A new high-resolution photo scanning system enables rapid, high-throughput analysis of C. elegans toxicology. For example, an experiment showed that phosphine resistance granted by DLD suppression is dependent on the master stress regulator DAF-16. The scanning system is capable of automatically counting tens of thousands of individual C. elegans at once, allowing for high throughput analysis of C. elegans phenotypes and genetic influences on phosphine resistance.

1. biosecurity built on science
A new system using
high – resolution photo
scanners.
Enabling rapid, high–
throughput analysis of C.
elegans toxicology
For example:
Phosphine resistance granted by DLD
suppression is dependant on the master stress
regulator DAF-16
500ppm
0
10
20
30
40
50
60
70
80
90
100
Phosphine parts per million
%survivors
Daf16 mutant / DLD
suppressed
Daf16 mutant
Wild type / DLD
suppressed
Wild type
Daf16 upregulated /
DLD suppressed
Daf16 upregulated
Capable of automatically
counting tens of thousands of
individual C. elegans at once.
High throughput C. elegans phenotype analysis and genetic influences on
phosphine resistance (Timothy Puckering, University of Queensland)