- Retinal artery macroaneurysms (RAMs) are fusiform or saccular dilatations of the retinal arteries that commonly cause macular exudation and hemorrhage, resulting in decreased vision. - RAMs predominantly affect hypertensive females over 60 years of age and can be asymptomatic or cause vision loss from leakage, hemorrhage, or cystoid macular edema. - Treatment may include observation, laser photocoagulation to reduce leakage from the RAM, or anti-VEGF injections to decrease vascular permeability and exudation. Most RAMs have a good visual prognosis with these treatments or spontaneous involution.

1. Dr. Amey Tamhane

2. INTRODUCTION
RAMs are defined as fusiform or saccular dilatations of the retinal arteries, usually
emanating from the first three branches of the arteriolar tree.
They are commonly associated with macular exudation and haemorrhage, which may
result in decreased visual acuity.
Female preponderance (ratio of 3:1), typically after 60 years of age, and with a medical
history of systemic hypertension and/or arteriosclerotic vascular disease.
10 % of patients have bilateral disease and 20 % have multiple macro-aneurysms.
The term “simple RAM” refers to isolated vascular ectasia, while “complex RAM” is
used when the ectasia is accompanied by haemorrhage.

3. CLINICAL PRESENTATION
Often, RAM is noted on clinical examination but the patient is
asymptomatic.
The involved artery may be narrowed proximally and distally to the
macroaneurysm.
Severe vision loss can occur from leakage of the aneurysm with
resultant haemorrhage into the vitreous cavity, subhyaloid space
and/or intraretinally or subretinally.
Many times, “hourglass haemorrhages” defined as the simultaneous
presence of preretinal and subretinal haemorrhage, can be seen.
Serous fluid can also collect intraretinally, producing diffuse or focal
cystoid macular oedema with or without the accumulation of lipid
exudates.

4. DIFFERENTIAL DIAGNOSIS
Exudative ARMD
Branch Retinal Vein Occlusion
Capillary Hemangioma
Cavernous Hemangioma
Diabetic Macular Oedema
Subretinal neovascular membranes
Radiation Retinopathy
Leber Miliary Aneurysms

5. VASCULAR SIGNS & SITES
OF OCCURRENCE
Macroaneurysms more commonly affect the right eye than the left.
The supero temporal artery is most commonly involved.
However, macroaneurysms also have been reported in cilioretinal arteries, on the optic nerve head, and
associated with congenital retinal macrovessels.
Usually, leakage of protein-rich serum occurs, leading to circinate exudation and macular oedema.
Serous retinal detachment can occur.
Bleeding is a common complication of aneurysm formation and can occur beneath the retina, the retinal
pigment epithelium (RPE), or the internal limiting membrane (ILM), or into the vitreous.
Pulsatile flow occasionally is observed but does not necessarily indicate a higher risk of haemorrhage.

6. PATHOGENESIS
The pathogenesis of RAM is thought to be secondary to several
mechanisms causing blood vessel wall weakness and subsequent
aneurysmal dilatation.
Systemic arteriosclerosis Fibrosis of vessel wall Decreased
Elasticity Systemic Hypertension Macroaneurysm.
Histopathologically, RAMs are found to have arterial dilatation with
variable degrees of artery wall hyalinization and surrounding retinal
exudate or haemorrhages.
Microvascular abnormalities (eg. widening of the periarterial capillary free
zone, capillary dilation, nonperfusion, intra-arterial collaterals) have been
identified.
Lipid-laden macrophages, hemosiderin, and fibroglial reaction are also
observed.
Histopathology of a ruptured RAM with
preretinal, intraretinal and subretinal
hemorrhage.

7. IMAGING OF RAM
A complete assessment of RAM requires a combination of clinical examination and imaging
studies, such as B-scan ultrasonography, fundus fluorescein angiography (FFA), indocyanine
green angiography (ICGA), and optical coherence tomography (OCT).
B scan If extensive vitreous haemorrhage obscures the view of the fundus, ultrasound B scan
can be used to exclude conditions such as retinal tears, detachments, and breakthrough
haemorrhage from polypoidal choroidal vascuolopathies.
FFA The typical RAM fills up uniformly in the early phase, revealing a fusiform dilation of the
arteriole with late leakage. The presence of a thrombus may result in filling defects. Areas of
blocked fluorescence due to the overlying blood may also be present. With the aid of dynamic
FFA, pulsatility of the macroaneurysm may be observed in 10% of cases.
ICGA If significant haemorrhage renders FFA inconclusive, ICGA may be a useful alternative,
allowing deeper penetration through the areas of haemorrhage.

8. FFA VS. ICGA. In the presence of excessive blood with significant blocked hyperfluorescence, ICGA
may be superior to FFA. RAM is completely obscured by blood on FFA (2A) but can be seen clearly
on ICGA (2B).

9. IMAGING OF RAM
OCT SD-OCT enables visualization of the lesion as well as associated complications. The macroaneurysm
will appear as a round or oval hyperreflective lesion in the inner retinal layers. In addition, it may demarcate
the extent of lipid deposition and accumulation of intraretinal and/or subretinal fluid.
Diagnostic challenges Despite several imaging options at our disposal, diagnosing RAM may prove
challenging when extensive haemorrhage is present.
In such cases, examining the fellow eye closely may help guide the physician. Important diagnostic clues for
RAM include absence of drusen and the presence of significant hypertensive retinopathy in the fellow eye in
the setting of an asymmetric vascular lesion with lipid or blood concentrated around the bifurcation of an
arteriole in the affected eye.
Horizontal SD-OCT section scan showing sub- internal limiting membrane (ILM) haemorrhage in the scan passing through upper part of
haemorrhage and boat-shaped subhyaloid haemorrhage in lower part.

10. TREATMENT
The majority of RAMs can be observed, and many will spontaneously involute.
In a natural-history study, Cathleen McCabe and colleagues described a series of 41
patients with macular haemorrhages secondary to RAMs managed solely with
observation.
The patients average visual acuity at baseline was 20/200 or worse. After an average
follow-up of 15.7 months, 37 % of eyes achieved a final visual acuity of 20/40 or better,
29 % achieved 20/50 to 20/100, and 34 % were 20/200 or worse.
While good visual acuity outcomes can be achieved with observation alone, poorer
visual acuity was associated with macular pigmentary changes after resorption of blood.
McCabe CM, Flynn HW Jr, McLean WC et al. Nonsurgical management of macular hemorrhage secondary to retinal
artery macroaneurysm. Arch Ophthalmol 2000;118:780-785.

15. LASER TREATMENT
Intervention may be required in cases of exudative or hemorrhagic RAMs, or
recurrent/persistent cystoid macular oedema.
Laser photocoagulation, first described by J. Donald M. Gass in 1976, was shown
to reduce leakage in approximately 16 to 27 percent of RAMs.
Laser of the artery and surrounding area may decrease flow and intraluminal
pressure, thereby reducing the macroaneurysm.
However, this therapy can be associated with the risk of vascular occlusion, early
increase in exudates from selective reabsorption of fluid, arteriovenous shunts,
macular pucker and scotomas.

16. LASER
PHOTOCOAGULATION
The most frequently cited indication for laser photocoagulation of a
macroaneurysm is persistence or progression of macular exudation.
The current recommendation for photocoagulation of macroaneurysms is the
use of the argon green or yellow dye laser for direct photocoagulation of the
lesion.
Low power settings are preferred, sufficient to create a light to moderate burn
intensity, using a large spot size (500µm) and long-duration (0.5s) pulses
directly on the lesion, to avoid rupture of the RAM
It has been reported that only 16% to 27% of RAMs are successfully
thrombosed after treatment with laser photocoagulation.
Meyer JC et al. Graefes Arch Clin Exp Ophthalmol. 2015;253(4):537-541.

17. LASER HYAIOLODOTOMY
In the setting of dense subhyaloid
haemorrhage, YAG-laser hyaloidotomy has
been performed to release the sequestered
blood into the vitreous cavity.
Release of blood may reduce the risk of
macular scarring and epiretinal fibrosis.
This approach remains controversial due to
the possible complications of macular hole,
retinal detachment, or vitreous
haemorrhage requiring vitrectomy.
Ulbig MW et al. Arch Ophthalmol. 1998;116(11):1465-1469.

18. ANTI VEGF
Anti-vascular endothelial growth factor therapy has emerged as a useful treatment
modality for RAMs.
VEGF inhibition is thought to decrease vascular permeability, block angiogenesis
to reduce further bleeding and exudation, and decrease the binding of pro-
thrombotic VEGF receptor.
A recent report demonstrated improvement of vision from 20/60 to 20/30 in a
patient with a RAM and macular exudation after a series of six injections; however,
ultimately focal laser photocoagulation was needed due to recurrence of CME with
stabilization of vision at 20/30 at 19 months of follow-up.
Leung EH, Reddy AK, Vedula AS, Flynn HW Jr. Serial bevacizumab injections and laser photocoagulation for macular edema associated
with a retinal artery macroaneurysm. Clin Ophthalmol 2015;9:601-609.

19. SURGICAL EVACUATION
In rare settings in which vitreous haemorrhage is present and the etiology of bleeding is unclear, vitrectomy
may be indicated. However, removal of dense subretinal haemorrhage is very controversial and has the
potential to cause many serious complications.
In one study from Mark Humayun and co-workers described nine eyes with submacular haemorrhage
secondary to ruptured RAMs, treated with submacular surgery with tissue plasminogen activator-assisted
thrombolysis, showed that 89 percent of eyes achieved a corrected visual acuity of 20/60 or better.
These options are currently used less often with thin submacular haemorrhages, given the positive response
with anti-VEGF agents.

20. PROGNOSIS
The visual prognosis is excellent for many patients with macroaneurysm.
The natural history of these lesions suggests that most close spontaneously, with
restoration of near-normal vision.
In some patients, the Valsalva maneuver may be associated with an increased risk
of haemorrhage.
However, although reducing the risk of the Valsalva maneuver in patients with
active, pulsatile retinal macroaneurysms may be beneficial, this has not been
proven to reduce the incidence of haemorrhage in these patients.

21. COMPLICATIONS
Clinical complications of retinal macroaneurysms include vitreous haemorrhage, retinal
detachment, macular holes, and choroidal neovascular membrane formation.
Vision loss from macular oedema due to chronic exudation is well documented in many
patients, and laser treatment may be appropriate.
Vision loss resulting from retinal macroaneurysms usually results from scarring in the
macula due to either chronic oedema or haemorrhage.
Several studies suggests that patients with preretinal haemorrhage or vitreous
haemorrhage due to retinal macroaneurysms have a good visual prognosis.
In contrast, the visual prognosis is poor in patients with submacular haemorrhage.

22. TAKE HOME MESSAGE
RAMs are rare clinical findings occurring most often in older, hypertensive
women.
While anti-VEGF therapy can be a useful treatment option to improve vision and
decrease macular oedema, more complex RAMs may require laser
photocoagulation and / or surgical intervention.