over the tarsal tunnel repeatedly. Pain or tingling in the distribution of the nerve
is a positive test. Sensitivity is low at 25% to 75%; specificity is 70% to 90%. The dorsiflexion-eversion test involves
passively dorsiflexing and everting the ankle to end range of motion and holding for 10 seconds. Reproduction of
symptoms is a positive sign due to compression of the posterior tibial nerve in this position. This test is positive in
82% of patients with tarsal tunnel syndrome.
Tarsal Tunnel Syndrome Severity Rating Scale
A score of 10 indicates a normal foot and 0 indicates the most symptomatic foot.
Scoring for each symptom:
2 points for the absence of features
1 point for some features
0 points for definite features
The five symptoms:
Spontaneous pain or pain with movement,
Burning pain
Tinel sign
Sensory disturbance
Muscle atrophy or weakness
Evaluation
Plain radiographs of the ankle and, possibly, the foot are the initial imaging study of choice. These may help identify
any structural abnormalities including osteophytes, hindfoot varus and valgus, tarsal coalition, or evidence of previous
trauma. Magnetic Resonance Imaging (MRI) is not sensitive for the diagnosis of the tarsal tunnel but may help
include or exclude other causes of the patient's symptoms. Ultrasound can be used to evaluate the soft tissue
structures. The nerve and its bifurcations can be observed. Either ultrasound or MRI can evaluate other soft tissue
abnormalities including tendonitis or tenosynovitis, lipomas or other growths, varicose veins, and ganglion cysts.[7]
Electromyography (EMG) and nerve conduction studies (NCS) are frequently abnormal in patients with tarsal tunnel
syndrome. Sensory nerve conduction studies are more likely to be abnormal than motor nerve conduction studies;
however, the sensitivity and specificity are suboptimal. False-negative tests are not uncommon and thus do not rule
out the diagnosis.
Treatment / Management
Management of tarsal tunnel syndrome remains challenging due to diagnostic uncertainty and lack of clarity over
which patients would benefit from conservative versus surgical management. Tarsal tunnel syndrome can be managed
nonoperatively or operatively. This decision is generally guided by the etiology of the disease, degree of loss of
function of the foot and ankle, as well as muscle atrophy.[8][9]
Conservative management and success vary based upon the etiology of tarsal tunnel syndrome. The goal is to
decrease pain, inflammation, and tissue stress. Ice can be used. Oral analgesics including acetaminophen and non-
steroidal anti-inflammatory drugs (NSAIDs) can be helpful. Neuropathic pain medications include gabapentin,
pregabalin, and tricyclic antidepressants can be tried. Topical medications can also be used, including lidocaine and
NSAIDs.
Physical therapy soft tissue modalities that may help include ultrasound, iontophoresis, phonophoresis, and E-stim.
Calf stretching and nerve mobility or nerve gliding can also help with symptoms. Strengthening the tibialis posterior
can help. Activity modification also plays a role in managing symptoms. Kinesiology tape can be used for arch
support and biomechanical stress reduction.
Orthotic shoes can be used to correct biomechanical abnormalities and offload the tarsal tunnel. A medial heel wedge
or heel seat may reduce traction on the nerve by inverting the heel. Night splints can be tried, and patients who fail to
respond to the above therapy can be placed in a walking boot temporarily. Footwear with appropriate arch support
may help reduce symptoms. CAM (controlled, ankle, motion) walker or walking boots may be tried.
If a ganglion cyst is present, it can be aspirated under ultrasound guidance. Corticosteroid injections into the tarsal
tunnel may help with edema.
Surgery is indicated if conservative management fails to resolve the patient’s symptoms or if a definitive cause of
entrapment is identified. Patients with symptoms caused by a space-occupying lesion generally respond well to
surgical management. Abnormally slow nerve conduction across the posterior tibial nerve is predictive of failed
conservative therapy.
Surgical management involves the release of the flexor retinaculum from its proximal attachment near the medial
malleolus down to the sustentaculum tali. Surgical success rates vary from 44% to 96%. Patients with a positive Tinel
sign preoperatively tend to respond better to surgical decompression than those who do not. Younger patients and
those with a short history of symptoms, early diagnosis, clear etiology, and no previous ankle pathology tend to
respond better to surgery.
Differential Diagnosis
The differential diagnoses of tarsal tunnel syndrome is broad, making diagnosis difficult. These include:
Achilles tendonitis
Compartment syndrome of the deep flexor compartment
Degenerative changes (calcaneal spurs, arthrosis of the joints of the foot)
Inflammatory conditions of the ligaments and fascia of the foot and ankle.
Intersection syndrome of the FHL and FDL at the knot of Henry
L5 and S1 nerve root compression
Morton metatarsalgia
Neurogenic intermittent claudication
Plantar fasciitis
Polyneuropathy
Retrocalcaneal bursitis
Prognosis
The prognosis of tarsal tunnel is variable. In patients with an identifiable etiology due to mass effect diagnosed early
in the disease course, the response is generally favorable. Patients without an identifiable cause and who do not
respond to conservative therapy generally do not do as well with surgical intervention. A positive Tinel sign is a
strong predictor of surgical relief.
Complications
Untreated or refractory tarsal tunnel syndrome can result in neuropathies of the posterior tibial nerve and its branches.
Patients may have persistent pain. Subsequent motor weakness and atrophy can develop. Postoperative complications
include impaired wound healing, infection, and scar formation. Surgical decompression may not adequately resolve
pain and other symptoms.
Postoperative and Rehabilitation Care
Postoperative rehab is aimed at protecting the joint and nerve integrity and controlling inflammation, pain, and
swelling. As rehab continues, the therapist and patient work to prevent contraction and adhesions of scar tissue while
maintaining soft tissue and joint mobility. Return to normal gait, walking, and running are long-term goals.
Consultations
The tarsal tunnel syndrome is a difficult, rare diagnosis. As such, cases are best managed by an orthopedic specialist.
Depending on the etiology, surgical management may be indicated.
Deterrence and Patient Education
There are no clear guidelines for the prevention or deterrence of tarsal tunnel syndrome.
Patients should be aware that there are many causes of foot and ankle pain, some of which are uncommon including
tarsal tunnel syndrome. If a patient has foot and ankle pain as well as other concerning symptoms such as burning,
numbness, tingling, and muscle weakness, they should seek the care of a medical professional.
Pearls and Other Issues
The tarsal tunnel syndrome is an entrapment neuropathy of the medial ankle.
It is an uncommon but underdiagnosed cause of foot and ankle pain.
The etiology is broad.
Patients tend to have pain originating from the tarsal tunnel radiating down to the plantar foot; however,
symptoms can vary.
There is no best test to diagnose tarsal tunnel syndrome, and it is a combination of history, exam, imaging, and
electromyography and nerve conduction studies.
Conservative therapy can be tried in most patients.
If a definitive cause is identified, surgical decompression can provide good results.
Enhancing Healthcare Team Outcomes
Management of tarsal tunnel syndrome remains challenging due to diagnostic uncertainty and lack of clarity over
which patients would benefit from conservative versus surgical management. Hence, the condition is best managed by
an interprofessional team that consists of a podiatrist, orthopedic surgeon, orthopedic nurse, and physical therapist.
Conservative treatment may help some patients but the key is physical therapy, change in shoes, and modification of
activity. For those with a compressive lesion, surgery may be beneficial. Regardless of the treatment path chosen, the
orthopedic nurse should monitor the results and report back to the clinician regarding progress or lack thereof, so
therapy can change if needed.
The overall prognosis for patients with tarsal tunnel syndrome is guarded. Relapse and remissions are common and
some patients never achieve complete relief from symptoms. [Level 5]
Review Questions
Access free multiple choice questions on this topic.
Comment on this article.
Figure
Tarsal Tunnel Syndrome. Image courtesy S Bhimji MD
Figure
Tarsal Tunnel Anatomy. Image courtesy O.Chaigasame
Figure
Anterior Tarsal Tunnel Syndrome- Note the dorsal soft tissue swelling and
dorsal osteophyte from the metatarsal-cuneiform joint causing distal
paresthesias due to medical dorsal cutaneous nerve entrapment. Contributed
by Mark A. Dreyer, DPM, FACFAS
References
Calvo-Lobo C, Painceira-Villar R, López-López D, García-Paz V, Becerro-de-Bengoa-Vallejo R, Losa-Iglesias
ME, Palomo-López P. Tarsal Tunnel Mechanosensitivity Is Increased in Patients with Asthma: A Case-Control
Study. J Clin Med. 2018 Dec 12;7(12) [PMC free article] [PubMed]
Stødle AH, Molund M, Nilsen F, Hellund JC, Hvaal K. Tibial Nerve Palsy After Lateralizing Calcaneal
Osteotomy. Foot Ankle Spec. 2019 Oct;12(5):426-431. [PubMed]
Zuckerman SL, Kerr ZY, Pierpoint L, Kirby P, Than KD, Wilson TJ. An 11-year analysis of peripheral nerve
injuries in high school sports. Phys Sportsmed. 2019 May;47(2):167-173. [PubMed]
Rinkel WD, Castro Cabezas M, van Neck JW, Birnie E, Hovius SER, Coert JH. Validity of the Tinel Sign and
Prevalence of Tibial Nerve Entrapment at the Tarsal Tunnel in Both Diabetic and Nondiabetic Subjects: A Cross-
Sectional Study. Plast Reconstr Surg. 2018 Nov;142(5):1258-1266. [PubMed]
Hong CH, Lee YK, Won SH, Lee DW, Moon SI, Kim WJ. Tarsal tunnel syndrome caused by an uncommon
ossicle of the talus: A case report. Medicine (Baltimore). 2018 Jun;97(25):e11008. [PMC free article] [PubMed]
Komagamine J. Bilateral Tarsal Tunnel Syndrome. Am J Med. 2018 Jul;131(7):e319. [PubMed]
Schuh A, Handschu R, Eibl T, Janka M, Hönle W. [Tarsal tunnel syndrome]. MMW Fortschr Med. 2018
Apr;160(6):58-59. [PubMed]
Mansfield CJ, Bleacher J, Tadak P, Briggs MS. Differential examination, diagnosis and management for tingling
in toes: fellow's case problem. J Man Manip Ther. 2017 Dec;25(5):294-299. [PMC free article] [PubMed]
Tu P. Heel Pain: Diagnosis and Management. Am Fam Physician. 2018 Jan 15;97(2):86-93. [PubMed]
Copyright © 2021, StatPearls Publishing LLC.
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In this Page
Continuing Education Activity
Introduction
Etiology
Epidemiology
Pathophysiology
History and Physical
Evaluation
Treatment / Management
Differential Diagnosis
Prognosis
Complications
Postoperative and Rehabilitation Care
Consultations
Deterrence and Patient Education
Pearls and Other Issues
Enhancing Healthcare Team Outcomes
Review Questions
References
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nerve in the tarsal tunnel]. [Acta Ortop Mex. 2013]
Review Median Nerve Palsy
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