NeoPlexTM COVID-19 has advantages over PowerChek 2019-nCoV for PCR-based detection of COVID-19 including higher sensitivity detecting down to 10-5 compared to 10-3 for PowerChek, targeting two genes (RdRp and N) specific to COVID-19 versus one broadly reactive gene, and including an internal process control for nucleic acid extraction and PCR. NeoPlex also offers advantages of being more user-friendly, requiring fewer PCR machines, allowing testing of more samples per kit, and having longer shelf life and reagent stability.

2. Comparative advantages of NeoPlex™ COVID-19
Advantages
Principle
NeoPlex
™ COVID-
19
Real-Time PCR
PowerChek
2019-nCoV
Real-Time PCR
Target genes RdRp, N RdRp, E
- RdRp & N genes: 2019-novel Coronavirus
specific dual target genes for better specificity
- RdRp & Egenes: possible to interfere each other.
Egene: broadly specific to commonbeta-Coronavirus
Specificity High NA
2Con f iden t ia l
- No cross reactivity tested with more than 50 of the respiratory
pathogens (bacteria and virus) including the existing
Coronavirus (229E, OC43, NL63,HKU1)
LoD 10-5 10-3
At least 10 times more sensitive and 6-log dynamic
Whole process
control
Available Not available
- Available to check both of PCRprocess and nucleic acid
extraction processes using endogenous gene in specimens as
internal control
1 2 User-friendly and less hands-on time
1 cycler 2 cyclers Lessneed for PCR machine
PCRtube reaction
per test
PCRmachine for
testing 96 samples
Number of test per kit
TAT
Shelf life
96
3 hrs
5 months
48
6 hrs
6 weeks
2-fold
Better Fast Turnaround Time
Excellent Reagent Stability
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3. Sensitivity :NeoPlex COVID-19 VsPowerChek 2019-nCoV
PowerChek 2019-nCoV
(RdRp, Egene)
NeoPlex COVID-19
(RdRp, N gene)
Vs
10-2
10-2
10-4
10-5
RdRp RdRp
E
N
10-2
10-2
10-4
10-5(N/A)
Con f iden t ia l
PowerChe
k 2019-
nCoV
(Kogen)
COVID-19
RNA(Original)
COVID-19
RNA(10-1)
COVID-19
RNA(10-2)
COVID-19
RNA(10-3)
COVID-19
RNA(10-4)
COVID-19
RNA(10-5)
RdRp gene 22.04 25.67 28.73 32.18 36.27 N/A
Egene 19.32 22.31 25.34 29.43 33.01 36.64 3
Ct ≤ 38, Positive
NeoPlex
COVID-19
(GeneMatrix)
COVID-19
RNA(Original)
COVID-19
RNA(10-1)
COVID-19
RNA(10-2)
COVID-19
RNA(10-3)
COVID-19
RNA(10-4)
COVID-19
RNA(10-5)
RdRp gene 22.32 25.84 29.14 32.09 35.04 37.14
N gene 20.04 23.17 26.78 30.34 33.25 36.50
Ct ≤ 35, Positive
10-2 10-2
Test materials : 10-2 10-2
Standard 2019-nCoV RNAs 10-4 10-4
supplied by Korean CDC 10-5 10-5
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