This document discusses reducing unnecessary antipsychotic medication use in dementia patients. It begins by outlining the risks of antipsychotic medications, including an FDA black box warning about increased mortality in elderly patients with dementia. It then discusses initiatives by CMS and others to reduce off-label and unnecessary antipsychotic use by 15% through improved behavioral interventions and regulatory oversight. The document emphasizes using a non-pharmacological ABC approach and emphasizes improving care through staff education, careful medication reviews, and data tracking of antipsychotic use.
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Questions
1.
Do you ever feel that taking your medications is a nuisance or inconvenience? Do you have a difficult time remembering to take your medications or forget?
•&νβσπ;&νβσπ;&νβσπ;&νβσπ;&νβσπ;&νβσπ;Developing a medication schedule, It is difficult to come up with a schedule to take medications every day for some patients. Collaboratively we need to come up with a convenient time to take the antidepressant and the other prescribed medication for them to be effective.
2.
Does your prescribed medications and treatment regimen still leave you feeling depressed? Do you have a difficult time adhering to a prescribed regimen?
•&νβσπ;&νβσπ;&νβσπ;&νβσπ;&νβσπ;&νβσπ;The patient discontinued his Effexor although it appeared to be effective. It is essential to find out the patient’s reason for not following the prescribed regimen and come up with a solution together.
•&νβσπ;&νβσπ;&νβσπ;&νβσπ;&νβσπ;&νβσπ;It is crucial for the patient to take his antidepressants accordingly, as well as not skip or alter the dosage, nor terminate the medication once you start feeling better.
3.
Have the side effects of your medications been difficult to cope with or manage? Do you sometimes stop taking your medications because of the adverse effects?
Sertraline has been prescribed in the past and discontinued several times. The patient experienced side effects of sexual dysfunction and stopped taking. Encourage the patient to monitor any side effects, physical and emotional changes or occurrences.
Stopping medications and treatment regimens prematurely or abruptly have been associated with high relapse rates and can cause serious withdrawal symptoms (Henssler, Heinz, Brandt, & Bschor, 2019).
Important People
Family members and other caregivers bring personal knowledge on the suitability or lack thereof regarding different treatments for the patient's circumstances and preferences (Smith, 2013). The patient is married, so I would address additional questions to his wife. After getting permission to discuss his medical records with his family members, I would ask the wife if she knew what medications her husband was taking? If she knew why he was taking them? Informed and en.
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Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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3. Antipsychotics
• Antipsychotic drugs (AP)
– 8 antipsychotic drugs approved in the US
• Only FDA approved for use in schizophrenia & bipolar
disease
• “Off label use”
• “Black Box warning” FDA
– Typical (TAP) – the most common example is
haloperadol (Haldol). Side effects were
common….
– Then came the atypical (AAP) antipsychotics…
4. Most Common atypical antipsychotics
Medication Most Common Brand Names
Aripiprazole Abilify
Clozapine Clozaril
Olanzapine Zyprexa
Quetiapine Seroquel
Risperidone Risperdal
Ziprasidone Geodon or Zeldox
Expensive, yet thought to be safer. Were heavily
marketed as the solution for “challenging behaviors”
5. FDA Black Box Warning
WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-
RELATED PSYCHOSIS
Elderly patients with dementia-related psychosis treated with antipsychotic drugs
are at an increased risk of death. Analyses of seventeen placebo-controlled trials
(model duration of 10 weeks) largely in patients taking atypical antipsychotic
drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times
the risk of death in placebo-treated patients. Over the course of a typical 10-week
controlled trial, the rate of death in drug-treated patients was about 4.5%,
compared to a rate of about 2.6% in the placebo group. Although the causes of
death were varied, most of the deaths appeared to be either cardiovascular (e.g.,
heart failure, sudden death) or infectious (e.g., pneumonia) in nature.
Observational studies suggest that, similar to atypical antipsychotic drugs,
treatment with conventional antipsychotic drugs may increase mortality. The
extent to which the findings of increased mortality in observational studies may be
attributed to the antipsychotic drug as opposed to come characteristic(s) of the
patients is not clear.
7. • In 2008, FDA extended the black box warning to the conventional
(first-generation) antipsychotics
– Elderly patients with dementia-related psychosis treated with conventional or
atypical antipsychotic drugs are at increased risk of death
– Antipsychotic drugs are not approved for the treatment of dementia-related
psychosis. Furthermore, there is no approved drug for the treatment of
dementia-related psychosis. Health care professionals should consider other
management options
– Physicians who prescribe antipsychotics to elderly patients with dementia-
related psychosis (“off-label” use) should discuss this risk of increased mortality
with their patients, patient’s families, and caregivers
Source: Information for Healthcare Professionals: Conventional Antipsychotics FDA ALERT [6/16/2008]
http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm124830.htm
7
8. Antipsychotic Risks
• Analyses of 17 placebo controlled trials (modal
duration of 10 weeks, largely in patients taking atypical
antipsychotic drugs, revealed a risk of death in the drug
treated patients of between 1.6 to 1.7 times that seen
in placebo treated patients. Over the course of a typical
10-week controlled trial, the rate of death in drug
treated patients was about 4.5% compared to a rate of
about 2.6% in the placebo group. Although the causes
of death were varied, most of the deaths appeared to
be either cardiovascular (e.g., heart failure, sudden
death) or infectious (e.g., pneumonia) in nature.
9. Why do we use these drugs?
• Strong belief in pharmacology as a solution
• Numerous studies show very modest improvements
– At best only 20-30% showed even marginal improvement in
behavior or function
– Thus 70-80% did not respond!
• Calculating the risk
– For every 53 dementia patients treated with these drugs – one
will die
– For every 9-25 that benefits – one will die
Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for
dementia: meta-analysis of randomized placebo-controlled trials. JAMA, Oct 19 2005;
294(15):1934-1943.
Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Atypical antipsychotic drugs and the risk of
sudden cardiac death. NEJM, Jan 15 2009; 360(3):225-235.
11. OIG Report
• Office of the Inspector General May 2011 Report
(Jan-June 2007 data): Medicare Atypical
Antipsychotic Drug Claims for Elderly Nursing
Home Residents
– Senator Charles Grassley initiated
• Using AP’s on demented elders is elder abuse
– 14% of elderly NH residents had claims for atypical
antipsychotics
– 83% of Medicare claims for AAP for elderly NH
residents were off-label use
– 22% of AAP were not administered according to CMS
standards regarding unnecessary drug use in NH’s
13. % use of antipsychotic meds
10%
20%
25%
30%
35%
15%
0%
5%
TN
LA
GA
TX
AL
VT
AR
MS
CT
KY
NH
ME
UT
MA
OK
ID
FL
MO
OH
NM
KS
AZ
IN
US
RI
2011
VA
WA
PA
IL
NV
SC
DE
NY
MT
State-State Average
NE
IA
SD
DC
NC
Off-Label Use of Antipsychotics
OR
WV
MD
ND
CO
Nat
Avg
CA
WY
WI
NJ
MN
MI
AK
HI
14. CMS Initiative
• Centers for Medicare & Medicaid Services (CMS):
New initiative to improve behavioral health &
reduce unnecessary antipsychotic use
– Kick-off national video stream March 29, 2012 with
two panels
• Clinical panel
• CMS officials panel
– Goal: reduce antipsychotic use by 15% by the end of
2012
– Began April 1, 2012
15. CMS Initiative
– National Action Plan
• Raising awareness
• Non-pharmacological interventions first
• Regulatory oversight
• Training
• Research
• Targeting patient-centered care, particularly those with
dementia
• PUBLIC REPORTING
16. www.nhqualitycampaign.org
• Advancing Excellence has added a new goal of
improving appropriate use of medications –
using reduction of inappropriate
antipsychotics as the first area of focus.
• Currently goals and targets are being created
and will be released Oct, 2012
• The Campaign website will also have links to
model practices and other NH tools for use
17. Facts about Human Behavior
• We begin to develop individual patterns of behavior at birth
• Generally we know what others mean by listening to what
they say and watching what they do
• In the absence of verbal communication we possess the
ability to understand what others are communicating
• If we lose the ability to speak our actions become our method
of communication
18. How dementia impacts human
behavior-Moderate Dementia
• Difficulty with short and long –term
memory. Struggles to learn new
things
• Difficulties with understanding and
being understood
• Knows comfort and discomfort
• Can’t self regulate emotions
• Often easily upset or frustrated
• Can become fearful
• May misinterpret the actions of
others
19. How dementia impacts human
behavior-Advanced Dementia
• Limited/no short and long-term
memory-often lives in the
moment
• Can’t learn new information or
pick up new routines
• Unable to carry on meaningful
conversation
• May appear withdrawn and can
have difficulty interacting or
responding to surroundings
20. In short – what we label as “behavior” in
dementia is really a method of
communication by the person affected. Our
job is to figure that out and respond
appropriately
21. THE REGULATIONS
State Operations Manual
Appendix PP - Guidance to Surveyors for Long
Term Care Facilities
F329 – Unnecessary Drugs
pp. 344 - 427
F428 – Drug (Medication) Regimen Review
pp. 536 - 551
http://www.cms.gov/manuals/Downloads/som107ap_pp_guidelines_ltcf.pdf
21
22. F329: Unnecessary Drugs
1. General.
Each resident’s drug regimen must be free from unnecessary
drugs. An unnecessary drug is any drug when used:
(i) In excessive dose (including duplicate therapy); or
(ii) For excessive duration; or
(iii) Without adequate monitoring; or
(iv) Without adequate indications for its use; or
(v) In the presence of adverse consequences which indicate the dose
should be reduced or discontinued; or
(vi) Any combinations of the reasons above.
22
23. F329: Unnecessary Drugs
2. Antipsychotic Drugs. Based on a comprehensive
assessment of a resident, the facility must ensure that:
(i) Residents who have not used antipsychotic drugs are not given
these drugs unless antipsychotic drug therapy is necessary to
treat a specific condition as diagnosed and documented in the
clinical record; and
(ii) Residents who use antipsychotic drugs receive gradual dose
reductions, and behavioral interventions, unless clinically
contraindicated, in an effort to discontinue these drugs.
23
24. F329: Intent and Goals
• The medication regimen helps promote or maintain
the resident’s highest practicable
mental, physical, and psychosocial well-being, as
identified by the resident and/or representative(s) in
collaboration with the attending physician and
facility staff;
• Each resident receives only those medications, in
doses and for the duration clinically indicated to
treat the resident’s assessed condition(s);
24
25. F329: Considerations
• The indications for initiating, withdrawing, or withholding
medication(s), as well as the use of non-pharmacological
approaches, are determined by assessing the resident’s
underlying condition, current signs and symptoms, and
preferences and goals for treatment. This includes, where
possible, the identification of the underlying cause(s), since a
diagnosis alone may not warrant treatment with medication.
25
26. F329: Medication Management
• Under these regulations, medication
management includes consideration of:
I. Indications for use of medication (including initiation or
continued use of antipsychotic medication);
II. Monitoring for efficacy and adverse consequences;
III. Dose (including duplicate therapy);
IV. Duration;
V. Tapering of a medication dose/gradual dose reduction for
antipsychotic medications; and
VI. Prevention, identification, and response to adverse
consequences.
26
27. F329: Medication Management
• Gradual Dose Reduction (GDR)
– The requirements underlying this guidance
emphasize the importance of seeking an
appropriate dose and duration for each
medication and minimizing the risk of adverse
consequences.
– The purpose of tapering a medication is to find an
optimal dose or to determine whether continued
use of the medication is benefiting the resident.
27
28. F329: Medication Management
• Gradual Dose Reduction (GDR)
– Tapering may be indicated when the resident’s
clinical condition has improved or stabilized, the
underlying causes of the original target symptoms
have resolved, and/or non-pharmacological
interventions, including behavioral
interventions, have been effective in reducing the
symptoms.
28
29. F428: MRR
• “Medication Regimen Review” (MRR) is a thorough
evaluation of the medication regimen of a
resident, with the goal of promoting positive
outcomes and minimizing adverse consequences
associated with medication. The review includes
preventing, identifying, reporting, and resolving
medication-related problems, medication
errors, or other irregularities, and collaborating
with other members of the interdisciplinary team.
29
30. Approach to Problematic Behavior:
“ABC” Framework
• “A-B-C” concept
– A: What are the antecedents to the behavior?
– B: What is the behavior?
– C: what are the consequences of the behavior?
– Two Case Studies – a tale of Esther and Walter
30
31. “Don’t leave me alone”
• Esther is in her room – she seems “agitated”, the room is
dark and she is alone – she starts to bang on the bed rail
and eventually yells
• An aide comes in to calm her down – but that works for
only a couple of minutes
• Staff finally bring her out to the nurses station where she
seems more happy
• When she goes back to her room – she starts her
vocalizations again – eventually striking out when the aide
comes in to “calm her down”
• If this continues for several days – what does Esther
“learn”?
• What are the ABC’s to this situation?
32. “I’ve had ENOUGH!”
• Walter has always been a “quiet man”. Worried he is
withdrawn the staff bring him to a day room that has a
piano, a bird, a TV and other loud activities
• Walter begins to get restless – and when an aide walks
by, he strikes out at her
• Walter is then put in his room for “time out” and he
seems much calmer
• The next day the same thing happens
• How long before Walter figures out the best way to get
out of the noisy setting is to hit someone?
• What are the ABC’s to this situation?
33. Putting Change into Practical Terms for your
Nursing Home
1. Consider a check-list before starting an antipsychotic
What is the indication? Is it an appropriate indication? Is it
caused by something else that needs to be addressed?
Is there a non-medication approach? Has such been tried? Is
there a reason why it should not be tried first?
If the medication is started – is it working? Are there adverse
affects? (have you documented both effect and adverse
reactions?) Has the individual’s function improved?
What is the shortest time and the lowest dose the person can
be on the drug? Can you stop after 2 weeks? 1 month?
Have you had a discussion with the family and/or legal
representative of the resident about the drug, the reasons for
its use, the risks and benefits?
34. Putting Change into Practical Terms
for your Nursing Home
2. Do you have a process to review each new start of an
antipsychotic drug with the IDT? Within 7 days?
3. Does your medical director work with the consulting
pharmacist to review residents who have been on
antipsychotics for longer than 3 months
4. Do you track incidence (number of new orders over a
given time period) and prevalence (number residents
who are on antipsychotics over a given time period)?
5. Do you share this data with your IDT? Medical
Director? Attending physicians?
35. Putting Change into Practical Terms for
your Nursing Home
6. What is your process for addressing individuals
who are admitted to the nursing home on an
antipsychotic?
– Why was the medication started and when?
– Has it been effective?
– Can the family or others identify what tends to get
the resident upset or frightened?
– Can the family or others share what activities ten to
give the individual pleasure or calm them down?
– Have you incorporated this into the care plan?
– Is it time to reduce or discontinue the antipsychotic?
36. Non-pharmacological Approaches to
Dementia Care
• Growing body of evidence to support the
effectiveness of behavioral or non-
pharmacological intervention or approaches
• It starts with a culture of comfort and person-
centeredness
• CMS and Advancing Excellence are building
clearinghouses for model programs and
outcomes to be replicated
• Success will require changes in beliefs by
staff, families, physicians and other clinicians
ACROSS settings of care
37. What you need to do now
• Make sure that all antipsychotic medication orders are
in compliance with F-329 and that your documentation
supports use, that you are monitoring for effect and
adverse events and that gradual dosage reductions
occur
• Review routine medication reviews by your consultant
pharmacist and review with your medical director
• Be prepared for public reporting (it is coming!) and
probably consent requirement (likely to follow)
• Start the dialogue with staff and families….
38. A New Framework
Remember when we believed that restraints were
necessary for safety and that it was impossible to
have a “restraint free” goal?
That same kind of thinking will get us to
Improved dementia care!