The document summarizes a presentation given at the eurammon Symposium 2017 about using R290 and R1270 refrigerants in commercial refrigeration systems. It discusses the properties of R290 and R1270 and their impacts on system design criteria, such as lower pressure drops and mass flows compared to R22 and HFCs. It also addresses the influence of hydrocarbons on compressor lubrication, such as stronger oil dilution, and measures needed for reliable operation like minimum refrigerant charges and suction superheating. Outdoor chiller/heat pump units using R290/R1270 blends are presented as a promising future solution.