Theodore E. Harrison, MD presents on regenerative aesthetic procedures. He discusses his background and credentials in emergency medicine and anti-aging. Regenerative medicine uses cells, growth factors, and supplements to treat injury and disease, rather than surgery, drugs, or radiation. Procedures discussed include platelet-rich plasma injections for skin rejuvenation, hair regrowth, snoring treatment, and urinary incontinence; stem cell fat grafting; and prolotherapy. Costs range from $400-5000 depending on the procedure. Training is obtained through various conferences and institutes specializing in regenerative techniques.

1. Regenerative
Aesthetics
Look Better and Feel Younger
Theodore E. Harrison, MD MBA FACEP ABAARM

2. My Background
 B.A. Washington University
 M.D. Washington University
 M.B.A. University of Pennsylvania Wharton School
 Internship – Los Angeles County/University of Southern
California Medical Center
 Residency – Johns Hopkins Hospital, Emergency Medicine
 Board certified – Emergency Medicine
 Board certified – Anti-aging and Regenerative Medicine

3. Disclosures
 Rejuvacare Inc., Port Angeles, WA
 No commercial conflicts of interest

4. What is “Regenerative Medicine”?
 “Cellular Medicine”, “Cell Medicine”
 The use of cells and cell components to treat injury or
disease
 NOT surgery – although surgery is used for transplants
 NOT traditional drugs – although some medications, notably
bioidentical hormones, may be used
 NOT radiation therapy – although laser light may be used

5. Regenerative Modalities
 Platelet-Rich Plasma
 Laser light
 Stem cells
 Bioidentical hormones
 Supplements

6. Platelet-Rich Plasma (PRP)
 How is it similar to stem cells?
 Growth factors
 Cytokines

7. How do we get PRP?

8. What do platelets do?
 Stop bleeding
 Release cytokines and growth factors which:
 Attract stem cells
 Cause stem cells to replicate and differentiate
 Cause new blood vessel growth

9. The Healing Process

10. Skin Anatomy

11. Collagen and Hyaluronic Acid
 Essential components of skin
 Collagen
 Long fibrous molecules
 Strength
 Flexibility
 Hyaluronic Acid (HA)
 Absorbs water
 Hydration
 Softness
 Lubrication

12. Skin Loses Collagen with Age

13. Skin Loses HA with Age

14. This Leads to Thin, Weak, Dull,
Wrinkled Skin

15. First lines of defense
 Collagen – a protein
 Meat, cartilage
 Vitamin C
 Type I collagen supplements
 Hyaluronic Acid – a sugar polymer
 HA lozenges, capsules, tablets
 Topical creams and cosmetics

16. Regenerating Your Skin

17. Depends on Age and Skin
Condition
 30 to 40s: laser regeneration and/or PRP facial
 Regenerate collagen and epidermis
 45 to about 60: Vampire Facelift
 Regenerate collagen and epidermis
 Replace volume with HA
 About 55 and up: autologous stem cell fat graft
 Regenerate collagen and epidermis
 Replace volume with fat

18. Vampire (PRP) Facelift
 First inject HA
 Then inject PRP

19. Vampire Facelift Results

20. Hair Regrowth

21. Hair Loss
Dihydrotestosterone
Rx dependent on
Stem cell survival

22. PRP Hair Regeneration
 Anesthetize scalp
 Prepare mixture of
 PRP
 Vitamins
 Acell matrix
 Inject subcutaneously in grid pattern

23. Snoreplasty
 Quality of life issue
 May be sign of sleep apnea

25. What Causes Snoring?

26. The Snoreplasty Procedure
 Anesthetize soft palate
 Inject PRP under the inside skin layer
 ~80% effective

31. What the O-Shot Does
 Restores urinary continence
 Improves female sexual function

32. Urinary Stress Incontinence
 Inability to retain urine in bladder during coughing,
laughing, exercise, and other things that cause
increased intraabdominal pressure
 Causes
 Weakening of the pelvic floor muscles and ligaments from
 Childbirth
 Surgery
 Age

33. UI Anatomy

34. Consequences and Treatment
 Quality of life issues
 Inability to exercise
 Restriction of social activities
 Restriction of sexual activity
 Urinary tract infections
 Depression
 Treatments
 Weight loss
 Devices
 Drugs
 Surgery

35. The O-Shot Procedure

36. Efficacy
 No controlled trials
 One small (n=9) trial of a very similar technique
reported 100% success
 No reported complications or problems

37. Side Effects
 Improvements in sexual function for women with:
 Female Sexual Arousal Disorder
 Hypoactive Sexual Desire Disorder
 Female Orgasmic Disorder
 Dyspareunia
 About 20% (reported) prevalence total

38. Side Effects include
 Greater arousal from clitoral stimulation
 Younger, smoother skin of the vulva (lips of the vagina).
 A tighter introitus (vaginal opening)
 Stronger orgasm
 More frequent orgasm
 Increased sexual desire
 Increased ability to have a vaginal orgasm
 Decreased pain for those with dyspareunia (painful intercourse)
 Increased natural lubrication
 Effects seem to wear off in about 18 months

39. Caveat Emptor
 No clinical trials or case series
 How much placebo effect?
 Very difficult to measure some of these clinical
outcomes

40. Where do docs learn this stuff?
 Mostly from each other. There are no formal training
programs.
 Ageless Regenerative Institute, Florida
 U.S. Stem Cell Training, Florida
 Charles Runels MD, Alabama
 TOBI Conference
 Regenerative Medicine Practice Conference

41. How do I find a competent
Doctor?
 VFL & O-Shot
 Must be trained by Dr. Runels
 Trademarks licensed by Dr. Runels
 Stem cell fat graft
 Ageless Regenerative Institute
 US Stem Cell Training
 Bioheart Inc.
 Prolotherapy
 Hackett-Hemwall Foundation
 American Association for Orthopedic Medicine

42. How much does it cost?
 Facelift
 Vampire: ~US$1900
 Fat graft: ~US$5000
 Hair regeneration: ~US$1000
 Snoreplasty: ~US$400
 O-Shot: ~US$500-900
 Prolotherapy
 Low back, Neck: ~US$400-700
 Knee, Shoulder, Hip: ~US$250-500

43. Resources
 http://www.oshot.info/
 http://vampirefacelift.com
 http://nyhairloss.com/hair-regeneration-acell-
extracellularmatrix
 Prolotherapy
 Getprolo.com
 AAOM

44. Today on Amazon.com!
FREE!