Dr. George L. Bakris, MD, prepared T2DM infographics for this CME activity titled "Show Me the Data: Improving Renal Outcomes With Glucose-Lowering Therapy in the Individualized Management of T2DM." For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at https://bit.ly/32r5mw6. CME credit will be available until November 1, 2021.
Diabetic nephropathy considered one of the most common complications of DM. This presentation answer the question are some diabetic patient immune to diabetic nephroapthy
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Cardiovascular safety of anti-diabetic drugs.Cardiovascular Outcome Trials ...magdy elmasry
Cardiologists and diabetes.Target organs and action mechanism of antidiabetic drugs.Cardiovascular Outcome Trials
( CVOTs ) in Diabetes.Completed and ongoing CVOTs in type 2 diabetes.Diabetes Medications
and
Cardiovascular Impact.Recommendations for management of diabetes
Cardiovascular safety of anti-diabetic drugs.
Dr. George L. Bakris, MD, prepared T2DM infographics for this CME activity titled "Show Me the Data: Improving Renal Outcomes With Glucose-Lowering Therapy in the Individualized Management of T2DM." For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at https://bit.ly/32r5mw6. CME credit will be available until November 1, 2021.
Diabetic nephropathy considered one of the most common complications of DM. This presentation answer the question are some diabetic patient immune to diabetic nephroapthy
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Cardiovascular safety of anti-diabetic drugs.Cardiovascular Outcome Trials ...magdy elmasry
Cardiologists and diabetes.Target organs and action mechanism of antidiabetic drugs.Cardiovascular Outcome Trials
( CVOTs ) in Diabetes.Completed and ongoing CVOTs in type 2 diabetes.Diabetes Medications
and
Cardiovascular Impact.Recommendations for management of diabetes
Cardiovascular safety of anti-diabetic drugs.
Glucagon like peptide-1 (GLP-1) is an incretin secretory molecule. GLP-1 receptor agonists (GLP-1RAs) are widely used in the treatment of type 2 diabetes (T2DM) due to their attributes such as body weight loss, protection of islet β cells, promotion of islet β cell proliferation and minimal side effects. Studies have found that GLP-1R is widely distributed on pancreatic and other tissues and has multiple biological effects, such as reducing neuroinflammation, promoting nerve growth, improving heart function, suppressing appetite, delaying gastric emptying, regulating blood lipid metabolism and reducing fat deposition. Moreover, GLP-1RAs have neuroprotective, anti-infectious, cardiovascular protective, and metabolic regulatory effects, exhibiting good application prospects. Growing attention has been paid to the relationship between GLP-1RAs and tumorigenesis, development and prognosis in patient with T2DM. Here, we reviewed the therapeutic effects and possible mechanisms of action of GLP-1RAs in the nervous, cardiovascular, and endocrine systems and their correlation with metabolism, tumours and other diseases.
Apelin and Sirtuin 1 Dysregulation induce Endocrine and Metabolic Disorders i...CrimsonPublishersGJEM
Apelin and Sirtuin 1 Dysregulation induce
Endocrine and Metabolic Disorders in Chronic Disease by Ian James Martins in Global Journal of Endocrinological Metabolism
COMPARATIVE ASSESSMENT OF THE EEFFECT OF ARGINASE INHIBITOR L-NORVALINE AND M...ShubhamBaliyan13
Having metabolic syndrome can induce the risk of developing especially Type 2 Diabetes, insulin resistance , Atherosclerosis, cardiovascular disease, visceral Obesity, Dyslipidemias.
This study aimed at determining the prevalence of metabolic syndrome ( MetS) and its individual components and the most critical predictive risk factors of MetS in Type 2 Diabetes .
Potential role of uric acid in correlation with epidemics of hypertension and...Apollo Hospitals
Diabetic nephropathy (DN) is a microvascular complication of Type 2 diabetes mellitus. Uric acid (UA) is the end product of purine nucleotide metabolism and its primary mode of clearance is by renal excretion. Modifiable factors such as blood pressure, albuminuria, glycemic control, etc., play an important role in the progression of DN and none of them are curative. Hence, there is a pressing interest to identify other potentially modifiable factors such as UA in the progression of DN.
Study of Endothelial Dysfunction in Type 2 Diabetes Mellitusiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Association of cardio metabolic risk factors, serum nitric oxide metabolite a...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
1. Research Findings
Dr. PM PiattiDr. PM Piatti
Scientific InstituteScientific Institute
San RaffaeleSan Raffaele
MilanoMilano
2. PIATTI PM, MONTI LD, CONTI M,
BARUFFALDI L, GALLI L, PHAN VC,
GUAZZINI B, PONTIROLI AE, POZZA
G
Hypertriglyceridemia and
hyperinsulinemia are potent inducers of
endothelin-1 release in man.
Diabetes, 45:316-321, 1996.
3. The purpose of the study was to evaluate
fasting endothelin-1 levels in subjects with
syndrome X, in subjects with insulinoma,
and in normal subjects.
The single and synergistic contributions of
insulin and triglyceride levels to
endothelin-1 release were studied in
normal subjects.
Piatti et al Diabetes 1996; 45: 316-321
4. Subjects with metabolic syndrome X
showed higher endothelin-1 levels than
normal subjects and subjects with
insulinoma.
These levels were reproduced in normal
subjects by a simultaneous increase in
insulin and triglyceride levels.
Piatti et al Diabetes 1996; 45: 316-321
5. PIATTI PM, MONTI LD, VALSECCHI
G, CONTI M, NASSER R, GUAZZINI
B, FOCHESATO E, PHAN VC,
PONTIROLI AE, POZZA G
Effects of low dose heparin infusion on
arterial endothelin-1 release in man.
Circulation, 94:2703-2707, 1996.
6. The aim of this study was to evaluate the
effect of low-dose heparin infusion on
arterialized endothelin-1 (ET-1) release
in the presence of fasting or high insulin
levels in healthy humans.
Piatti et al Circulation 1996; 94:2703-07
7. Piatti et al Circulation 1996; 94:2703-07
The present study showed that it is
possible to decrease ET-1 levels by use of
low-dose heparin infusion in humans. This
effect seems mediated by a simultaneous
increase in nitric oxide levels and is
completely reversed by a mild increase in
insulin concentrations.
8. PIATTI PM, MONTI LD, GALLI L,
FRAGASSO G, VALSECCHI G,
PONTIROLI AE
Relationship between endothelin-1
concentrations and the metabolic
alterations typical of the Insulin
Resistance Syndrome.
Metabolism 49:748-752, 2000
9. The purpose of the study was to examine the
relationship between the endothelin-1 (ET-1)
concentration and the metabolic variables
characteristic of the insulin resistance syndrome
([IRS] hyperinsulinemia, insulin resistance,
hypertriglyceridemia, low high-density
lipoprotein [HDL] cholesterol, visceral obesity,
and glycemic abnormalities). The measurement
of circulating ET-1 is a well-recognized marker
of endothelial atherosclerotic and cardiovascular
disease.
Piatti et al. Metabolism 2000, 49:748-52
10. Piatti et al. Metabolism 2000, 49:748-52
At simple regression analysis, ET-1 levels
significantly correlated with insulin, glycosylated
hemoglobin, body weight, waist to hip ratio, and
triglyceride values. At multiple regression
analysis, only triglycerides (p<0.009) and
glycosylated hemoglobin (p<0.001) remained
independently correlated with ET-1.
This cross-sectional study indicates that
glycosylated hemoglobin and triglycerides are
independently correlated with ET-1 levels in
patients with IRS.
11. PIATTI PM, MONTI LD, ZAVARONI
I, VALSECCHI G, SOLERTE SB,
POZZA G, PONTIROLI AE, REAVEN
G
Alterations in Nitric Oxide/Cyclic-GMP
Pathway in Non Diabetic Siblings of
Patients with type 2 Diabetes
J Clin Endocrinol Metab 85:2416-2420,
2000
12. In this study, we have compared
resistance to insulin-mediated glucose
disposal and plasma concentrations of
nitric oxide (NO) and cyclic-GMP in
healthy volunteers with or without at
least one sibling and one parent with
type 2 diabetes.
Piatti et al. JCEM 2000, 85:2416-2420
13. Piatti et al. JCEM 2000, 85:2416-2420
We demonstrated that alterations of
the NO/cyclic-GMP pathway seem to
be an early event in nondiabetic
individuals with a family history of
type 2 diabetes and these changes are
correlated with the degree of insulin
resistance.
14. PIATTI PM, MONTI LD,
VALSECCHI G, MAGNI F, SETOLA
E, MARCHESI F, GALLI-KIENLE M,
POZZA G, ALBERTI KGMM
Long-term oral L-arginine
administration improves peripheral
and hepatic insulin sensitivity in type 2
diabetic patients.
Diabetes Care 24: 875-880, 2001
15. Piatti et al. Diabetes Care 2001, 24:875-880
The aim of this study was to evaluate
whether long-term administration of
arginine acting through a normalization
of NO/cyclic-guanosine-3' 5'-cyclic
monophosphate (cGMP) pathway was
able to ameliorate peripheral and
hepatic insulin sensitivity in 12 lean type
2 diabetic patients.
16. Piatti et al. Diabetes Care 2001, 24:875-880
We found that, in lean type 2 diabetic
patients, treated with diet alone, L-
Arginine treatment significantly
improved peripheral and hepatic
insulin sensitivity.
17. FRAGASSO G, PIATTI PM, MONTI LD,
CHUNZENG L, VALSECCHI G, SETOLA
E, PALLOSHI A, POZZA G,
MARGONATO A, CHIERCHIA S
Acute effects of heparin administration on
the ischemic threshold of patients with
coronary artery disease: Evaluation of the
protective role of the metabolic modulator
trimetazidine.
J.Am.Coll.Cardiol. 39:413-419, 2002
18. Fragasso, Piatti et al. J Am Coll Cardiol 2002, 39:413-419
We sought to assess the effects of heparin
and the potential protective effects of
trimetazidine (TMZ) on exercise
performance, plasma nitric oxide (NO),
endothelin-1 (ET-1) and free fatty acid
(FFA) release in patients with stable
coronary artery disease (CAD).
19. Fragasso, Piatti et al. J Am Coll Cardiol 2002, 39:413-419
In patients with CAD, heparin reduces the
ischemic threshold. Trimetazidine reduces the
effects of heparin, probably by inhibiting FFA
oxidation and enhancing glucose metabolism.
The concomitant novel observation of reduced
ET-1 release is likely to be also dependent on
TMZ-induced improvement of endothelial
metabolism or reduction of myocardial
ischemia.
20. MONTI LD, ALLIBARDI S, PIATTI PM,
VALSECCHI G, COSTA S, POZZA G,
CHIERCHIA S, SAMAJA M
Triglycerides impair post-ischemic recovery
in isolated hearts: roles of endothelin-1 and
trimetazidine.
Am J Physiol Heart Circ Physiol 281:H1122-
30, 2001
21. Monti, Piatti et al. Am J Physiol Heart Circ Physiol 2001:281:H1122-30
There is growing evidence that
hypertriglyceridemia exacerbates
ischemic injury. We tested the
hypothesis that triglycerides impair
myocardial recovery from low-flow
ischemia in an ex vivo model and that
such an effect is related to endothelin-1.
22. Monti, Piatti et al. Am J Physiol Heart Circ Physiol 2001:281:H1122-30
We conclude that high triglyceride
levels impair myocardial recovery
after low-flow ischemia in association
with endothelin-1 release. The
endothelium-mediated effect of
triglycerides on both contractile
recovery and endothelin-1 release is
prevented by 1 microM trimetazidine.
23. PIATTI PM, FRAGASSO G, MONTI LD,
CAUMO A, PHAN CV, VALSECCHI G,
COSTA S, FOCHESATO E, POZZA G,
PONTIROLI AE, CHIERCHIA S
Endothelial and metabolic characteristics of
patients with angina and angiographically
normal coronary arteries. Comparison with
subjects with insulin resistance syndrome
and normal controls.
J.Am.Coll.Cardiol. 34:1452-1460, 1999
24. This study was performed to
characterize the endothelial and
metabolic alterations of patients with
angina and angiographically normal
coronary arteries ("cardiac" syndrome
X [CSX]) compared with subjects with
insulin resistance syndrome
("metabolic" syndrome X [MSX]) and
normal controls.
Piatti et al. J Am Coll Cardiol 1999, 34:1452-60
25. Piatti et al. J Am Coll Cardiol 1999, 34:1452-60
We observed that blunted nitric oxide
and endothelin responsiveness to
intravenously infused insulin is a typical
feature of patients with angina pectoris
and angiographically normal coronary
arteries and may contribute to the
microvascular dysfunction observed in
these subjects.
26. PIATTI PM, FRAGASSO G, MONTI LD,
SETOLA E, LUCOTTI P, FERMO I, PARONI
R, GALLUCCIO E, POZZA G, CHIERCHIA
S, MARGONATO A
Acute Intravenous L-Arginine Infusion
Decreases Endothelin-1 Levels and Improves
Endothelial Function in Patients with Angina
Pectoris and Normal Coronary Arteriograms:
Correlation with ADMA Levels.
Circulation 2003:107:429-36.
27. We tested the hypothesis that
asymmetric dimethylarginine (ADMA)
levels could be elevated and influence
endothelin-1 and nitric oxide release
and action in patients with cardiac
syndrome X (CSX). In addition, we
evaluated whether an intravenous
infusion of L-arginine would improve
endothelial function in these subjects.
Piatti et al. Circulation 2003, 107:429-36
28. We demonstrated that ADMA levels are
increased in patients with CSX and positively
correlated with basal endothelin-1 levels and
negatively with insulin-induced incremental
levels of NOx.
An increment in nitric oxide availability by an
acute L-arginine infusion, decreases endothelin-
1 levels and therefore, improves endothelial
function in patients with CSX.
These data suggest that increased ADMA levels
play a role in the abnormal vascular reactivity
that is observed in patients with CSX.