Radiation Risk from CT Scan and the possibility of getting cancer after receiving high dose of radiation.
Dr. Khalid Shokor Mahmood, neurosurgeon, Iraq
Radiation Risk from CT Scan and the possibility of getting cancer after receiving high dose of radiation.
Dr. Khalid Shokor Mahmood, neurosurgeon, Iraq
A short overview of Image Guided Radiotherapy process in Lung Cancer presented at TMC Kolkata circa 2016. Basic principles and concepts as well as examples are outlined.
Find the best doctor of PET CT Scan in Pune at Onco Life Cancer Centre, Satara.
For more info, please visit: https://www.oncolifehospitals.com/services/pet-ct-scan/
https://www.snmclub.com/presentation
PET/MRI Current & Future Status
DALE BAILEY PhD , Principal Physicist
Departement of Nuclear Medicine, Royal North Shore Hospital
Professor in Medical Radiation Sciences, University of Sydney
Sydney, Australia
icrm2018
Individually Optimized Contrast-Enhanced 4D-CT for Radiotherapy Simulation in...Wookjin Choi
Purpose/Objectives: To develop an individually optimized contrast-enhanced (CE) 4D-CT for radiotherapy simulation in pancreatic adenocarcinoma (PDA).
Materials/Methods: Ten PDA patients were enrolled and underwent three CT scans: a 4D-CT immediately following a CE 3D-CT, and an individually optimized CE 4D-CT using a test injection to estimate the peak contrast enhancement time and to optimize the delay time. Three physicians contoured the tumor and pancreatic tissues. We compared image quality scores, tumor volume, motion, image noise, tumor-to-pancreas contrast, and contrast-to- noise ratio (CNR) in the three CTs. We also evaluated inter-observer variations in contouring the tumor using simultaneous truth and performance level estimation (STAPLE).
Results: The average image quality scores for CE 3D-CT and CE 4D-CT were comparable (4.0 and 3.8, p=0.47), and both were significantly better than that for 4D-CT (2.6, p<0.001). The tumor-to- pancreas contrast in CE 3D-CT and CE 4D-CT were comparable (15.5 and 16.7 HU, p=0.71), and the later was significantly higher than that in 4D-CT (9.2 HU, p=0.03). Image noise in CE 3D-CT (12.5 HU) was significantly lower than that in CE 4D-CT (22.1 HU, p<0.001) and 4D-CT (19.4 HU, p=0.005). The CNR in CE 3D-CT and CE 4D-CT were comparable (1.4 and 0.8, p=0.23), and the former was significantly better than that in 4D-CT (0.6, p=0.04). The average tumor volume was smaller in CE 3D-CT (29.8 cm 3 ) and CE 4D-CT (22.8 cm 3 ) than in 4D-CT (42.0 cm 3 ), though the differences were not statistically significant. The tumor motion was comparable in 4D-CT and CE 4D-CT (7.2 and 6.2 mm, p=0.23). The inter-observer variations were comparable in CE 3D-CT and CE 4D-CT (Jaccard index 66.0% and 61.9%), and the former was significantly smaller than that of 4D-CT (55.6%, p=0.047).
Conclusions: The CE 4D-CT demonstrated largely comparable characteristics to the CE 3D-CT. It has high potential for simultaneously delineating the tumor and quantifying the tumor motion with a single scan.
Research into the effectiveness of daily image guided radiotherapy on the pro...Genesis Care
To assess the effect of frequency of verification imaging on the dose delivered to target volume and organs at risk, during a course of image-guided radiotherapy (IGRT) for prostate cancer.
A short overview of Image Guided Radiotherapy process in Lung Cancer presented at TMC Kolkata circa 2016. Basic principles and concepts as well as examples are outlined.
Find the best doctor of PET CT Scan in Pune at Onco Life Cancer Centre, Satara.
For more info, please visit: https://www.oncolifehospitals.com/services/pet-ct-scan/
https://www.snmclub.com/presentation
PET/MRI Current & Future Status
DALE BAILEY PhD , Principal Physicist
Departement of Nuclear Medicine, Royal North Shore Hospital
Professor in Medical Radiation Sciences, University of Sydney
Sydney, Australia
icrm2018
Individually Optimized Contrast-Enhanced 4D-CT for Radiotherapy Simulation in...Wookjin Choi
Purpose/Objectives: To develop an individually optimized contrast-enhanced (CE) 4D-CT for radiotherapy simulation in pancreatic adenocarcinoma (PDA).
Materials/Methods: Ten PDA patients were enrolled and underwent three CT scans: a 4D-CT immediately following a CE 3D-CT, and an individually optimized CE 4D-CT using a test injection to estimate the peak contrast enhancement time and to optimize the delay time. Three physicians contoured the tumor and pancreatic tissues. We compared image quality scores, tumor volume, motion, image noise, tumor-to-pancreas contrast, and contrast-to- noise ratio (CNR) in the three CTs. We also evaluated inter-observer variations in contouring the tumor using simultaneous truth and performance level estimation (STAPLE).
Results: The average image quality scores for CE 3D-CT and CE 4D-CT were comparable (4.0 and 3.8, p=0.47), and both were significantly better than that for 4D-CT (2.6, p<0.001). The tumor-to- pancreas contrast in CE 3D-CT and CE 4D-CT were comparable (15.5 and 16.7 HU, p=0.71), and the later was significantly higher than that in 4D-CT (9.2 HU, p=0.03). Image noise in CE 3D-CT (12.5 HU) was significantly lower than that in CE 4D-CT (22.1 HU, p<0.001) and 4D-CT (19.4 HU, p=0.005). The CNR in CE 3D-CT and CE 4D-CT were comparable (1.4 and 0.8, p=0.23), and the former was significantly better than that in 4D-CT (0.6, p=0.04). The average tumor volume was smaller in CE 3D-CT (29.8 cm 3 ) and CE 4D-CT (22.8 cm 3 ) than in 4D-CT (42.0 cm 3 ), though the differences were not statistically significant. The tumor motion was comparable in 4D-CT and CE 4D-CT (7.2 and 6.2 mm, p=0.23). The inter-observer variations were comparable in CE 3D-CT and CE 4D-CT (Jaccard index 66.0% and 61.9%), and the former was significantly smaller than that of 4D-CT (55.6%, p=0.047).
Conclusions: The CE 4D-CT demonstrated largely comparable characteristics to the CE 3D-CT. It has high potential for simultaneously delineating the tumor and quantifying the tumor motion with a single scan.
Research into the effectiveness of daily image guided radiotherapy on the pro...Genesis Care
To assess the effect of frequency of verification imaging on the dose delivered to target volume and organs at risk, during a course of image-guided radiotherapy (IGRT) for prostate cancer.
Streamlining assessment, feedback, and archival with auto-multiple-choiceMatthew Leingang
Auto-multiple-choice (AMC) is an open-source optical mark recognition software package built with Perl, LaTeX, XML, and sqlite. I use it for all my in-class quizzes and exams. Unique papers are created for each student, fixed-response items are scored automatically, and free-response problems, after manual scoring, have marks recorded in the same process. In the first part of the talk I will discuss AMC’s many features and why I feel it’s ideal for a mathematics course. My contributions to the AMC workflow include some scripts designed to automate the process of returning scored papers
back to students electronically. AMC provides an email gateway, but I have written programs to return graded papers via the DAV protocol to student’s dropboxes on our (Sakai) learning management systems. I will also show how graded papers can be archived, with appropriate metadata tags, into an Evernote notebook.
The utility of 18F-fluorocholine PET/CT in the imaging of parathyroid adenomasNukleer Tıp Uzmanı
Introduction:
The aim of the study was to estimate the sensitivity of 18F-FCH PET/CT in preoperative localisation of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism (PHPT).
Material and methods:
Sixty-five consecutive patients with PHPT, who underwent neck ultrasound (US) and 99mTc/99mTc-MIBI dual-phase parathyroid scintigraphy, were prospectively enrolled. Twenty-two patients had unsuccessful parathyroid surgery prior to the study. PET/CT scans were performed 65.0 ± 13.3 min after injection of 218.5 ± 31.9 MBq of 18F-fluorocholine (FCH). Three experienced nuclear medicine physicians assessed the detection rate of hyperfunctioning parathyroid tissue. Response to parathyroidectomy and clinical follow-up served as a reference test. Per-patient sensitivity and positive predictive value (PPV) were calculated for patients who underwent surgery.
Results:
18F-FCH PET/CT was positive in 61 patients, and negative in 4. US and parathyroid scintigraphy showed positive and negative results in 20, 45 and 17, 48, respectively. US showed nodular goitre in 31 patients and chronic thyroiditis in 9 patients. Parathyroid surgery was performed in 43 (66%) patients. 18F-FCH PET/CT yielded a sensitivity of 100% (95% CI: 87.99–100) and PPV of 85.7% (95% CI: 70.77–94.06). Similar values were observed in patients with chronic thyroiditis, nodular goitre, and patients after an unsuccessful parathyroid surgery. PET/CT identified hyperparathyroidism complications (kidney stones, osteoporotic bone fractures, and brown tumours) in 11 patients.
Conclusions:
18F-FCH PET/CT effectively detected hyperfunctioning parathyroid tissue and its complications. The method showed excellent sensitivity and positive predictive value, including patients with nodular goitre, chronic thyroiditis, and prior unsuccessful parathyroidectomy. PET/CT performance was superior to neck ultrasound and parathyroid scintigraphy.
18F-FCH PET/CT; fluorocholine; hyperparathyroidism; parathyroid imaging
Effect of Time of Echo on 1H-magnetic Resonance Spectroscopy Imaging of Metab...submissionclinmedima
The aim of this study is to evaluate the effect of time of echo (TE) on magnetic resonance spectroscopy imaging (MRSI) of metabolites in maxillofacial carcinoma. 1.2. Methods: Twenty maxillofacial carcinoma patients and 10 healthy volunteers were recruited to undergo 1.5-Tesla high-resolution routine MRI and multi-voxel MRSI with a TE of 35 ms and 144 ms.
Comparison of 7.0- and 3.0-T MRI and MRA in ischemic-type moyamoya disease: ...Manuela Pohlemann
Autores: Xiaofeng Deng, MD , Zihao Zhang, PhD, Yan Zhang, MD , PhD, Dong Zhang, MD , PhD,
Rong Wang, MD , PhD, Xun Ye, MD , PhD, Long Xu, MD , PhD, Bo Wang, PhD, Kai Wang, MD ,
and Jizong Zhao, MD
Departments of Neurosurgery and Neuroradiology, Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (NCRC-ND); Center of Stroke, Beijing Institute for Brain Disorders; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease; State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences; and Graduate School, University of Chinese Academy of Sciences, Beijing, China.
Journal of Neurosurgery
Posted online on November 6, 2015.
Link del Abstract: http://thejns.org/doi/abs/10.3171/2015.5.JNS15767?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&
Intensity-modulated radiotherapy with simultaneous modulated accelerated boos...Enrique Moreno Gonzalez
To present our experience of intensity-modulated radiotherapy (IMRT) with simultaneous modulated accelerated radiotherapy (SMART) boost technique in patients with nasopharyngeal carcinoma (NPC).
Detection of Cystathionine, 2-Hydroxyglutarate and Citrate in Oligodendroglio...Uzay Emir
The semi-LASER sequence optimized for 2-HG detection with a TE of 110 ms successfullydemonstrated distinct cystathionine peaks in glioma patients with molecularly definedoligodendroglioma (IDH-mutant and 1p/19q codeleted) at 7T. While a prospective, betterpowered study is needed to confirm our observations, we propose that our method has thepotential to allow presurgical stratification of patients with IDH-mutant glioma into those witholigodendrogliomas and astrocytomas; which is of important prognostic significance.
(PDF) Detection of Cystathionine, 2-Hydroxyglutarate and Citrate in Oligodendrogliomas at 7T using Long-TE Semi-LASER. Available from: https://www.researchgate.net/publication/349575306_Detection_of_Cystathionine_2-Hydroxyglutarate_and_Citrate_in_Oligodendrogliomas_at_7T_using_Long-TE_Semi-LASER [accessed Mar 03 2021].
Abstract—Colorectal cancer is leading cancer-related public health problem. This study was conducted to determine the effect of High-Dose-Rate intraluminal brachytherapy (HDR-BT) with or without interstitial brachytherapy during neoadjuvant chemoradiation for locally advanced rectal cancer. This randomized contrial was conducted on 28 patients attended with locally advanced rectal cancer (T3, T4 or N+) treated initially with concurrent capecitabine (800 mg/m2 twice daily for 5 days per week) and pelvic external beam radiation therapy (45Gy in 25 Fractions) after one week MRI for all patients; received intraluminal HDR-BT with 4Gy x 2 Fractions with one week interval for those had gross residual disease within 1cm of rectal wall and receiveed intraluminal and interstitial brachytherapy with 4Gy x 2 Fractions with one week interval for those had gross residual disease far from 1cm of rectal wall. All patients underwent surgery within 4-8 week after completion of neoadjuvant therapy. In the control group which were not randomized, twenty-eight patients underwent neoadjuvant chemoradiation (45Gy in 25 Fraction with concurrent capecitabine 800mg/m2 twice daily for 5 days per week) followed by surgery. It was found that in HDR-BT group pathologic complete response (pCR), pathologic partial response (pPR) and pathologic response rates (pCR+pPR) based on AJCC TNM staging for colorectal cancer were %35.7, %35.7, and %71.4 respectively. The pCR, pPR, and pRR were %25, %17, and %42 in the control group respectively. pCR, pPR, and pRR were improved with HDR-BT. However, only response rate improvement was statistically significant (p=0.031). There was no a statistically significant difference in the complications between the two groups (p > 0.05). So it can be concluded that HDR intraluminal with or without interstitial brachytherapy may be an effective method of dose escalation technique in neoadjuvant chemoradiation therapy of locally advanced rectal cancer with higher response rate and manageable side effects.
In vivo characterization of breast tissue by non-invasive bio-impedance measu...ijbesjournal
Biological tissues have complex electrical impedance related to the tissue dimension, the internal structure
and the arrangement of the constituent cells. Since different tissues have different conductivities and
permittivities, the electrical impedance can provide useful information based on heterogeneous tissue
structures, physiological states and functions. In vivo bio-impedance breast measurements proved to be a
dependable method where these measurements can be adopted to characterize breast tissue into normal
and abnormal by a developed normalized coefficient of variation (NCV) as a numerical criterion of the bioimpedance
measurements. In this study 26 breasts in 26 women have been scanned with a homemade
Electrical Bio-impedance System (EBS). Characteristic breast conductivity and permittivity measurements
emerged for Mammographically normal and abnormal cases. CV and NCV are calculated for each case,
and the value of NCVs greater than 1.00 corresponds to abnormalities, particularly tumours while NCVs
less than 1.00 correspond to normal cases. The most promising results of (NCV) for permittivity at 1 MHz,
it detects 73% of abnormal cases including 100% tumor cases while it detects 82% of normal cases. The
numerical criterion NCV of in-vivo bio-impedance measurements of the breast appears to be promising in
breast cancer screening.
Breast conserving surgery followed by adjuvant radiotherapy is adopted in the early detected cases and mastectomy followed by radiotherapy or chemotherapy in the advanced cases are the general practices.
The Importance of Community Nursing Care.pdfAD Healthcare
NDIS and Community 24/7 Nursing Care is a specific type of support that may be provided under the NDIS for individuals with complex medical needs who require ongoing nursing care in a community setting, such as their home or a supported accommodation facility.
The global radiation oncology market size reached US$ 8.1 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 14.5 Billion by 2032, exhibiting a growth rate (CAGR) of 6.5% during 2024-2032.
More Info:- https://www.imarcgroup.com/radiation-oncology-market
Letter to MREC - application to conduct studyAzreen Aj
Application to conduct study on research title 'Awareness and knowledge of oral cancer and precancer among dental outpatient in Klinik Pergigian Merlimau, Melaka'
KEY Points of Leicester travel clinic In London doc.docxNX Healthcare
In order to protect visitors' safety and wellbeing, Travel Clinic Leicester offers a wide range of travel-related health treatments, including individualized counseling and vaccines. Our team of medical experts specializes in getting people ready for international travel, with a particular emphasis on vaccines and health consultations to prevent travel-related illnesses. We provide a range of travel-related services, such as health concerns unique to a trip, prevention of malaria, and travel-related medical supplies. Our clinic is dedicated to providing top-notch care, keeping abreast of the most recent recommendations for vaccinations and travel health precautions. The goal of Travel Clinic Leicester is to keep you safe and well-rested no matter what kind of travel you choose—business, pleasure, or adventure.
Rate Controlled Drug Delivery Systems, Activation Modulated Drug Delivery Systems, Mechanically activated, pH activated, Enzyme activated, Osmotic activated Drug Delivery Systems, Feedback regulated Drug Delivery Systems systems are discussed here.
LGBTQ+ Adults: Unique Opportunities and Inclusive Approaches to CareVITASAuthor
This webinar helps clinicians understand the unique healthcare needs of the LGBTQ+ community, primarily in relation to end-of-life care. Topics include social and cultural background and challenges, healthcare disparities, advanced care planning, and strategies for reaching the community and improving quality of care.
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
Cold Sores: Causes, Treatments, and Prevention Strategies | The Lifesciences ...The Lifesciences Magazine
Cold Sores, medically known as herpes labialis, are caused by the herpes simplex virus (HSV). HSV-1 is primarily responsible for cold sores, although HSV-2 can also contribute in some cases.
Navigating Women's Health: Understanding Prenatal Care and Beyond
Skm symps poster 2015 spect ct
1. 7-A Block R III, Johar Town, Lahore, Pakistan
www.shaukatkhanum.org.pk
SHAUKAT KHANUM MEMORIAL
CANCER HOSPITAL & RESEARCH CENTRE
ReferencesConclusion
MATERIALS & METHODS
We analyzed 151 patients injected with 99mTc-MDP for bone scan, 20 patients for stress 99mTc-MIBI, 6 patients for 99mTc-
MIBI para-thyroid, 21 patients 99mTc HSA Sentinel, 45 patients Iodine whole-body post therapy. The CT and radiotracer
doses were calculated using ICRP conversion factors. The CT portion of SYMBIA T16 system has variable tube current
ranges from 20–345 mA.
Shahid Younas1, Syed Haris Ali1, Dr. Khalid Nawaz1, Humayun Bashir Dr1 , Sahar Shahid1, Asma Nisar1,
Dr. Maimoona Siddiqui1, Muhammad Bilal2, Ashfaq Zaman2, Madeeha Khalid3,
1- Nuclear Medicine department, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan
2- Department of Physics, PIEAS, Islamabad.
3- Department of Physics, The Islamia University of Bahawalpur, Pakistan.
SPECT-CT: HOW MUCH RADIATION DOSE CT CONSTITUTE
CONCLUSION
The risk factor in our case is 0.016% with the addition of diagnostic CT for SPECT/CT. Considering the benefit to the patient in
comparison to conventional diagnostic CT the induced radiation doses by SPECT/CT are quite low in our calculations However,
effective dose of CT may be balanced further by decreasing the injected nuclear medicine activity at the cost of increased patient
scanning time.
RESULTS
The maximum dose for bone patients (%
increase with respect to radiotracer) is
1.99 mSv (45.76%) for 99mTc trunk
patients and least for head which bears
0.1 mSv (1.79%). The CT dose for
abdomen & Pelvis, Chest, Head & neck
is 0.78, 0.64, 0.18 mSv respectively.
However, chest dose in case 99mTc-MIBI
is 3.56 mSv in one phase of the
myocardial perfusion imaging. The
calculated neck CT dose for 99mTc
parathyroid is 0.8 mSv where as it
decreased to 0.75 mSv for the 99mTc
Sentinel chest patients. The negligible
dose rise is observed in case of Iodine-
131 post therapy patients with an
average CT dose of 1.02 mSv for trunk
areas against 1976 mSv dose from
radioactive Iodine.
OBJECTIVE:
Effective dose (E) is a single parameter to reflect the relative risk from exposure to ionizing radiation in term of
detrimental biologic effects on whole-body exposure. SPECT with multi-slice CT systems has been employed for better
attenuation correction and localization. The study was conducted to calculate effective radiation dose both from
radiotracer and the CT component of SPECT CT to patients scanned from August, 2014, to August, 2015, on SYMBIA T16
SPECT CT in the department of Nuclear Medicine.
REFERENCES
1. AAPM Task Group Report # 108
2. Pakistan Nuclear Regulatory Authority , PNRA, Regulation: Pak/904: Radiation Protection
3. Dose Record from Pakistan Institute of Nuclear Sciences and Technology (PINSTECH), Islamabad, Pakistan.
Sr. Primary Scan Radiation Induce Dose in SYMBIA T16 SPECT/CT
CT Dose
(mSv)
Radiopharmaceutical Dose
(mSv)
Accumulative
Dose
% increase
1
99m
Tc-MDP Bone
Chest 0.65
4.95
5.6 13.13
Abdomen & Pelvis 0.87 5.75 16.17
Trunk 10.45 15.4 211.11
Neck 0.29 5.24 5.85
2
99m
Tc-MIBI Myocardial Perfusion
Chest 3.67 6.96 10.62 52.72
3
99m
Tc-MIBI Parathyroid
Neck 0.8 7.58 8.37 10.55
4
99m
Tc-Sentinal
Chest 1.03 -
5
99m
Tc-Thyriod
Neck 0.01 2.15 2.16 0.46
6 131
NaI Post Therapy 0.43 2790 2790.43 0.015