This document discusses tubulointerstitial diseases, which are disorders involving injury to the kidney tubules and interstitium. Tubulointerstitial diseases include acute tubular necrosis, acute or chronic tubulointerstitial nephritis, and conditions like reflux nephropathy. The document defines various tubulointerstitial diseases like pyelonephritis, which is a kidney infection that may cause symptoms like fever and back pain. Rare diseases like pyeloureteritis cystica are also discussed. The guidelines provide ICD-10 codes for classifying different types of tubulointerstitial and tubular diseases.

2. 
 Tubulointerstitial diseases are clinically
heterogeneous disorders that share similar features
of tubular and interstitial injury. In severe and
prolonged cases, the entire kidney may become
involved, with glomerular dysfunction and even
renal failure.
INTRODUCTION

3. 
 The primary categories of tubulointerstitial disease are
 Acute tubular necrosis
 Acute or chronic tubulointerstitial nephritis
 Contrast nephropathy is acute tubular necrosis caused by
an iodinated radiocontrast agent.
 Analgesic nephropathy, reflux nephropathy,
and myeloma kidney are types of chronic
tubulointerstitial nephritis.
 Tubulointerstitial disorders can also result from metabolic
disturbances and exposure to toxins.

4. 
 Renal tubulo-interstitial diseases includes
pyelonephritis and pyeloureteritis cystica
 Some drugs and heavy metals may induce renal
tubulo-interstitial diseases
 Some other renal tubulo-interstitial diseases like
balkan nephropathy, balkan endemic nephropathy

5. 
 Pyelonephritis is an inflammation of the
kidney tissue, calyces, and renal pelvis. It is
commonly caused by bacterial infection that has
spread up the urinary tract or travelled through the
bloodstream to the kidneys
 A similar term is "pyelitis" which means
inflammation of the pelvis and calyces
DEFINITIONS

6. 
 pyelitis together with nephritis is collectively known
as pyelonephritis.
 Severe cases of pyelonephritis can lead
to pyonephrosis (pus accumulation around the
kidney), sepsis (a systemic inflammatory response of
the body to infection), kidney failure and even death.

7. 
 fever
 accelerated heart rate
 painful urination
 abdominal pain radiating to the back
 nausea
 tenderness at the costovertebral angle
SIGNS&SYMPTOMS

8. 
 Pyeloureteritis cystica is a rare situation of the renal
pelvis and ureters, characterized by cystical
formations of the epithelium.
 The etiology is unknown and there is no specific
treatment. It is usually diagnosed accidently during
imaging of the upper urinary tract for different
reasons.

9. 
 Hydronephrosis in simple words water in kidney’s,
is a condition caused by urinary retention due to
obstruction of the free flow of urine from the kidney.
 Stricture of ureter is defined as narrowing of the
ureter lumen in size

10. 
 Balkan nephropathy also known as Balkan endemic
nephropathy-is a form of interstitial nephritis.

11. 
 Acute pyelonephritis-N10
 Chronic tubulo-interstitial nephritis- N11
 Tubulo-interstitial nephritis, not specified as acute or
chronic- N12
 Obstructive and reflux uropathy- N13
ICD-10-CM
GUIDELINES

12. 
 Drug- and heavy-metal-induced tubulo-interstitial
and tubular conditions- N14
 Other renal tubulo-interstitial diseases- N15
 Renal tubulo-interstitial disorders in diseases
classified elsewhere- N16
 https://www.medesunglobal.com

13. 
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