Karen Zapata Montenegro
Dermatology and Dermatology surgery
CSS
 Introduction
UV Radiation
Concept
UV radiation damage
Photoprotection
Concept
• Isaac Newton.
• “Colors phenomenon”1666
•William Herschel.
•Infrared radiation
1800
•Johann Ritter.
• Ultraviolet radiat...
 Ultraviolet light or
ultraviolet
radiation?
 “beyond violet”
 Exposure to UV and
its several sequellae
◦ 1932 Copenhag...
Less than
9% UV
Elliptical orbit
◦ 3.4 % perihelion (January 3)
◦ Aphelion (July 5)
◦ 7% UVR variation
UV radiation
UV
Radiation
Hour
Month
of the
year
Geographic
position
Sun
Position
UVB 5%
UVA 95%
UVB causes
80% skin
damage
Clouds
decrease
UV
radiation
Chlorofluorocarbon
decreases ozone layer
Maverakis ...
Measure of the amount UVR at the surface, during
maximum radiation
Scale 0-11
1 unit = 25 miliWatt/m2
UV-B index
Snow Desert area
90%
5% 15-30%
Climatic
changes
Photosynthesis
Food
Chain
Living
forms
Energy
source
Elevates mood and improves
energy
5 to 20 minutes of daily exposure
Vitamin D production
Skin cancer
Mutagenic
effects
Eye DamageImmune
system
alteration
Skin cancer
ICAM-1
Immune System alteration
DNA
Mutagenic
effects
Malignancy
Melanin
Genetics
Environment
Family
History
An estimaded 3.5 millions of new cases each year in USA. 1/5 during
lifetime. The most common skin cancer.
Outdoor
activit...
 Most common cancer in humans
 3-8% of annual increase since 1960
 Firm association with UV exposure
 40 -50% recurren...
• Intermittent exposure
• Childhood exposureCBC
• Chronic exposure
CEC
3-7% increase
since 1970
Annual incidence
7.89 to 22.52
for each 100000
More related with
mortality
Kanavy H, Gerstenblith...
Melanoma geographical distribution is bigger next to this
area. 1% decrease in ozone layer increase melanoma
mortality 1-2...
Chronic and
intermittent
Indoor tanning
Skin cancer risk
factor since
2009
High-altitude regions tend to have a higher
melanoma rate that may be related to the
higher UV fluences (J/cm2) noted at t...
Other diseases
Key points
Gilaberte Y, González S. Actas Dermo-Sifiliográficas. 2010; 101: 659-72
Gilaberte Y, González S. Actas Dermo-Sifiliográficas. 2010; 101: 659-72
 Sunscreens are photochemical systems that
absorb or reflect UV radiation.
 Frequently use of sunscreens is the best
pho...
Absorption
Dispersion
UVR
Chemical or physical filters
Reflection
 La capacidad de eritema depende
◦ Longitud de onda de radiación
◦ Fotosensibilidad del individuo
◦ DEM uso estudios obse...
 La capacidad de eritema depende
◦ Longitud de onda de radiación
◦ Fotosensibilidad del individuo
◦ DEM uso estudios obse...
FILTERS ACTION SPECTRUM
INORGÁNICOS- FÍSICOS
Dióxido de titanio al 25% 350 UVA, UVB
Óxido de cinc al 25% 350 UVA, UVB
ORGÁ...
FILTERS ACTION SPECTRUM
Filtros para UVB
Aminobenzoatos (derivados del PABA)
PABA al 1 5% 283 UVB
Padimato O (octil dimeti...
20 min before and 2 - 3
hours
 SPF 30 (97.5 UVB)
◦ 370nm
 High UVA protection
SPF 30
UVA high
protection
50- 80% solar damage is
before 18
Correct solar protection
Walker D. Journal of Pediatric nursing. 2011 Article in press
UPF higher than 40
Dark colors, nylon and
polyester
DFMO: difluorometilornitina
Camp et al. Semin Cutan Med Surg. 2011; 30: 6-13
Sunlight and Skin Cancer
Sunlight and Skin Cancer
Sunlight and Skin Cancer
Sunlight and Skin Cancer
Sunlight and Skin Cancer
Sunlight and Skin Cancer
Sunlight and Skin Cancer
Sunlight and Skin Cancer
Sunlight and Skin Cancer
Sunlight and Skin Cancer
Sunlight and Skin Cancer
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Sunlight and Skin Cancer

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Sunlight and Skin Cancer

  1. 1. Karen Zapata Montenegro Dermatology and Dermatology surgery CSS
  2. 2.  Introduction UV Radiation Concept UV radiation damage Photoprotection
  3. 3. Concept
  4. 4. • Isaac Newton. • “Colors phenomenon”1666 •William Herschel. •Infrared radiation 1800 •Johann Ritter. • Ultraviolet radiation1801 Diffey B. Methods. 2002; 28: 4-13
  5. 5.  Ultraviolet light or ultraviolet radiation?  “beyond violet”  Exposure to UV and its several sequellae ◦ 1932 Copenhaguen  UVC Maverakis E, et al. Journal of Autoimmunity. 2010; 34: 47-57
  6. 6. Less than 9% UV
  7. 7. Elliptical orbit ◦ 3.4 % perihelion (January 3) ◦ Aphelion (July 5) ◦ 7% UVR variation UV radiation
  8. 8. UV Radiation Hour Month of the year Geographic position Sun Position
  9. 9. UVB 5% UVA 95% UVB causes 80% skin damage Clouds decrease UV radiation Chlorofluorocarbon decreases ozone layer Maverakis E, et al. Journal of Autoimmunity. 2010; 34: 47-57
  10. 10. Measure of the amount UVR at the surface, during maximum radiation Scale 0-11 1 unit = 25 miliWatt/m2 UV-B index
  11. 11. Snow Desert area 90% 5% 15-30%
  12. 12. Climatic changes Photosynthesis Food Chain Living forms Energy source
  13. 13. Elevates mood and improves energy
  14. 14. 5 to 20 minutes of daily exposure Vitamin D production
  15. 15. Skin cancer
  16. 16. Mutagenic effects Eye DamageImmune system alteration Skin cancer
  17. 17. ICAM-1 Immune System alteration
  18. 18. DNA Mutagenic effects Malignancy Melanin
  19. 19. Genetics Environment Family History
  20. 20. An estimaded 3.5 millions of new cases each year in USA. 1/5 during lifetime. The most common skin cancer. Outdoor activities UV artificial sources Ozone layer Camp et al. Semin Cutan Med Surg. 2011; 30: 6-13
  21. 21.  Most common cancer in humans  3-8% of annual increase since 1960  Firm association with UV exposure  40 -50% recurrent CBC  80% older than 60 year Madan V, Lear J, Szeimies R. Lancet. 2010; 375:373-85
  22. 22. • Intermittent exposure • Childhood exposureCBC • Chronic exposure CEC
  23. 23. 3-7% increase since 1970 Annual incidence 7.89 to 22.52 for each 100000 More related with mortality Kanavy H, Gerstenblith M. Seminars in cutaneous Medicine and surgery. 2011; 222-8
  24. 24. Melanoma geographical distribution is bigger next to this area. 1% decrease in ozone layer increase melanoma mortality 1-2%. Kanavy H, Gerstenblith M. Seminars in cutaneous Medicine and surgery. 2011; 222-8
  25. 25. Chronic and intermittent Indoor tanning Skin cancer risk factor since 2009
  26. 26. High-altitude regions tend to have a higher melanoma rate that may be related to the higher UV fluences (J/cm2) noted at these sites
  27. 27. Other diseases
  28. 28. Key points
  29. 29. Gilaberte Y, González S. Actas Dermo-Sifiliográficas. 2010; 101: 659-72
  30. 30. Gilaberte Y, González S. Actas Dermo-Sifiliográficas. 2010; 101: 659-72
  31. 31.  Sunscreens are photochemical systems that absorb or reflect UV radiation.  Frequently use of sunscreens is the best photoprotection strategy.  The first sunscreen was marketed in 1930  Actually there are 28 chemical filters in Australia, 26 in Europe and 14 in USA. Kockler J, Oelgemoller M, Robertson S, Glass B. Journal of Photochemistry and Photobiology. 2012; 1-17
  32. 32. Absorption Dispersion UVR Chemical or physical filters Reflection
  33. 33.  La capacidad de eritema depende ◦ Longitud de onda de radiación ◦ Fotosensibilidad del individuo ◦ DEM uso estudios observacionales SPF = ---------------- MED protected MED unprotected Kockler J, Oelgemoller M, Robertson S, Glass B. Journal of Photochemistry and Photobiology. 2012; 1-17
  34. 34.  La capacidad de eritema depende ◦ Longitud de onda de radiación ◦ Fotosensibilidad del individuo ◦ DEM uso estudios observacionales UVA FP = ---------------- MPD protected MPD unprotected DPM: dosis de pigmento mínima Kockler J, Oelgemoller M, Robertson S, Glass B. Journal of Photochemistry and Photobiology. 2012; 1-17
  35. 35. FILTERS ACTION SPECTRUM INORGÁNICOS- FÍSICOS Dióxido de titanio al 25% 350 UVA, UVB Óxido de cinc al 25% 350 UVA, UVB ORGÁNICOS - QUÍMICOS Filtros para UVA Benzofenonas Oxibenzonas al 6% 288-325 UVB, UVA II Sulisobenzonas al 10% 366 UVA Dioxibenzona al 3% 352 UVA Dibenzolimetanos Avobenzona 3% 360 UVA1 Antralatos Medalimato al 3% 340 UVAII Ecamsul (mexorilo SX) 345 UVB, UVA Ácido terephtalilideno diaalcanforsulfínico al 10%
  36. 36. FILTERS ACTION SPECTRUM Filtros para UVB Aminobenzoatos (derivados del PABA) PABA al 1 5% 283 UVB Padimato O (octil dimetil PABA) al 8% 311 UVB Cinamatos Cinoxato al 3% 289 UVB Octinoxate (octil metoxicinamato) al 7.5% 311 UVB Salicilatos Octilsalate (octil salicilato) al 5% 307 UVB Homosalat (homentil salicilato) al 15% 306 UVB Trolamina salicilato al 12% 306 UVB Otros Octocrileno al 10% 303 UVB, UVAII Ensulizolo al 4% 310 Metileno-bis-benzotriazolila Tetrametilbutifenol (Tinosorb M) al 10% 305- 360 UVB, UVA Filtro inorgánico y orgánico Bis-etilhexiloxifenol metoxifenil triazina (Tinosorb S) al 10% 310- 340 Moreno M, Moreno L. Rev Asoc Colomb Dermatol. 2009; 10: 1-9
  37. 37. 20 min before and 2 - 3 hours  SPF 30 (97.5 UVB) ◦ 370nm  High UVA protection SPF 30 UVA high protection
  38. 38. 50- 80% solar damage is before 18 Correct solar protection Walker D. Journal of Pediatric nursing. 2011 Article in press
  39. 39. UPF higher than 40 Dark colors, nylon and polyester
  40. 40. DFMO: difluorometilornitina Camp et al. Semin Cutan Med Surg. 2011; 30: 6-13

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