This document discusses sex determination in mammals. It outlines that in mammals, the Y chromosome contains the SRY gene which determines male development. Specifically, when SRY is expressed in an indifferent gonad, it causes testes to form. The testes then secrete testosterone and anti-Mullerian hormone which cause the development of male internal and external sex organs and the degeneration of female structures, respectively. In the absence of SRY, ovaries form from the gonad and female development occurs.