The document discusses several key points about medication and breastfeeding:
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2. The amount transferred depends on factors like the mother's serum drug level, protein binding, lipophilicity, and molecular weight of the drug.
3. The infant's exposure also depends on the volume of milk consumed and the infant's ability to absorb and eliminate the drug.
4. Drugs are generally classified based on their safety profile during breastfeeding, with categories for compatible, compatible with monitoring, avoid if possible, and contraindicated drugs.
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Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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1.
2. Advice on infant feeding
• Breast milk is the best form of nutrition for infants.
• Exclusive breastfeeding for the first 6 months.
• Breastfeeding (and/or formula milk) with appropriate solid food after 6 months, ideally for
up to 1 year.
3.
4. Medication and breastfeeding
• Breast-feeding has many benefits.
• Potential harm to the nursing infant from maternal drugs is a reason to discontinue breast-
feeding.
• Physicians receive little education about breast-feeding and even less training on the effects
of maternal drugs on the nursing infant.
7. Methods of drug transfer into milk
• Passive diffusion
• Active transport against a concentration gradient
• Transcellular diffusion
8. • Diffusion
– Plasma levels in the mother
– Lipid solubility of the drug and fat content of milk
– Milk ph
– Molecular size of the drug
– Protein binding of the drug in mother’s plasma
– Maternal half-life of the drug
– Molecular weight of drug
– Bioavailability of the medication to the infant
9. Transfer of dugs into Breast Milk
• Nearly all drugs transfer into breast milk to some extent.
• Notable exceptions are heparin and insulin {too large to cross biological membranes}.
• Drug transfer from maternal plasma to milk is, with rare exceptions, by passive diffusion
across biological membranes.
• Almost all medication appears in small amounts, usually less than 1% of the maternal dose
• Very few drugs are contraindicated for nursing mothers
10. • Transfer of drug into Breast Milk
• The amount of breast milk consumed by the infant.
• The pharmacologic activity of the drug: absorption, distribution, metabolism and elimination
by the infant.
• Condition of the infant:
• Greater precaution for infants
– premature or
– compromised or
– in the first week of life than for older, healthy infants.
11.
12.
13. Drug therapy during lactation
• Drugs that passes minimally into milk:
– Acid drug
– Highly protein bound drug
– E.g NSAID
– Weekly basic drug with low plasma
protein binding and highly lipophilic
will achieve higher concentration in
milk
– E.g. sotalol.
14. Factors affecting drug transfer
• The maternal serum drug concentration.
• Drugs:
– pKa of drug (fraction of drug that is ionized at a given pH)
• Basic drugs -> ionized at acidic pH(low pH) -> trapped in milk
• Acidic drug ionized at higher pH -> trapped in maternal plasma
– Protein binding (highly protein bound drug -> less transfer to milk)
– Lipipophilicity: (high lipophilic drugs-> more drug in milk).
– Molecular weight of drug: high MW -> less drug in milk (insulin, heparin do not enter
breast milk)
15. Factors determining drug concentration in milk
• Milk composition
– Milk at the end of a feed (hindmilk) contains considerably more fat than foremilk and
may concentrate fat-soluble drugs.
• Age of infant:
• In the early postpartum period, large gaps between the mammary alveolar cells allow
many dugs to pass. These gaps close by the 2nd week of lactation.
• Premature babies & infants less than 1 month have a different capacity to absorb and
excrete drugs than older infants.
• Nursing time of baby.
• Milk to plasma concentration(M/P) ratio: for most drug M/P ratio is <1 (drugs with higher
M/P ratio (e.g. 5) are unsafe)
16. Estimating risk to infant
• Milk to plasma concentration (M/P) ratio:
• If M/P ratio of a drug is known
• Amount (dose) of drug ingested by infant can be calculated by
• Dinfant = Cpmat x M/P x Vmax
• Cpmat: average maternal plasma concentration
• Vmax: volume of milk which is assumed to be 150ml
• For most drug, an exposure <10% of weight adjusted maternal dose is acceptable.
17. Calculation of infant exposure to drugs
• The infant dose (mg/kg)
– D infant (mg/kg/day)= C maternal (mg/L) x M/PAUC x V infant (L/kg/day)
Cmaternal= maternal plasma concentration
M/PAUC ratio = milk to plasma concentration ratio area under curve.
Vinfant= volume of milk ingested
• As a percentage of the maternal dose (mg/kg). The volume of milk ingested by infants is
commonly estimated as 0.15 L/kg/day.
An arbitrary cut-off of 10% has been selected as a guide to the safe use of drugs during
lactation.
18. How much of the medicine reaches the baby?
Depends on:
• Blood level of medicine in the mother.
• Characteristics of the medicine.
• Amount of medicine passed into breast milk.
• Amount of milk taken by baby per feed (approx 150mL/kg).
19. Methods of decreasing toxicity in nursing infant
• Select safe drug
• Nurse immediately before taking drug.
• Take drug 3-4 hours before next feeding
• Avoid feeding when drug reaches peak concentration in milk and plasma
• Use drug with short half life
• Instruct patient to monitor ADRs
20. General advice
• Avoid unnecessary use of medicines.
• Assess risk / benefit for mother and baby.
• Higher risk for premature babies.
• Check if medicine licensed for babies.
• Avoid long-acting medicines
• Avoid new medicines.
• Try to time feed to avoid when drug levels in milk are highest.
• Monitor baby for adverse effects.
21. Essential questions to ask
• Has mum already taken the medicine(s) or is she wanting to take?
• Medicine(s), indication, dose, frequency, route & duration of exposure?
• Has this been prescribed or self-treating?
• Have any other medicines been considered or tried?
• What age is the baby? Full term & healthy?
• How often is baby feeding? – Totally breast fed or bottle too?
22. WHO classification of drugs during breastfeeding (2002)
• 1. Compatible with breastfeeding
• 2. Compatible with breastfeeding {occasional mild side effects} Monitor infant for side
effects
• 3. Avoid if possible. {significant side effects} Monitor infant for side-effects
• 4. Avoid if possible. {May inhibit lactation}. Monitor for amount of milk
• 5. Contraindicated {dangerous side effects}
23. Compatible with breastfeeding
• There are no known or theoretical contraindications for their use, and it is considered safe for
the mother to take the drug and continue to breastfeed.
24. Compatible with breastfeeding {Occasional mild side-effects}
Monitor infant for side-effects
• If side-effects:
– stop the drug, and
– find an alternative.
• If the mother cannot stop the drug, she may need to stop breastfeeding and feed her baby
artificially until her treatment is completed.
25. Avoid if possible {significant side effects}
Monitor infant for side-effect
27. Contraindicated {Dangerous side-effects}.
• If they are essential:
• stop breast feeding until treatment is completed.
• If treatment is prolonged, she may need to stop breastfeeding altogether.
• There are very few drugs in this category apart from anticancer drugs and radioactive
substances.
31. DRUG CLASSIFICATION BY AAP
• Cytotoxic drugs
• Drugs of abuse for which adverse effects on the infant
• Radioactive compounds that require temporary cessation of breastfeeding
• Drugs for which the effect on nursing infants in unknown but may be concern
• Drugs that have been associated with significant effects on some nursing infants and should
be given to nursing mothers with caution
• Maternal medication usually compatible with breastfeeding
32.
33. Before prescribing drugs to lactating women
• Is drug really necessary? If drugs are required, consultation between the pediatrician and the
mother’s physician can be most useful in determining what options to choose.
• The safest drug should be chosen e.g. acetaminophen rather than aspirin for analgesia.
• If there is a possibility that a drug may present a risk to the infant, consideration should be
given to measurement of blood concentrations in the nursing infant.
• Drug exposure to the nursing infant may be minimized
34. • Choose medications with the shortest half-life and highest protein-binding ability.
• Choose medications that are well-studied in infants.
• Choose medications with the poorest oral absorption.
• Choose medications with the lowest lipid solubility.
35. Medication dosing
• Administer single daily-dose drugs just before the longest sleep interval for the infant, usually
after the bed-time feeding.
• Breast-feed infant immediately before medication dose when multiple daily doses are needed
36. Common drugs excreted in breast milk
• Most antibiotics taken by nursing mothers can be detected in breast milk
• Tetracycline concentrations in breast milk is 70% of maternal serum concentrations and
present a risk of permanent tooth staining in infant
• Isonized rapidly reaches equilibrium between breast milk and maternal blood. So that signs of
pyridoxine deficiency may occur in the infant if the mother is not given pyridoxine
supplements.
• Most sedatives and hypnotics enters breast milk sufficient to produce a pharmacologic effect
in infants.
• Barbiturates taken in hypnotic doses by mother can produce lethargy, sedation, and poor suck
reflexes in infant.
37. • Chloral hydrate can produce sedation if infant is fed at peak milk concentrations.
• Diazepam can have a sedative effect on the nursing infant
• Lithium enters breast milk in concentrations equal to those in maternal serum
• Radioiodine can cause thyroid suppression
• Breast-feeding is contraindicated after large doses of radioiodine and should be withheld for
days to weeks after small doses.
38. • Breast-feeding should be avoided in mothers receiving cancer chemotherapy
• Opioids such as heroin, methadone, and morphine enter breast milk (neonatal narcotic
dependence).
• Very small amounts of caffeine are excreted in the breast milk of coffee-drinking mothers.