Bronchial hyper-reactivity causes reversible airway obstruction from smooth muscle constriction and mucus hypersecretion. There are two types: extrinsic and intrinsic. Extrinsic is more common, often starts in childhood, and is caused by allergies that trigger the release of mast cell mediators. Intrinsic is less common, starts in adulthood, and is non-allergic, triggered by stress, reflux, or vagal responses. Diagnosis involves history, exams, imaging, spirometry, skin tests, and blood tests. Management includes education, avoidance of irritants, and medications depending on diagnosis and severity, such as bronchodilators, corticosteroids, and other drugs.