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Staple Line Reinforcement. Options and Does it Make Sense? Samer G. Mattar, MD, FRCS, FACS Associate Professor of Surgery Indiana University
Outline	 Why use SLR? Options of SLR. Case for its use. Case against it. Conclusions
Why use SLR? Mechanical staplers are now standard devices and are widely used in all areas of the GI Tract. Even most experienced surgeons will over or under- estimate the thickness of tissue. The majority of staplers are reliable, but very rarely, some will fail.
Why use SLR? Staple line leaks, especially in Sleeve gastrectomy, can be devastating. There is concern for postoperative bleeding that may result in blood transfusions or return to the
Hand-sewn vs. Stapled anastomoses Cochrane review of stapled versus hand-sewn anastomoses: 1233 patients, 9 trials Lustosa SA, et al. Cochrane Database Syst Rev 2001:; CD003144
Hemostasis? 20 patients undergoing BPD-DS A: 10 patients had SLR (Seamguard) B: 10 patients no SLR Consten et al. ObesSurg 2004;14:1360-6
Hemostasis? Blood Loss Group A: 120mls. Blood Loss Group B: 210 mls. LOS: 3.8 days (A) vs. 4.6 das (B). Consten et al. ObesSurg 2004;14:1360-6
Fibrin glue Used successfully in animal studies.* Used to reinforce anastomoses. Used to reinforce long staple lines. Used to control non-surgical bleeding. *Nguyen et al. J Surg Res 2004;122(2):218-24
Types of SLR Gore – Seamguard (synthetic bioabsorbable) Cook SIS (biologic) Synovis Veritas (collagen matrix  derived from bovine pericardium) Covidien Duet (absorbable synthetic polyester)
Comparison in Hemostasis Animal study Swine capsular stripping model. Veritas and Duet were compared. Veritas and Syvek were more successful (<10 min). Collagen buttresses are superior to synthetic. Specter et al. SurgEndosc 2011;25(4):1148-52
Comparison of Tissue Handling and Slippage Ex-vivo canine gastric tissue model. SULU alone vs. Seamguard vs. Duet. Volckmann et al. Poster presented at SAGES 2010
Comparison of Tissue Handling and Slippage Volckmann et al. Poster presented at SAGES 2010
Comparison of Burst Pressures Small intestine stapled swine model. Gastric staple line in rabbit model. Arnold & Shikora. ObesSurg 2005;16:164-71
Comparison of Burst Pressures P = 0.0137 Arnold & Shikora. ObesSurg 2005;16:164-71
Prospective Randomized Trial Group 1: No SLR Group 2: Seamguard Group 3: Suture reinforcement Dapri, Cadiere, Himpens. ObesSurg 2010(20) 462-7
Prospective Randomized Trial Group 1 (no SLR) was associated with shortest OP duration. Seamguard reduced blood loss. No difference among all groups in incidence of postoperative leaks. Dapri, Cadiere, Himpens. ObesSurg 2010(20) 462-7
Fibrin sealant and Strictures? 529 LRYGB patients. 104 with no fibrin. 425 with fibrin reinforcement Stricture rate: 5.8% vs. 11.3%. Ibele et al. Presented at SAGES 2011
Conclusion Tissue stapler technology is in evolution. There is no perfect tissue stapler. There are a variety of SLR products; absorbable versus permanent, synthetic versus biologic, and solid versus liquid. Generally, SLRs provide additional security from bleeding and maybe leaks.
Conclusions Complications may include increased adhesions and strictures. More research is needed to assess cost-effectiveness of these products.
Thank you!

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Staple line reinforcement

  • 1. Staple Line Reinforcement. Options and Does it Make Sense? Samer G. Mattar, MD, FRCS, FACS Associate Professor of Surgery Indiana University
  • 2. Outline Why use SLR? Options of SLR. Case for its use. Case against it. Conclusions
  • 3. Why use SLR? Mechanical staplers are now standard devices and are widely used in all areas of the GI Tract. Even most experienced surgeons will over or under- estimate the thickness of tissue. The majority of staplers are reliable, but very rarely, some will fail.
  • 4. Why use SLR? Staple line leaks, especially in Sleeve gastrectomy, can be devastating. There is concern for postoperative bleeding that may result in blood transfusions or return to the
  • 5. Hand-sewn vs. Stapled anastomoses Cochrane review of stapled versus hand-sewn anastomoses: 1233 patients, 9 trials Lustosa SA, et al. Cochrane Database Syst Rev 2001:; CD003144
  • 6. Hemostasis? 20 patients undergoing BPD-DS A: 10 patients had SLR (Seamguard) B: 10 patients no SLR Consten et al. ObesSurg 2004;14:1360-6
  • 7. Hemostasis? Blood Loss Group A: 120mls. Blood Loss Group B: 210 mls. LOS: 3.8 days (A) vs. 4.6 das (B). Consten et al. ObesSurg 2004;14:1360-6
  • 8. Fibrin glue Used successfully in animal studies.* Used to reinforce anastomoses. Used to reinforce long staple lines. Used to control non-surgical bleeding. *Nguyen et al. J Surg Res 2004;122(2):218-24
  • 9. Types of SLR Gore – Seamguard (synthetic bioabsorbable) Cook SIS (biologic) Synovis Veritas (collagen matrix derived from bovine pericardium) Covidien Duet (absorbable synthetic polyester)
  • 10. Comparison in Hemostasis Animal study Swine capsular stripping model. Veritas and Duet were compared. Veritas and Syvek were more successful (<10 min). Collagen buttresses are superior to synthetic. Specter et al. SurgEndosc 2011;25(4):1148-52
  • 11. Comparison of Tissue Handling and Slippage Ex-vivo canine gastric tissue model. SULU alone vs. Seamguard vs. Duet. Volckmann et al. Poster presented at SAGES 2010
  • 12. Comparison of Tissue Handling and Slippage Volckmann et al. Poster presented at SAGES 2010
  • 13. Comparison of Burst Pressures Small intestine stapled swine model. Gastric staple line in rabbit model. Arnold & Shikora. ObesSurg 2005;16:164-71
  • 14. Comparison of Burst Pressures P = 0.0137 Arnold & Shikora. ObesSurg 2005;16:164-71
  • 15. Prospective Randomized Trial Group 1: No SLR Group 2: Seamguard Group 3: Suture reinforcement Dapri, Cadiere, Himpens. ObesSurg 2010(20) 462-7
  • 16. Prospective Randomized Trial Group 1 (no SLR) was associated with shortest OP duration. Seamguard reduced blood loss. No difference among all groups in incidence of postoperative leaks. Dapri, Cadiere, Himpens. ObesSurg 2010(20) 462-7
  • 17. Fibrin sealant and Strictures? 529 LRYGB patients. 104 with no fibrin. 425 with fibrin reinforcement Stricture rate: 5.8% vs. 11.3%. Ibele et al. Presented at SAGES 2011
  • 18. Conclusion Tissue stapler technology is in evolution. There is no perfect tissue stapler. There are a variety of SLR products; absorbable versus permanent, synthetic versus biologic, and solid versus liquid. Generally, SLRs provide additional security from bleeding and maybe leaks.
  • 19. Conclusions Complications may include increased adhesions and strictures. More research is needed to assess cost-effectiveness of these products.