This document discusses staple line reinforcement (SLR) options and whether they are useful in gastrointestinal surgery. It outlines the rationale for using SLR to prevent staple line leaks and bleeding. Several SLR products are described, including synthetic, biologic, and fibrin sealants. Studies comparing SLR products found some reduced bleeding and leaks compared to controls. However, SLR may increase risks of adhesions and strictures. More research is still needed to determine the cost-effectiveness of routine SLR use.