condoslation

1. STUDY OF
CONSOLIDATION
PARAMETERSPresented by : ADITYA SINGH
M.PHARM 1st year (1st Sem.)
Modern pharmaceutics
Integral university

2. CONSOLIDATION
An increase in the mechanical strength of the material resulting
from particle or particle interaction.

3. CONTENT
• Diffusion parameter
• Pharmacokinetic parameters
• Heckel plot
• Similarity factors f1 and f2

4. DIFFUSION PARAMETERS
• This is given by higuchi.
• Q=KT
• Where q is amount of drug released in time t per unit area,
• K is higuchi constant
• T is the time in hours
• Application : modified release pharmaceutical dosage forms,
transdermal systems and matrix tablets with water soluble
drugs.

5. DISSOLUTION PARAMETERS
• Dissolution is a process in which a solid substances solubilizes
in a given solvent i.e mass transfer from the solid surface to
liquid phase.

6. Dissolution parameters
• Effect of agitation
• Effect of dissolution fluid
• Influence of pH of dissolution fluid
• Effect of surface tension of the dissolution medium.
• Effect of temperature of the dissolution medium.

7. Pharmacokinetic parameters
• Pharmacokinetics is defined as the kinetics of drug absorption,
distribution, metabolism, and excretion and their relationship
with pharmacologic, therapeutic response.

8. PLASMA CONCENTRATION TIME
PROFILE
• Three important pharmacokinetic parameters:
• Peak plasma concentration (Cmax).
• Time of peak concentration (Tmax)
• Area under curve (AUC)

9. Cmax
• The point of maximum concentration of a drug in plasma is
called as peak and the concentration of drug at peak is known
as peak plasma concentration.
• It is also called peak height concentration and maximum drug
concentration.
• Cmax is expressed in mcg/ml.

10. Tmax
• The time for drug to reach peak concentration in plasma (after
extravascular administration) is called the time of peak
concentration.
• It is expressed in hours.
• Onset time and onset of action is dependent upon Tmax.

11. AUC
• It represents the total integrated area under the plasma level-
time profile and expresses the total amount of drug that
comes in to systemic circulation after its administration.
• AUC is expressed in mcg/ml X HRS.

12. Heckel plot

13. • The heckel analysis is most popular method of deforming reduction
under compression pressure.
• Powder packing with increasing compression load is normally
attributed to particles rearrangement , elastic and plastic
deformation and particle fragmentation.

18. Similarity factor F1 and F2

22. THANKING YOU