The document summarizes the research of Rafael Giraldo's group, which aims to develop microbial model systems for applications related to protein amyloidosis. The group studies ligand-induced conformational switches in proteins and designs protein devices to control DNA replication and amyloid assembly. Current projects examine conformational activation of protein-DNA complexes and new microbial models for protein amyloidosis. The group collaborates with other researchers and has expertise in cell biology, molecular biology, biophysics, and screening techniques like fluorescence microscopy and spectroscopy.