Accidents are caused by multiple interacting factors including human error, equipment failures, and environmental conditions. Major causes of workplace injuries in the US include overexertion, impacts, falls, and exposure to chemicals and extreme temperatures. Legislation like Workers' Compensation aims to provide benefits to injured workers while encouraging safety. Government agencies like OSHA and NIOSH were established to set and enforce safety standards in industries. Accidents result from interactions between human, job, equipment, and environmental factors.