This document summarizes Boris Fačkovec's thesis on intramolecular interactions in globular proteins. It discusses the development of methods to study protein structure and energetics over time, from early theories to modern computational techniques. The thesis aims to characterize interaction energies within proteins using an interaction energy matrix approach. It analyzes distributions of interaction energies between different residue types and defines optimal cutoffs for determining inter-residue contacts. The results provide insight into factors influencing protein domain size and stability.