Know everything about Osteoporosis- prevention and management.
Did You Know?
The incidence of hip fracture is 1 woman to 1 man in India
Know more such facts and useful information on prevention of Osteoporosis.
This document discusses the pathophysiology, epidemiology, presentation, diagnosis, and treatment of osteoporosis. It notes that bone undergoes constant remodeling by osteoblasts and osteoclasts. Estrogen deficiency accelerates bone loss via increased osteoclast activity. Risk factors include female gender, older age, family history, smoking, low calcium intake, and certain medications. Vertebral fractures often cause back pain and kyphosis. Treatment involves lifestyle modifications, calcium/vitamin D supplementation, and pharmacotherapy like bisphosphonates, denosumab, teriparatide, calcitonin, and SERMs. Medication choice depends on factors like fracture risk, side effect profile, and cost.
Bone loss occurs without symptoms and the first sign may be a fracture due to weakened bones caused by a sudden strain. Osteoporosis is characterized by compromised bone strength that increases the risk of fracture. While bone loss occurs without symptoms, the first sign is often a fracture that results from a minor strain or impact that would not normally cause a break in healthy bone.
The document discusses osteoporosis and questions whether it should be considered a disease. It summarizes the WHO conference that defined osteoporosis and established T-scores. It raises concerns about the definition and how DEXA scans are used to diagnose based on measurements that may not be accurate or applicable to all groups. Risk factors are highlighted and questions are raised about whether they apply to all populations equally.
This document discusses osteoporosis and bone health. It begins by noting the impact of osteoporosis on older patients, including increased hospital admissions and length of stay. It then discusses definitions of osteoporosis from WHO and treatment gaps. The document covers bone structure, cells, mineralization, remodeling cycles, and factors influencing bone health like hormones and lifestyle. Diagnostic methods like DXA are summarized. Treatment options focused on prevention of fractures through calcium, vitamin D, bisphosphonates, PTH, and fall prevention are outlined.
Osteoporosis is a disease characterized by low bone mass and deterioration of bone tissue. It increases bone fragility and risk of fracture. While not a natural part of aging, risk is higher for post-menopausal women over 65 and all races and sexes can be affected. Bone density testing is recommended for women over 65, men over 70, and younger adults with clinical risk factors to diagnose osteoporosis. Dual energy x-ray absorptiometry (DEXA) is the gold standard test which measures bone mineral density at the hip and spine.
Osteoporosis is a disease of bone that leads to an increased risk of fracture. In osteoporosis the bone mineral density (BMD) is reduced, bone micro architecture is disrupted, and the amount and variety of proteins in bone is altered. Osteoporosis is defined by the World Health Organization (WHO) in women as a bone mineral density 2.5 standard deviations below peak bone mass (20-year-old healthy female average) as measured by DXA; the term "established osteoporosis" includes the presence of a fragility fracture.
Osteoporosis is a disease where bones become brittle and weak, increasing the risk of fractures. It is caused by low bone density due to lack of calcium and other minerals in bones. Symptoms include back pain and loss of height. Risk factors include age, gender, family history, and medications like corticosteroids. It is diagnosed through tests like DXA scans and treated through lifestyle changes, medications, and hormone therapy.
Osteoporosis is a serious public health problem that is often silent until fractures occur. It is estimated to affect over 200 million women worldwide. The definition is a skeletal disorder characterized by compromised bone strength and increased risk of fracture. Diagnosis is based on bone mineral density T-scores assessed via dual-energy X-ray absorptiometry (DXA) scans. Fracture risk assessment tools like FRAX can provide 10-year probability of fracture based on BMD and clinical risk factors. However, risk factors like falls are not included, and clinical judgment is also important. Overall prevention of osteoporotic fractures remains an important challenge given lack of awareness and underdiagnosis.
This document provides information on osteoporosis, including its definition, prevalence, risk factors, symptoms, diagnosis, and management. Some key points:
- Osteoporosis is a metabolic bone disease characterized by low bone mass and deterioration of bone tissue, leading to increased bone fragility and fracture risk.
- It is a major public health problem worldwide due to its association with pain, disability, and loss of quality of life.
- Risk factors include age, gender, family history, smoking, excessive alcohol, low body weight, and certain medications like glucocorticoids.
- It is usually asymptomatic until a fracture occurs. Common fracture sites are the spine, hip, and wrist
Osteoporosis is a disease characterized by low bone mass and deterioration of bone tissue, leading to fragile bones and an increased risk of fractures. Common sites of osteoporotic fractures include the spine, causing severe back pain. Spinal fractures are typically triggered by everyday activities and result in loss of height, kyphosis, and pain when bending or twisting. Low back pain is also linked to osteoporosis, as fractured vertebrae from weakened bones can press on nerves and cause chronic pain. Treatment focuses on preventing further bone loss and fractures through medications, calcium/vitamin D supplementation, exercise, and lifestyle changes.
Osteoporosis is a systemic skeletal disease characterized by low bone mass and deterioration of bone tissue, leading to fragile bones that are prone to fractures. It often presents without symptoms until a fracture occurs. Key risk factors include advanced age, female sex, small body frame, family history, smoking, excessive alcohol use, low calcium intake, physical inactivity, and certain medications. Screening high-risk individuals is important for diagnosis and treatment before fractures manifest.
This document provides an overview of osteoporosis, including its definition, bone structure, epidemiology, pathophysiology, risk factors, clinical features, investigations, treatment, and management. It defines osteoporosis as a reduction in bone strength that increases fracture risk. Key points include that it occurs more in women after menopause due to estrogen loss, common risk factors, the roles of osteoblasts and osteoclasts in bone remodeling, biochemical markers used in diagnosis, DXA scans to measure bone mineral density, and first-line pharmaceutical treatments including bisphosphonates.
This document discusses fragility fractures caused by osteoporosis. It defines fragility fractures as fractures caused by a fall from standing height. Osteoporosis is characterized by low bone mass and deterioration of bone structure, increasing risk of fractures. The document reviews diagnosis of osteoporosis using DXA scans, risk factors, management including lifestyle changes and medications, and challenges of treating fragility fractures in osteoporotic patients. It emphasizes the importance of rehabilitation and secondary prevention including fall prevention and osteoporosis treatment to prevent further fractures.
This document provides an overview of osteoporosis including its definition, epidemiology, pathophysiology, causes, clinical features, diagnosis, and treatment. Some key points include:
- Osteoporosis is a skeletal disorder characterized by compromised bone strength and increased risk of fracture. It is defined by the WHO as a bone density 2.5 standard deviations below the mean.
- It is a major global health problem, particularly affecting post-menopausal women and the elderly. Lifetime risk of osteoporotic fractures is 30-50% in females and 15-30% in males.
- Causes include failure to achieve peak bone mass, increased bone resorption, and inadequate bone formation
The document summarizes information about osteoporosis from a lecture by Dr. Shahjada Selim. It discusses how bone remodeling occurs throughout life, leading to peak bone mass and then age-related bone loss. It defines osteoporosis as a disorder causing fragile bones from low bone mass and deteriorated bone structure. Key points include how osteoporosis is diagnosed using BMD tests and fracture risk tools, treatments include medications to reduce fracture risk, and lifestyle changes can help prevent osteoporotic fractures.
Know everything about Osteoporosis- prevention and management.
Did You Know?
The incidence of hip fracture is 1 woman to 1 man in India
Know more such facts and useful information on prevention of Osteoporosis.
This document discusses the pathophysiology, epidemiology, presentation, diagnosis, and treatment of osteoporosis. It notes that bone undergoes constant remodeling by osteoblasts and osteoclasts. Estrogen deficiency accelerates bone loss via increased osteoclast activity. Risk factors include female gender, older age, family history, smoking, low calcium intake, and certain medications. Vertebral fractures often cause back pain and kyphosis. Treatment involves lifestyle modifications, calcium/vitamin D supplementation, and pharmacotherapy like bisphosphonates, denosumab, teriparatide, calcitonin, and SERMs. Medication choice depends on factors like fracture risk, side effect profile, and cost.
Bone loss occurs without symptoms and the first sign may be a fracture due to weakened bones caused by a sudden strain. Osteoporosis is characterized by compromised bone strength that increases the risk of fracture. While bone loss occurs without symptoms, the first sign is often a fracture that results from a minor strain or impact that would not normally cause a break in healthy bone.
The document discusses osteoporosis and questions whether it should be considered a disease. It summarizes the WHO conference that defined osteoporosis and established T-scores. It raises concerns about the definition and how DEXA scans are used to diagnose based on measurements that may not be accurate or applicable to all groups. Risk factors are highlighted and questions are raised about whether they apply to all populations equally.
This document discusses osteoporosis and bone health. It begins by noting the impact of osteoporosis on older patients, including increased hospital admissions and length of stay. It then discusses definitions of osteoporosis from WHO and treatment gaps. The document covers bone structure, cells, mineralization, remodeling cycles, and factors influencing bone health like hormones and lifestyle. Diagnostic methods like DXA are summarized. Treatment options focused on prevention of fractures through calcium, vitamin D, bisphosphonates, PTH, and fall prevention are outlined.
Osteoporosis is a disease characterized by low bone mass and deterioration of bone tissue. It increases bone fragility and risk of fracture. While not a natural part of aging, risk is higher for post-menopausal women over 65 and all races and sexes can be affected. Bone density testing is recommended for women over 65, men over 70, and younger adults with clinical risk factors to diagnose osteoporosis. Dual energy x-ray absorptiometry (DEXA) is the gold standard test which measures bone mineral density at the hip and spine.
Osteoporosis is a disease of bone that leads to an increased risk of fracture. In osteoporosis the bone mineral density (BMD) is reduced, bone micro architecture is disrupted, and the amount and variety of proteins in bone is altered. Osteoporosis is defined by the World Health Organization (WHO) in women as a bone mineral density 2.5 standard deviations below peak bone mass (20-year-old healthy female average) as measured by DXA; the term "established osteoporosis" includes the presence of a fragility fracture.
Osteoporosis is a disease where bones become brittle and weak, increasing the risk of fractures. It is caused by low bone density due to lack of calcium and other minerals in bones. Symptoms include back pain and loss of height. Risk factors include age, gender, family history, and medications like corticosteroids. It is diagnosed through tests like DXA scans and treated through lifestyle changes, medications, and hormone therapy.
Osteoporosis is a serious public health problem that is often silent until fractures occur. It is estimated to affect over 200 million women worldwide. The definition is a skeletal disorder characterized by compromised bone strength and increased risk of fracture. Diagnosis is based on bone mineral density T-scores assessed via dual-energy X-ray absorptiometry (DXA) scans. Fracture risk assessment tools like FRAX can provide 10-year probability of fracture based on BMD and clinical risk factors. However, risk factors like falls are not included, and clinical judgment is also important. Overall prevention of osteoporotic fractures remains an important challenge given lack of awareness and underdiagnosis.
This document provides information on osteoporosis, including its definition, prevalence, risk factors, symptoms, diagnosis, and management. Some key points:
- Osteoporosis is a metabolic bone disease characterized by low bone mass and deterioration of bone tissue, leading to increased bone fragility and fracture risk.
- It is a major public health problem worldwide due to its association with pain, disability, and loss of quality of life.
- Risk factors include age, gender, family history, smoking, excessive alcohol, low body weight, and certain medications like glucocorticoids.
- It is usually asymptomatic until a fracture occurs. Common fracture sites are the spine, hip, and wrist
Osteoporosis is a disease characterized by low bone mass and deterioration of bone tissue, leading to fragile bones and an increased risk of fractures. Common sites of osteoporotic fractures include the spine, causing severe back pain. Spinal fractures are typically triggered by everyday activities and result in loss of height, kyphosis, and pain when bending or twisting. Low back pain is also linked to osteoporosis, as fractured vertebrae from weakened bones can press on nerves and cause chronic pain. Treatment focuses on preventing further bone loss and fractures through medications, calcium/vitamin D supplementation, exercise, and lifestyle changes.
Osteoporosis is a systemic skeletal disease characterized by low bone mass and deterioration of bone tissue, leading to fragile bones that are prone to fractures. It often presents without symptoms until a fracture occurs. Key risk factors include advanced age, female sex, small body frame, family history, smoking, excessive alcohol use, low calcium intake, physical inactivity, and certain medications. Screening high-risk individuals is important for diagnosis and treatment before fractures manifest.
This document provides an overview of osteoporosis, including its definition, bone structure, epidemiology, pathophysiology, risk factors, clinical features, investigations, treatment, and management. It defines osteoporosis as a reduction in bone strength that increases fracture risk. Key points include that it occurs more in women after menopause due to estrogen loss, common risk factors, the roles of osteoblasts and osteoclasts in bone remodeling, biochemical markers used in diagnosis, DXA scans to measure bone mineral density, and first-line pharmaceutical treatments including bisphosphonates.
This document discusses fragility fractures caused by osteoporosis. It defines fragility fractures as fractures caused by a fall from standing height. Osteoporosis is characterized by low bone mass and deterioration of bone structure, increasing risk of fractures. The document reviews diagnosis of osteoporosis using DXA scans, risk factors, management including lifestyle changes and medications, and challenges of treating fragility fractures in osteoporotic patients. It emphasizes the importance of rehabilitation and secondary prevention including fall prevention and osteoporosis treatment to prevent further fractures.
This document provides an overview of osteoporosis including its definition, epidemiology, pathophysiology, causes, clinical features, diagnosis, and treatment. Some key points include:
- Osteoporosis is a skeletal disorder characterized by compromised bone strength and increased risk of fracture. It is defined by the WHO as a bone density 2.5 standard deviations below the mean.
- It is a major global health problem, particularly affecting post-menopausal women and the elderly. Lifetime risk of osteoporotic fractures is 30-50% in females and 15-30% in males.
- Causes include failure to achieve peak bone mass, increased bone resorption, and inadequate bone formation
The document summarizes information about osteoporosis from a lecture by Dr. Shahjada Selim. It discusses how bone remodeling occurs throughout life, leading to peak bone mass and then age-related bone loss. It defines osteoporosis as a disorder causing fragile bones from low bone mass and deteriorated bone structure. Key points include how osteoporosis is diagnosed using BMD tests and fracture risk tools, treatments include medications to reduce fracture risk, and lifestyle changes can help prevent osteoporotic fractures.
Major hotel chains will focus less on amenities like TVs and phones in 2015, instead prioritizing free high-speed WiFi. Hotel occupancy is reaching new heights, causing room rates to rise, so hotels will emphasize savings opportunities. Travelers can expect to see more bundled packages that combine flights, rooms, and car rentals to provide affordable options. Emerging technologies like smartphone room keys and wearable devices will continue changing the travel experience.
Eco-nomics, The hidden costs of consumptionJosh Beatty
Joe, an average consumer, spends $25,000 annually on goods and consumes $100,000 worth of natural resources, but he only pays the direct retail costs and is unaware of the various hidden environmental, health, and security costs associated with production and transportation. These hidden costs—which include pollution cleanup, resource depletion, subsidies, and climate change impacts—add up to over $1 trillion annually for U.S. consumers. The document urges people to reduce their consumption, support sustainable businesses, and make more informed choices to limit these hidden costs that will otherwise be passed on to future generations.
This document provides a summary of common mistakes in PowerPoint presentation design and tips to avoid them. It identifies the top 5 mistakes as including putting too much information on slides, not using enough visuals, using poor quality visuals, having a disorganized "visual vomit" style, and lack of preparation. The document emphasizes telling a story over slide design, using whitespace on slides, consistent formatting, and spending significant time preparing presentations.
Today we all live and work in the Internet Century, where technology is roiling the business landscape, and the pace of change is only accelerating.
In their new book How Google Works, Google Executive Chairman and ex-CEO Eric Schmidt and former SVP of Products Jonathan Rosenberg share the lessons they learned over the course of a decade running Google.
Covering topics including corporate culture, strategy, talent, decision-making, communication, innovation, and dealing with disruption, the authors illustrate management maxims with numerous insider anecdotes from Google’s history.
In an era when everything is speeding up, the best way for businesses to succeed is to attract smart-creative people and give them an environment where they can thrive at scale. How Google Works is a new book that explains how to do just that.
This is a visual preview of How Google Works. You can pick up a copy of the book at www.howgoogleworks.net
What Would Steve Do? 10 Lessons from the World's Most Captivating PresentersHubSpot
The document provides 10 tips for creating captivating presentations based on lessons from famous presenters like Steve Jobs, Scott Harrison, and Gary Vaynerchuk. The tips include crafting an emotional story with a beginning, middle, and end; creating slides that answer why the audience should care, how it will improve their lives, and what they must do; using simple language without jargon; using metaphors; ditching bullet points; showing rather than just telling through images; rehearsing extensively; and that excellence requires hard work with no shortcuts.
New ulmonary arterial hypertension in rheumatic diseases 財團法人風濕病基金會台灣抗風濕病聯盟
This document summarizes a presentation on pulmonary artery hypertension (PAH) in rheumatic diseases. It begins with a case presentation of a patient diagnosed with limited systemic sclerosis and PAH who was treated with various medications. It then provides background on PAH classification and the pathophysiology of PAH in connective tissue diseases. Specifically, it discusses the prevalence of PAH in different rheumatic diseases like systemic sclerosis, the mechanisms involved in pathogenesis, and differences in phenotypes between SSc-PAH and non-SSc PAH. Treatment approaches are also summarized.
Current diagnosis and management of PAH from cardiologist point of view財團法人風濕病基金會台灣抗風濕病聯盟
1. Pulmonary arterial hypertension (PAH) is often misdiagnosed or diagnosed late due to non-specific symptoms. Right heart catheterization is the gold standard diagnostic test.
2. PAH can be classified into 5 groups, with Group 1 including idiopathic PAH and PAH associated with conditions like connective tissue diseases.
3. PAH progresses from a reversible stage of endothelial dysfunction and vasoconstriction to an irreversible stage involving structural changes to the pulmonary vasculature. This leads to increased pulmonary vascular resistance and pressures over time.
This document discusses pulmonary hypertension (PH) in patients with connective tissue diseases (CTD). It finds that treatment is less effective for CTD-associated PH (CTD-PAH) compared to idiopathic PAH, with less improvement in walking distance and higher rates of clinical worsening. Combination therapy may be more effective than monotherapy for CTD-PAH. The prognosis of CTD-PAH patients is better if they are short-term responders to treatment or were initially treated with glucocorticoids and immunosuppressants upon PAH and CTD diagnosis. However, treatment outcomes are worse if CTD-PAH patients also have interstitial lung disease. Right ventricular size measured
1. Rheumatoid arthritis (RA) is an autoimmune disease where the immune system mistakenly attacks the body's own tissues, causing inflammation in the joints.
2. If left uncontrolled, long-term inflammation from RA can cause joint deformity, disability, and loss of function.
3. RA occurs when cytokines that regulate inflammation become imbalanced, leading to excess production of pro-inflammatory cytokines like interleukin-6, interleukin-1, and tumor necrosis factor-alpha.
