This document discusses intra nasal drug delivery systems. Some key points: - Intra nasal delivery allows for systemic drug absorption through the nasal cavity and offers advantages over injection like avoidance of first pass metabolism and rapid onset of action. - The nasal cavity has features like a large surface area and blood vessels that enable drugs to be absorbed. It also has aqueous and lipoidal routes for transporting water-soluble and lipophilic drugs. - Various intra nasal drug formulations have been developed like drops, sprays, gels, and aerosols. These systems can deliver peptides, proteins, and other drugs that intra nasal administration offers benefits for.

1. Intra Nasal Route Of Drug
Delivery System
Prepared by : Aditya singh
M.pharm. Ist year
Integral University

2. Content
• Introduction
• Intra nasal drug delivery
• Advantages
• Anatomy & physiology
• Mechanism
• Types
• Evaluation
• application

4. Introduction
• Administration of drug through nasal route is
referred as intra nasal drug delivery system.
• It is considered as potential administration
route to achieve faster and high level of drug
absorption.
• It is an ideal alternative to parentals for
systemic drug delivery.
• Intranasal medication administration offers a
truly needleless solution to drug delivery.

5. Intra Nasal Drug Delivery
• The use of the nasal route for delivery of
challenging drugs such as small polar
molecules, vaccines, hormones, peptides and
protein has created much interest nowadays.
• In recent years many drugs have been shown
better bioavailability through nasal route.
• Nasal route recognized form of treatment in
the Ayurvedic systems of Indian medicine, It is
also called NASAYA KARMA.

6. ADVANTAGES
• Drug degradation that observed in the
gastrointestinal tract is absent.
• Rapid drug absorption and quick onset of
action can be achieved.
• The nasal bioavailability for smaller drug
molecules is good.
• Hepatic first pass metabolism is avoided.

7. Anatomy & Physiology
• The nasal cavity is divided into two halves by the
nasal septum and extends posterior to the
nasopharynx, while the most anterior part of the
nasal cavity, the nasal vestibule, opens to the face
through nostril.
• The nasal cavity consists 3 main regions are nasal
vestibule, olfactory region and respiratory region.
• Enlarge surface area 150cm2 and covered with
mucosal membrane.

9. • Nasal cavity has nonolfactory and olfactory
epithelium.
• The mucus secretion is composed of about
95% water, 2% mucin, 1% of other protein
such as albumin, immunoglobulin s, lysozyme
and lactoferrin, and 1% lipid.
• The absorbed drugs from the nasal cavity
must pass through the mucus layer.

10. Mechanism
• First mechanism : aqueous route transport
which is known as paracellular route slow and
passive. Water-soluble
• Second mechanism : it involves transport a
lipoidal route it is known as transcellular
process for lipophillic drugs.

11. Types
• Nasal Drops : are one most simple and
convenient system developed for nasal delivery.
• Nasal spray : Both solution and suspension
formulation can be formulated in to nasal sprays.
• Nasal gels : high viscosity thickened solution or
suspension
• Nasal powder : solution and suspension can not
developed lack of stability.
• Nasal aerosols : formulation active drug,
surfactant, cosolvent and propellant i.e
Budesonide nasal aerosol inhaler.

12. Evaluation
• In vitro nasal [permeation studies] : hans
chamber using [ chamber consist of u-shaped
tubing system, usually made of glass, filled with
experimental solution.
• Barrier used are excised nasal mucosa from rats
or rabbits.
• Drug solution is introduced into the mucosal side
of the chamber and samples were collected from
the receiver chamber
• Ex nasal perfusion model

13. Application
• Delivery of non peptide pharmaceuticals:
example [progesteron, propranolol]
• Delivery of peptide based pharmaceutical :
example [insulin, Calcitonin]
• Delivery of diagnostic drugs
• Delivery of drugs to brain
• Delivery of vaccines.

14. THANKINK
YOU…….