Etilefrine is a withdrawn adrenergic agonist and vasoconstrictive agent that binds to beta-2 and alpha-1-adrenergic receptors, causing smooth muscle constriction and increasing pulse rate, cardiac output, and blood pressure. It was previously used to treat low flow priapism and hypotension. Etilefrine is now withdrawn and no longer indicated for use due to its adrenergic effects.

1. By: Alaa Fadhel Hassan
‫االدوية‬ ‫استعالمات‬ ‫مركز‬ /‫الدوائي‬ ‫الرصد‬ ‫وحدة‬
Short notes: EFFORTIL
Chemical name: Etilefrine [ethyl phenylephrine] (1)(2).
Status: withdrawn (3).
Classification: adrenergic agonist,
vasoconstrictive, cardiotonic
sympathomimetic agent. It bind to beta-2
and alpha-1-adrenergic receptors of
arteriolar & venous vasculature. Causing
smooth muscle constriction leading to
decrease venous pooling & increases the pulse rate, cardiac output, stroke
volume,
central venous pressure and mean arterial
pressure of healthy individuals (2)(4)(5)
Indications: Low flow priapism (2), antihypotensive (5).
References
1. Drugs.com website
2. PubChem website
3. Drug bank
4. The cardiovascular effects of etilefrine, European Journal of Clinical
Pharmacology January 1975, Volume 8, Issue 1
5. National center for advancing translational sciences, Inxight: Drugs website