SlideShare a Scribd company logo
Sex Determination
Read pp65-75 in text
Outline
1.Different mechanisms for sex
determination
2. Mammalian Y chromosome
3. SRY
4. Testosterone
mammals Drosophila
XX female female
XY male male
Chromosomal sex determination in
mammals and flies
mammals Drosophila
XX female female
XY male male
XO female male
XXY male female
XYY male male
Sex is determined differently
in mammals and flies
Mechanisms of sex determination
Chromosomal sex determination:
In flies and mammals females are the homogametic sex (XX) and
males the heterogametic sex (XY).
In butterflies and birds males are the homogametic sex (ZZ) and
females the heterogametic sex (ZW).
Drosophila melanogaster (fruit fly)
XX females; XY males
X:autosome ratio determines sex
1.0 female; 0.5 male
Mammals
The single Y-linked gene SRY determines the male phenotype.
Environmental sex determination
In some reptiles, the temperature of embryonic
development determines sex.
Clownfish live in small groups
inhabiting a single anemone.
The group consist of a
breeding pair, which cohabit
with a few non-reproductive,
smaller male clownfish. When
the female dies, the dominant
male changes sex and becomes
the female.
Outline
1.Different mechanisms for sex
determination
2. Mammalian Y chromosome
3. SRY
4. Testosterone
The Y chromosome is necessary and
sufficient for male development!
But what on Y is important for male
development?
The Y chromosome is a wasteland;
it contains very few genes.
Which one controls maleness.
Outline
1.Different mechanisms for sex
determination
2. Mammalian Y chromosome
3. SRY
4. Testosterone
SRY is both necessary and sufficient
for male development
SRY is a transcription factor
Indifferent gonad
SRY no SRY
Testes Ovaries
Outline
1.Different mechanisms for sex
determination
2. Mammalian Y chromosome
3. SRY
4. Testosterone
Sry
Testes form from gonad
Testosterone anti-Mullerian hormone
Mullerian ducts degenerate
receptor
AMH
Testosterone (steroid) and anti-Mullerian hormone (peptide)
both regulate transcription
Steroids are lipid soluble and can pass through
the plasma membrane. Their receptors are in
the cell.
Peptide hormones cannot pass through the
plasma membrane. Their receptors are in the
cell membrane.
5 alpha reductase
Testes
Sry OFF
Ovaries form from gonad
No AMH No testosterone No DHT
Mullerian ducts Wollfian ducts
degenerate
Internal female structures External female structures
Oviduct, cervix, uterus, upper vagina Uterus, lower vagina,
clitoris, labia

More Related Content

What's hot

XX-XO Sex Determination
XX-XO Sex DeterminationXX-XO Sex Determination
XX-XO Sex Determination
Asr Cv
 
Sex determination - chromosomal theory of sex determination.
Sex determination - chromosomal theory of sex determination.Sex determination - chromosomal theory of sex determination.
Sex determination - chromosomal theory of sex determination.
Jennifer Joy
 
Sex Determnation and sex based inheritance(Genetic)
Sex Determnation and sex based inheritance(Genetic)Sex Determnation and sex based inheritance(Genetic)
Sex Determnation and sex based inheritance(Genetic)
Azida Affini
 
Sex determination in animals
Sex determination in animalsSex determination in animals
Sex determination in animals
Dr. Manoj Bangadkar
 
Sex determination
Sex determinationSex determination
Sex determination
Swathi Shetty
 
XX-XY sex determination in plants
XX-XY sex determination in plantsXX-XY sex determination in plants
XX-XY sex determination in plants
Asr Cv
 
SEX DETERMINATION MECHANISMS IN PLANTS
SEX  DETERMINATION  MECHANISMS  IN   PLANTSSEX  DETERMINATION  MECHANISMS  IN   PLANTS
SEX DETERMINATION MECHANISMS IN PLANTS
alagappa university, Karaikudi
 
Sex determination
Sex determinationSex determination
Sex determination (p.a.c 2015)
Sex determination (p.a.c 2015)Sex determination (p.a.c 2015)
Sex determination (p.a.c 2015)
Siddhanth Singh
 
Sex determination in plants
Sex determination in plantsSex determination in plants
Sex determination in plants
Golla Upendarrao
 
Sex determination in animals
Sex determination in animalsSex determination in animals
Sex determination in animals
Kalpesh Damor
 
Sex chromosome
Sex chromosomeSex chromosome
Sex chromosome
amritsudershan
 
Sex determination & linkage
Sex determination & linkageSex determination & linkage
Sex determination & linkage
Bianca Joy Sarabia
 
Sex determination in animals
Sex determination in animals Sex determination in animals
Sex determination in animals
Darshana Ajith
 
Sex Determination in Humans
Sex Determination in HumansSex Determination in Humans
Sex Determination in Humans
SAROJ KUMAR PUJHARI
 
Sex determination in plants
Sex determination in plantsSex determination in plants
Sex determination in plants
SHRIKANT YANKANCHI
 
Sex Determination 8
Sex Determination 8Sex Determination 8
Sex Determination 8
scuffruff
 
SEX DETERMINATION (GENETICS)
SEX DETERMINATION (GENETICS)SEX DETERMINATION (GENETICS)
SEX DETERMINATION (GENETICS)
Sukanta Sarkar
 
Sex determination, M. Sc. Zoology, University of Mumbai
Sex determination, M. Sc. Zoology, University of MumbaiSex determination, M. Sc. Zoology, University of Mumbai
Sex determination, M. Sc. Zoology, University of Mumbai
Royston Rogers
 

What's hot (19)

XX-XO Sex Determination
XX-XO Sex DeterminationXX-XO Sex Determination
XX-XO Sex Determination
 
Sex determination - chromosomal theory of sex determination.
Sex determination - chromosomal theory of sex determination.Sex determination - chromosomal theory of sex determination.
Sex determination - chromosomal theory of sex determination.
 
Sex Determnation and sex based inheritance(Genetic)
Sex Determnation and sex based inheritance(Genetic)Sex Determnation and sex based inheritance(Genetic)
Sex Determnation and sex based inheritance(Genetic)
 
Sex determination in animals
Sex determination in animalsSex determination in animals
Sex determination in animals
 
Sex determination
Sex determinationSex determination
Sex determination
 
XX-XY sex determination in plants
XX-XY sex determination in plantsXX-XY sex determination in plants
XX-XY sex determination in plants
 
SEX DETERMINATION MECHANISMS IN PLANTS
SEX  DETERMINATION  MECHANISMS  IN   PLANTSSEX  DETERMINATION  MECHANISMS  IN   PLANTS
SEX DETERMINATION MECHANISMS IN PLANTS
 
Sex determination
Sex determinationSex determination
Sex determination
 
Sex determination (p.a.c 2015)
Sex determination (p.a.c 2015)Sex determination (p.a.c 2015)
Sex determination (p.a.c 2015)
 
Sex determination in plants
Sex determination in plantsSex determination in plants
Sex determination in plants
 
Sex determination in animals
Sex determination in animalsSex determination in animals
Sex determination in animals
 
Sex chromosome
Sex chromosomeSex chromosome
Sex chromosome
 
Sex determination & linkage
Sex determination & linkageSex determination & linkage
Sex determination & linkage
 
Sex determination in animals
Sex determination in animals Sex determination in animals
Sex determination in animals
 
Sex Determination in Humans
Sex Determination in HumansSex Determination in Humans
Sex Determination in Humans
 
Sex determination in plants
Sex determination in plantsSex determination in plants
Sex determination in plants
 
Sex Determination 8
Sex Determination 8Sex Determination 8
Sex Determination 8
 
SEX DETERMINATION (GENETICS)
SEX DETERMINATION (GENETICS)SEX DETERMINATION (GENETICS)
SEX DETERMINATION (GENETICS)
 
Sex determination, M. Sc. Zoology, University of Mumbai
Sex determination, M. Sc. Zoology, University of MumbaiSex determination, M. Sc. Zoology, University of Mumbai
Sex determination, M. Sc. Zoology, University of Mumbai
 

Similar to Sex determination

Sex Determination.ppt
Sex Determination.pptSex Determination.ppt
Sex Determination.ppt
juuisha
 
Salazar
SalazarSalazar
Sex Differentiation and Development
Sex Differentiation and DevelopmentSex Differentiation and Development
Sex Differentiation and Development
Saraswati yadav
 
sex determination
sex determinationsex determination
sex determination
Aashish Patel
 
Sex Determination
Sex DeterminationSex Determination
Sex Determination
MuhammadMoaz17
 
Sex determination and differentiation.ppt
Sex determination and differentiation.pptSex determination and differentiation.ppt
Sex determination and differentiation.ppt
Sudha Sudha
 
Sex determination and sex ratio..2013 university sulaiamany.biology.dashty ri...
Sex determination and sex ratio..2013 university sulaiamany.biology.dashty ri...Sex determination and sex ratio..2013 university sulaiamany.biology.dashty ri...
Sex determination and sex ratio..2013 university sulaiamany.biology.dashty ri...
Dashty Rihany
 
Matters of sex
Matters of sexMatters of sex
Matters of sex
Abigail Sapico
 
Sex-determination and Sex-linked Inheritance.pptx
Sex-determination and Sex-linked Inheritance.pptxSex-determination and Sex-linked Inheritance.pptx
Sex-determination and Sex-linked Inheritance.pptx
SeemaGaikwad15
 
Sex Differentiation TDF
Sex Differentiation TDFSex Differentiation TDF
Sex Differentiation TDF
RAHANAMOIDEENKOYAVK
 
Development of the male and female genital tracts
Development of the male and female genital tractsDevelopment of the male and female genital tracts
Development of the male and female genital tracts
Chiemezie Nwachukwu
 
Sexual Differentiation (Learn easy way)
Sexual Differentiation (Learn easy way)Sexual Differentiation (Learn easy way)
Sexual Differentiation (Learn easy way)
Vamsi Krishna Chowdary
 
Development of gonads
Development of gonadsDevelopment of gonads
Development of gonads
Prachee Rajput
 
Genetic Source
Genetic Source Genetic Source
Genetic Source
MelodyVillaGalanoDul
 
Chromosomes 221009
Chromosomes 221009Chromosomes 221009
Chromosomes 221009
marudhan
 
10 sex detrmination 2-2.pdf hzulqarnain640@gmail.com
10 sex detrmination 2-2.pdf hzulqarnain640@gmail.com10 sex detrmination 2-2.pdf hzulqarnain640@gmail.com
10 sex detrmination 2-2.pdf hzulqarnain640@gmail.com
Zulqarnainhaider72387
 
Reproductive physiology
Reproductive physiologyReproductive physiology
Reproductive physiology
Kern Rocke
 
Sexual Determination and Differentiation
Sexual Determination and DifferentiationSexual Determination and Differentiation
Sexual Determination and Differentiation
MohammedMusslem
 
sex determination
sex determinationsex determination
sex determination
Dr. PRABHAT KUMAR SINGH
 
Sex determination
Sex determination  Sex determination
Sex determination
had89
 

Similar to Sex determination (20)

Sex Determination.ppt
Sex Determination.pptSex Determination.ppt
Sex Determination.ppt
 
Salazar
SalazarSalazar
Salazar
 
Sex Differentiation and Development
Sex Differentiation and DevelopmentSex Differentiation and Development
Sex Differentiation and Development
 
sex determination
sex determinationsex determination
sex determination
 
Sex Determination
Sex DeterminationSex Determination
Sex Determination
 
Sex determination and differentiation.ppt
Sex determination and differentiation.pptSex determination and differentiation.ppt
Sex determination and differentiation.ppt
 
Sex determination and sex ratio..2013 university sulaiamany.biology.dashty ri...
Sex determination and sex ratio..2013 university sulaiamany.biology.dashty ri...Sex determination and sex ratio..2013 university sulaiamany.biology.dashty ri...
Sex determination and sex ratio..2013 university sulaiamany.biology.dashty ri...
 
Matters of sex
Matters of sexMatters of sex
Matters of sex
 
Sex-determination and Sex-linked Inheritance.pptx
Sex-determination and Sex-linked Inheritance.pptxSex-determination and Sex-linked Inheritance.pptx
Sex-determination and Sex-linked Inheritance.pptx
 
Sex Differentiation TDF
Sex Differentiation TDFSex Differentiation TDF
Sex Differentiation TDF
 
Development of the male and female genital tracts
Development of the male and female genital tractsDevelopment of the male and female genital tracts
Development of the male and female genital tracts
 
Sexual Differentiation (Learn easy way)
Sexual Differentiation (Learn easy way)Sexual Differentiation (Learn easy way)
Sexual Differentiation (Learn easy way)
 
Development of gonads
Development of gonadsDevelopment of gonads
Development of gonads
 
Genetic Source
Genetic Source Genetic Source
Genetic Source
 
Chromosomes 221009
Chromosomes 221009Chromosomes 221009
Chromosomes 221009
 
10 sex detrmination 2-2.pdf hzulqarnain640@gmail.com
10 sex detrmination 2-2.pdf hzulqarnain640@gmail.com10 sex detrmination 2-2.pdf hzulqarnain640@gmail.com
10 sex detrmination 2-2.pdf hzulqarnain640@gmail.com
 
Reproductive physiology
Reproductive physiologyReproductive physiology
Reproductive physiology
 
Sexual Determination and Differentiation
Sexual Determination and DifferentiationSexual Determination and Differentiation
Sexual Determination and Differentiation
 
sex determination
sex determinationsex determination
sex determination
 
Sex determination
Sex determination  Sex determination
Sex determination
 

Recently uploaded

Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Leonel Morgado
 
Sciences of Europe journal No 142 (2024)
Sciences of Europe journal No 142 (2024)Sciences of Europe journal No 142 (2024)
Sciences of Europe journal No 142 (2024)
Sciences of Europe
 
Microbiology of Central Nervous System INFECTIONS.pdf
Microbiology of Central Nervous System INFECTIONS.pdfMicrobiology of Central Nervous System INFECTIONS.pdf
Microbiology of Central Nervous System INFECTIONS.pdf
sammy700571
 
Evidence of Jet Activity from the Secondary Black Hole in the OJ 287 Binary S...
Evidence of Jet Activity from the Secondary Black Hole in the OJ 287 Binary S...Evidence of Jet Activity from the Secondary Black Hole in the OJ 287 Binary S...
Evidence of Jet Activity from the Secondary Black Hole in the OJ 287 Binary S...
Sérgio Sacani
 
The debris of the ‘last major merger’ is dynamically young
The debris of the ‘last major merger’ is dynamically youngThe debris of the ‘last major merger’ is dynamically young
The debris of the ‘last major merger’ is dynamically young
Sérgio Sacani
 
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
hozt8xgk
 
The binding of cosmological structures by massless topological defects
The binding of cosmological structures by massless topological defectsThe binding of cosmological structures by massless topological defects
The binding of cosmological structures by massless topological defects
Sérgio Sacani
 
fermented food science of sauerkraut.pptx
fermented food science of sauerkraut.pptxfermented food science of sauerkraut.pptx
fermented food science of sauerkraut.pptx
ananya23nair
 
Applied Science: Thermodynamics, Laws & Methodology.pdf
Applied Science: Thermodynamics, Laws & Methodology.pdfApplied Science: Thermodynamics, Laws & Methodology.pdf
Applied Science: Thermodynamics, Laws & Methodology.pdf
University of Hertfordshire
 
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
Travis Hills MN
 
The cost of acquiring information by natural selection
The cost of acquiring information by natural selectionThe cost of acquiring information by natural selection
The cost of acquiring information by natural selection
Carl Bergstrom
 
Anti-Universe And Emergent Gravity and the Dark Universe
Anti-Universe And Emergent Gravity and the Dark UniverseAnti-Universe And Emergent Gravity and the Dark Universe
Anti-Universe And Emergent Gravity and the Dark Universe
Sérgio Sacani
 
Tissue fluids_etiology_volume regulation_pressure.pptx
Tissue fluids_etiology_volume regulation_pressure.pptxTissue fluids_etiology_volume regulation_pressure.pptx
Tissue fluids_etiology_volume regulation_pressure.pptx
muralinath2
 
Immersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths ForwardImmersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths Forward
Leonel Morgado
 
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Sérgio Sacani
 
HOW DO ORGANISMS REPRODUCE?reproduction part 1
HOW DO ORGANISMS REPRODUCE?reproduction part 1HOW DO ORGANISMS REPRODUCE?reproduction part 1
HOW DO ORGANISMS REPRODUCE?reproduction part 1
Shashank Shekhar Pandey
 
8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf
by6843629
 
Direct Seeded Rice - Climate Smart Agriculture
Direct Seeded Rice - Climate Smart AgricultureDirect Seeded Rice - Climate Smart Agriculture
Direct Seeded Rice - Climate Smart Agriculture
International Food Policy Research Institute- South Asia Office
 
Discovery of An Apparent Red, High-Velocity Type Ia Supernova at 𝐳 = 2.9 wi...
Discovery of An Apparent Red, High-Velocity Type Ia Supernova at  𝐳 = 2.9  wi...Discovery of An Apparent Red, High-Velocity Type Ia Supernova at  𝐳 = 2.9  wi...
Discovery of An Apparent Red, High-Velocity Type Ia Supernova at 𝐳 = 2.9 wi...
Sérgio Sacani
 
Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titrationCompexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
Vandana Devesh Sharma
 

Recently uploaded (20)

Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
 
Sciences of Europe journal No 142 (2024)
Sciences of Europe journal No 142 (2024)Sciences of Europe journal No 142 (2024)
Sciences of Europe journal No 142 (2024)
 
Microbiology of Central Nervous System INFECTIONS.pdf
Microbiology of Central Nervous System INFECTIONS.pdfMicrobiology of Central Nervous System INFECTIONS.pdf
Microbiology of Central Nervous System INFECTIONS.pdf
 
Evidence of Jet Activity from the Secondary Black Hole in the OJ 287 Binary S...
Evidence of Jet Activity from the Secondary Black Hole in the OJ 287 Binary S...Evidence of Jet Activity from the Secondary Black Hole in the OJ 287 Binary S...
Evidence of Jet Activity from the Secondary Black Hole in the OJ 287 Binary S...
 
The debris of the ‘last major merger’ is dynamically young
The debris of the ‘last major merger’ is dynamically youngThe debris of the ‘last major merger’ is dynamically young
The debris of the ‘last major merger’ is dynamically young
 
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
 
The binding of cosmological structures by massless topological defects
The binding of cosmological structures by massless topological defectsThe binding of cosmological structures by massless topological defects
The binding of cosmological structures by massless topological defects
 
fermented food science of sauerkraut.pptx
fermented food science of sauerkraut.pptxfermented food science of sauerkraut.pptx
fermented food science of sauerkraut.pptx
 
Applied Science: Thermodynamics, Laws & Methodology.pdf
Applied Science: Thermodynamics, Laws & Methodology.pdfApplied Science: Thermodynamics, Laws & Methodology.pdf
Applied Science: Thermodynamics, Laws & Methodology.pdf
 
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
 
The cost of acquiring information by natural selection
The cost of acquiring information by natural selectionThe cost of acquiring information by natural selection
The cost of acquiring information by natural selection
 
Anti-Universe And Emergent Gravity and the Dark Universe
Anti-Universe And Emergent Gravity and the Dark UniverseAnti-Universe And Emergent Gravity and the Dark Universe
Anti-Universe And Emergent Gravity and the Dark Universe
 
Tissue fluids_etiology_volume regulation_pressure.pptx
Tissue fluids_etiology_volume regulation_pressure.pptxTissue fluids_etiology_volume regulation_pressure.pptx
Tissue fluids_etiology_volume regulation_pressure.pptx
 
Immersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths ForwardImmersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths Forward
 
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
 
HOW DO ORGANISMS REPRODUCE?reproduction part 1
HOW DO ORGANISMS REPRODUCE?reproduction part 1HOW DO ORGANISMS REPRODUCE?reproduction part 1
HOW DO ORGANISMS REPRODUCE?reproduction part 1
 
8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf
 
Direct Seeded Rice - Climate Smart Agriculture
Direct Seeded Rice - Climate Smart AgricultureDirect Seeded Rice - Climate Smart Agriculture
Direct Seeded Rice - Climate Smart Agriculture
 
Discovery of An Apparent Red, High-Velocity Type Ia Supernova at 𝐳 = 2.9 wi...
Discovery of An Apparent Red, High-Velocity Type Ia Supernova at  𝐳 = 2.9  wi...Discovery of An Apparent Red, High-Velocity Type Ia Supernova at  𝐳 = 2.9  wi...
Discovery of An Apparent Red, High-Velocity Type Ia Supernova at 𝐳 = 2.9 wi...
 
Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titrationCompexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
 

Sex determination

  • 2. Outline 1.Different mechanisms for sex determination 2. Mammalian Y chromosome 3. SRY 4. Testosterone
  • 3. mammals Drosophila XX female female XY male male Chromosomal sex determination in mammals and flies
  • 4. mammals Drosophila XX female female XY male male XO female male XXY male female XYY male male Sex is determined differently in mammals and flies
  • 5. Mechanisms of sex determination Chromosomal sex determination: In flies and mammals females are the homogametic sex (XX) and males the heterogametic sex (XY). In butterflies and birds males are the homogametic sex (ZZ) and females the heterogametic sex (ZW). Drosophila melanogaster (fruit fly) XX females; XY males X:autosome ratio determines sex 1.0 female; 0.5 male Mammals The single Y-linked gene SRY determines the male phenotype.
  • 6. Environmental sex determination In some reptiles, the temperature of embryonic development determines sex.
  • 7. Clownfish live in small groups inhabiting a single anemone. The group consist of a breeding pair, which cohabit with a few non-reproductive, smaller male clownfish. When the female dies, the dominant male changes sex and becomes the female.
  • 8. Outline 1.Different mechanisms for sex determination 2. Mammalian Y chromosome 3. SRY 4. Testosterone
  • 9. The Y chromosome is necessary and sufficient for male development! But what on Y is important for male development?
  • 10. The Y chromosome is a wasteland; it contains very few genes. Which one controls maleness.
  • 11.
  • 12. Outline 1.Different mechanisms for sex determination 2. Mammalian Y chromosome 3. SRY 4. Testosterone
  • 13. SRY is both necessary and sufficient for male development
  • 14. SRY is a transcription factor
  • 15. Indifferent gonad SRY no SRY Testes Ovaries
  • 16.
  • 17. Outline 1.Different mechanisms for sex determination 2. Mammalian Y chromosome 3. SRY 4. Testosterone
  • 18. Sry Testes form from gonad Testosterone anti-Mullerian hormone Mullerian ducts degenerate
  • 19. receptor AMH Testosterone (steroid) and anti-Mullerian hormone (peptide) both regulate transcription Steroids are lipid soluble and can pass through the plasma membrane. Their receptors are in the cell. Peptide hormones cannot pass through the plasma membrane. Their receptors are in the cell membrane.
  • 21. Sry OFF Ovaries form from gonad No AMH No testosterone No DHT Mullerian ducts Wollfian ducts degenerate Internal female structures External female structures Oviduct, cervix, uterus, upper vagina Uterus, lower vagina, clitoris, labia