1. P4 medicine requires vast amounts of data because biology and disease are incredibly complex, arising from random and chaotic evolutionary processes that build upon existing structures in complex ways, like Rube Goldberg machines.
2. Viewing biology through an informational lens helps organize vast amounts of data by recognizing two types of biological information - genetic and environmental - that are integrated across molecular, cellular, tissue, and systemic levels in hierarchical networks and machines.
3. Studying the progression of prion disease in mice revealed over 7,000 differentially expressed genes across disease progression, which was reduced to around 300 genes most associated with neurodegeneration through various subtractions. These 300 genes mapped to four major biological networks involved in
Behavioral immunology ( Behavioral immunology” refers to the branch of behavioral medicine concerned with bidirectional interactions between behavior and the immune system).
Behavioral immunology ( Behavioral immunology” refers to the branch of behavioral medicine concerned with bidirectional interactions between behavior and the immune system).
Gene therapy is the therapeutic delivery of nucleic acid into a patient's cells as a drug to treat disease. The first attempt at modifying human DNA was performed in 1980 by Martin
Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990. Between 1989 and February
2016, over 2,300 clinical trials had been conducted, more than half of them in phase I. Not all medical procedures that introduce alterations to a patient's genetic makeup can be
considered gene therapy. Bone marrow transplantation and organ transplants in general have been found to introduce foreign DNA into patients. Gene therapy is defined by the
precision of the procedure and the intention of direct therapeutic effects.
Lectins are carbohydrate-binding proteins or glyco-proteins binding selectively without the involvement of enzymes, Gene responsible for expression lection found in chromosome 10q11.2-q21
Found in plnats grains, legume, soy bean, kidney bean
Lectins recognize tumor marker which play important role for diagnosing tumor cell, screening tumour and able to detect subtle neoplastic changes
Wagner College Forum for Undergraduate Research, Vol. 18 No. 1Wagner College
The Fall 2019 issue contains abstracts by Briana Bettencourt, Nicholas Buhta, Alexis Costa, Joseph Fabozzi, Sarah McGee, Kayla Diggs, Elizabeth Patton, Kelsey Savje, Oskar Sundberg and Kaela Teele. It also contains articles by Maria Humphries, Kathleen Leavey, Angela Zagami, Lindy Pokorny and L. Elise Whisler.
What is bioinformatics?
About human genome
Human genome project
Aim of human genome project
History
Sequencing Strategy
Benefits of Human Genome Project research
Disadvantages of human genome project
Conclusion
References
GENE THERAPY: TYPES, METHODS, FACTORS AND STANDARDS AND ITS APPLICATION IN HEALTHCARE FIELD
INVIVO THERAPY AND EXVIVO THERAPY
CHEMICAL AND PHYSICAL METHODS TO CARRY ON GENE THERAPY
DEFECTIVE GENE IDENTIFICATION IN GENE THERAPY AND TREATMENT OF GENETICALLY AFFECTED GENE BY GENE THERAPY
Gene therapy is the therapeutic delivery of nucleic acid into a patient's cells as a drug to treat disease. The first attempt at modifying human DNA was performed in 1980 by Martin
Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990. Between 1989 and February
2016, over 2,300 clinical trials had been conducted, more than half of them in phase I. Not all medical procedures that introduce alterations to a patient's genetic makeup can be
considered gene therapy. Bone marrow transplantation and organ transplants in general have been found to introduce foreign DNA into patients. Gene therapy is defined by the
precision of the procedure and the intention of direct therapeutic effects.
Lectins are carbohydrate-binding proteins or glyco-proteins binding selectively without the involvement of enzymes, Gene responsible for expression lection found in chromosome 10q11.2-q21
Found in plnats grains, legume, soy bean, kidney bean
Lectins recognize tumor marker which play important role for diagnosing tumor cell, screening tumour and able to detect subtle neoplastic changes
Wagner College Forum for Undergraduate Research, Vol. 18 No. 1Wagner College
The Fall 2019 issue contains abstracts by Briana Bettencourt, Nicholas Buhta, Alexis Costa, Joseph Fabozzi, Sarah McGee, Kayla Diggs, Elizabeth Patton, Kelsey Savje, Oskar Sundberg and Kaela Teele. It also contains articles by Maria Humphries, Kathleen Leavey, Angela Zagami, Lindy Pokorny and L. Elise Whisler.
What is bioinformatics?
About human genome
Human genome project
Aim of human genome project
History
Sequencing Strategy
Benefits of Human Genome Project research
Disadvantages of human genome project
Conclusion
References
GENE THERAPY: TYPES, METHODS, FACTORS AND STANDARDS AND ITS APPLICATION IN HEALTHCARE FIELD
INVIVO THERAPY AND EXVIVO THERAPY
CHEMICAL AND PHYSICAL METHODS TO CARRY ON GENE THERAPY
DEFECTIVE GENE IDENTIFICATION IN GENE THERAPY AND TREATMENT OF GENETICALLY AFFECTED GENE BY GENE THERAPY
Shared By The Many: Advances in technology are allowing for the provision of affordable, decentralized healthcare for the masses and are lowering the barriers to entry in less developed markets.
The analysis in PSFK’s Future of Health Report has yielded a number of insights, the most evident of which is mobile technology as a catalyst for change. The mobile phone and connected tablet computer are allowing for the distribution of a broad range of medical and support services. This is especially important in countries with little or no healthcare infrastructure and areas in which there are few trained healthcare professionals. These technologies also allow trained professionals to perform quality control remotely.
Amongst the many significant developments is a shift towards one-on-one, in- field diagnostics and monitoring. Services that were once only available at a doctor’s office or hospital are now available on-demand through low-tech, affordable solutions. Personal systems allow for ‘good enough’ diagnostics that would have been difficult, expensive and timely to attain previously.
Using a basic phone with adapted software, a health worker can test for myriad symptoms - even cancer. This information can be relayed to a central medical care center where doctors and trained professionals can react to the data, provide prompt diagnosis and suggest treatment options. The ability to capture this data and get quick responses remotely means better healthcare, fewer trips to the hospital (which, for many means days away from home and family), and less time away from work.
A change is also occurring that is seeing increased access to and sharing of health information. This is made possible by the proliferation of systems designed to overcome infrastructure insufficiencies. these systems are enabling the broadcast of information and receipt of subsequent feedback in virtually any setting. From ‘town crier’ systems to ‘internet by text’, the collective knowledge found on the web is being made available to populations around the world who previously lacked access. The connectivity that is enabling the sharing of health information is also powering the growth of social networks focused on health and medical care. These networks are allowing professionals, health workers and individuals to connect and share knowledge quickly.
PSFK’s Future of Health Report details 15 trends that will impact health and wellness around the world. Simple advances such as off-the-grid energy and the introduction of gaming into healthcare service offerings sit alongside more future-forward developments such as bio-medical printing. It is our hope that this report will inspire your thinking and lead to services, applications and technologies which will allow for more available, quality healthcare.
For a download of this report - visit: http://www.psfk.com/future-of-health
The Now and Next of Learning and TechnologyDavid Kelly
These slides were used in support of a talk I deliver at conferences and events..
If you're interested in bringing this talk/workshop into your event or organization, please contact me at LnDDave@gmail.com.
How do we see the healthcare's digital future and its impact on our lives?Jane Vita
"Healthcare is undergoing major changes spurred on by, but not limited to, technology.
Digitalisation is changing the way we think about health, what taking care of it really entails, our personal role in healthcare systems and the way we interact with technology in the context of health.
In many ways, we are entering a post-institutional age of increased personal responsibility, which presents healthcare service providers and other players in the field with major opportunities and great risks. Technology has the potential to empower people and help them become more active in the management of their and their families’ health. This will change the relationship of the patient and the caregiver in profound ways." Mirkka Länsisalo
A co-creation with Mirkka Läansisalo and Sala Heinänen, at Futurice.
What is the best Healthcare Data Warehouse Model for Your Organization?Health Catalyst
Join Steve Barlow as he addresses the strengths and weaknesses of each of the following three primary Data Model approaches for data warehousing in healthcare:
1. Enterprise Data Model
2. Independent Data Marts
3. Late-binding Solutions
P4 Medicine: A Vision For Your Molecular HealthSachin Rawat
Medicine is undergoing tremendous change. Unlike today, medicine of tomorrow would be pro-active rather than reactive.Medicine would be personalized to individual patient's genome. It would predict, and hence prevent, diseases even before they manifest. Also, this medicine would require active societal participation to bring it from labs to clinics.
Dr. Leroy Hood lectured to a group of Ohio State University College of Medicine students and faculty on May 13, 2010 in advance of an announcement of a partnership between the Ohio State University Medical Center and the Institute for Systems Biology. The partnership will be known as
The Foundation of P4 Medicine Keynote Presentation as presented by Leroy Hood, M.D., PhD, at the Ohio State University Personalized Health Care National Conference 2010.
Proteome-Based Pathway Modelling of Psychiatric Disorders that describes a new analytical paradigm to definitively move research from plethoric statistical biomarkers.
The Max Planck Institute, BMsystems
In June this year, Prof Martin-Sanchez traveled to Heidelberg, Germany to represent HBIR and University of Melbourne participating in a three day scientific symposium "Biomedical Informatics: Confluence of Multiple Disciplines”.
These are the slides from the presentation he gave to the symposium.
PharmacoPsychiatry publishes the first invited review describing a productive vision of Systems Medicine that will change R&D organization and interactions between clinicians & researchers.
The invited review explains how the world\'s first explanation of the mechanisms of the Creutzfeldt-Jakob disease led to the discovery of a truly innovative psychiatric treatment
For most scientists and scientific organizations, external communications is an afterthought. In this age of “instant” news and nonstop social media feeds, how can scientists break through the noise and broaden the appeal of their research to garner media attention and grow public understanding? Hsiao-Ching Chou, the Director of Communications at Institute for Systems Biology, shares some insight about how she was able to transform the communications program at ISB from zero to a bustling network of news – and on a nonprofit budget.
Monica Orellana is a senior scientist at the Institute for Systems Biology. Her paper was published in PNAS in August 2011. Title: Marine microgels as a source of cloud condensation nuclei in the high Arctic.