Planning and decision making to manage plant biosecurity risks is inherently complex, often contentious, involves unknowns and uncertainty, and needs to be adaptable to rapidly changing situations. The aim of this project is to develop a collaborative planning and shared decision making
framework that will result in better and faster decisions to respond more quickly to plant biosecurity risks, resulting in reduced impacts and costs, and more equitable and favourable outcomes for stakeholders and affected parties.
The disruption to trade caused by quarantine pests and diseases is a significant issue for Australian and New Zealand horticulture. There is an urgent need to review and improve the current disinfestation methods to develop new export protocols that are effective, economic and safe to use.
The project team consisting of researchers from across Australia and New Zealand, has reviewed all the published and unpublished phytosanitary research conducted against these pests.
Invasive pests and pathogens can have devastating and unpredicted impacts on native ecosystems. The threat that Puccinia psidii (myrtle/eucalyptus/guava rust) posed to Australian industries was well recognised, but until its introduction in 2010, there was scant consideration of the impacts this disease may have on endemic Myrtaceous plant species and associated communities in native environments. Since its detection in Australia, the distribution and host range of P. psidii has rapidly expanded and entire species and plant communities are now under threat.
The research being undertaken into myrtle rust has enabled improved species selection for production and retail nurseries, and for urban tree planting.
The Australia-Africa Plant Biosecurity Partnership has brought together plant biosecurity professionals in ten African countries and established linkages with Australian researchers, helping
to reduce pest and disease impacts in sub-Saharan Africa. At the outset of this initiative, diagnostic skills were identified as a priority area in connecting Australian expertise with Africa and improving surveillance capability, post-entry quarantine, early warning and phytosanitary certification. This presentation will briefly examine the application of improved diagnostic skills in African Plant Protection Organisations and the longer term relationships that have been established with Australian mentors.
Long distance natural (wind-assisted) dispersal of exotic plant pests and pathogens into Australia, is a very real and underestimated, biosecurity risk.
The Global Eradication and Response Database (GERDA) summarises incursion response and eradication programmes from around the world. The purpose of GERDA is to determine which characteristics lead to the success or failure of eradication programmes.
The disruption to trade caused by quarantine pests and diseases is a significant issue for Australian and New Zealand horticulture. There is an urgent need to review and improve the current disinfestation methods to develop new export protocols that are effective, economic and safe to use.
The project team consisting of researchers from across Australia and New Zealand, has reviewed all the published and unpublished phytosanitary research conducted against these pests.
Invasive pests and pathogens can have devastating and unpredicted impacts on native ecosystems. The threat that Puccinia psidii (myrtle/eucalyptus/guava rust) posed to Australian industries was well recognised, but until its introduction in 2010, there was scant consideration of the impacts this disease may have on endemic Myrtaceous plant species and associated communities in native environments. Since its detection in Australia, the distribution and host range of P. psidii has rapidly expanded and entire species and plant communities are now under threat.
The research being undertaken into myrtle rust has enabled improved species selection for production and retail nurseries, and for urban tree planting.
The Australia-Africa Plant Biosecurity Partnership has brought together plant biosecurity professionals in ten African countries and established linkages with Australian researchers, helping
to reduce pest and disease impacts in sub-Saharan Africa. At the outset of this initiative, diagnostic skills were identified as a priority area in connecting Australian expertise with Africa and improving surveillance capability, post-entry quarantine, early warning and phytosanitary certification. This presentation will briefly examine the application of improved diagnostic skills in African Plant Protection Organisations and the longer term relationships that have been established with Australian mentors.
Long distance natural (wind-assisted) dispersal of exotic plant pests and pathogens into Australia, is a very real and underestimated, biosecurity risk.
The Global Eradication and Response Database (GERDA) summarises incursion response and eradication programmes from around the world. The purpose of GERDA is to determine which characteristics lead to the success or failure of eradication programmes.
Three years of research to date have produced a robust, accurate, sensitive detection tool and sampling strategy for the damaging apid-like insect phylloxera (Daktulosphaira vitifoliae), which feeds on grapevine roots
Here we update on fundamental systematics research and the development of new potential molecular markers to improve on current diagnostic tools. We also link these molecular tools with physical specimens, documenting the range of morphological variation so as to greatly improve on available resources used to diagnose fruit flies in the field as part of surveillance programmes or at border interceptions.
This multifaceted project is seeking to protect the grains industry by improving the robustness and efficiency of the pest management and plant biosecurity system.
Myrtle rust (Puccinia psidii) is an invasive fungus native to South America that was first detected in Australia in 2010. It has spread rapidly along the east coast, and is currently recorded in sites as far north as the Northern Territory and south to Tasmania.
In order to better understand myrtle rust extent and impacts in Australian native and managed landscapes, a survey was sent to national parks, botanical gardens, councils, natural resource
managers, nurseries and forestry agencies in all states where the fungus is present (NT, QLD, NSW, VIC and TAS). The survey revealed that Myrtle rust is widespread in NSW and QLD gardens and streets as well as in native vegetation.
An optimal surveillance system is one where the available sampling resources are allocated in time and space to best achieve detection objectives. This project aims to develop new methods for designing optimal surveillance systems that properly account for organism biology, trapping or sampling efficacy, and landscape characteristics.
This research project is collecting data on past pest invasions in both Australia and New Zealand, in order to identify common patterns in plant biosecurity pests.
The aim of this research project is to establish Australian developed seed testing protocols as an international standard for the detection of viroids and cucumber green mottle mosaic virus (CGMMV) in seed, and to reduce the risks of contaminated traded seed.
Research investigating the use a genome-informed approach to develop diagnostic tools, for the detection of exotic phytopathogenic bacteria that pose a threat to Australian agriculture.
Research presented in this session will explore some of our innovative research to improve pest management and help maintain and build market access for our grains industries.
Biosecurity issues impact on key crops and environmental values across NZ and Australia. A key outcome for the project team will be the ability of indigenous communities, and relevant regulatory authorities and industries, to better manage the social, environmental and economic impacts of biosecurity threats, and to participate in biosecurity strategies through improved bicultural engagement models that build empowerment and ownership in indigenous communities and their response to those threats. The teams have developed an engagement model adapted to the indigenous peoples and their communities of each country.
Three years of research to date have produced a robust, accurate, sensitive detection tool and sampling strategy for the damaging apid-like insect phylloxera (Daktulosphaira vitifoliae), which feeds on grapevine roots
Here we update on fundamental systematics research and the development of new potential molecular markers to improve on current diagnostic tools. We also link these molecular tools with physical specimens, documenting the range of morphological variation so as to greatly improve on available resources used to diagnose fruit flies in the field as part of surveillance programmes or at border interceptions.
This multifaceted project is seeking to protect the grains industry by improving the robustness and efficiency of the pest management and plant biosecurity system.
Myrtle rust (Puccinia psidii) is an invasive fungus native to South America that was first detected in Australia in 2010. It has spread rapidly along the east coast, and is currently recorded in sites as far north as the Northern Territory and south to Tasmania.
In order to better understand myrtle rust extent and impacts in Australian native and managed landscapes, a survey was sent to national parks, botanical gardens, councils, natural resource
managers, nurseries and forestry agencies in all states where the fungus is present (NT, QLD, NSW, VIC and TAS). The survey revealed that Myrtle rust is widespread in NSW and QLD gardens and streets as well as in native vegetation.
An optimal surveillance system is one where the available sampling resources are allocated in time and space to best achieve detection objectives. This project aims to develop new methods for designing optimal surveillance systems that properly account for organism biology, trapping or sampling efficacy, and landscape characteristics.
This research project is collecting data on past pest invasions in both Australia and New Zealand, in order to identify common patterns in plant biosecurity pests.
The aim of this research project is to establish Australian developed seed testing protocols as an international standard for the detection of viroids and cucumber green mottle mosaic virus (CGMMV) in seed, and to reduce the risks of contaminated traded seed.
Research investigating the use a genome-informed approach to develop diagnostic tools, for the detection of exotic phytopathogenic bacteria that pose a threat to Australian agriculture.
Research presented in this session will explore some of our innovative research to improve pest management and help maintain and build market access for our grains industries.
Biosecurity issues impact on key crops and environmental values across NZ and Australia. A key outcome for the project team will be the ability of indigenous communities, and relevant regulatory authorities and industries, to better manage the social, environmental and economic impacts of biosecurity threats, and to participate in biosecurity strategies through improved bicultural engagement models that build empowerment and ownership in indigenous communities and their response to those threats. The teams have developed an engagement model adapted to the indigenous peoples and their communities of each country.
Meg Bowen, implementation manager at the Informed Medical Decisions Foundation, provides a brief overview of the Foundation's shared decision making implementation history and introduces our three panelists for the webinar.
Charlie Keller, a primary care physician at Mercy Clinics, Inc. describes Mercy's experience with shared decision making implementation.
This presentation was part of a Shared Decision Making Month webinar -- Shared Decision Making in the Real World: Stories from the Frontline.
Presentation given at the Foundation's Jan. 26, 2011 Research and Policy Forum by David Swieskowski, MD, MBA and Kelly Taylor, RN, MSN, CCM from Mercy Clinics in Des Moines, IA.
The results of a baseline study on motivation and incentives involved in the decisions to control fruit fly highlight the variability of motivations within demographic groups.
Maureen Corry, executive director of Childbirth Connection, provides an overview of the state of shared decision making and maternity care.
This presentation was part of a Shared Decision Making Month webinar -- Maternity Care and Shared Decision Making: Improving Care for Mothers and Babies.
The risk myrtle rust poses to threatened Myrtaceae species in Australia is becoming more apparent with significant dieback and tree death recorded as a result of repeated infection.
Research presented in this session addresses the need to better understand the impacts of pests and diseases on the environment and the various ways that social science and the rules of community engagement can be applied for better biosecurity.
Ben Moulton, JD, MPH, provides an overview of the shared decision making policy landscape.
This presentation was part of a Shared Decision Making Month webinar -- Turning Shared Decision Making Policy into a Reality: Can We Really Improve the Quality of Care While Reducing the Costs.
The spread of invasive species continues to provide significant challenges to those government biosecurity agencies charged with protecting a country’s borders. In an increasingly connected world, these invasive species are potentially able to spread further and more rapidly. Human mediated pathways such as ships and airlines are the most obvious ways in which invasive species can be spread. Direct routes from one port to another are currently monitored, but indirect pathways,
in which a ship picks up an invasive species and then travels to a number of different locations before arriving at the final destination, present more challenging scenarios. For the Australian Government Department of Agriculture, one particular concern is for ships arriving into Australia carrying viable eggs of the Asian gypsy moth (Lymantria dispar). We are developing a real time tool that will analyse the pathways for incoming ships and determine the likelihood the ship could be carrying viable eggs.
Presented by Theo Knight-Jones and Lucy Robinson at the open session of the standing technical and research committees of the European Commission for the control of foot and mouth disease, Cavtat, Croatia, 29-31 October 2014.
3d WBF Conference - Panel 4 - Future of bananas Managing the risks of Fusariu...ExternalEvents
Presentation support realized and used by Fazil Dusunceli, Agricultural Officer, Plant Production and Protection division, FAO, during the Third Conference of the World Banana Forum on the subject of Fusarium TR4 and the threat it represents for the banana industry. It provides a brief presentation of the global programme on TR4 launched by the FAO in October 2017.
Integrated disease management (IDM), which combines biological, cultural, physical, mechanical, legislative and chemical control strategies in a holistic way rather than using a single component strategy proved to be more effective and sustainable.
This corporate presentation summarizes the report done by a Committee commisioned by the National Academies of Science, Engineering and Medicine examining issues related to genetically engineered crops.
El 12 de mayo de 2017 celebramos en la Fundación Ramó Areces una jornada con IS Global y Unitaid sobre enfermedades transmitidas por vectores, como la malaria, entre otras.
Vote --- YES
> MAYOR ALAN ARAKAWA
> VOTER INITIATIVE: GMO Engineered Organisms
Maui No Ka Oi --- Maui is the Best
Keep Maui The Best --- The Best Place in the World to Live, Work, Play and Raise Families …
This presentation was designed by Mariam Otmani Del Barrio for the VERDAS consortium workshop held on Thursday 2 March at the University of Valle in Cali, Colombia.
The workshop was the Verdas Consortium presentation of its research results, a synthesis of knowledge on urban health interventions for the prevention and control of vector-borne diseases.
The diagnosis of viral pathogens is a crucial component of plant biosecurity surveillance and preventing the introduction of exotic plant viruses and viroids at the border. Existing quarantine procedures can be time-consuming and require detailed knowledge of potential infecting viral pathogens. Currently, imported plants can spend as long as two years in quarantine, with associated costs.
To simplify the post-entry quarantine process researchers have developed a plant diagnostic toolkit for plant viruses and viroids. The toolkit takes advantage of the natural antiviral system of plants, using small RNA next generation sequencing (sRNA-seq) technology to detect nearly all known viruses and viroids in a single test. The new test, and associated toolkit, will reduce the time imported plant material spends in Australia’s quarantine system while improving accuracy of detection in a single sRNA-seq experiment.
This research has developed recommendations for stakeholders involved in area-wide management of fruit fly, including social and institutional requirements.
This project aims to build the ability of indigenous communities (Maori and Aboriginal), regulatory authorities and industries to better manage the impact of biosecurity threats. Models have been developed for Indigenous engagement.
This social biosecurity project, aims to improve plant biosecurity management by developing the capacity of regional and remote communities to engage in biosecurity surveillance activities.
Surveillance systems are an essential component of biosecurity. Design of biosecurity surveillance systems may include designs of grids of static traps, plans for field sampling, or deployment of potentially "game-changing" mobile trap technology. The aim of these systems is to achieve defined detection objectives, (e.g. early detection, supporting area-freedom status) at minimum cost. This project will develop and apply statistically-based surveillance systems that account for organism biology, trap behaviour and landscape characteristics.
Ships arriving in Australia may have visited multiple ports along the way. These complex pathways present opportunities for pest species, such as the Asian Gypsy Moth, to arrive into Australia from indirect routes. Understanding those pathways that link Australia directly or indirectly to countries in which a pest or disease occurs is necessary to identify arriving ships with the highest likelihood of carrying hitchhiker species. This project proposes to address three important questions:
1. What general shipping pathways pose the greatest risk?
2. How to make decisions regarding what ships to search?
3. How much inspection to conduct?
This research will investigate technologies to enable the development of spore traps capable of in-field detection, and identification, of specific biosecurity threats.
Chlorine dioxide was tested in three pilot scale structures including the mini silo, the column, and the flat box against five stored-product insect pests, including adults of Rhyzopertha dominica (F.), Tribolium castaneum (Herbst), Oryzaephilus surinamensis (L.), Sitophilus zeamais Motschulsky, and
Sitophilus oryzae (L.).
Bacterial leaf spot (BLS) is a disease of tomato, chilli and capsicum caused by four species of Xanthomonas. BLS can cause severe crop damage and is a limiting factor of production across the world.
With the loss of chemical control options such as Fenthion and Dimethoate for postharvest treatment of horticulture commodities susceptible to fruit fly infestation, it has become even more important to understand how stress-based control techniques such as heat, cold, irradiation and bacteria parasite
can be used most effectively for disinfestation. This project aims to explore the stress-induced molecular response of two fruit fly species of horticultural significance, Mediterranean fruit fly (Ceratitis capitata) and Queensland fruit fly (Bactrocera tryoni), by characterising the cellular pathways involved in both overall and stressor-specific responses.
Biosecurity is often conceptualised and managed as an issue of biological risk. However, turning the focus to how to build collaboration between stakeholders in biosecurity can shed new light on why and how biosecurity surveillance programs can be successful – or not.
More from Plant Biosecurity Cooperative Research Centre (14)
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Session 10: Better biosecurity risk management through collaborative planning and shared decision making
1. biosecurity built on science
Better plant biosecurity risk management through
collaborative planning and shared decision making
Suzy Perry and Rebecca Laws
Principal Scientist and Research Scientist
Plant Biosecurity, Biosecurity Queensland
Plant Biosecurity Cooperative Research Centre
PBCRC 4115
2. biosecurity built on science
For more information, please email suzy.perry@daf.qld.gov.au or rebecca.laws@daf.qld.gov.au
Suzy Perry (DAF)^
Rebecca Laws (DAF)@
Mike Ashton (DAF)*
Kim Ritman (DAWR)*
Rodney Turner (PHA)*
Craig Jennings (DAF)
Jim Pekin (ABGC)*
Michelle McKinlay (ABGC)*
Andrew Bishop (DPIPWE)*
PBCRC4115 Project team
Darren Phillips (DPIPWE)
Lois Ransom (DAWR)*
Rebecca Sapuppo (DAF)
Ceri Pearce(DAF)
John McDonald (NGIA)*
Fiona Macbeth*
(Blackwoodkemp)
David Teulon (PFRNZ)*
Garry Hill (PFRNZ)
Ken Pegg (DAF)
Lindy Coates (DAF)
Cathy Robinson (CSIRO)
Wendy Coombs (DEDJTR)
Gabrielle Vivian-Smith (DEDJTR)*#
^
Project leader
@
Postdoctoral research scientist
*
Project mentor network
#
Project end-user advocate
3. biosecurity built on science
Biosecurity planning and decision making:
- Is inherently complex
- Is often contentious
- Is affected by competing priorities
- Involves unknowns and uncertainty
- Involves consideration of a large amount of diverse information
- Needs to be adaptable to rapidly changing situations
- Is subject to considerable time pressure
Required by international standards to be 'science-based’
and informed by risk analysis
Inevitably also influenced by other factors such as
political or social pressures; or operational or legal
constraints
Biosecurity decision making is complex
4. biosecurity built on science
A day in the life of a Chief Plant Health Manager
Dr Kim Ritman (ACPPO) and
Mike Ashton (CPHM, Qld)
at the Panama disease TR4
emergency response Local
Control Centre (LCC) (April
2015)
5. biosecurity built on science
A day in the life of a Chief Plant Health Manager
Prevention Preparedness
Diagnostics
Ongoing
management
Market access
Surveillance
Response
Control &
containment
6. biosecurity built on science
A day in the life of a Chief Plant Health Manager
Prevention Preparedness
Diagnostics
Ongoing
management
Market access
Surveillance
Response
Control &
containment
Planning and decision makingPlanning and decision making
7. biosecurity built on science
analyse large amounts of diverse scientific, technical and practical information and account for
information gaps and unknowns
deal with high levels of uncertainty, competing priorities, and potentially conflicting interests
amongst stakeholders
take an iterative approach to adapt and respond to a dynamic and often rapidly changing
situation
ensure that plans and decisions can be implemented from a policy, operational, logistical, legal
and social perspective
ensure plans align with relevant legal requirements, national and international obligations,
policies, standards etc.
develop and implement the plans and decisions under considerable time pressure and within
significant resource constraints
ensure that plans are comprehensively, recorded, documented and reviewed
Plant biosecurity decision makers must be able to:
8. biosecurity built on science
analyse large amounts of diverse scientific, technical and practical information and account for
information gaps and unknowns
deal with high levels of uncertainty, competing priorities, and potentially conflicting interests
amongst stakeholders
take an iterative approach to adapt and respond to a dynamic and often rapidly changing
situation
ensure that plans and decisions can be implemented from a policy, operational, logistical, legal
and social perspective
ensure plans align with relevant legal requirements, national and international obligations,
policies, standards etc.
develop and implement the plans and decisions under considerable time pressure and within
significant resource constraints
ensure that plans are comprehensively, recorded, documented and reviewed
Plant biosecurity decision makers must be able to:
There is rarely an ‘ideal’ plan or decision option, so decision
makers must be able to analyse and evaluate all of the risk
management options; and often have to then make trade-offs in
determining the most appropriate course of action.
9. biosecurity built on science
An integrated
planning and
decision making
system for plant
biosecurity risk
management
10. biosecurity built on science
Panama disease is one of the most destructive
plant diseases ever recorded
In Australia, Panama disease TR4 was first
detected in the NT in 1997, and then in north
Qld in 2015
No effective disease control measures
No immediate replacements for Cavendish
Affects all commercial cultivars of banana
Panama disease TR4 Emergency
Response
11. biosecurity built on science
Decision criteria and management options identified
Decision tools developed (argument tree and decision
tree) and evaluated by decision makers through
scenario workshops
Multiple meetings with policy, scientific, technical and
operational staff, to gather input
Decision criteria refined and updated
Tool helped decision makers identify true decision
criteria
Panama disease TR4 Emergency
Response
12. biosecurity built on science
Factors influencing the spread of Panama TR4 from an infested site
Number of diseased plants detected at the infested site
Density of plants at the infested site
Location of diseased plants in the landscape
Position of infected plants within block
Direction of rows across block
Rainfall events
Irrigation
Factors influencing the spread from an infested block to the wider farm
Number of diseased plants previously found on the property
Quarantine and disinfection procedures in place between blocks within the
farm
Irrigation
Factors influencing the likelihood that the disease will spread to other farms
Distance from boundary of adjoining banana farm
Slope gradient and direction in relation to adjoining farms or shared irrigation
channels
Distance from public or shared private road
Factors influencing the impact of the protocol on the grower
Size of the block and the farm
Continuing impact of biosecurity activities on farm
Factors influencing the ability for Biosecurity Queensland to implement and enforce
the strategy
Legal and regulatory ability to enforce the destruction protocol
Panama disease TR4 Emergency
Response
13. biosecurity built on science
Factors influencing the spread of Panama TR4 from an infested site
Number of diseased plants detected at the infested site
Density of plants at the infested site
Location of diseased plants in the landscape
Position of infected plants within block
Direction of rows across block
Rainfall events
Irrigation
Factors influencing the spread from an infested block to the wider farm
Number of diseased plants previously found on the property
Quarantine and disinfection procedures in place between blocks within the
farm
Irrigation
Factors influencing the likelihood that the disease will spread to other farms
Distance from boundary of adjoining banana farm
Slope gradient and direction in relation to adjoining farms or shared irrigation
channels
Distance from public or shared private road
Factors influencing the impact of the protocol on the grower
Size of the block and the farm
Continuing impact of biosecurity activities on farm
Factors influencing implementation and enforcement the strategy
Legal and regulatory ability to enforce the destruction protocol
Panama disease TR4 Emergency
Response
Only 3 Key Factors
Number of diseased plants on the block
Size of the block
Ability of BQ to implement and enforce
destruction area
14. biosecurity built on science
Five possible disease management options were
evaluated:
1. Destruction of the entire farm
2. Destruction of the whole block
3. Destruction of part of a block
4. Destruction of banana plants within a 10 m radius
5. No destruction of banana plants
Only two disease management options were considered:
• Destruction of the whole block
• Destruction of banana plants within a 10 m radius
2. Considered the importance of allowing the grower to
maintain a livelihood, when more extensive destruction
was unlikely to impact on the build up of disease inoculum
3. Strategies were based on known disease epidemiology
Panama disease TR4 Emergency
Response
15. biosecurity built on science
Arguments Sub-arguments Evidence Source of Evidence
The low inoculum load on the block doesn’t
require destruction of the whole block to
prevent high inoculum loads on the whole
farm
Sub argument – The are insufficient clusters of infected
plants (six or more plants all of which are within 20 m
of at least one other plant in the group) to indicate
that the level of inoculum on the block is high
In a block smaller than 10 hectares there is no more than one
cluster
Infected plants and their locations identified and
diagnostic testing confirms the presence of Foc TR4
In a block 10-20 hectares there are no more than two clusters
In a block larger than 20 hectares there are no more than three
clusters
Sub argument – There are insufficient individual
infected plants in the block to indicate that the level of
inoculum in the block is high
In a block smaller than 10 hectares there are fewer than 15 infected
plants
Infected plants and their locations identified and
diagnostic testing confirms the presence of Foc TR4
In a block 10-20 hectares there are fewer than 30 infected plants
In a block larger than 20 hectares there are fewer than 60 infected
plants
High inoculum load in the block means that
the whole block should be destroyed to
prevent the inoculum from spreading and
infecting more plants.
Sub-argument - The number of clusters of infected
plants (six or more plants all of which are within 20 m
of at least one other plant in the group) indicate that
the level of inoculum in the block is high.
In a block smaller than 10 hectares there are two or more clusters
Infected plants and their locations identified and
diagnostic testing confirms the presence of Foc TR4In a block 10-20 hectares there are three or more clusters
In a block 20 or more hectares there are four or more clusters
Sub-argument – The number of individual infected
plants in the block indicate that the level of inoculum
in the block is high
Evidence - In a block smaller than 10 hectares there are 15 or more
infected plants
Infected plants and their locations identified and
diagnostic testing confirms the presence of Foc TR4
In a block 10-20 hectares there are 30 or more infected plants
In a block larger than 20 hectares there are 60 or more infected
plants
BQ has the ability to enforce the destruction of a 10 m radius around infected plants
Evidence - BQ has the legal and regulatory authority to enforce
destruction of a 10 m radius around infected plants
Evaluation of the situation against the provisions of the
current legislation
Evidence - BQ has the resourcing to enforce and oversee the
destruction of a 10 m radius around the infected plant
Evaluation of the logistical requirements of the
destruction
BQ doesn’t have the ability to enforce the destruction of a 10 m radius around infected plants
Evidence - BQ doesn’t have the legal and regulatory authority to
enforce destruction of a 10 m radius around the infected plant
Evaluation of the situation against the provisions of the
current legislation
Evidence - BQ doesn’t have the resourcing to enforce and oversee
the destruction of a 10 m radius around the infected plant
Evaluation of the logistical requirements of the
destruction
Panama disease TR4 Emergency
Response
16. biosecurity built on science
PBCRC4115 project outcomes
More informed decision making that integrates scientific,
technical and practical knowledge
Better decision making that factors in political, social and
economic values
More likely acceptance of the decision making outcomes
Adaptation towards shared responsibility in plant biosecurity
risk management
Improved risk management practices and strategies
17. biosecurity built on science
End-users and beneficiaries
National and state plant health managers
Government agricultural and environmental agencies
Plant industry leaders and managers, and growers
End-users will be able to better manage plant biosecurity risks, with a logical and
analytical planning and decision mass.
18. biosecurity built on science
“In our multi-disciplinary team, the
development of the argument trees
(and the associated discussion during
their development) provided a valuable
interface between science, policy and
regulatory views. In a fast-paced
regulatory environment, it is not only
important to arrive at a decision point,
but to ensure that you consider each
question in a way that is flexible,
relevant, documented and defensible.”
End-user’s perspective
Rebecca Sapuppo (Program leader, Panama TR4 Program)
Editor's Notes
Plant Biosecurity CRC project 4115 ‘Collaborative planning and shared decision making amongst stakeholders in plant biosecurity risk management’.
PBCRC project team
A network of project mentors has been formed to lead the development and adoption of the collaborative planning and shared decision making framework. This mentor network was designed to include (i) end-users; (ii) senior managers with a high level of interest and influence in plant biosecurity; and (iii) representatives of different plant biosecurity stakeholder groups.
The mentor network includes Australia’s Chief Plant Protection Officer (ACPPO), Dr Kim Ritman, who is the primary representative and advisor to the Australian Government on all matters relating to plant health and plant biosecurity in Australia.
Several members of the mentor network also fulfil the role of Chief Plant Health Manager (CPHM) for their state or territory and have the responsibility for plant biosecurity planning and decision making on a day to day basis, across a broad range of issues.
Other members of the mentor network are in senior management roles and responsible for coordinating government and industry plant health and biosecurity activities at the national or state level.
Planning and decision making to manage plant biosecurity risks is inherently complex, often contentious, involves unknowns and uncertainty, and needs to be adaptable to rapidly changing situations.
International obligations as a member of the WTO and a signatory to the SPS Agreement
International standards for risk management in plant health developed through the IPPC
Australia’s biosecurity system
Plant health legislation at the national and state levels
Roles and responsibilities of governments and industry
Biosecurity reform initiatives, such as the IGAB which aims to develop a national risk-based decision making and investment framework based on risk return, transparent and objective decision making procedures, and joint decision making and co-investment
Dr Kim Ritman, is Australia’s Chief Plant Protection Officer (ACCPO) and is primary representative and advisor to the Australian Government on all matters relating to plant health and plant biosecurity in Australia.
Mike Ashton is General Manager for Plant Biosecurity (and Product Integrity) in Biosecurity Queensland (DAF) and also in this role is the Chief Plant Health Manager for Queensland.
Leading and managing specialised plant health and biosecurity services at the state and national levels
Ensuring that appropriate risk management strategies are in place to effectively respond to plant biosecurity incidents
Prioritising resources and activities to mitigate high risk plant biosecurity threats
Ensuring that appropriate policy frameworks are in place to effectively manage the prevention, preparedness, surveillance, diagnostics, emergency response and ongoing management relating to plant biosecurity threats
Developing and maintaining productive relationships, networks and partnerships with stakeholders, including government, community and industry leaders to facilitate effective plant health and biosecurity outcomes
Scalable to different levels of strategic, contingency, operational, tactical planning and decision making
The key requirements for the collaborative planning and shared decision making framework must align with the operating environment for plant biosecurity i.e. the international agreements and standards for risk management and within the context of the national biosecurity system.
The framework will be developed based on the evaluation and adaptation of existing frameworks for risk analysis, risk management, planning and decision making, stakeholder engagement, and risk governance; and to meet end-user requirements.
Scientific and risk based (or risk informed)
Considers the potential economic, social, and environmental impacts
Properly aligned with policies, practices, standards and procedures
Aligned with relevant legal requirements, and national and international obligations
Flexible enough to be used in a wide range of different circumstances
Simple and able to be applied quickly
Robust even when little information is available
well informed by all relevant knowledge and information
well informed by professional judgement
robust even when little information is available
applied in a timely manner
necessary and proportionate to the risk
technically feasible
cost beneficial
considers the potential economic, social, and environmental impacts
properly aligned with policies, practices, standards and procedures
aligned with relevant legal requirements, and national and international obligations
flexible enough to be used in a wide range of different circumstances
based on an open and consultative process
well communicated and include meaningful engagement with stakeholders
sound administrative decisions
resource efficient
comprehensively documented and recorded
in accordance with any conflict of interest
The two remaining disease management options that were considered, and used to evaluate the decision tools were:
2. Destruction of the whole block on which an infected plant/s is/are detected
Destruction of banana plants within a 10m radius around infected plant/s
These two remaining levels of plant destruction that were considered as possible disease management options were based on Panama disease management strategies carried out historically, and founded on the biology and epidemiology of the disease.
Who will benefit from your research? Who will directly use your research?
National and state plant health managers
Agricultural, environmental and other government agencies
Plant industry leaders and managers, and growers
How will you deliver it to end-users?
End-users have been involved in the project since its inception, to determine the project objectives, deliverables and outcomes
They also oversight the project through the mentor network
The project will be delivered to end-users as a ‘decision making handbook for plant biosecurity’, and through workshops and training in the framework and decision making tools
How will they use your research?
End-users will be able to better manage plant biosecurity risks, with a logical and analytical planning and decision making process.