The inner lining of the uterus is called the endometrium. During pregnancy, the endometrium thickens and develops glands and blood vessels to form the placenta, which supplies nutrients and oxygen to the developing fetus. If implantation does not occur, the endometrial lining is shed through menstruation. The uterus grows and changes throughout pregnancy under the influence of hormones to support gestation, the carrying of the fetus for approximately 40 weeks.
Introduction to female reproductive physiology (the guyton and hall physiology)Maryam Fida
Introduction to female reproductive physiology
Formation of female gametes, ova
Reception of male gametes, spermatozoa
Provision of suitable environments for fertilization of the ovum by spermatozoa and development of the resultant fetus
Parturition (childbirth)
Lactation, the production of breast milk, which provides complete nourishment for the baby in its early life
Onset of adult sexual life
Developing of female glands
Enlargement of breasts and erection of nipples
Growth of body hair, most prominently underarm and pubic hair
Greater development of thigh muscles behind the femur, rather than in front of it
Widening of hips
lower waist to hip ratio than adult males
Smaller hands and feet than men
Rounder face
Smaller waist than men
Changed distribution in weight and fat; more subcutaneous fat and fat deposits, mainly around the buttocks, thighs, and hips
Effect of Estrogens on the Uterus and External Female Sex Organs
Enlargement of external genitalia due to fat deposition
Change of Vaginal epithelium from cuboidal to stratified
Increased size of uterus after puberty
Proliferation of endometrial stroma
Effect of Estrogens on the Fallopian Tubes
Glandular tissue proliferation
Number of ciliated epithelial cells increase
Effect of Estrogens on the Breasts
development of the stromal tissues of the breasts
Growth of an extensive ductile system
Deposition of fat in the breasts.
Effect of Estrogens on the Skeleton
Estrogens inhibit osteoclastic activity in the bones stimulating bone growth
uniting of the epiphyses with the shafts of the long bones
Osteoporosis of the Bones Caused by Estrogen deficiency in Old Age
increased osteoclastic activity in the bones
decreased bone matrix
decreased deposition of bone calcium and phosphate
Effect of Estrogens on Protein Deposition
Slight increase in total body protein
BMR increased only1/3rd as compared to testosterone
Increased deposition of fate in:
Subcutaneous tissue
Breasts, buttocks and thighs
Effect of Estrogens on Hair Distribution
No effect
Effect of Estrogens on the Skin
Makes skin soft and smooth
Increased skin vascularity
Effect of Estrogens on Electrolyte Balance
Slight sodium and water reabsorption
Introduction to female reproductive physiology (the guyton and hall physiology)Maryam Fida
Introduction to female reproductive physiology
Formation of female gametes, ova
Reception of male gametes, spermatozoa
Provision of suitable environments for fertilization of the ovum by spermatozoa and development of the resultant fetus
Parturition (childbirth)
Lactation, the production of breast milk, which provides complete nourishment for the baby in its early life
Onset of adult sexual life
Developing of female glands
Enlargement of breasts and erection of nipples
Growth of body hair, most prominently underarm and pubic hair
Greater development of thigh muscles behind the femur, rather than in front of it
Widening of hips
lower waist to hip ratio than adult males
Smaller hands and feet than men
Rounder face
Smaller waist than men
Changed distribution in weight and fat; more subcutaneous fat and fat deposits, mainly around the buttocks, thighs, and hips
Effect of Estrogens on the Uterus and External Female Sex Organs
Enlargement of external genitalia due to fat deposition
Change of Vaginal epithelium from cuboidal to stratified
Increased size of uterus after puberty
Proliferation of endometrial stroma
Effect of Estrogens on the Fallopian Tubes
Glandular tissue proliferation
Number of ciliated epithelial cells increase
Effect of Estrogens on the Breasts
development of the stromal tissues of the breasts
Growth of an extensive ductile system
Deposition of fat in the breasts.
Effect of Estrogens on the Skeleton
Estrogens inhibit osteoclastic activity in the bones stimulating bone growth
uniting of the epiphyses with the shafts of the long bones
Osteoporosis of the Bones Caused by Estrogen deficiency in Old Age
increased osteoclastic activity in the bones
decreased bone matrix
decreased deposition of bone calcium and phosphate
Effect of Estrogens on Protein Deposition
Slight increase in total body protein
BMR increased only1/3rd as compared to testosterone
Increased deposition of fate in:
Subcutaneous tissue
Breasts, buttocks and thighs
Effect of Estrogens on Hair Distribution
No effect
Effect of Estrogens on the Skin
Makes skin soft and smooth
Increased skin vascularity
Effect of Estrogens on Electrolyte Balance
Slight sodium and water reabsorption
Prenatal development includes the development of the embryo and of the fetus during a viviparous animal's gestation. Prenatal development starts with fertilization, in the germinal stage of embryonic development, and continues in fetal development until birth.
Prenatal development includes the development of the embryo and of the fetus during a viviparous animal's gestation. Prenatal development starts with fertilization, in the germinal stage of embryonic development, and continues in fetal development until birth.
With more and more businesses now trying to tout sustainability messaging, Green is the new “Black.” It seems that every company has a Green message these days but how do you translate that message to saving green.
Most companies want to go Green but do not possess the resources to develop an environmental action plan. To help, BMI+ImageNet has put together this checklist in order to assess a company’s Greenability.
Zeeniveaustijging, golfdempers en zeedijkrvandenhaak
Onze rivieren stijgen met het zeeniveau mee. De Westerschelde en de Nieuwe Waterweg zullen in de toekomst moeten worden gesloten. De zandsuppletie is niet vol te houden.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
3. The function of the endometrium as a lining of the
uterus to be an implantation site for a blastocyte
upon its arrival to the uterus. By that time, the
endometrium is a thick, blood vessel rich tissue
layer.
During pregnancy, the glands and blood vessels
increase in number and size which then forms the
placenta that supplies the baby with nutrients and
oxygen.
It consists of a single layer of columnar epithelium,
resting on a layer of connective tissue, which varies
in thickness according to hormonal influences -
the stroma.
4. Menstruation
The endometrial lining undergoes cyclic regeneration
It initially proliferates under the influence of estrogen. However,
once ovulation occurs, in addition to estrogen, the ovary will also
start to produce progesterone.
If the blastocycte does not implant and provide feedback to the
body with human cortico goandotropin and continued feedback
through pregnancy with placental progesterone and estrogen, the
endometrial lining is either reabsorbed (estrous cycle) or shed
(menstrual cycle).
The process of shedding involves the breaking down of the
lining, the tearing of small connective blood vessels, and the loss
of the tissue and blood that had constituted it through the vagina.
The entire process occurs over a period of several days.
Menstruation may be accompanied by a series of uterine
contractions; These help expel the menstrual endometrium.
5. Pregnancy
In case of implantation, it remains as decidua
which becomes part of the placenta; it
provides support and protection for the
gestation.
The glands and blood vessels in the
endometrium further increase in size and
number. Vascular spaces fuse and become
interconnected, forming the placenta, which
supplies oxygen and nutrition to
the embryo and fetus.
6. The organ in which the developing fetus
resides in is called the uterus.
7. The Uterus
The uterus (also know as the womb) is a
hollow, pear-shaped organ with a thick
muscular wall, a mucous membrane lining,
and a rich supply of blood. It is located in a
woman's lower abdomen between the
bladder and the rectum.
The narrow, lower portion of the uterus is the
cervix; the broader, upper part is the corpus.
The corpus is made up of two layers of
tissue.
8. The endometrial lining of the uterus that
contains a rich blood supply, reacts to
hormonal changes that prepare it to receive a
fertilized ovum that plants itself into the
endometrial wall. It provides nutrients and
protection for the baby.
9. The uterus during pregnancy
During pregnancy the uterus grows upwards out of the woman's pelvis.
The top of the uterus (or fundus) can be felt by your caregiver feeling
your belly after about 12 weeks of pregnancy. By 24 weeks of
pregnancy, the myometrium muscles start stretching upwards, forming
the thicker upper segment of the uterus. This leaves a thinner layer of
muscle below it, known as the lower segment. The lower segment
separates the cervix from the upper segment and has the role of 'taking
up' or absorbing the cervix as it dilates during labor.
The muscles in the lower segment encircle the lower third of the uterus
and is a relatively weaker layer of muscle with less blood supply,
compared to the upper segment. This is why the cut to perform
a Caesarean operation is done in the lower segment (across the top of
the pubic hairline), where it is less likely to cause excessive bleeding.
The uterus has a natural tendency to lean slightly towards the woman's
right side during later pregnancy, but is held in place by ligaments.
These ligaments stretch as the uterus grows, acting like supportive
anchors to stabilize it, while facilitating the baby's movements within.
11. Gestation
The carrying of an embryo or fetus inside a female animal.
Pregnancy can be divided into three trimesters, each three
months long. The first trimester is from the last period to the 13th
week, the second trimester is from the 14th to 27th week, and
the third trimester is from the 28th week through the 40th week.
Birth normally occurs at a gestational age of about 40 weeks,
though a normal range is from 37 to 42 weeks which is 9 months
and 1 week. Childbirth occurring before 37 weeks of gestation is
considered preterm, (premature) whereas childbirth after 42
weeks is considered post term (late). Preterm and low birth
weight babies make up the second leading cause of infant death
at about 17%. Preterm births solely consist of 12% of infant
deaths with an 84% majority within the 32–36 week period. It is
estimated that two million babies worldwide die annually within
24 hours of birth.