Respiratory stimulants, or analeptics, are drugs that stimulate respiration and are useful in situations like coma, fainting, or respiratory insufficiency. They can act directly on the respiratory center or through reflex actions, but their use carries risks of adverse reactions such as overdose and tachycardia. These stimulants have applications in treating conditions like asthma and apnea in premature infants.

1. Respiratory
Stimulants
[ANALEPTICS]
Almas J. Momin

2. • Definition:
 These Are Those Drugs Which Can Stimulate The
Respiration And Can Have Resuscitative Value In
Coma And Fainting.
[Resuscitative Value – Property To Restore Consciousness]
 Lungs Are Unable To Eliminate Carbon Dioxide(CO2)
Or Do Not Get Sufficient Amount Of Oxygen(O2).

3.  Margin of Safety Is Narrow when They Stimulate The Respiration.
 Intake Of High Dose In Coma Patient Which May Get Convulsions.
 They May Help To Stimulate Coughing Which Help To Patient For Expel
Out Secretion.
 Mechanical Support To Respiration which is more effective And Safe.

4.  Stimulation Of Respiratory Organ And Their Functions.
 Respiratory Stimulants Occurs With Multiple Factors Like,
Allergens,
Neurological Functions,
Hypoxia, Etc.

5. • Role Of Analeptics:
 Overdose With Sedative/ Hypnotic.
 Suffocation On Drowning.
 Acute Respiration Insufficiency.
 Apnea In Premature Infants.

6. • Classification Of Respiration:
 Drugs Directly Acting On Respiratory Centre:
1. Caffeine
2. Bemegride
3. Etimizole
Drugs Acting By Reflex Action:
1. Cytition
2. Lobeline
 Drugs Shows Mixed Type Of Action:
1. Nikethamide
2. Carbogen

7. • Mechanism Of Action:
Low Doses
↓
Selective For The Respiratory
Centre
(Medulla Oblongata)
↓
Promoting Excitation Of
Central Neurons
↓
Respiratory Stimulation
1.

8. Stimulation Through Carotid
And Aortic Body
Chemoreceptors
↓
Respiratory Stimulation
↓
Falling Blood Pressure Rises
2.

9. • Adverse Drug Reactions:
1. Overdose ( Blood Pressure Increases)
2. Tachycardia (Heart Rate Increases)
3. Insomnia (Trouble Falling a Sleep)
4. Perspiration (Sweating)
5. Headache
6. Vomating
7. Cough
8. Convulsions
9. Hallucination

10. • Uses:
1.Asthma- 2.Respiratory Depression -

11. 3. Chronic obstruction Pulmonary Disorder (COPD)-
. 4. Apnea Of Prematurity-

12. • Marketed Products: