The document discusses the North American smallpox epidemic that occurred between 1775-1782. It spread rapidly across North America, infecting virtually the entire continent and killing an estimated 145,000 people. The epidemic reached Native American tribes and British camps, reducing one tribe's population by 25%. George Washington took measures to try to prevent its spread like quarantining infected soldiers, but the disease threatened his army during battles in the American Revolution. The close-knit communities of Native Americans were hit hard as smallpox could easily spread through contact with infected bed sheets or clothing. By the end, it had reached as far as Alaska and the Pacific Coast.