This document provides an overview of the innervation of maxillofacial structures. It begins with basics of the nervous system, including definitions of neurons, nuclei and ganglia. It then describes the 12 cranial nerves in detail, including their origins, pathways, functions and clinical significance. Specific focus is given to the trigeminal nerve and its three divisions that provide sensory innervation to the face and motor innervation to the muscles of mastication. The document concludes with a section on secretomotor fibers that innervate the major salivary glands.