1) Semi-welded plate heat exchangers are increasingly being used in R717 (ammonia) / R744 (CO2) cascade systems due to their safety and efficiency. 2) Two case studies are presented of semi-welded plate heat exchangers in the Netherlands that have operated reliably for over 10 years in coffee and poultry processing plants. 3) The semi-welded design eliminates the risk of media intermixing and has very high fatigue resistance, making it the most reliable solution for R717/R744 cascade applications.