The document discusses pharmaceutical suspensions. It defines a suspension as a coarse dispersion where an insoluble solid drug is uniformly dispersed throughout a liquid medium. Suspensions offer advantages like increased drug stability and controlled drug release. Key considerations in developing suspensions include particle size, sedimentation, wettability, and Brownian motion. Common applications are oral suspensions to mask bitter tastes or for poorly soluble drugs. The document outlines classification, evaluation, stabilization, and manufacturing of pharmaceutical suspensions.
Pharmaceutical suspensions are heterogeneous mixtures containing solid particles dispersed in a liquid medium. They allow insoluble drugs to be formulated into liquid dosage forms. Suspensions are administered via several routes including orally, ocularly, parenterally, and topically. Qualities of a good suspension include maintaining homogeneity during use and easy re-suspension of sediment. Suspensions have advantages over other dosage forms like permitting formulation of poorly soluble drugs and prolonging drug action.
Classification of Dispersion Systems by Rohit Kumar TrivediRohit Kumar Trivedi
Classification of Dispersion Systems
Dispersion (dispersed system) is a mixtures of two substances, one of which (dispersed phase) is distributed in form of subdivided particles/droplets/globules throughout another substance (continuous phase, dispersion medium).
There are three kind of Dispersed Systems:
1. Molecular 2. Colloidal 3. Coarse
The only difference among them is the “size” of dispersed phase not its composition.
Dispersions contain one internal phase that is dispersed in a dispersion medium.
Dispersion System: Classification
Suspensions can be classified based on their composition, properties, and evaluation methods. They consist of small particulate matter dispersed throughout a continuous phase. Sedimentation, rheological, electrokinetic, and micromeric methods are used to evaluate suspension stability over time based on properties like sedimentation volume, zeta potential, viscosity, and particle size distribution. Proper evaluation allows formulators to improve stability and compare products.
Settling in Suspensions, Formulation of Flocculated and Defloculated Suspens...Suyash Jain
Suspension
Settling in Suspensions,
Stroks law
Theory Of Sedimentation
Formulation of suspensions
Precipitation method:
Dispersion method
Comparision of partical setteling in Defloculated Suspension and Floculated Suspension
Characteristics of an Ideal Suspensions
Formulation of Flocculated and Defloculated Suspensions
This document discusses disperse systems, which are mixtures where one substance is dispersed throughout another. It defines three main types of disperse systems: true solutions (particles <1 nm), colloidal dispersions (particles 1 nm to 500 nm), and heterogeneous dispersions (particles >500 nm). It provides characteristics of each type, such as visibility of particles, ability to pass through filters or membranes, sedimentation rates, and thermal motion of particles. The document also classifies disperse systems based on the state of the dispersed and continuous phases (gas, liquid, solid) and lists some key properties like colligative effects, diffusion rates, optical properties, and methods of separation.
Pharmaceutical Suspensions Brief Presentation on Definition, Classification of suspension, Sedimentation, Brownian movement, Electro kinetic Properties of suspension, Stability of suspensions, Formulation of Suspensions, Preparation of Suspensions, Quality control of Suspensions, Recent Advancement in Suspensions
poorly soluble drugs and solid dispersionsrcdreddi
The document discusses amorphous solid dispersions and their advantages over crystalline forms. It examines the preparation and characterization of solid dispersions using hydrocortisone as a model drug and PVP as a carrier. The influence of drug to carrier ratio, solvent composition, and processing method are investigated. Spray drying and freeze drying were used to prepare dispersions from ethanol or ethanol/water solutions. Drug to carrier ratio, solvent composition, and processing method all impacted properties like glass transition temperature, moisture content, and drug dissolution rate from the solid dispersions. Further characterization and stability testing of the amorphous dispersions are recommended.
Pharmaceutical suspensions are heterogeneous mixtures containing solid particles dispersed in a liquid medium. They allow insoluble drugs to be formulated into liquid dosage forms. Suspensions are administered via several routes including orally, ocularly, parenterally, and topically. Qualities of a good suspension include maintaining homogeneity during use and easy re-suspension of sediment. Suspensions have advantages over other dosage forms like permitting formulation of poorly soluble drugs and prolonging drug action.
Classification of Dispersion Systems by Rohit Kumar TrivediRohit Kumar Trivedi
Classification of Dispersion Systems
Dispersion (dispersed system) is a mixtures of two substances, one of which (dispersed phase) is distributed in form of subdivided particles/droplets/globules throughout another substance (continuous phase, dispersion medium).
There are three kind of Dispersed Systems:
1. Molecular 2. Colloidal 3. Coarse
The only difference among them is the “size” of dispersed phase not its composition.
Dispersions contain one internal phase that is dispersed in a dispersion medium.
Dispersion System: Classification
Suspensions can be classified based on their composition, properties, and evaluation methods. They consist of small particulate matter dispersed throughout a continuous phase. Sedimentation, rheological, electrokinetic, and micromeric methods are used to evaluate suspension stability over time based on properties like sedimentation volume, zeta potential, viscosity, and particle size distribution. Proper evaluation allows formulators to improve stability and compare products.
Settling in Suspensions, Formulation of Flocculated and Defloculated Suspens...Suyash Jain
Suspension
Settling in Suspensions,
Stroks law
Theory Of Sedimentation
Formulation of suspensions
Precipitation method:
Dispersion method
Comparision of partical setteling in Defloculated Suspension and Floculated Suspension
Characteristics of an Ideal Suspensions
Formulation of Flocculated and Defloculated Suspensions
This document discusses disperse systems, which are mixtures where one substance is dispersed throughout another. It defines three main types of disperse systems: true solutions (particles <1 nm), colloidal dispersions (particles 1 nm to 500 nm), and heterogeneous dispersions (particles >500 nm). It provides characteristics of each type, such as visibility of particles, ability to pass through filters or membranes, sedimentation rates, and thermal motion of particles. The document also classifies disperse systems based on the state of the dispersed and continuous phases (gas, liquid, solid) and lists some key properties like colligative effects, diffusion rates, optical properties, and methods of separation.
Pharmaceutical Suspensions Brief Presentation on Definition, Classification of suspension, Sedimentation, Brownian movement, Electro kinetic Properties of suspension, Stability of suspensions, Formulation of Suspensions, Preparation of Suspensions, Quality control of Suspensions, Recent Advancement in Suspensions
poorly soluble drugs and solid dispersionsrcdreddi
The document discusses amorphous solid dispersions and their advantages over crystalline forms. It examines the preparation and characterization of solid dispersions using hydrocortisone as a model drug and PVP as a carrier. The influence of drug to carrier ratio, solvent composition, and processing method are investigated. Spray drying and freeze drying were used to prepare dispersions from ethanol or ethanol/water solutions. Drug to carrier ratio, solvent composition, and processing method all impacted properties like glass transition temperature, moisture content, and drug dissolution rate from the solid dispersions. Further characterization and stability testing of the amorphous dispersions are recommended.
This document discusses suspensions, including definitions, classifications, formulation, packing, evaluation, and storage. Suspensions are defined as preparations containing finely divided drug particles distributed uniformly throughout a vehicle. They are classified based on factors such as intended use (oral, external, parenteral), nature of solid particles (flocculated, deflocculated), and proportion of solid particles. Formulation involves selecting appropriate suspending agents, thickeners, and preservatives. Suspensions are packed in containers allowing for mixing and evaluated using sedimentation, rheological, and electrokinetic methods. Proper storage conditions help maintain stability.
The document discusses key concepts and steps in preformulation testing. Preformulation involves investigating the physical and chemical properties of a drug substance alone and when combined with excipients. This generates useful information for formulating stable and safe dosage forms with good bioavailability. Some important properties discussed include solubility, particle size and shape, melting point, thermal analysis profile, hygroscopicity, and polymorphism potential. Determining these properties of a new drug substance is an important first step before developing drug formulations.
A pharmaceutical suspension is a coarse dispersion of insoluble solid particles in a liquid medium. ... However, it is difficult and also impractical to impose a sharp boundary between the suspensions and the dispersions having finer particles. Suspensions are an important class of pharmaceutical dosage forms
This document provides information about pharmaceutical suspensions. It defines a suspension as a coarse dispersion where an insoluble solid active ingredient is uniformly dispersed throughout an external aqueous or non-aqueous liquid phase. Suspensions are formulated when drugs are insoluble, to mask bitter tastes, increase stability, or achieve sustained release. Key factors in formulating stable suspensions include particle size, shape, wettability, and use of suspending agents to decrease interparticle attraction and impart viscosity. Proper manufacturing controls suspension quality.
Rheological Properties of Disperse Systems & SemisolidsPriyanka Modugu
This document discusses the rheological properties of disperse systems and semisolids. It begins by introducing disperse systems and classifying them as either colloidal or coarsely dispersed systems. It then discusses various factors that affect the rheology of colloidal dispersions and describes the non-Newtonian flow properties of these systems. The document also addresses the rheological properties of coarsely dispersed systems like suspensions and emulsions. Finally, it covers the rheological evaluation of semisolid dosage forms and how their rheological characteristics influence properties like structure, stability and drug diffusion.
This document discusses coarse dispersion suspensions. It defines suspensions as heterogeneous systems with two phases, a solid dispersed phase and a liquid continuous phase. The key points covered include:
- Classifying suspensions based on particle size as coarse, colloidal, or molecular dispersions.
- Theories behind sedimentation behavior, Brownian motion, and electrokinetic properties that impact suspension stability.
- Factors that influence flocculation vs deflocculation like zeta potential, electrolyte concentration, and addition of surfactants or polymers.
- DLVO theory explaining the balance of attractive van der Waals forces and repulsive electrostatic forces between particles.
- How temperature changes can impact physical
Suspension, type of suspension, interracial property of suspended particles Dheeraj Saini
Here you find
Suspension , types of suspension, difference between flocculated and deflocculated suspension and interfacial properties of suspended particles
A suspension is a biphasic system with solid particles uniformly dispersed in a liquid. Suspensions can be used orally, parenterally, or topically for patients who cannot swallow solid dosage forms. Key properties include small, uniform particle size; lack of settling or easy redispersibility; optimal viscosity; and stability. Suspensions are classified by particle aggregation (flocculated or deflocculated) and route of administration. Flocculating agents cause particles to aggregate into flocs. Proper formulation and manufacturing can overcome issues like sedimentation and dispersion of hydrophobic drugs.
This document discusses spherical crystallization, which is a particle engineering technique that transforms drug crystals into spherical shapes. It has several advantages over traditional manufacturing like reduced processing time and equipment needs. The document outlines the basic materials and methods used, including solvents, polymers, and factors that affect the process. Common evaluation tests and applications are also mentioned, along with references for further reading.
A pharmaceutical suspension is a coarse dispersion of insoluble solid particles in a liquid medium. ... However, it is difficult and also impractical to impose a sharp boundary between the suspensions and the dispersions having finer particles. Suspensions are an important class of pharmaceutical dosage forms
The document discusses coarse dispersions and suspensions. It defines a suspension as an insoluble solid dispersed in a liquid medium where the particles are larger than 0.1 μm. Common types of suspensions include orally administered, ophthalmic, and injectable suspensions. Desirable qualities include minimal settling, uniform distribution, and appropriate viscosity. The document outlines factors that influence particle interactions like surface energy and interfacial tension. It also discusses strategies to achieve stability including controlled flocculation, use of surfactants, polymers, and structured vehicles.
This document discusses pharmaceutical suspensions. It begins by defining suspensions as heterogeneous systems with one substance dispersed in small units throughout another substance. Suspensions are classified based on route of administration and electrokinetic nature. Benefits include masking unpleasant tastes and controlling drug release. Challenges include physical instability and accurate dosing. Key factors in developing suspensions are preventing sedimentation, achieving uniformity, and pleasing attributes. Formulation considers vehicle structure, controlled flocculation, suspending agents, viscosity, surface tension, wetting agents, and solvents.
This document discusses pharmaceutical suspensions. It defines suspensions as dispersions of solid drug particles in a liquid vehicle. Suspensions are classified based on particle size as molecular dispersions (<1nm), colloidal dispersions (1nm-0.5um) or coarse dispersions (>0.5um). Most pharmaceutical suspensions are coarse dispersions. The document outlines factors to consider in suspension formulation including particle wetting and size, sedimentation rate, electrokinetic properties, and methods of controlling flocculation. Structured vehicles and controlled flocculation are described as methods for producing stable suspensions. Key qualities of ideal suspensions are also provided such as resistance to settling and caking.
This document discusses dissolution testing, which involves measuring how quickly a solid drug substance dissolves in solution. It defines dissolution and factors that affect the rate. These include drug properties like solubility, particle size, and solid form, as well as dosage form properties and excipients. Common in vitro dissolution testing models are described, including basket, paddle, and flow-through methods. Acceptance criteria for dissolution testing and methods for comparing dissolution profiles are also summarized.
Dissolution study-Dissolution studies Factor affecting dissolution and Invitr...DRx.Yogesh Chaudhari
This document discusses dissolution, which is the process by which a solid substance solubilizes in a solvent to form a solution. It is affected by various factors related to the chemical properties of the drug and formulation, as well as the testing conditions. The rate of dissolution can be modeled using theories like the diffusion layer model. Dissolution testing is important for optimization, quality control, and showing bioequivalence between batches. Common techniques to increase dissolution rate include reducing particle size, forming salts, selecting appropriate excipients, and processing methods like wet granulation.
The document discusses suspensions, including definitions, classifications, properties, advantages, disadvantages, formulation methods, components, and general formulation procedures. Some key points:
- A suspension is a heterogeneous system with insoluble particles dispersed uniformly throughout a liquid medium. Suspending agents help maintain uniform dispersion.
- Suspensions can be classified based on physical state, proportion of solids, behavior of dispersed phase, particle size, and general type (oral, topical, parenteral).
- Important properties include easy redispersion, no sediment compaction, optimal viscosity, and stability.
- Common formulation methods are precipitation, dispersion, controlled flocculation, and use of structured vehicles. Key components are suspending
formulation and evalution of effervescent tablet Akash Chaurasiya
Effervescent tablets dissolve quickly upon contact with water, releasing carbon dioxide bubbles through a chemical reaction between a carbonate or bicarbonate salt (e.g. sodium bicarbonate) and a weak organic acid (e.g. citric or tartaric acid). This reaction facilitates rapid disintegration without needing additional disintegrants. Effervescent tablets offer benefits like fast onset of action, improved palatability and absorption, but are more expensive to produce than regular tablets due to additional excipients required and specialized manufacturing processes. They are commonly used to formulate medicines that are difficult to digest or cause irritation when swallowed.
This document provides information on pharmaceutical suspensions. It begins by defining a suspension as a disperse system where an insoluble internal phase is dispersed uniformly throughout an external phase. The key differences between solutions and suspensions are explained. Suspensions require suspending agents to prevent particles from settling due to gravity. Common suspending agents include natural, semi-synthetic, and synthetic polymers. The document also discusses factors that influence sedimentation rate based on Stokes' equation and the differences between flocculated and deflocculated suspensions.
This document discusses suspensions, including definitions, classifications, formulation, packing, evaluation, and storage. Suspensions are defined as preparations containing finely divided drug particles distributed uniformly throughout a vehicle. They are classified based on factors such as intended use (oral, external, parenteral), nature of solid particles (flocculated, deflocculated), and proportion of solid particles. Formulation involves selecting appropriate suspending agents, thickeners, and preservatives. Suspensions are packed in containers allowing for mixing and evaluated using sedimentation, rheological, and electrokinetic methods. Proper storage conditions help maintain stability.
The document discusses key concepts and steps in preformulation testing. Preformulation involves investigating the physical and chemical properties of a drug substance alone and when combined with excipients. This generates useful information for formulating stable and safe dosage forms with good bioavailability. Some important properties discussed include solubility, particle size and shape, melting point, thermal analysis profile, hygroscopicity, and polymorphism potential. Determining these properties of a new drug substance is an important first step before developing drug formulations.
A pharmaceutical suspension is a coarse dispersion of insoluble solid particles in a liquid medium. ... However, it is difficult and also impractical to impose a sharp boundary between the suspensions and the dispersions having finer particles. Suspensions are an important class of pharmaceutical dosage forms
This document provides information about pharmaceutical suspensions. It defines a suspension as a coarse dispersion where an insoluble solid active ingredient is uniformly dispersed throughout an external aqueous or non-aqueous liquid phase. Suspensions are formulated when drugs are insoluble, to mask bitter tastes, increase stability, or achieve sustained release. Key factors in formulating stable suspensions include particle size, shape, wettability, and use of suspending agents to decrease interparticle attraction and impart viscosity. Proper manufacturing controls suspension quality.
Rheological Properties of Disperse Systems & SemisolidsPriyanka Modugu
This document discusses the rheological properties of disperse systems and semisolids. It begins by introducing disperse systems and classifying them as either colloidal or coarsely dispersed systems. It then discusses various factors that affect the rheology of colloidal dispersions and describes the non-Newtonian flow properties of these systems. The document also addresses the rheological properties of coarsely dispersed systems like suspensions and emulsions. Finally, it covers the rheological evaluation of semisolid dosage forms and how their rheological characteristics influence properties like structure, stability and drug diffusion.
This document discusses coarse dispersion suspensions. It defines suspensions as heterogeneous systems with two phases, a solid dispersed phase and a liquid continuous phase. The key points covered include:
- Classifying suspensions based on particle size as coarse, colloidal, or molecular dispersions.
- Theories behind sedimentation behavior, Brownian motion, and electrokinetic properties that impact suspension stability.
- Factors that influence flocculation vs deflocculation like zeta potential, electrolyte concentration, and addition of surfactants or polymers.
- DLVO theory explaining the balance of attractive van der Waals forces and repulsive electrostatic forces between particles.
- How temperature changes can impact physical
Suspension, type of suspension, interracial property of suspended particles Dheeraj Saini
Here you find
Suspension , types of suspension, difference between flocculated and deflocculated suspension and interfacial properties of suspended particles
A suspension is a biphasic system with solid particles uniformly dispersed in a liquid. Suspensions can be used orally, parenterally, or topically for patients who cannot swallow solid dosage forms. Key properties include small, uniform particle size; lack of settling or easy redispersibility; optimal viscosity; and stability. Suspensions are classified by particle aggregation (flocculated or deflocculated) and route of administration. Flocculating agents cause particles to aggregate into flocs. Proper formulation and manufacturing can overcome issues like sedimentation and dispersion of hydrophobic drugs.
This document discusses spherical crystallization, which is a particle engineering technique that transforms drug crystals into spherical shapes. It has several advantages over traditional manufacturing like reduced processing time and equipment needs. The document outlines the basic materials and methods used, including solvents, polymers, and factors that affect the process. Common evaluation tests and applications are also mentioned, along with references for further reading.
A pharmaceutical suspension is a coarse dispersion of insoluble solid particles in a liquid medium. ... However, it is difficult and also impractical to impose a sharp boundary between the suspensions and the dispersions having finer particles. Suspensions are an important class of pharmaceutical dosage forms
The document discusses coarse dispersions and suspensions. It defines a suspension as an insoluble solid dispersed in a liquid medium where the particles are larger than 0.1 μm. Common types of suspensions include orally administered, ophthalmic, and injectable suspensions. Desirable qualities include minimal settling, uniform distribution, and appropriate viscosity. The document outlines factors that influence particle interactions like surface energy and interfacial tension. It also discusses strategies to achieve stability including controlled flocculation, use of surfactants, polymers, and structured vehicles.
This document discusses pharmaceutical suspensions. It begins by defining suspensions as heterogeneous systems with one substance dispersed in small units throughout another substance. Suspensions are classified based on route of administration and electrokinetic nature. Benefits include masking unpleasant tastes and controlling drug release. Challenges include physical instability and accurate dosing. Key factors in developing suspensions are preventing sedimentation, achieving uniformity, and pleasing attributes. Formulation considers vehicle structure, controlled flocculation, suspending agents, viscosity, surface tension, wetting agents, and solvents.
This document discusses pharmaceutical suspensions. It defines suspensions as dispersions of solid drug particles in a liquid vehicle. Suspensions are classified based on particle size as molecular dispersions (<1nm), colloidal dispersions (1nm-0.5um) or coarse dispersions (>0.5um). Most pharmaceutical suspensions are coarse dispersions. The document outlines factors to consider in suspension formulation including particle wetting and size, sedimentation rate, electrokinetic properties, and methods of controlling flocculation. Structured vehicles and controlled flocculation are described as methods for producing stable suspensions. Key qualities of ideal suspensions are also provided such as resistance to settling and caking.
This document discusses dissolution testing, which involves measuring how quickly a solid drug substance dissolves in solution. It defines dissolution and factors that affect the rate. These include drug properties like solubility, particle size, and solid form, as well as dosage form properties and excipients. Common in vitro dissolution testing models are described, including basket, paddle, and flow-through methods. Acceptance criteria for dissolution testing and methods for comparing dissolution profiles are also summarized.
Dissolution study-Dissolution studies Factor affecting dissolution and Invitr...DRx.Yogesh Chaudhari
This document discusses dissolution, which is the process by which a solid substance solubilizes in a solvent to form a solution. It is affected by various factors related to the chemical properties of the drug and formulation, as well as the testing conditions. The rate of dissolution can be modeled using theories like the diffusion layer model. Dissolution testing is important for optimization, quality control, and showing bioequivalence between batches. Common techniques to increase dissolution rate include reducing particle size, forming salts, selecting appropriate excipients, and processing methods like wet granulation.
The document discusses suspensions, including definitions, classifications, properties, advantages, disadvantages, formulation methods, components, and general formulation procedures. Some key points:
- A suspension is a heterogeneous system with insoluble particles dispersed uniformly throughout a liquid medium. Suspending agents help maintain uniform dispersion.
- Suspensions can be classified based on physical state, proportion of solids, behavior of dispersed phase, particle size, and general type (oral, topical, parenteral).
- Important properties include easy redispersion, no sediment compaction, optimal viscosity, and stability.
- Common formulation methods are precipitation, dispersion, controlled flocculation, and use of structured vehicles. Key components are suspending
formulation and evalution of effervescent tablet Akash Chaurasiya
Effervescent tablets dissolve quickly upon contact with water, releasing carbon dioxide bubbles through a chemical reaction between a carbonate or bicarbonate salt (e.g. sodium bicarbonate) and a weak organic acid (e.g. citric or tartaric acid). This reaction facilitates rapid disintegration without needing additional disintegrants. Effervescent tablets offer benefits like fast onset of action, improved palatability and absorption, but are more expensive to produce than regular tablets due to additional excipients required and specialized manufacturing processes. They are commonly used to formulate medicines that are difficult to digest or cause irritation when swallowed.
This document provides information on pharmaceutical suspensions. It begins by defining a suspension as a disperse system where an insoluble internal phase is dispersed uniformly throughout an external phase. The key differences between solutions and suspensions are explained. Suspensions require suspending agents to prevent particles from settling due to gravity. Common suspending agents include natural, semi-synthetic, and synthetic polymers. The document also discusses factors that influence sedimentation rate based on Stokes' equation and the differences between flocculated and deflocculated suspensions.
This document provides information about pharmaceutical suspensions. It begins by defining a suspension as a disperse system where an insoluble solid internal phase is uniformly dispersed throughout an external liquid phase. Particle size is important for suspensions to be classified as coarse or colloidal. Suspensions differ from solutions in that particles remain dispersed rather than dissolving. Sedimentation occurs over time due to particle size and density. Suspending agents are added to prevent sedimentation by increasing viscosity. The document discusses formulation, applications, advantages, and disadvantages of suspensions.
A pharmaceutical suspension is a heterogeneous system in which finely divided solid particles are dispersed in a liquid medium. Unlike solutions, where solutes are completely dissolved, suspensions involve particles that are only partially soluble or insoluble in the liquid. These suspensions are commonly used in the pharmaceutical industry to deliver medications that may be poorly soluble or unstable in their pure form. The solid particles, often in the form of powders or crystals, are dispersed throughout the liquid phase, creating a stable mixture through the use of suspending agents or stabilizers. These agents prevent the settling of particles, ensuring uniform distribution and ease of redispersion upon shaking before administration. Pharmaceutical suspensions offer advantages in terms of flexibility in dosing and formulation, enabling the delivery of therapeutic agents in various forms such as oral liquids, injectables, or topical preparations, enhancing patient compliance and therapeutic efficacy. The formulation and stability of pharmaceutical suspensions require careful consideration of factors such as particle size, density, and the choice of stabilizers to maintain a consistent and reliable product.
Pharmaceutical Suspension Dosage Form (PPT)Prachi Pandey
A pharmaceutical suspension is a heterogeneous system in which finely divided solid particles are dispersed in a liquid medium. Unlike solutions, where solutes are completely dissolved, suspensions involve particles that are only partially soluble or insoluble in the liquid. These suspensions are commonly used in the pharmaceutical industry to deliver medications that may be poorly soluble or unstable in their pure form. The solid particles, often in the form of powders or crystals, are dispersed throughout the liquid phase, creating a stable mixture through the use of suspending agents or stabilizers. These agents prevent the settling of particles, ensuring uniform distribution and ease of redispersion upon shaking before administration. Pharmaceutical suspensions offer advantages in terms of flexibility in dosing and formulation, enabling the delivery of therapeutic agents in various forms such as oral liquids, injectables, or topical preparations, enhancing patient compliance and therapeutic efficacy. The formulation and stability of pharmaceutical suspensions require careful consideration of factors such as particle size, density, and the choice of stabilizers to maintain a consistent and reliable product.
This document defines suspensions as finely divided solid particles dispersed in a liquid or semisolid vehicle. It discusses the characteristics, types, theory, formulation, evaluation, and recent advances of suspensions. The key points are: Suspensions can be oral, parenteral, ophthalmic or for external use. Their stability depends on particle size, electrokinetic properties, and Brownian movement. Recent advances include nano suspensions, taste masked suspensions, and sustained release suspensions. Suspensions are prepared by grinding and dispersing ingredients, then evaluated based on sedimentation, particle size, and pH.
Suspension are biphasic liquids dosage form in which insoluble solid particulate are uniformly distributed in liquid phase which may be stabilized by inclusion of suspending agents.
This document discusses suspensions, which are heterogeneous systems consisting of solid particles dispersed throughout a liquid. It defines suspensions and describes their classification based on particle size. Key points include that suspensions have solid particles too large to be considered a true solution, stability is important to prevent settling or caking, and suspending agents are often added to help disperse particles and maintain stability. The document also covers formulation considerations like choice of vehicle and processing steps.
Suspensions are liquid dosage forms containing finely dispersed solid particles. They are used for drugs that are insoluble, unstable, or need to be absorbed slowly. Suspensions can be administered orally, ocularly, otically, rectally, parenterally, or topically. Factors in formulation include the nature and size of particles, viscosity, and physical stability. Structured vehicles and controlled flocculation are used to prepare deflocculated and flocculated suspensions, respectively. Evaluation tests assess properties like sedimentation, redispersibility, and zeta potential. Packaging requires containers with headspace and instructions to shake before use.
Pharmaceutical suspensions... a brief reviewbk fatima
This document provides information on suspensions, including:
- Definitions of suspensions and their advantages over other dosage forms.
- Classification of suspensions based on factors like concentration, particle size, and sedimentation.
- Guidelines for formulating stable suspensions, such as using suspending agents and controlling flocculation.
- Methods for evaluating properties of suspensions like sedimentation, viscosity, and particle size over time to assess stability.
- Common suspending agents used to increase viscosity and prevent caking or sedimentation.
This document provides an overview of suspensions including:
- Definitions of suspensions as heterogeneous systems with solid particles dispersed in a liquid.
- Classification based on concentration, particle size, and electrokinetic properties.
- Advantages like masking taste and controlling drug release and disadvantages like stability issues.
- Theoretical considerations for suspensions including sedimentation, Brownian motion, and zeta potential which influence particle behavior.
- Applications for insoluble drugs, stability, taste-masking and topics like formulation, evaluation, and stability are also covered.
Pharmaceutical suspension can be classified based on the dispersed phase, vehicle used, proportion of solid particles, particle size, etc. They can be stabilized using suspending agents, viscosity increasing agents, surface charge, etc. Recent advances include nano suspensions to improve solubility, taste masked suspensions to improve palatability, and sustained release suspensions to reduce dosing frequency. Evaluation methods include sedimentation studies, rheological measurements, and zeta potential determination.
The document discusses suspensions, which are heterogeneous systems with small, solid particles dispersed throughout a liquid medium. Suspensions can be used orally, parenterally, or externally. They are divided into coarse and colloidal suspensions based on particle size. Various factors including particle size and distribution, viscosity, and stability must be considered for suspension formulation and production. Common methods for preparing suspensions involve using mortar and pestle or mixing equipment depending on the materials used.
Suspensions for B.pharmacy Suspensions in Pharmaceuticsgamerking23012001
The document discusses suspensions, which are heterogeneous systems with small, finely divided solid particles distributed throughout a liquid vehicle. Suspensions can be classified based on particle size, concentration of solids, electrokinetic properties, and application. Key points covered include the properties of flocculated and deflocculated suspensions, factors affecting sedimentation, and the roles of suspending, wetting, dispersing, and flocculating agents. Common mixing and milling equipment used for producing suspensions are also summarized.
This Slide Contains A Brief Lecture On Suspensions and Its Types Based On The Factors Affecting The Preparation Of Dosage Form In The Field Of Pharmaceutics
Suspension is a two-phase system with a solid dispersed in a liquid. Suspensions offer advantages like masking unpleasant tastes, providing prolonged drug release, and increased bioavailability. Factors like particle size, viscosity, and density difference between solid and liquid affect sedimentation rate per Stokes' law. Formulating stable suspensions requires choosing vehicles that maintain particles in deflocculated state or produce redispersible floccules. Wetting powder particles thoroughly before adding to the vehicle aids in proper dispersion.
This document provides an overview of suspensions, including their classification, properties, formulation, and stability. Key points include:
- Suspensions are heterogeneous systems with an insoluble dispersed phase distributed throughout a continuous phase. They can be classified based on their intended use, concentration of solids, particle size, and electrokinetic properties.
- Interfacial properties like surface tension affect particle flocculation and sedimentation. Surfactants can reduce surface tension to promote deflocculation.
- Particle size, concentration, and Brownian motion influence sedimentation rates. Flocculated particles settle faster but are easier to redisperse than deflocculated particles.
- Stable suspensions are formulated using vehicles to
The document summarizes key information about pharmaceutical suspensions. It defines suspensions as coarse dispersions of insoluble solids suspended in a liquid medium. Suspensions consist of two phases, with the internal solid phase dispersed throughout the external liquid phase using mechanical agitation and excipients. Suspensions are advantageous for stable delivery of drugs that are insoluble or unstable in solution. The document outlines factors that influence sedimentation of particles in suspensions and methods for achieving physical stability, including controlling particle size and flocculation.
The medical termination of pregnancy act 1971Sneha Patel
The document discusses the legal framework around abortion in India, as outlined in the Medical Termination of Pregnancy Act of 1971 and subsequent rules and regulations. It provides definitions of key terms, outlines when abortions are considered legal and the conditions that must be met. These include the gestational age of the pregnancy, consent requirements, opinions of medical practitioners, and where the procedure can be conducted. It also summarizes the training requirements for practitioners, approval process for clinics, forms used, and record-keeping and reporting procedures that must be followed under the Act.
The Poisons Act of 1919 was passed to regulate the import, possession, and sale of poisons in India, as the 1904 act was deemed insufficient. Key objectives were to control trafficking of poisons and prevent misuse. The central government regulates import through licensing, while state governments make rules for possession and sale within their territories. Rules cover licensing, record keeping, storage, labeling, transport, and penalties for non-compliance. The act aims to ensure the safe and legitimate use of poisons.
Hospital pharmacy and its organization Sneha PatelSneha Patel
This document discusses the organization and management of hospital pharmacies. It defines a hospital pharmacy as the department responsible for procuring, storing, manufacturing, testing, packaging and distributing drugs. The objectives of hospital pharmacies are to professionalize pharmaceutical services, ensure availability of the right medications, and participate in education and research. Key functions of hospital pharmacies include dispensing drugs, managing inventory, providing drug information, and participating in teaching and research. The roles and responsibilities of hospital pharmacists are also outlined.
The document discusses the organization and functions of hospitals. It defines a hospital as a facility that provides medical care through specialized equipment and trained staff. Hospitals can be classified in various ways, including by clinical specialty (e.g. maternity, surgery), ownership (government, private), medical system practiced (homeopathy, Ayurveda), or size based on bed count. The key roles in a hospital include administrative staff led by a superintendent, medical staff including residential, associate, consulting and honorary doctors and nurses, and supportive services like pharmacy and housekeeping.
The document provides information on distillation, including definitions, history, introduction, types of distillation, equipment used, and principles of operation. Specifically, it defines distillation as a process of separating components of a liquid mixture based on differences in volatility through selective evaporation and condensation. It also discusses various types of distillation such as simple distillation, flash distillation, vacuum distillation, and fractional distillation. The key equipment used in distillation like the still, condenser, and receiver are also described.
The document discusses posology, which is the science of determining safe and effective drug dosages based on factors like age, weight, condition of the patient, and how the body processes drugs. It outlines many factors that influence drug dosages, such as age, weight, metabolism, and drug interactions. The document also provides formulas and guidelines for calculating appropriate drug dosages for children and animals based on their age, weight, and other characteristics.
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar Kanvaria
How to Build a Module in Odoo 17 Using the Scaffold MethodCeline George
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
This presentation includes basic of PCOS their pathology and treatment and also Ayurveda correlation of PCOS and Ayurvedic line of treatment mentioned in classics.
Strategies for Effective Upskilling is a presentation by Chinwendu Peace in a Your Skill Boost Masterclass organisation by the Excellence Foundation for South Sudan on 08th and 09th June 2024 from 1 PM to 3 PM on each day.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
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Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
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Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
3. SUSPENSIONS
Formulation of suspensions
Packing of suspensions
Storage requirement & labelling
Evaluation of suspension
Dissolution study of suspensions
Innovation of suspensions
3 2 March 2020
5. SUSPENSIONS5
The term "Disperse System" refers to a system in which
one substance (The Dispersed Phase) is distributed, in
discrete units, throughout a second substance (the
continuous Phase ).
Each phase can exist in solid, liquid, or gaseous state .
Suspensions are heterogenous system consisting of 2
phases.
DISPERSE SYSTEM
2 March 2020
6. SUSPENSIONS6
A solid in liquid dispersion in which the particles are
of colloidal size.
DISPERSE SYSTEM
DISPERSED MEDIUM DISPERSED PHASE
oAqueous oily liquid oInsoluble solid
2 March 2020
7. SUSPENSIONS
Definition
A Pharmaceutical suspension is a coarse dispersion in which internal
phase (therapeutically active ingredient)is dispersed uniformly
throughout the external phase.
7 2 March 2020
8. SUSPENSIONS
The internal phase consisting of insoluble solid particles
having a range of size(0.5 to 5 microns) which is
maintained uniformly through out the suspending vehicle
with aid of single or combination of suspending agent.
The external phase (suspending medium) is generally
aqueous in some instance, may be an organic or oily
liquid for non oral use.
8 2 March 2020
9. SUSPENSIONS
The reasons for the formulation of a pharmaceutical
suspension:
-- when the drug is insoluble in the delivery vehicle.
–To mask the bitter taste of the drug.
–To increase drug stability.
–To achieve controlled/sustained drug release.
9 2 March 2020
14. SUSPENSIONS
Based on Size of Solid Particles
Colloidal suspensions (< 1 micron)
-Suspensions having particle sizes of suspended solid less than
about 1micron in size are called as colloidal suspensions.
14 2 March 2020
15. SUSPENSIONS
Coarse suspensions (>1 micron)
Suspensions having particle sizes of greater than about
1micron in diameter are called as coarse suspensions.
Suspensions are the biphasic colloidal dispersions of
nanosized drug particles stabilized by surfactants.
Size of the drug particles is less than 1mm.
Nano suspensions (10 ng)
Coarse dispersion
Barium sulphate
15 2 March 2020
16. SUSPENSIONS
Advantages And Disadvantages
.Suspension can improve chemical stability of certain drug.
E.g. Procaine penicillin G.
Drug in suspension exhibits higher rate of bioavailability than other
dosage forms.
Solution > Suspension > Capsule > Compressed Tablet > Coated tablet
Duration and onset of action can be controlled.
E.g. Protamine Zinc-Insulin suspension.
Suspension can mask the unpleasant/ bitter taste of drug.
E.g. Chloramphenicol
16
Advantages
2 March 2020
17. SUSPENSIONS
Physical stability , sedimentation and compaction can causes
problems.
It is bulky sufficient care must be taken during handling and
transport.
It is difficult to formulate.
Uniform and accurate dose can not be achieved unless
suspension are packed in unit dosage form.
17
Disadvantages
2 March 2020
18. SUSPENSIONS
Applications
Suspension is usually applicable for drug which is insoluble
(or ) poorly soluble.
E.g. Prednisolone suspension
To prevent degradation of drug or to improve stability of
drug.
E.g. Oxy tetracycline suspension
To mask the taste of bitter of unpleasant drug.
E.g. Chloramphenicol palmitate suspension
Suspension of drug can be formulated for topical application
e.g. Calamine lotion
18 2 March 2020
19. SUSPENSIONS
Suspension can be formulated for parentral application in order to
control rate of drug absorption. E.g. penicillin procaine
Vaccines as a immunizing agent are often formulated as suspension.
E.g. Cholera vaccine
X-ray contrast agent are also formulated as suspension .
eg: Barium sulphate for examination of alimentary tract.
19 2 March 2020
20. SUSPENSIONS
The suspended particles should not settle rapidly and sediment
produced, must be easily re-suspended by the use of moderate
amount of shaking.
It should be easy to pour yet not watery and no grittiness.
It should have pleasing odour , colour and palatability.
Good syringeability.
It should be physically,chemically and microbiologically stable.
Parenteral /Ophthalmic suspension should be sterilizable.
Features Desired In Pharmaceutical Suspensions
20 2 March 2020
21. SUSPENSIONS
THEORITIC CONSIDERATION OF SUSPENSIONS
A knowledge of the theoretic considerations pertaining to
suspension s technology ultimately help formulator to select
ingredients that are
Appropriate for suspension preparation
That available for milling
Mixing equipment
21 2 March 2020
23. SUSPENSIONS23
Particle size control:
- Particle size of any suspension is critical and must
be reduced within the range .
-Too large or too small particles should be avoided.
Larger particles will:
settle faster at the bottom of the container
particles > 5 um impart a gritty texture to the product
and also cause irritation if injected or instilled to the eye
particles > 25 um may block the needle
-Too fine particles will easily form hard cake at the bottom
of the container.
2 March 2020
24. SUSPENSIONS24
Wetting of the particles
Hydrophilic materials (talc, ZnO, Mg2CO3) are easily
wetted by water while hydrophobic materials (sulphur , charcoal)
are not due to the layer of adsorbed air on the surface.
Thus, the particles, even high density, float on the surface of the
liquid until the layer of air is displaced completely.
The use of wetting agent allows removing this air from
the surface and to easy penetration of the vehicle into the pores.
However hydrophobic materials are easily wetted by
non-polar liquids.
2 March 2020
26. SUSPENSIONS
2.1.
Velocity of sedimentation expressed by Stoke’s equation
Where,
d = Diameterof particle
r = radius of particle
vsed.= sedimentation velocity in cm / sec
ρ s= density of disperse phase
ρ o= density of disperse media
g = acceleration due to gravity
η o = viscosity of disperse medium in poise
26 2 March 2020
27. SUSPENSIONS
Limitation Of Stoke’s Equation .
Stoke's equation applies only to:
Spherical particles in a very dilute suspension (0.5 to 2 gm per
100 ml)
Particles which freely settle without collision .
Particles with no physical or chemical attraction.
27 2 March 2020
28. SUSPENSIONS
Sedimentation Parameters
28
Sedimentation volume (F) or height (H) for
flocculated suspensions:
Definition:
Sedimentation volume is a ratio of the ultimate volume of
sediment (Vu) to the original volume of sediment (VO)
before settling.
F = V u / VO
Where,
Vu = final or ultimate volume of sediment
VO = original volume of suspension before settling
2 March 2020
29. SUSPENSIONS29
F has values ranging from less than one to greater than one.
When F < 1 Vu < Vo
When F =1 Vu = Vo
The system is in flocculated equilibrium and show no clear
supernatant on standing.
When F > 1 Vu > Vo
Sediment volume is greater than the original volume due
to the network of flocs formed in the suspension and so
loose and fluffy sediment
2 March 2020
30. SUSPENSIONS
The sedimentation volume gives only a qualitative account of
flocculation.
Fig : Suspensions quantified by sedimentation volume (f)
30 2 March 2020
31. SUSPENSIONS31
Degree of flocculation (β)
It is the ratio of the sedimentation volume of the
flocculated suspension ,F , to the sedimentation volume
of the deflocculated suspension, F∞
ß = F / F∞
(Vu/Vo) flocculated
ß = --------------------
(Vu/Vo) deflocculated
The minimum value of ß is 1,when flocculated suspension
sedimentation volume is equal to the sedimentation volume
of deflocculated suspension.
2 March 2020
32. SUSPENSIONS
.
2.Brownian Movement (Drunken walk)
Brownian movement of particle prevents sedimentation
by keeping the dispersed material in random motion.
Brownian movement depends on the density of dispersed
phase and the density and viscosity of the disperse medium.
32
The kinetic bombardment of the particles by the molecules of the
suspending medium will keep the particles suspending, provided that
their size is below critical radius (r).
2 March 2020
33. SUSPENSIONS
Brownian movement can be observed,
If particle size is about 2 to 5mm,
When the density of particle & viscosity of medium are
favorable.
33 2 March 2020
34. SUSPENSIONS
Brownian motion is given by equation:
Where, R = gas constant
T = temp. in degree Kelvin
N = Avogadro’s number
η = viscosity of medium
t = time
r = radius of the particle
34 2 March 2020
35. SUSPENSIONS
3.Electro kinetic Properties
Zeta Potential
The zeta potential is defined as the difference in potential between the
surface of the tightly bound layer (shear plane) and electro-neutral
region of the solution.
35 2 March 2020
36. SUSPENSIONS
b As the potential drops off rapidly at first, followed more gradual
decrease as the distance from the surface increases.
This is because the counter ions close to the surface acts as a
screen that reduce the electrostatic attraction between the
charged surface and those counter ions further away from the
surface.
36 2 March 2020
37. SUSPENSIONS
Zeta potential has practical application in stability of systems
containing dispersed particles .
Since this potential, rather than the Nernst potential, governs the
degree of repulsion between the adjacent, similarly charged,
dispersed particles.
If the zeta potential is reduced below a certain value , the attractive
forces exceed the repulsive forces, and the particles come together.
This phenomenon is known as flocculation.
37 2 March 2020
38. SUSPENSIONS
The flocculated suspension is one in which zeta potential of
particle is -20 to +20 mV.
Thus the phenomenon of flocculation and de flocculation
depends on zeta potential carried by particles.
38 2 March 2020
39. SUSPENSIONS39
Deflocculation and flocculation
Flocculated Suspensions
In flocculated suspension, formed flocs (loose aggregates) will cause
increase in sedimentation rate due to increase in size of sedimenting
particles.
Hence, flocculated suspensions sediment more rapidly.
Here, the sedimentation depends not only on the size of the flocs but
also on the porosity of flocs.
2 March 2020
40. SUSPENSIONS40
Deflocculated suspensions
In deflocculated suspension, individual particles are
settling.
Rate of sedimentation is slow , which prevents
entrapping of liquid medium which makes it difficult to
re-disperse by agitation.
This phenomenon called ‘caking’ or ‘claying’.
In deflocculated suspension larger particles settle fast
and smaller remain in supernatant liquid so supernatant
appears cloudy.
2 March 2020
41. SUSPENSIONS
The formulation of a suspension depends on whether the
suspension is flocculated or deflocculated.
Three approaches are commonly involved
1. Use of structured vehicle
2. Use of controlled flocculation
3. Combination of both of the methods
:FORMULATION OF SUSPENSIONS
41 2 March 2020
43. SUSPENSIONS
Structured vehicles called also thickening or suspending
agents.
They are aqueous solutions of natural and synthetic gums.
These are used to increase the viscosity of the suspension.
It is applicable only to deflocculated suspensions.
E.g. methyl cellulose, sodium carboxy methyl cellulose,
acacia, gelatin and tragacanth.
43
Structured vehicle
2 March 2020
44. SUSPENSIONS
These structured vehicles entrapped the particle and
reduces the sedimentation of particles.
Thus, the use of deflocculated particles in a structure vehicle
may form solid hard cake upon long storage.
44 2 March 2020
45. SUSPENSIONS
Too high viscosity is not desirable as:
a) It causes difficulty in pouring and administration.
b) It may affect drug absorption since they adsorb on the
surface of particle and suppress the dissolution rate.
Structured vehicle is not useful for Parenteral suspension
because they may create problem in syringeability due to high
viscosity.
45 2 March 2020
46. SUSPENSIONS
° Controlled flocculation of particles is obtained by
adding flocculating agents, which are:
(1) electrolytes
(2) surfactants
(3) polymers
46
Controlled flocculation
2 March 2020
47. SUSPENSIONS
Sometimes suspending agents can be added to
flocculated suspension to retard sedimentation
° Examples of these agents are:
Carboxymethylcellulose (CMC),
Carbopol 934,
Veegum, and bentonite
47
Flocculation in structured vehicles
2 March 2020
49. SUSPENSIONS
.
Wetting agents They are added to disperse solids in continuous
liquid phase.
Flocculating
agents
They are added to floc the drug particles
Thickeners They are added to increase the viscosity of
suspension.
Buffers
and pH adjusting agents
They are added to stabilize the suspension to a
desired pH range.
Osmotic
agents
They are added to adjust osmotic pressure
comparable to biological fluid.
Coloring
agents
They are added to impart desired color to
suspension and improve elegance.
Preservatives They are added to prevent microbial growth.
External
liquid vehicle
They are added to construct structure of the
final suspension.
49 2 March 2020
50. SUSPENSIONS
Suspending agent are also known as hydrophilic colloids
which form colloidal dispersion with Water and increase the
viscosity of the continous phase.
Suspending agent form film around particle and decrease
interparticle attraction.
50
Most suspending agents perform two functions
i.e. besides acting as a suspending agent
they also imparts viscosity to the solution.
Suspending agents
2 March 2020
51. SUSPENSIONS
Preferred suspending agents are those that give thixotropy to the
media such as
51
Xanthan gum,
Carageenan,
Na CMC/MC mixers,
Avicel RC 591
Avicel RC 581 and
Avicel CL 611.
.
2 March 2020
52. SUSPENSIONS
Suspending agents Stability pH
range
Concentrations used
as suspending
agent
Sodium alginate 4-10 1– 5 %
Methylcellulose 3-11 1– 2 %
Hydroxyethyl cellulose 2-12 1-2%
Hydroxypropyl cellulose 6-8 1-2%
Hydroxypropyl
methylcellulose
3-11 1-2%
CMC 7-9 1-2%
Colloidal
silicon dioxide
0-7.5 2- 4 %
Stability pH range and concentrations of most commonly used suspending agents.
52 2 March 2020
53. SUSPENSIONS
List of Suspending Agents
Alginates
•Methylcellulose
•Hydroxyethylcellulose
•Carboxymethylcellulose
•Sodium Carboxymethylcellulose
•Microcrystalline cellulose
•Acacia
•Tragacanth
•Xantham gum
•Bentonite
•Carbomer
•Carrageen
•Powdered cellulose
•Gelatin
53 2 March 2020
54. SUSPENSIONS
Alginates
Alginate salts have about same suspending action to that
of Tragacanth.
Alginate solution looses its viscosity when heated above 60ºC.
due to polymerization.
Alginate granules
54 2 March 2020
55. SUSPENSIONS
Maximum viscosity is observed at a pH range of 5-9 of
alginate.
Chemically alginates are polymers composed of mannuronic
acid and glucuronic acid monomers.
In practice, alginate is used at concentration less than 10 %
w/w, particularly at 5 % w/w.
55 2 March 2020
56. SUSPENSIONS
Methylcellulose
Methylcellulose is available in several viscosity grades.
The difference in viscosity is due to difference in methylation
and polymer chain length.
Methylcellulose is more soluble in cold water than hot water.
Methylcellulose is stable at pH range of 3-11.
Methyl cellulose
powder
56
Methyl cellulose on
heating
Gel form
on
cooling
Solution form
2 March 2020
57. SUSPENSIONS
Hydroxy ethylcellulose:
Hydroxyethylcellulose (HEC) is another good
suspending agent having somewhat similar characteristics
to methylcellulose.
In HEC hydroxyethyl group is attached to cellulose chain.
Unlike methylcellulose, HEC is soluble in both hot and cold water
and do not form gel on heating.
57 2 March 2020
58. SUSPENSIONS
Carboxy methylcellulose (CMC)
Carboxy methylcellulose is available at different viscosity grades.
Low, medium and high viscosity grades are commercially
available.
In case of HV-CMC, the viscosity significantly decreases when
temperature rises to 40 ºC from 25 ºC.
Therefore, to improve viscosity and stability of suspension MV-CMC
is widely accepted.
58 2 March 2020
59. SUSPENSIONS
Microcrystalline Cellulose (MCC; Tradename-Avicel)
It is not soluble in water, but it readily disperses in water to give
thixotropic gels.
It is used in combination with Na-CMC, MC or HPMC, because
they facilitate dispersion of MCC.
59 2 March 2020
60. SUSPENSIONS
The advantages of MCC:
Alginate complex compositions are that they provide excellent
stability.
Formulation of dry powder suspensions with MCC;
Alginate complexes produce an excellent dry readily hydratable
and dispersible formulation for reconstitution.
60 2 March 2020
61. SUSPENSIONS
Hydrophilic materials are easily wetted by water while hydrophobic
materials are not.
However hydrophobic materials are easily wetted by non-polar
liquids.
The extent of wetting by water is dependent on the hydrophillicity of
the materials.
If the material is more hydrophilic less difficulty in wetting by
water.
The concentration used is less than 0.5 %.
61
Wetting Agents
2 March 2020
62. SUSPENSIONS
.
Surfactants decrease the interfacial tension between drug particles
and liquid thus liquid is penetrated in the pores of drug particle
displacing air from them and thus ensures wetting.
Generally, we use non-ionic surfactants but ionic surfactants can
also be used depending upon certain conditions.
Polysorbate 80 is most widely used due to its following advantages
It is non-ionic so no change in pH of medium
No toxicity. Safe for internal use.
62
Surfactants
2 March 2020
63. SUSPENSIONS
Hydrophilic colloids coat hydrophobic drug particles
in one or more than one layer.
This will provide hydrophillicity to drug particles and facilitate
wetting.
They cause deflocculation of suspension because force of
attraction is declined. e.g. acacia, tragacanth, alginates, guar
gum.
63
Hydrophilic Colloids
2 March 2020
64. SUSPENSIONS
The most commonly used solvents used are alcohol,
glycerin, polyethylene glycol and polypropylene glycol.
The mechanism by which they provide wetting is that they
are miscible with water and reduce liquid air interfacial tension.
Liquid penetrates in individual particle and facilitates wetting.
64
Solvents
2 March 2020
65. SUSPENSIONS
n.
Buffers are the materials which when dissolved in a
solvent will resist any change in pH when an acid or base is added.
To encounter stability problems all liquid formulation should be
formulated to an optimum pH.
Rheology, viscosity and other property are also dependent on the
pH of the system.
65
Buffers
2 March 2020
66. SUSPENSIONS
. Generally pH of suspension preferably at 7.4-8.4.
Most commonly used buffers are salts of weak acids such as
carbonates,
citrates,
gluconates,
phosphate and tartrates.
66 2 March 2020
67. SUSPENSIONS
They are added to produce osmotic pressure comparable to
biological fluids when suspension is to be intended for
ophthalmic or injectable preparation.
Most commonly used osmotic agents are
dextrose,
mannitol
sorbitol.
sodium chloride,
sodium sulfate
glycerol.
67
Osmotic Agents
2 March 2020
68. SUSPENSIONS
Naturally occurring suspending agents such as tragacanth, acacia,
xanthan gum are susceptible to microbial contamination.
This leads to:
loss in suspending activity of suspending agents,
loss of color, flavor and odor,
change in elegance etc.
68
Preservatives
2 March 2020
69. SUSPENSIONS
Name of preservatives Concentration range
Propylene glycol 5-10%
Disodium EDTA 0.1%
Benzalkonium chloride 0.01-0.02%
Benzoic acid 0.1%
Butyl paraben 0.006-0.05% oral
suspension
0.02-0.4% topical
formulation
Disodium EDTA benzalkanonium
69 2 March 2020
70. SUSPENSIONS
They are added to increase patient acceptance.
Only sweetening agent are not capable of complete taste masking
of unpleasant drugs therefore, a flavoring agents are incorporated.
70
Flavoring And Coloring Agents
2 March 2020
72. SUSPENSIONS
Colors are obtained from natural or synthetic sources.
Plant colors are most widely used for oral suspension.
The synthetic dyes should be used within range of( 0.0005 % to
0.001%)
72
Coloring agents
Color aids in identification of the product.
The color used should be acceptable by the
particular country.
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73. SUSPENSIONS
Most widely used colors are as follows.
· Titanium dioxide (white)
· Brilliant blue (blue)
· Indigo carmine(blue)
· Amaranth (red)
·Tartarazine (yellow)
73
Annatto seeds(yellow to orange)
Annatto seeds
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74. SUSPENSIONS
They are used for taste masking of bitter drug particles.
Bulk sweeteners
Sugars such as xylose, ribose, glucose, mannose.
Sugar alcohols such as sorbitol, xylitol, mannitol
A bulk sweeteners is used at concentration of 15-70 %
74
Sweetening Agents
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76. SUSPENSIONS
Humectants absorb moisture and prevent degradation of API by
moisture.
Examples of humectants most commonly used in
suspensions are
propylene glycol
glycerol.
Total quantity of humectants should be between 0-10 % w/w.
76
Humectants
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77. SUSPENSIONS
Ascorbic acid derivatives such as ascorbic acid, erythorbic acid,
Thiol derivatives such as thio glycerol, cytosine, acetylcysteine,
Tocopherols
Butylated hydroxy anisole(BHA)
Butylated hydroxytoluene (BHT)
Sodium bi sulfite,
Sodium sulfateacetone
77
Antioxidant
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78. SUSPENSIONS
Following consideration are important for manufacturing
pharmacist
Selection of right material that go into the manufacture.
The step involved and their sequence in the manufacture.
Preservation and storage of the product.
78
PREPARATION OF SUSPENSIONS
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79. SUSPENSIONS
Small scale preparation of suspensions:
Step 1:
Suspensions are prepared by grinding (or) levigating the insoluble
materials in the mortar to a smooth paste with a vehicle containing the
wetting agent.
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80. SUSPENSIONS
Step 2:
All soluble ingredients are dissolved in same portion of the
vehicle and added to the smooth paste to step1 to get slurry.
Step 3:
The slurry is transformed to a graduated cylinder, the mortar is
rinsed with successive portion of the vehicle.
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81. SUSPENSIONS
Step 4:
Decide whether the solids are
Suspended in a structured vehicle
Flocculated
Flocculated and then suspended
Add the vehicle containing the suspending agent (or) flocculating agent
81
Make up the dispersion to the final volume .
Thus suspension is prepared.
Step-5
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82. SUSPENSIONS
Introduction
Pharmaceutical suspensions for oral use are generally packed
in wide mouth container having adequate space above the
liquid to ensure proper mixing.
Parenteral suspensions are packed in either glass ampoules or
vials.
82
Packaging of Suspensions
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83. SUSPENSIONS
Ideal Requirements of Packaging Material
It should be inert.
It should effectively preserve the product from light,
air, and other contamination through shelf life.
It should be cheap.
It should effectively deliver the product without any
difficulty.
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84. SUSPENSIONS
Materials Used For Packaging
Generally glass and various grades of plastics are used in
packaging of suspension.
Glass
Generally soda lime and borosilicate glass are used
in preparation of non sterile suspensions.
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85. SUSPENSIONS
Amber glass doesn’t allow U.V light to pass through.
Amber characteristics can be developed in the
glass by addition of various types of additives.
Type of glass Additive giving amber
color
Soda lime FeO + sulfur (in
presence of reducing
agent)
Borosilicate FeO+TiO 2
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86. SUSPENSIONS
Disadvantages of Glass Materials:
They are fragile.
They are very heavy as compared to plastic so
handling and transport is difficult.
Most important disadvantage of glass that
glass constituents get extracted into the product.
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87. SUSPENSIONS
Plastic
Due to the negative aspects of glass, plastic material
significantly use of plastic as packaging material for sterile as
well as non-sterile pharmaceutical suspension increased.
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90. SUSPENSIONS
Factors affecting in selecting closure:
Compatibility with product.
Seal integrity.
It should be stable throughout the shelf life.
90
Factors affecting in selecting liner:
Chemical resistance.
Appearance
Gas and vapor transmission.
Removal torque.
Heat resistance.
Shelf life.
Economical factors 2 March 2020
91. SUSPENSIONS
STORAGE REQUIREMENTS & LABELLING
Labelling:
Shake well before use
Do not freeze
Protect from direct light(for light sensitive drugs)
In case of dry suspensions powder the specified amount of
vehicle to be mixed may indicated clearly on label.
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93. SUSPENSIONS
STORAGE :
Suspensions should be stored in cool place but should not be kept
in a refrigerator
Freezing at very low temperatures should be avoided which may
lead to aggregation Of suspended particles
93
Stored at controlled temperature from 20-25 c0
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95. SUSPENSIONS
Sedimentation method
Rheological method
Electro kinetic method
Micromeritic method
Evaluation of stability of Suspensions
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96. SUSPENSIONS
Sedimentation method :
Two parameters are studied for determination of sedimentation.
1. Sedimentation volume,
2. Degree of flocculation.
,
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97. SUSPENSIONS97
Sedimentation volume
The suspension formulation (50 mL) was poured separately into
100 mL measuring cylinders and sedimentation volume was read
after 1, 2, 3 and 7 days, and thereafter at weekly intervals for 12 weeks.
Triplicate results were obtained for each formulation.
Sedimentation volume was calculated according to the equation:
Where, F = sedimentation volume, Vu = ultimate height of sediment
and Vo = initial height of total suspension
F = Vu/Vo
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98. SUSPENSIONS
Rheological method
It provide information about Settling behaviour .
The arrangement of the vehicle and the particle structural
features.
Brookfield viscometer is used to study the viscosity of the
suspension .
It is mounted on heli path stand and using T-bar spindle.
T-bar spindle is made to descend slowly into the suspension
and the dial reading on the viscometer is then a measure of the
resistance the spindle meets at various level.
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99. SUSPENSIONS
This technique also indicates at which level of the suspension
the structure is greater owing to particle agglomeration.
The dial reading is plotted against the number of turns of the
spindle.
The better suspension show a lesser rate of increase of dial
reading with spindle turns, i.e. the curve is horizontal for long
period.
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100. SUSPENSIONS
Electro kinetic method
Measurement of Zeta-potential using Micro electrophoresis
apparatus & ZetaPlus (Brookhaven Instruments Corporation, USA)
It shows the stability of a disperse system.
Micro-Electrophoresis
Apparatus Mk I
100
ZetaPlus
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101. SUSPENSIONS101
Zeta potential
The zeta potential of the formulated suspensions was determined
using a ZetaPlus (Brookhaven Instruments Corporation, USA).
Approximately 1 mL of suspension was transferred into a plastic
cuvette using a pipette and diluted with distilled water.
The Brookhaven zeta potential software was used for the
measurement .
Parameters set to a temperature of 250C and refractive index (1.33)
The zeta potential of the formulations was determined on day 0, 7,
14, 21 and day 28 post formulation.
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102. SUSPENSIONS
Micromeritic method :
The stability of suspension depends on the particle size of the
dispersed phase.
Change in the particle size with reference to time will provide
useful information regarding the stability of a suspension.
A change in particle size distribution and crystal habit studied by
microscopy
coulter counter method
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103. SUSPENSIONS103
PHOTOMICROSCOPIC TECHNIQUE
The microscope can be used estimate and detect changes in
particle size distribution and crystal form.
Rapid processing of photo micrographs is enhanced by attaching
Polaroid camera to the piece of monomolecular microscope
By using this photo micrographs we can
determine the changes in physical properties
and stability of suspensions.
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104. SUSPENSIONS
Freeze-Thaw test conducted by placing the sample in a freezer
for 18 hours followed by thawing at room temperature for 4 to
6 hours.
Repeat the Freeze-Thaw cycle for up to 10 times.
FREEZE- THAW TEST
Freeze-thaw testing freezer INNER CHAMBER
104
This test is conducted to determine the tendency to crystallize or cloud
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105. SUSPENSIONS
pH MEASUREMENT
The measurement and maintenance pH is also very important step in
the Quality control testing .
Generally there are 2 different types of methods used in the
measurement of pH.
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106. SUSPENSIONS
METHODS FOR pH MEASUREMENT:
The simplest and cheapest is to dip a piece of pH paper into the
sample.
The paper is impregnated with chemicals that change color and the
color may be compared to a chart supplied with the paper to give
the pH of the sample.
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107. SUSPENSIONS
If greater accuracy is required a pH meter should be
used.
A typical pH meter consists of a special measuring glass
electrode connected to an electronic meter that measures and
displays the pH reading.
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108. SUSPENSIONS
VISUAL INSPECTION:
With visual inspection, the ingredients and the final
products are carefully examined for purity and for
appearance .
Physical appearance of products for patient adherence
and compliance is critical so it should be:
Good looking
Elegance in appearance .
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109. SUSPENSIONS
DISSOLUTION STUDY OF SUSPENSIONS
Introduction:
The drug release from suspensions is mainly through dissolution.
Suspensions share many physico-chemical characteristics of
tablet & capsules with respect to the process of dissolution.
As tablets & capsules disintegrate into powder and form
suspensions in the biological fluids.
So dissolution is carried as follows
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111. SUSPENSIONS
Dissolution profile of the 500 mg sample suspension is
determined at 37°C in 900 ml of
pH 7.2 phosphate buffer using
the FDA paddle method at 25 RPM.
111
The apparatus consists of a cylindrical 1000- ml round bottom
flask in a multiple – spindle dissolution drive apparatus and
immersed in a controlled temp bath maintained
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112. SUSPENSIONS
The paddle should position to extend to exactly 2.5 cm
above the flask bottom.
The suspension is to be introduced carefully into the
flask at the bottom using a 10- ml glass syringe with an
attachment 19-cm needle.
Withdraw 5 ml of dissolution medium (and replace
with an equal volume of drug –free buffer) in a 5 ml glass
syringe.
Immediately filter through a 0.2 µm membrane and
analyze.
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115. SUSPENSIONS
Nano suspensions are the biphasic colloidal dispersions
of nano sized drug particles stabilised by surfactants
without the matrix materials.
They can also be defined as a biphasic system consisting of
pure drug particles dispersed in an aqueous vehicle in which
the diameter of the suspended particle is less than 1 μm in
size.
115
1. Nano suspensions:
2 March 2020
117. SUSPENSIONS
Un-palatability due to bad taste is a major concern
in most of the dosage forms containing bitter drugs.
In case of suspensions also taste masking is being applied to
mask bitterness of drugs formulated.
117
2.Taste Masked Pharmaceutical
Suspensions .
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118. SUSPENSIONS
The taste masking approaches for suspensions are:
a. Polymer coating of drugs.
b. Encapsulation with basic drugs.
c. Polymer coating with basic substances.
d. Coating and pH control.
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119. SUSPENSIONS
a. Polymer Coating of Drugs
The polymer coat allows the time for all of the particles to be
swallowed before the threshold concentration is reached in the
mouth and the taste is perceived.
The polymers used for coating are
•Ethyl cellulose
•Eudragit RS 100
•Eudragit RL 100
•Eudragit RS 30 D
•Eudragit RL 30 D
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120. SUSPENSIONS
b. Encapsulation with a Basic Substance
Here a basic substance is mixed with a bitter tasting drug which is
insoluble at high pH.
The mixer is then encapsulated with a polymer (cellulose
derivative, vinyl derivative or an acid soluble polymer
Eg: copolymer of dimethyl ammonium methyl methacrylate).
The drug after encapsulation are suspended, dispersed or
emulsified in suspending medium to give the final dosage form.
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121. SUSPENSIONS
c. Coating and pH Control
Those drugs which are soluble at high pH are preferably be
maintained in a suspension at a low pH where the drug exhibit
maximum insolubility.
Similarly drugs which are soluble at low pH are preferably
maintained in suspension at a high pH where the drug is insoluble.
Also applying polymeric coating to the drug substance avoids
solubilization of drug when administered providing taste masking.
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122. SUSPENSIONS
Some Examples of Taste Masked Suspensions
Sr.No Name of the drug Taste masking approach
1 RISPERIDONE pH
control and polymer coating
(with Eudragit RS)
2 DICLOFENAC Polymer
coating with Eudragit RS
100
3 LEVOFLOXACIN Polymer
coating (Eudragit
&cellulose acetate,)
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123. SUSPENSIONS
Sustained release is a method to increase only the duration of
action of drug being formulated without affecting onset of
action.
In suspension sustained release affected by coating the drug to be
formulated as suspension by insoluble polymer coating.
The polymer coating provides sustained release and also masks
the taste of the bitter drug.
123
Sustained Release Suspensions
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124. SUSPENSIONS
The polymer used for sustained release in suspension is
as follows as
Ethyl cellulose,
Eudragit,
Cellulose acetate, etc.
The main advantage of sustained release
suspension is decrease in dosing frequency.
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125. SUSPENSIONS
Approaches used in formulation of sustained release oral suspensions
1. Ion exchange resin.
2. Microencapsulation technique
3. Saturated drug suspension as a suspending medium.
4. Using non aqueous vehicle.
5. Reconstitution.
6. Protective coating.
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126. SUSPENSIONS
Subramanyam C.V.S., Second edition, “Suspensions” Text
Book of Physical Pharamaceutics, PageNo. 374-387.
Ansel C., Allen L.V., Popovich N.G. Eighth edition
“Disperse systems” Pharmaceutical Dosage Forms & Drug
Delivery Systems, Lippincott Williams and Wilkins,
Philadelphia 2005, Page No. Page No. 387-389, 398.
126
REFERENCES
2 March 2020
127. SUSPENSIONS
Cooper & Gun, Sixth edition, “Dispersed system” Tutorial
Pharmacy, Page No. 75-78.
Aulton M.E. Second edition, “Suspension” Pharmaceutics-
The Science of Dosage Form Design, Churchill Livingstone,
Edinburgh 2002, PageNo. 84-86, 273.
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128. SUSPENSIONS
Remington, Twentieth edition, “Colloidal
Dispersions” The Science and Practice of
Pharmacy, Lippincott Williams and Wilkins,
Philadelphia 2000, Page No. 298-307.
Martin A. Fourth edition, “Coarse dispersion”
Physical Pharmacy, Lippincott Williams and Wilkins,
Philadelphia 2001, Page No. 479-481.
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