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The Catalan
nanobiomedicine
        alliance




      BioNanoMed
      Catalunya
BioNanoMed
Catalunya

    The Catalan    Nanobiomedicine is one of the strong points of research in Catalonia (Biocat
                   Report 2009*). Catalonia is the pioneer in Spain and has created specialised
nanobiomedicine    centres which are now international references in this area. According to

        alliance   publications by the United States National Library of Medicine (PubMed) a
                   member of the NIH (National Institute of Health), Barcelona is the second
                   city in the world, after Boston, for the origin of scientific publications on
                   nanomedicine.

                   Catalonia – one of the most outstanding bioregions in Southern Europe - has
                   a growing number of biotechnology and chemical-pharmaceutical companies
                   doing research on, or using, nanotechnology in their processes. Proof of
                   this is the information contained in this brochure, a collection of research
                   groups, institutions and companies whose priority area is research into
                   nanobiomedicine.

                   On the basis of this potential, the BioNanoMed Catalonia alliance has been
                   created to favour synergy between groups, centres, hospitals and companies
                   carrying out research in nanotechnology applied to health and biotechnology in
                   Catalonia, enabling them to create new business and research opportunities,
                   and to further increase the international footprint of this platform.

                   * www.biocat.cat/en/publications/report
Activity   Technology
                                                                  AROMICS
                                                                     BIOKIT
          BIO/NON-BIO INTERACTIONS FOR REGENERATIVE MEDICINE GROUP (IBEC)
                                       CELLULAR BIOMECHANICS GROUP (IBEC)
                                          NANOBIOENGINEERING GROUP (IBEC)
                              NANOPROBES AND NANOSWITCHES GROUP (IBEC)
CENTRE D’INVESTIGACIONS EN BIOQUIMICA I BIOLOGIA MOLECULAR PER NANOMEDICINA
                                              ENDOR NANOTECHNOLOGIES SL
                                                       GP PHARM / LIPOTEC
                                                 HEREDITARY CANCER GROUP
                          MOLECULAR NANOSCIENCE AND ORGANIC MATERIALS
                                 NANOBIOELECTRONICS & BIOSENSORS GROUP
                   NANOBIOSENSORS AND BIOANALYTICAL APPLICATIONS GROUP
                NANOBIOTECHNOLOGY AND BIOMOLECULAR DIAGNOSTICS GROUP
                                             HOSPITAL CLÍNIC DE BARCELONA
                                                                     LEITAT
AROMICS                                                                                                            NANOBIOENGINEERING GROUP
www.aromics.es - Carme Plasencia | carme.plasencia@aromics.es                                                      Josep Samitier
Applied Research using Omic Sciences (AROMICS) is a Barcelona-based biotechnology company that                     Converging and assembling micro-nano-bio systems to develop exciting nanomedicine applications.The
specializes in functional genomics and proteomics technologies and their application in research and development   expertise on biosensors and integration is combined to yield lab-on-a-chip solutions for point-of-care
of novel therapies and diagnostic products targeting relevant human health diseases. As a company, we are          diagnostics. The group also works to provide tools for the functionalization of biomaterials at the nanoscale,
focused on three major therapeutic areas: oncology, infectious diseases and neurodegenerative diseases.            providing physical and chemical cues to control cell development.
                                                                                                                          Human health                        Biomaterials
       Nanotechnology
                                                                                                                          - In vitro diagnosis                Nanotechnology

ADVANCELL
www.advancell.net - Clara Campas / Ana Vila
                                                                                                                   NANOPROBES AND NANOSWITCHES GROUP
Biotechnology company with its own technology and continuous innovation; it deals with unresolved questions
                                                                                                                   Pau Gorostiza | Fausto Sanz
in health and wellbeing using value-added efficient products and services. The company thrives on its
discoveries from the academic environment and improving, developing and licensing them to third parties or         Developing Nano scale tools to study biological systems. These tools include instrumentation based on proximity
launching them on the market.                                                                                      probes, like Electrochemical Tunneling Microscopy and Spectroscopy that we are applying to study metal oxides
                                                                                                                   and redox proteins.
BIOKIT                                                                                                                    Biotechnology                       Nanotechnology
www.biokit.com - Pau Brugera | pbruguera@biokit.com                                                                       Human health                        Optics / photonics
                                                                                                                          - Imaging diagnostic
Biokit is an in-vitro diagnostics company which develops innovative, high quality proprietary and OEM
immunoassays for infectious serology, clinical chemistry, immunochemistry and coagulation testing. The
company specializes in antigen and antibody production and purification, ELISA, latex agglutination and
chemiluminescence.
      Biotechnology                     Biomaterials
                                                                                                                   CENTRE D’INVESTIGACIONS EN BIOQUÍMICA I BIOLOGIA
      Human health                      Other                                                                      MOLECULAR PER NANOMEDICINA (CIBBIM-NANOMEDICINA)
                                                                                                                   VALL D’HEBRON INSTITUT DE RECERCA- VHIR
INSTITUTE FOR BIOENGINEERING OF CATALONIA (IBEC)                                                                   www.cibbim.eu - Simó Schwartz Jr | sschwartz@ir.vhebron.net
www.ibecbarcelona.eu | info@ibecbarcelona.eu
                                                                                                                   Our projects and current patents (13) are focused into the identification of new disease biomarkers and
BIO/NON-BIO INTERACTIONS FOR REGENERATIVE MEDICINE GROUP                                                           therapeutic targets, and the development of new drug delivery and targeting approaches for clinical applications in
Josep A. Planell                                                                                                   oncology and rare diseases.

A cross-disciplinary approach to deliver smart, third generation biomaterials for tissue engineering and                  Biotechnology                   - In vitro diagnosis            In silico analysis    Nanotechnology
regenerative medicine. Engineering advanced polymer surfaces with nanoscale tools and techniques for their                Human health                    - Imaging diagnostic            Biostatistics         Peptides & proteins
functionalization and characterization.                                                                                   - Pharmacological or            Others: pre-clinic studies      Bioinformatics        Proteomics
                                                                                                                            biological therapeutics                                       Biomaterials          Others
      Biotechnology             Others:                      Biophysics              Nanotechnology
      Human health              Bioengineering and           Biomaterials            Peptides & proteins                                                                                  Genomics
      - Medical devices         nanomedicine                 Cristalography

CELLULAR BIOMECHANICS GROUP                                                                                        ENDOR NANOTECHNOLOGIES SL
Daniel Navajas                                                                                                     www.endornanotech.com - Marc Ramis | marc.ramis@endornanotech.com
Study of the mechanical properties of the airway and lung tissues and the changes that occur in the context of     EDS lead program for therapeutics is an innovative delivery system for agents with great potential to be applied
the mechanical dysfunction associated with respiratory diseases. Development and application of cutting edge       in oncology. EDS is an advanced delivery system for therapeutic agents both small molecules and biologicals
nanotechnology and advanced biophysical techniques to probe the mechanical behavior of the cells and their         (organic drugs, siRNA, proteins or monoclonal antibodies).
mechanical interactions with the microenvironment.
                                                                                                                          Human health                    - Medical devices               Nanotechnology
       Biotechnology                    Biophysics                                                                        - Pharmacological or            - In vitro diagnosis            Medicinal chemistry
       Human health                     Nanotechnology                                                                      biological therapeutics
       - Imaging diagnostic
GP PHARM /LIPOTEC                                                                                                   NANOBIOTECHNOLOGY AND BIOMOLECULAR
www.gp-pharm.com - Alberto Bueno                                                                                    DIAGNOSTICS GROUP
GP Pharm, is a Spanish biopharmaceutical company of the Lipotec Group. The company is focused on research,          INSTITUT DE QUÍMICA AVANÇADA DE CATALUNYA-CSIC
development, manufacturing and marketing of products for injection within Urology and Oncology fields, based in
                                                                                                                    www.iqac.csic.es/amrg - Pilar Marco | pilar.marco@cid.csic.es
proprietary Drug Delivery Systems. These technological platforms include micronanospheres and liposomes.
                                                                                                                    New approaches and strategies for improved diagnostic methods and devices based on the combination of micro/
       Human health                                                                                                 nanotechnological and biotechnological advances to create functional (bio)hybrid materials, in which optical or
                                                                                                                    electrical signals can be recorded as a consequence of specific biorecognition events. Development of antibodies
HEREDITARY CANCER GROUP                                                                                             with tailored properties.

ICO-IDIBELL-IMPPC                                                                                                          Biotechnology               - In vitro diagnosis              Biomaterials
                                                                                                                           Food & nutrition            Animal health                     Bioprocesses
Gabriel Capella - gcapella@idibell.cat
                                                                                                                           Human health                - In vitro diagnosis              Nanotechnology
Molecular characterization of alleles of moderate risk predisposing to colorectal cancer: I1307K as a model                - Medical devices           Others: Nutrition                 Peptides & proteins
system. Search of new genes predisposing to familial breast and colorectal cancer. Risk quantification in
neurofibromatosis. Psychological impact of genetic counseling.
       Biotechnology
       Human health
                                  or biological therapeutics
                                - In vitro diagnosis
                                                                   In silico analysis
                                                                   Biostatistics
                                                                                              Genomics
                                                                                              Proteomics
                                                                                                                    HOSPITAL CLÍNIC DE BARCELONA
       - Pharmacological                                           Bioinformatics                                   www.hospitalclinic.org - Joan Bigorra | bigorra@clinic.ub.es
                                                                                                                    Translational Research in Cancer, GI and Liver Diseases, Cardiovascular, Pulmonary Diseases,
MOLECULAR NANOSCIENCE AND ORGANIC MATERIALS                                                                         Neurosciences, Diabetes, Metabolic Diseases, Infectious Diseases. NOTES Surgery, Medical Imaging,
                                                                                                                    Telemedicine, Health System Research.
NANOMOL
                                                                                                                           Bioinformatics              - Pharmacological or              - In vitro diagnosis
www.icmab.es/nanomol - www.icmab.es/nmmo - Jaume Veciana | vecianaj@icmab.es
                                                                                                                           Biotechnology                 biological therapeutics         - Imaging diagnosis
       Fine chemistry             biological therapeutics          biological therapeutics    Biophysics                   Human health                - Medical devices                 - E-health / electro medicine
       Food & nutrition         - E-health / electromedicine     - Medical devices            Biomaterials
       Human health:            Animal health:                   - E-health /                 Nanotechnology
       - Pharmacological or     - Pharmacological or               electromedicine            Medicinal chemistry   IDIBELL
                                                                                                                    www.idibell.cat - Emilià Pola / Montse Ballarin
NANOBIOELECTRONICS & BIOSENSORS GROUP                                                                               Bellvitge Biomedical Research Institute (IDIBELL) is a research centre focused on cellular medicine, where the
INSTITUT CATALÀ DE NANOTECNOLOGIA                                                                                   high level basic research focuses and works on relevant clinical matters and the economic development. The
www.icn.cat/nanobioele-ctronics-biosensors.php - Arben Merkoçi | arben.merkoci.icn@uab.es                           centre manages the research of the Bellvitge University Hospital, the Institut Català d’Oncologia (Catalan
                                                                                                                    Institute of Oncology), the University of Barcelona and the Institute of Image Diagnosis.
Development of low cost and efficient nanomaterials based sensors and biosensors including lab-on-a-chip for
diagnostics, environmental monitoring, safety and security between other industrial applications.
       Biotechnology                Animal health                       Biomaterials                                LEITAT
       Environment                  - Pharmacological or                Bioprocesses                                www.leitat.org - Francesc Mitjans | fmitjans@leitat.org
       Human health                   biological therapeutics           Nanotechnology                              Monoclonal antibodies , cellular models, in vivo models, ADME, cellular safety models. Ongoing FP7 European
       - In vitro diagnosis                                             Peptides & proteins                         Projects: NANOPOLYTOX, NANOTHER, and NANOTEST. Ongoing National Projects: VACMON,
                                                                                                                    NANOMOLECULAR, ROBOCELL, and ROBIOCAT.
NANOBIOSENSORS AND BIOANALYTICAL APPLICATIONS GROUP                                                                        Biotechnology              - Pharmacological or               Biomaterials
CIN2-CSIC; CIBER-BBN                                                                                                       Environment                  biological therapeutics          Bioprocesses
www.ci2.es/biosensores - Laura M. Lechuga | laura.lechuga@cin2.es                                                          Food & nutrition           - Medical devices                  Bioremediation
                                                                                                                           Human health               - In vitro diagnosis               Nanotechnology
Technological development of nanophotonic (plasmonics and silicon-based) and nanomechanical biosensors                                                - Imaging diagnosis                Peptides & proteins
based on proper technology, integration in point-of-care platforms and their application in real clinical
diagnostics. Two spin-offs have been launched.
       Biotechnology                Human health                        Nanotechnology
       Environment                  - In vitro diagnosis                Optics / photonics
BioNanoMed
             Catalunya




Edited by:




                               Institute for bioengineering
                               of Catalonia

info@bionanomedcat.org - www.bionanomedcat.org

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The Catalan Nanobiomedicine alliance

  • 1. The Catalan nanobiomedicine alliance BioNanoMed Catalunya
  • 2. BioNanoMed Catalunya The Catalan Nanobiomedicine is one of the strong points of research in Catalonia (Biocat Report 2009*). Catalonia is the pioneer in Spain and has created specialised nanobiomedicine centres which are now international references in this area. According to alliance publications by the United States National Library of Medicine (PubMed) a member of the NIH (National Institute of Health), Barcelona is the second city in the world, after Boston, for the origin of scientific publications on nanomedicine. Catalonia – one of the most outstanding bioregions in Southern Europe - has a growing number of biotechnology and chemical-pharmaceutical companies doing research on, or using, nanotechnology in their processes. Proof of this is the information contained in this brochure, a collection of research groups, institutions and companies whose priority area is research into nanobiomedicine. On the basis of this potential, the BioNanoMed Catalonia alliance has been created to favour synergy between groups, centres, hospitals and companies carrying out research in nanotechnology applied to health and biotechnology in Catalonia, enabling them to create new business and research opportunities, and to further increase the international footprint of this platform. * www.biocat.cat/en/publications/report
  • 3. Activity Technology AROMICS BIOKIT BIO/NON-BIO INTERACTIONS FOR REGENERATIVE MEDICINE GROUP (IBEC) CELLULAR BIOMECHANICS GROUP (IBEC) NANOBIOENGINEERING GROUP (IBEC) NANOPROBES AND NANOSWITCHES GROUP (IBEC) CENTRE D’INVESTIGACIONS EN BIOQUIMICA I BIOLOGIA MOLECULAR PER NANOMEDICINA ENDOR NANOTECHNOLOGIES SL GP PHARM / LIPOTEC HEREDITARY CANCER GROUP MOLECULAR NANOSCIENCE AND ORGANIC MATERIALS NANOBIOELECTRONICS & BIOSENSORS GROUP NANOBIOSENSORS AND BIOANALYTICAL APPLICATIONS GROUP NANOBIOTECHNOLOGY AND BIOMOLECULAR DIAGNOSTICS GROUP HOSPITAL CLÍNIC DE BARCELONA LEITAT
  • 4. AROMICS NANOBIOENGINEERING GROUP www.aromics.es - Carme Plasencia | carme.plasencia@aromics.es Josep Samitier Applied Research using Omic Sciences (AROMICS) is a Barcelona-based biotechnology company that Converging and assembling micro-nano-bio systems to develop exciting nanomedicine applications.The specializes in functional genomics and proteomics technologies and their application in research and development expertise on biosensors and integration is combined to yield lab-on-a-chip solutions for point-of-care of novel therapies and diagnostic products targeting relevant human health diseases. As a company, we are diagnostics. The group also works to provide tools for the functionalization of biomaterials at the nanoscale, focused on three major therapeutic areas: oncology, infectious diseases and neurodegenerative diseases. providing physical and chemical cues to control cell development. Human health Biomaterials Nanotechnology - In vitro diagnosis Nanotechnology ADVANCELL www.advancell.net - Clara Campas / Ana Vila NANOPROBES AND NANOSWITCHES GROUP Biotechnology company with its own technology and continuous innovation; it deals with unresolved questions Pau Gorostiza | Fausto Sanz in health and wellbeing using value-added efficient products and services. The company thrives on its discoveries from the academic environment and improving, developing and licensing them to third parties or Developing Nano scale tools to study biological systems. These tools include instrumentation based on proximity launching them on the market. probes, like Electrochemical Tunneling Microscopy and Spectroscopy that we are applying to study metal oxides and redox proteins. BIOKIT Biotechnology Nanotechnology www.biokit.com - Pau Brugera | pbruguera@biokit.com Human health Optics / photonics - Imaging diagnostic Biokit is an in-vitro diagnostics company which develops innovative, high quality proprietary and OEM immunoassays for infectious serology, clinical chemistry, immunochemistry and coagulation testing. The company specializes in antigen and antibody production and purification, ELISA, latex agglutination and chemiluminescence. Biotechnology Biomaterials CENTRE D’INVESTIGACIONS EN BIOQUÍMICA I BIOLOGIA Human health Other MOLECULAR PER NANOMEDICINA (CIBBIM-NANOMEDICINA) VALL D’HEBRON INSTITUT DE RECERCA- VHIR INSTITUTE FOR BIOENGINEERING OF CATALONIA (IBEC) www.cibbim.eu - Simó Schwartz Jr | sschwartz@ir.vhebron.net www.ibecbarcelona.eu | info@ibecbarcelona.eu Our projects and current patents (13) are focused into the identification of new disease biomarkers and BIO/NON-BIO INTERACTIONS FOR REGENERATIVE MEDICINE GROUP therapeutic targets, and the development of new drug delivery and targeting approaches for clinical applications in Josep A. Planell oncology and rare diseases. A cross-disciplinary approach to deliver smart, third generation biomaterials for tissue engineering and Biotechnology - In vitro diagnosis In silico analysis Nanotechnology regenerative medicine. Engineering advanced polymer surfaces with nanoscale tools and techniques for their Human health - Imaging diagnostic Biostatistics Peptides & proteins functionalization and characterization. - Pharmacological or Others: pre-clinic studies Bioinformatics Proteomics biological therapeutics Biomaterials Others Biotechnology Others: Biophysics Nanotechnology Human health Bioengineering and Biomaterials Peptides & proteins Genomics - Medical devices nanomedicine Cristalography CELLULAR BIOMECHANICS GROUP ENDOR NANOTECHNOLOGIES SL Daniel Navajas www.endornanotech.com - Marc Ramis | marc.ramis@endornanotech.com Study of the mechanical properties of the airway and lung tissues and the changes that occur in the context of EDS lead program for therapeutics is an innovative delivery system for agents with great potential to be applied the mechanical dysfunction associated with respiratory diseases. Development and application of cutting edge in oncology. EDS is an advanced delivery system for therapeutic agents both small molecules and biologicals nanotechnology and advanced biophysical techniques to probe the mechanical behavior of the cells and their (organic drugs, siRNA, proteins or monoclonal antibodies). mechanical interactions with the microenvironment. Human health - Medical devices Nanotechnology Biotechnology Biophysics - Pharmacological or - In vitro diagnosis Medicinal chemistry Human health Nanotechnology biological therapeutics - Imaging diagnostic
  • 5. GP PHARM /LIPOTEC NANOBIOTECHNOLOGY AND BIOMOLECULAR www.gp-pharm.com - Alberto Bueno DIAGNOSTICS GROUP GP Pharm, is a Spanish biopharmaceutical company of the Lipotec Group. The company is focused on research, INSTITUT DE QUÍMICA AVANÇADA DE CATALUNYA-CSIC development, manufacturing and marketing of products for injection within Urology and Oncology fields, based in www.iqac.csic.es/amrg - Pilar Marco | pilar.marco@cid.csic.es proprietary Drug Delivery Systems. These technological platforms include micronanospheres and liposomes. New approaches and strategies for improved diagnostic methods and devices based on the combination of micro/ Human health nanotechnological and biotechnological advances to create functional (bio)hybrid materials, in which optical or electrical signals can be recorded as a consequence of specific biorecognition events. Development of antibodies HEREDITARY CANCER GROUP with tailored properties. ICO-IDIBELL-IMPPC Biotechnology - In vitro diagnosis Biomaterials Food & nutrition Animal health Bioprocesses Gabriel Capella - gcapella@idibell.cat Human health - In vitro diagnosis Nanotechnology Molecular characterization of alleles of moderate risk predisposing to colorectal cancer: I1307K as a model - Medical devices Others: Nutrition Peptides & proteins system. Search of new genes predisposing to familial breast and colorectal cancer. Risk quantification in neurofibromatosis. Psychological impact of genetic counseling. Biotechnology Human health or biological therapeutics - In vitro diagnosis In silico analysis Biostatistics Genomics Proteomics HOSPITAL CLÍNIC DE BARCELONA - Pharmacological Bioinformatics www.hospitalclinic.org - Joan Bigorra | bigorra@clinic.ub.es Translational Research in Cancer, GI and Liver Diseases, Cardiovascular, Pulmonary Diseases, MOLECULAR NANOSCIENCE AND ORGANIC MATERIALS Neurosciences, Diabetes, Metabolic Diseases, Infectious Diseases. NOTES Surgery, Medical Imaging, Telemedicine, Health System Research. NANOMOL Bioinformatics - Pharmacological or - In vitro diagnosis www.icmab.es/nanomol - www.icmab.es/nmmo - Jaume Veciana | vecianaj@icmab.es Biotechnology biological therapeutics - Imaging diagnosis Fine chemistry biological therapeutics biological therapeutics Biophysics Human health - Medical devices - E-health / electro medicine Food & nutrition - E-health / electromedicine - Medical devices Biomaterials Human health: Animal health: - E-health / Nanotechnology - Pharmacological or - Pharmacological or electromedicine Medicinal chemistry IDIBELL www.idibell.cat - Emilià Pola / Montse Ballarin NANOBIOELECTRONICS & BIOSENSORS GROUP Bellvitge Biomedical Research Institute (IDIBELL) is a research centre focused on cellular medicine, where the INSTITUT CATALÀ DE NANOTECNOLOGIA high level basic research focuses and works on relevant clinical matters and the economic development. The www.icn.cat/nanobioele-ctronics-biosensors.php - Arben Merkoçi | arben.merkoci.icn@uab.es centre manages the research of the Bellvitge University Hospital, the Institut Català d’Oncologia (Catalan Institute of Oncology), the University of Barcelona and the Institute of Image Diagnosis. Development of low cost and efficient nanomaterials based sensors and biosensors including lab-on-a-chip for diagnostics, environmental monitoring, safety and security between other industrial applications. Biotechnology Animal health Biomaterials LEITAT Environment - Pharmacological or Bioprocesses www.leitat.org - Francesc Mitjans | fmitjans@leitat.org Human health biological therapeutics Nanotechnology Monoclonal antibodies , cellular models, in vivo models, ADME, cellular safety models. Ongoing FP7 European - In vitro diagnosis Peptides & proteins Projects: NANOPOLYTOX, NANOTHER, and NANOTEST. Ongoing National Projects: VACMON, NANOMOLECULAR, ROBOCELL, and ROBIOCAT. NANOBIOSENSORS AND BIOANALYTICAL APPLICATIONS GROUP Biotechnology - Pharmacological or Biomaterials CIN2-CSIC; CIBER-BBN Environment biological therapeutics Bioprocesses www.ci2.es/biosensores - Laura M. Lechuga | laura.lechuga@cin2.es Food & nutrition - Medical devices Bioremediation Human health - In vitro diagnosis Nanotechnology Technological development of nanophotonic (plasmonics and silicon-based) and nanomechanical biosensors - Imaging diagnosis Peptides & proteins based on proper technology, integration in point-of-care platforms and their application in real clinical diagnostics. Two spin-offs have been launched. Biotechnology Human health Nanotechnology Environment - In vitro diagnosis Optics / photonics
  • 6. BioNanoMed Catalunya Edited by: Institute for bioengineering of Catalonia info@bionanomedcat.org - www.bionanomedcat.org