1) The learner recognized signs of hemorrhagic shock in a patient with blunt abdominal trauma and initiated aggressive resuscitation with intravenous fluids and blood products.
2) Bedside ultrasound revealed free fluid in the Morrison's pouch, indicating possible intra-abdominal bleeding.
3) Given the unstable condition of the patient, the learner appropriately called for an emergency laparotomy without delaying for further imaging studies.
Abdominal Trauma
Blunt Abdominal Trauma
INDICATIONS FOR LAPAROTOMY
ROLE OF DIAGNOSTIC LAPAROSCOPY
FAST EXAM
HEPATIC AND SPLENIC INJURIES
RETROPERITONEAL HEMORRHAGE
DUODENAL AND PANCREATIC INJURY
DIAPHRAGMATIC RUPTURE
SMALL BOWEL INJURY
INJURY TO COLON AND RECTUM
Penetrating Abdominal Trauma
Stab Wounds: Stratification by loci
Gunshot Wounds
DIAGNOSTIC LAPAROSCOPY
Abdominal Trauma
Blunt Abdominal Trauma
INDICATIONS FOR LAPAROTOMY
ROLE OF DIAGNOSTIC LAPAROSCOPY
FAST EXAM
HEPATIC AND SPLENIC INJURIES
RETROPERITONEAL HEMORRHAGE
DUODENAL AND PANCREATIC INJURY
DIAPHRAGMATIC RUPTURE
SMALL BOWEL INJURY
INJURY TO COLON AND RECTUM
Penetrating Abdominal Trauma
Stab Wounds: Stratification by loci
Gunshot Wounds
DIAGNOSTIC LAPAROSCOPY
PICUDoctor.org is a medical reference e-book that covers the evolving knowledge in physiology and pathophysiology of pediatric cardiac critical care. From preoperative, perioperative and postoperative management through specific topics in critical care treatment, anaesthesia and analgesia, pharmacokinetics and pharmacodynamics, heart failure, circulatory mechanical assist and ECMO, the electronic format of PICUDoctor.org incorporates and allows implementation of up to date knowledge with multimedia.
PICUDoctor.org was first developed in 2011 with contributions from authors around the world. Further edits and the transition to an online e-book followed in 2013 and 2014. Initially a bedside tool, it evolved into a full reference e-textbook with multiple multi-media functions as well as links to PubMed® articles to further support the users’ education. PICUDoctor.org is a not peer reviewed, but open source. To limit costs for publication and distribution, PICUdoctor.org is available in portable document format, iTunes and Google https://www.facebook.com/picudoctor.org/ for more details.
Polytrauma and multiple traumata are medical terms describing the condition of a person who has been subjected to multiple traumatic injuries. This will be more prevalent in our country
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
2. Learning Objectives
• Recognize and respond appropriately to a
patient with hemorrhagic shock
• Assess via bedside methods the source
of hemorrhage
• Respond appropriately to evidence of
intra-abdominal hemorrhage with regards
to initial management and disposition
3. Introduction
• Blunt abdominal trauma is common.
• Unknown history, distracting injuries, and
altered mental status make these patients
difficult to diagnose and manage.
• Victims frequently have both abdominal
and extraabdominal injuries.
• Family physicians need to be able to
recognize and treat hemorrhagic shock.
4. Recognition of Hemorrhagic Shock
• Shock: oxygen delivery < tissue demands
• Treatment must restore tissue perfusion not
just blood pressure
• Shock does NOT SBP < 90mmHg
• Recognition includes: mechanism of injury,
patient’s appearance, vitals, level of
mentation, peripheral perfusion and urine
output
• Clinical parameters should be coupled with
objective markers of tissue perfusion--serum
lactate, base deficit, etc.
5. Practical Diagnosis of Shock
• Perform a targeted physical examination
• Diagnostic testing should include chest
radiography, pelvis radiography, and
bedside ultrasound
• Objective serum makers of tissue
perfusion (serum lactate or base deficit)
• Point of care H/H, send CBC, type/cross
• DON’T delay resuscitation for lab results
6. 6 Steps to Treat Hemorrhagic Shock
• Step 1: Effectively manage the airway and
optimize oxygenation.
• Step 2: Identify and control immediate threats to
central perfusion.
• Step 3: Identify and address severe intracranial
injuries.
• Step 4: Identify and control other potentially life-
threatening thoracic and abdominal injuries.
• Step 5: Identify and control potentially limb-
threatening injuries.
• Step 6: Identify and treat noncritical injuries.
7. Treatment of Hemorrhagic Shock
• Obtain immediate type and crossmatch
for 6-8 units of blood
• Massive transfusion defined as > 10 U of
PRBCs in 24 hrs
• Consider use of PRBC to platelet to FFP
ratio of 1:1:1
• May result in decreased need for blood
products
• Give calcium to prevent citrate toxicity
8. Assessing for Sources of Hemorrhage
• Chest radiography:
• Tension pneumothorax? Massive hemothorax?
Aortic injury?
• Pelvis radiography:
• Pelvic ring disruption?
• Focused Assessment with Sonography for
Trauma (FAST):
• Pneumo/hemothorax? Hemopericardium?
Hemoperitoneum?
• If positive, then emergency laparotomy.
• If negative, continue resuscitation, treat other causes.
9. FAST Facts
• Reliably identifies 200-250ml of
intraperitoneal fluid
• Cannot reliably evaluate
retroperitoneum/hollow viscous injury
• Sensitivity/specificity: 75%/98%, NPV:
94%; 86-97% accurate
• Performed using a curvilinear 2.5 or 3.5
MHz probe
10. FAST Views
• Cardiac: parasternal or subxiphoid,
hepatocardiac interface, pericardial space.
• RUQ: hepatorenal interface (Morrison’s
Pouch), diaphragm, inferior pole of kidney.
• LUQ: splenorenal interface, diaphragm,
inferior pole of kidney, inferior tip of spleen.
• Suprapubic: outline of bladder, silhouette of
uterus (females).
11. FAST Algorithm
• Unstable patient: + FAST = OR.
• Stable pt: + FAST = abdominal CT.
• Stable pt, low mechanism of injury:
- FAST = observation, serial exams.
• CT is the “Gold Standard”.
12. What About Diagnostic Peritoneal
Aspiration (DPA)?
• Can be performed if - FAST in blunt
abdominal trauma.
• If DPA +, then emergency laparotomy.
• If DPA -, then seek and treat other
sources.
• Perform serial abdominal exams.
• Perform serial FAST exams.
• If patient stabilizes, then CT.
• Get surgery involved!
13. Indications for Emergency
Laparotomy
• Peritonism
• Free air under the diaphragm
• Significant gastrointestinal hemorrhage
• Hypotension with + FAST scan or + DPA
• Do NOT keep trauma patients if you lack
resources to care for them!
14. Summary
• Recognize and treat hemorrhagic shock
aggressively with blood products
• Assess for hemorrhage with bedside
methods: CXR, pelvis, and FAST
• Unstable patient: + FAST = OR.
• Stable pt: + FAST = abdominal CT.
• Stable pt, low mechanism of injury:
- FAST = observation, serial exams.
15. References
1. Puskarich MA. Initial evaluation and management of blunt
abdominal trauma in adults. In: UpToDate, Hockberger RS,
Moreira ME (Ed), UpToDate, Waltham, MA, 2012.
2. Nickson C. “Trauma! Blunt abdominal trauma decision
making.” Weblog entry. Life in the Fastlane Blog.
http://lifeinthefastlane.com/2012/03/trauma-tribulation-023/
3. Eastern Association for the Surgery of Trauma Guidelines
Workgroup. Evaluation of blunt abdominal trauma. 2010
Edition. Chicago, IL.
http://www.east.org/resources/treatment-
guidelines/category/trauma
4. American College of Surgeons. ATLS Textbook, 9th Edition. 1
September 2012.
17. CRITICAL ACTIONS ME NI M SUSTAIN IMPROVE
Completes Primary Survey:
recognizes shock
MK2
Safety net – IV, oxygen,
monitors (2 x 16G IV)
MK2
Completes Secondary Survey:
recognizes abdominal source
MK2
Completes bedside FAST
(+ Morrison’s Pouch)
PC5
Recognizes positive FAST: calls
surgery
PC5
Bedside labs: POC CBC, lactate,
BAL, VBG, blood type/screen/X-
match
MK2
Bedside rads: port chest, lat C-
spine, AP pelvis
MK2
Gives emergency release blood
transfusion
MK2
If unstable: no CT, to OR
If stabilizes: CT, then OR
MK2
TOTAL
SBP
4
SCENARIO ALGORITHM
SET UP:
“Rural” ER Simulated Room
Bedside US and/or FAST simulator
Real patient with simulated skin/abdomen
PRE ARRIVAL:
FP in rural ER, lab, rad, OR
35 y/o male s/p unrestrained driver MVA
arrives via EMS, in c-collar. VS BP 90/50, HR
110, RR 18, SpO2 97% on RA, GCS 15
ARRIVAL:
Full spinal precautions, has 1 IV in place. Pt
awake, alert, conversing, but in mild distress,
no meds, no allergies, no sig PMHx or PSHx
PRIMARY SURVEY:
A – talking initially, then somnolent
B – labored, RR 24, nl breath sounds
C – BP 85/40, HR 130, cool extremities
D – GCS 14, somnolent, oriented to person
when responds to voice
E – no other trauma, mild abd distension,
hypoactive BS
SECONDARY SURVEY:
Other exam normal, c-spine non tender,
pelvis stable, rectal guaiac negative
Abdominal exam tense, tender, absent BS
LABS & IMAGES:
Chest, c-spine, pelvis negative
Labs – WBC 9, H/H 8/24, platelets 150,
lactate 4, VBG: 7.35/46/40/50%/-8
Positive FAST in RUQ, no CT indicated
Blood type and screen/X-match
DISPOSITION:
Must transfuse blood , call Surgeon and direct
to OR, otherwise pt dies of hemorrhage
Simulation Training Assessment Tool (STAT)– Blunt Abdominal Trauma
Date: 1 May 2013 Instructor(s): Clark, Maurer, Cuda Learner(s):
Learning Objectives:
1. Recognize and respond appropriately to a patient with hemorrhagic shock.
2. Assess via bedside methods the source of hemorrhage.
3. Respond appropriately to evidence of intra-abdominal hemorrhage with regards to initial
management and disposition.
ME = Meets Expectations; NI = Needs Improvement, M = Milestones (see debriefing sheet)