Rh incompatibility occurs when a pregnant woman with Rh negative blood is carrying a baby with Rh positive blood. During pregnancy or delivery, the baby's Rh positive blood can enter the mother's bloodstream and trigger an immune response. This response produces antibodies that can destroy the baby's red blood cells if the mother has a subsequent Rh positive baby. Rh incompatibility can cause jaundice, anemia and in severe cases hydrops fetalis in the baby. Diagnosis involves blood tests to check the mother's Rh status and antibody levels. Treatment may include Rh immunoglobulin injections during pregnancy to prevent sensitization.
This topic contains definition, meaning, classification, pathophysiology, clinical menifestations, metabolic and general changes, management of obstetrical shock
Rh Incompatibility I Hemolytic Disease of the NewbornSwatilekha Das
Rh Incompatibility I Hemolytic Disease of the Newborn-
Hi All,
I am Swatilekha Das, B.Sc, M.Sc Nurse and working as Assistant Professor of Nursing in a Nursing college. I worked as Clinical Instructor, nursing educator, nursing trainer, Nursing Tutor at hospitals, nursing schools and colleges.
ABOUT THIS ppt-
In this ppt I discussed about definition of rh incompatibility, cause, pathophysiology, diagnostic tests, treatment and screening and prevention of Rh incompatibility.
To know about it check the ppt till end.
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This topic contains definition, meaning, classification, pathophysiology, clinical menifestations, metabolic and general changes, management of obstetrical shock
Rh Incompatibility I Hemolytic Disease of the NewbornSwatilekha Das
Rh Incompatibility I Hemolytic Disease of the Newborn-
Hi All,
I am Swatilekha Das, B.Sc, M.Sc Nurse and working as Assistant Professor of Nursing in a Nursing college. I worked as Clinical Instructor, nursing educator, nursing trainer, Nursing Tutor at hospitals, nursing schools and colleges.
ABOUT THIS ppt-
In this ppt I discussed about definition of rh incompatibility, cause, pathophysiology, diagnostic tests, treatment and screening and prevention of Rh incompatibility.
To know about it check the ppt till end.
I hope you enjoy this ppt and if you do then please click on the like button and share the with your friends too . Don't Forget to follow to see more such ppt. Thank you for checking the ppt.
@All Rights Reserved..
Rh Incompatibility in Pregnancy. Rh incompatibility occurs when a pregnant woman whose blood type is Rh-negative is exposed to Rh-positive blood from her fetus, leading to the mother's development of Rh antibodies
Placental abruption is premature separation of placenta from the uterus/ in other words separates before childbirth.
It occurs most commonly around 25 weeks of pregnancy characterized by vaginal bleeding, lower abdominal pain, and dangerously low blood pressure
this is the first part of my FACE PRESENTATION.this ppt contains all the required content for a face presentation and mechanism of labour in face presntation and also for diagnosis i uploaded another ppt. the main objective of my ppt is the viewers shouldn't get bored of what we say this is simplified yet professional .. have a look at it and enjoy, thank you.
Rh Incompatibility in Pregnancy. Rh incompatibility occurs when a pregnant woman whose blood type is Rh-negative is exposed to Rh-positive blood from her fetus, leading to the mother's development of Rh antibodies
Placental abruption is premature separation of placenta from the uterus/ in other words separates before childbirth.
It occurs most commonly around 25 weeks of pregnancy characterized by vaginal bleeding, lower abdominal pain, and dangerously low blood pressure
this is the first part of my FACE PRESENTATION.this ppt contains all the required content for a face presentation and mechanism of labour in face presntation and also for diagnosis i uploaded another ppt. the main objective of my ppt is the viewers shouldn't get bored of what we say this is simplified yet professional .. have a look at it and enjoy, thank you.
ABO Blood grouping in-compatibility in pregnancyMs. Sapna Pal
Rhesus (Rh) incompatibility is a crucial topic in the realm of pregnancy and childbirth. This condition arises when a pregnant woman, who is Rh-negative, carries a fetus with Rh-positive blood, causing a potential mismatch that can lead to serious complications. Understanding the mechanisms and implications of Rh incompatibility is paramount for healthcare providers and expecting parents alike. Let's delve into this intricate interplay between blood types, antibodies, and pregnancy, to grasp the significance of Rh incompatibility and its management.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
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of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
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The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
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4. Differentiate between minute ventilation and alveolar ventilation
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Study Resources:
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2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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2. INTRODUCTION
Hemolytic diseases of the fetus and newborn occurs as a result of
paternally derved RBC antigens presenting on fetal redcells
which is absent in the mother.Rhesus iso immunisation seen in Rh
negative pregnant mothers remains the most common cause of
haemolytic diseases of the fetus and newborn.
When an Rh negative mother causes an Rh positive fetus,
transplacental haemorrhage from the fetus to the mother.
Fetal RBC enter the mothers blood stream stay in the maternal
circulation for their normal lifespan, facilitating stimulation of
maternal immune response and production of antibodies , the
fetus if Rh positive is affected resulting erythroblastosis fetalis.
3.
4. CAUSES
Factors that influence an Rh negative
pregnant female chance of developing
Rh incompatibility include the
following
Ectopic pregnancy
Placenta Previa
Placental abruption
Abdominal trauma
In uterofetal death
Spontaneous abortion
It is a condition that develops
when a pregnant women has Rh
negative blood and the baby in
her womb has Rh positive
blood.
DEFINITION
5.
6.
7.
8.
9. ETIO PATHOLOGY
Iso immunization can occur either following in compatible blood
transfusion.The normal serum in the human body contains small
amount of natural antibodies of IgM,IgG,Ig A isotypes that can react
with foreign or self antigens and these complexes may have the
potential to elicit an immune response.
The immune complexes between antigens and antibodies may form
at the onset and during the course of an immune response.
The initial response in case of a women exposed to the RhD antigen
is week.It is primarily composed of IgM , a large molecule that
cannot cross the placenta.
10. However this immune response changes to the production of IgG
within a period of 6 weeks to 6 months, which can cross the placenta
resulting in various complications in the fetus and the mother.Rh iso
immunization is generally observed n case of 2nd pregnancies .
As the maternal antibodies cross the placenta and destroy the fetal
Rh positive red cell, haemolytic anemia ensures along with
increased levels of bilirubin.
Severe anemia may be followed by erythroblastosis fetalis that is
characterized by extramedullary hematopoiesis,Heart failure,edema
and Percardial effusion.
11.
12. PATHOGENESIS
Hematopoisis in the fetus begin as early as 8th week of gestation up to 40% of
pregnancy.These cells pass through the placenta into maternal circulation.
If the fetus is Rh positive and mother Rh negative, the mother forms
antibodies against fetal blood cells.
First IgM antibodies that are too large to pass through the placenta and later
IgG antibodies that can cross the placenta.
This process of antibody formation is called Maternal sensitization.
During subsequent pregnancies antibodies form in response to repeated
contact with antigen from the fetal blood resulting in lysis.
Severe Rh incompatibility results in marked fetal haemolytic anemia because
the fetal erythrocytes are destroyed by maternal Rh positive antibodies.
13. Placenta usually clear the bilirubin generated by RBC
breakdown.In extreme cases fetal bilirubin level increases.This
results in fetal jaundice known as Icterus gravis.
The fetus compensates for the anemia by producing large number
of immature erythrocytes to replace those hremolyzed called as
Erythroblastosis fetalis.
Severe form ---Hydrops fetalis.
The fetus has marked anemia cardiomegaly, hepatosplenomegaly,
cardiac decompression.
Hypoxia results from the severe anemia because decreased
intravascular oncotic pressure involved.
15. ICTERUS GRAVIS NEONATORUM
The baby is born without evidences of jaundice but soon develops within 24
hours.
While fetus is in utero, there is destruction of fetal red cells with liberation of
un conjucated bilirubin which is mostly excreted the placenta in to the maternal
system.
As the umbilical cord is clamped with continuing haemolysis, the bilirubin
concentration is increased. Sooner or later baby develops jaundice.
If the bilirubin rises to the critical level of 20 mg per 100 ml (340micromol/l)
{normal—30 micromol/l}
The bilirubin crosses the blood brain barrier to damage the basal nuclei of the
brain permanently producing the clinical manifestation of kernicterus
16.
17. CONGENITAL ANEMIA OF THE
NEWBORN
The destruction of the red cells continues up to 6 weeks after which the
antibodies are not available for Haemolysis. The liver and spleen are enlarged.
CAUSES: Rh incompatibility
Risk factors:
Pregnant woman with Rh negative blood who had a prior pregnancy with fetus
that was Rh positive.
Pregnant woman who had a prior blood transfusion.
Pregnant woman with Rh negative blood who did not receive Rh immunization
prophylaxis during a prior pregnancy with Rh positive fetus.
18. SYMPTOMS
• High bilirubin level(greater than 18mg/cc)
• Extreme jaundice, absent startle reflex,Poor sucking
reflex, Lethargy
EARLY
• High pitch cry, Arched back with neck
Hyperextended backwards
• Bulging fontanel, Seizure
INTER
MEDIATE
• High pitched hearing loss, intellectual disability,
muscle rigidity, speech difficulties, seizures,
movement disorders
LATE
19. DIAGNOSIS: Blood test for Rh factor
TREATMENT:
IMMUNE GLOBULIN INJECTION: Give an injection of Rho immune globulin week 28th
of the pregnancy. This desensitizes mothers blood to Rh positive blood. Injection of
immune globulin within 72 hours after delivery .This is help ful for future pregnancy.
20.
21.
22. HYDROPS FETALIS
Excessive destruction of the fetal red cells lead to severe anemia , tissue
anoxaemia and metabolic acidosis.
Hyperplasia of the placental tissue occurs in an effort to increase the transfer of
oxygen but the available fetal red cells are progressively diminished due to
hemolysis.
As a result of fetal anoxaemia, there is damage to the liver leading to
hupoproteinaemia which responsible for generalised edema, ascities and
hydrothorax.
Fetal death occurs sooner due to cardiac failure. The baby is either still born or
macerated and even if born alive, dies soon after.
23.
24. TREATMENT
Amniocentesis to determine severity
Intrauterine fetal transfusion
Early induction of labour
A direct transfusion of packed red cells and also exchange transfusion of the
newborn.
This is done to rid the infants blood of the maternal antibodies that are
destroying the red blood cells.
Control the congestive failure and fluid retention.
26. DURATION OF PREGNANCY
Entry of fetal cell (trans placental hemorrhage) in to the maternal
circulation mostly occurs at the time of expulsion of the fetus. It can
occur during pregnancy as well. Both the frequency and magnitude of
bleeding increases as pregnancy advances.
Even spontaneous abortion is associated with transplacental
haemorrhage , but the incidence is less than 1%
Abortion in first trimester—3%
Abortion in second trimester--- 12%
Maximum risk—46% in the time of delivery.
As fetal Rh antigen can be detected early, when the fetus is only 38
days old, sensitisation can occur as early as 7 week of gestation.
27. AMOUNT OF TRANS PLACENTAL
HEMORRHAGE
The volume of fetal blood cells entering the maternal circulation
is not uniform in all pregnancies.
It may vary from 0.1 ml to more on average the blood may not be
more than 15 ml in term pregnancy.
The risk of immunisation is 3% with 0.1ml of fetal red cells, 25%
with 0.25-1 ml and increases to 65% with more than 5 ml.
29. IDENTIFICATION OF Rh
INCOMPATIBILITY
If the pregnant mother is Rh negative, then the husband’s blood
group is checked. In case husband Rh negative no further
investigation is required and pregnancy is managed as a normal
does not need any additional care.
If the pregnant mother’s blood group is Rh negative, the husband
is Rh positive then at the first visit, Indirect coomb’s test is done
to detect maternal serum anti –D antibodies which unbound, If
antibodies are not detected, the test is repeated in the second and
third trimester.
Anti partum prophylaxis with a dose of 300micro gram of anti-D
has been recommended.
30. DOPPLER STUDIES
DOPPLER USG of the middle cerebral artery of the fetus to determine the
Middle Cerebral Artery Peak Systolic Velocity (MCA-PSV )is being studied
fetal anemia.
The wave forms of the MCA are observed using colour Doppler and highest
point of the Doppler waveform is measured as MCA-PSV.
It has been propose that absolute MCA-PSV may be helpful in the
management od red cell iso immunization and rate of change in MCA-PSV
over time help predict fetal anemia.
It is advised periodically for evaluation of fetal heart size, edema, pericardial effusion,
ascites and AFI
ULTRA SONOGRAPHY
31. MANAGEMENT OF UNSENSITIZED
PREGNANCY-STANDARD PROTOCOL
Repeat Rh antibody titre.
USG examination of fetus.
IM Rh immunoglobulin 300 micro gram.
Analysis of the husband’s blood type.
To prevent this from occurring , an injection of Rh –D immunoglobulin is offered
to all unsensitised Rh negative women during the 28th week if a repeat Rh
antibody titre is still negative.
No need to perform an USG examination of the fetus.
The antibody screening must be repeated at 35th week gestation and if negative ,
the women kept on observation .If positive, she should be managed on the lines of
a sensitised patient.
32. VARIOUS DIAGNOSTIC MODALITIES
Rh ANTIBODY
ASSAY
USG EVALUATION
OF THE FETUS
MIDDLE
CEREBRAL
ARTERY
DOPPLER
AMNIOCENTESIS
AND
EXAMINATION OF
AMNIOTIC FLUID
33. Rh ANTIBODY ASSAY
Maternal titre
Human antiglobulin titre(Indirect coomb’s test)-to determine the degree of allo
immunisation.
Critical titre-the titre associated with high risk for fetal Hydrops.
If the coomb’s test is positive in dilution of further evaluation of the fetus is
required1:16.
If the titre is less than it is repeated every trimester.
Titre are repeated every 2 weeks thereafter to determine whether there is
trend.
34. METHOD OF TERMINATION
Indication:
Previous H/O still birth with father being homozygous.
Sudden rise in maternal antibody titre.
Sonographic features of fetal affection.
Mild affection-Pregnancy may be continue up to 38 weeks.
Severe affection-terminate the pregnancy before 34 weeks.
35. METHOD OF TERMINATION
AMNIOTOMY(LOW RUPTURE OF THE MEMBRANE)
Termination is done near term –vaginal PG E2 to make cervix ripe. Oxytocin
drip may be added.
If it is fail-caesarean section is preferred.
CAESAREAN SECTION:
When termination has to be done prematurely (34-37 weeks) if it is
unfavourable.
CARE DURING VAGINAL DELIVERY:
Careful fetal monitoring.
Prophylactic ergometrine during second stage.
Gentle handling of the uterus in third stage
To take care of PPH.
36. INTRA UTERINE FETAL TRANSFUSION
INTRA
PERIOTONEAL
TRANSFUSION
INTRA
VASCULAR
TRANSFUSION
37. INTRA PERITONEAL TRANSFUSION
Blood is transfused to fetal peritoneal cavity under USG guidance.
Correct the fetal anemia when transfuse the erythrocytes are taken up by sub-
diaphragmatic lymphatics.
It can be started at 18 weeks and repeated at intervals of 1-3 weeks to 32-34
weeks.
Type and amount of blood –blood group “o”.
Rh negative packed cell cross matched with the mother are to be transfused.
The quantity of blood is to be calculate as number of weeks of gestation.
The blood is to be infused slowly(5-10ml) through a polythene tube that has
been threaded through an introducing needle inserted in to the fetal abdomen
under guidance.
38. INTRA VASCULAR TRANSFUSION
Transfusion is made through umbilical cord vessel near its insertion in to the placenta
under guidance of USG.
Blood group “o” Rh negative packed cells compatible with mothers blood are
transfused.
Check the Hematocrit value at intervals during the procedure to determine the volume.
Goal: Achieve haematocrit of 50% ;Repeat transfusion is given 2 weeks.
Volume overload –fetal injury, preterm labour, fetal maternal hemorrhage,.
Fetal surveillance with USG and continuous electronic fetal monitoring.
Betamethasone (24 mg in divided dose) should be administered to the mother 24 hours
before transfusion from 26 weeks onwards to enhance pulmonary maturity.
39. PREVENTION
Anti-D immunoglobulin 300 micro gram of D Antibody is given to D-negative
, non sensitized mothers to prevent the hazards f sensitization.
Anti-D globulin is provided to D-negative mothers after miscarriage ,
evacuation of molar pregnancy or ectopic pregnancy.
It is also administered when there is heavy feto maternal bleeding such as
placental abruption, intrauterine manipulation.
Dose of 300 micro gram D-antibody will neutralize about 15ml of red cells.
Rosette test is done to all such mothers to know the accurate amount of
Anti-D required.