The spleen is located in the left upper quadrant of the abdomen. It is up to 12 cm long, 7 cm wide, and 3-4 cm thick, with its long axis along the tenth rib. The document describes the surfaces, blood supply, and radiological appearance of the spleen. The spleen receives blood from the splenic artery and drains into the splenic vein, which joins the superior mesenteric vein to form the portal vein. Imaging modalities like ultrasound, CT, and MRI can visualize the spleen and its relationship to surrounding organs.