Measuring RNA and DNA biomarkers in liquid biopsies
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The document discusses the use of plasma biomarkers for medical purposes such as diagnosis, prognosis, prediction, therapy response monitoring, and drug safety. It notes advantages of using liquid biopsies which involve sampling blood plasma or serum, including that they are minimally invasive, allow for serial sampling, and are more comfortable for patients. The document describes candidate nucleic acid biomarkers that can be measured in plasma, including extracellular cell-free circulating nucleic acids such as messenger RNA, microRNA, long non-coding RNA, and DNA. It indicates that Biogazelle can quantitatively measure over 500 miRNAs, 5000-10,000 mRNAs, and other biomarkers in plasma samples.
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- 1. applications of plasma biomarkers diagnosis prognosis prediction patient stratification ! therapy response monitoring drug safety advantages of liquid biopsies serial sampling minimally invasive reduced risk easy patient comfort faster sampling candidate nucleic acid biomarkers in plasma extracellular cell-free circulating nucleic acid messenger RNA micro- RNA long non- coding RNA DNA measuring nucleic acid biomarkers in plasma at Biogazelle totest known biomarkers with quantitative ordigitalPCR ** > 500 miRNAs 5000-10,000 mRNAs types of measurement expression level sequence variants (e.g. mutations and fusion genes) A A T C G A A T T C G A copy number variants 1-100 miRNAs 1-100 mRNAs & lncRNAs 1-10 DNAvariants © Biogazelle. 2017 reported numbers are the numberofmiRNAs and mRNAs typicallydetected in plasma reported numbers are the numberoffeatures typicallymeasured in a test * ** info@biogazelle.comwww.biogazelle.com to discovernewbiomarkers with RNAsequencing * Customized measurements of the RNA and DNA biomarkers in your liquid biopsies Customized measurements of the RNA and DNA biomarkers in your liquid biopsies