This document summarizes a study conducted by the NYC Project Hypothermia Working Group to evaluate the effects of intra-arrest induction of therapeutic hypothermia via large-volume ice-cold saline infusion on survival outcomes for out-of-hospital cardiac arrest. The study found that administering large volumes of ice-cold saline during cardiac arrest resuscitation efforts improved rates of return of spontaneous circulation and survival to hospital discharge when compared to a control period without this intervention. Further research is still needed to evaluate the long-term effects and most appropriate patient populations.